Magnesium sulfate treatment improves outcome in patients with subarachnoid hemorrhage: a meta-analysis study.

abstract：:Acute ischemic stroke (AIS) often results in degeneration of the blood-brain barrier (BBB), which can lead to vasogenic edema and an increased risk of intracerebral hemorrhage. Imatinib is an agent that may be able to protect the BBB and reduce the risk of the harmful consequences of BBB degeneration. We sought to mea...

journal_title：Translational stroke research

authors： Merali Z,Leung J,Mikulis D,Silver F,Kassner A

更新日期：2015-02-01 00:00:00

abstract：:Early infection after stroke is associated with a poor outcome. We aimed to determine whether delayed infections (up to 76 days post-stroke) are associated with poor outcome at 90 days. Data came from the international Efficacy of Nitric Oxide Stroke (ENOS, ISRCTN99414122) trial. Post hoc data on infections were obtai...

journal_title：Translational stroke research

authors： Learoyd AE,Woodhouse L,Shaw L,Sprigg N,Bereczki D,Berge E,Caso V,Christensen H,Collins R,Czlonkowska A,El Etribi A,Farr TD,Gommans J,Laska AC,Ntaios G,Ozturk S,Pocock SJ,Prasad K,Wardlaw JM,Fone KC,Bath PM,Truem

更新日期：2017-12-01 00:00:00

abstract：:Lifestyle risk factors, inflammation and genetics play a role in the development of atherosclerosis. We therefore studied Fc gamma receptor (FcγR) polymorphisms, interleukin (IL)-10 polymorphisms and other biomarkers related to carotid intima-media thickness (cIMT) in patients with ischemic stroke at a young age. Pati...

journal_title：Translational stroke research

authors： Waje-Andreassen U,Naess H,Thomassen L,Maroy TH,Mazengia KY,Eide GE,Vedeler CA

更新日期：2015-08-01 00:00:00

abstract：:Silent information regulator 1 (SIRT1) is a NAD+-dependent histone deacetylase that represses gene expression and plays a role in longevity. SIRT1 responds to diverse stress conditions and regulates metabolism in nutrient deficiency conditions; therefore, it is involved in adaptive pathways to better fulfill tissue ne...

journal_title：Translational stroke research

authors： Petegnief V,Planas AM

更新日期：2013-12-01 00:00:00

abstract：:We reported previously that both a cannabinoid receptor 2 (CB2R) agonist and a cannabinoid receptor 1 (CB1R) antagonist were protective in the treatment of transient middle cerebral artery occlusion/reperfusion injury (MCAO/R) and that they acted in a synergistic manner when administered in combination. The goal of th...

journal_title：Translational stroke research

authors： Zhang M,Mahadevan A,Amere M,Li H,Ganea D,Tuma RF

更新日期：2012-09-01 00:00:00

abstract：:This review focuses on assessment of behavioral outcomes following traumatic brain injury in juvenile animal models. In the 15 years since the first publication in this field, the majority of studies have used rats roughly equivalent to human toddlers in terms of brain development. Few studies have tested ages closer ...

journal_title：Translational stroke research

authors： Hartman RE

更新日期：2011-12-01 00:00:00

abstract：:Stroke prevention efforts typically focus on either ischemic or hemorrhagic stroke. This approach is overly simplistic due to the frequent coexistence of ischemic and hemorrhagic cerebrovascular disease. This coexistence, termed "mixed cerebrovascular disease", offers a conceptual framework that appears useful for str...

journal_title：Translational stroke research

authors： Fisher M,Vasilevko V,Cribbs DH

更新日期：2012-07-01 00:00:00

abstract：:Preconditioning is a paradigm in which sublethal stress-prior to a more injurious insult-induces protection against injury. In the central nervous system (CNS), preconditioning against ischemic stroke is induced by short durations of ischemia, brief seizures, exposure to anesthetics, and other stresses. Increasing evi...

journal_title：Translational stroke research

authors： Bell JD,Cho JE,Giffard RG

更新日期：2017-12-01 00:00:00

abstract：:Inflammation is a critical process behind cerebral aneurysm formation and rupture. Tumor necrosis factor alpha (TNF-α) is a key immune modulator that has been implicated in cerebral aneurysm pathophysiology. This may occur through TNF-α-mediated endothelial injury, smooth muscle cell phenotypic modulation, recruitment...

journal_title：Translational stroke research

authors： Starke RM,Raper DM,Ding D,Chalouhi N,Owens GK,Hasan DM,Medel R,Dumont AS

更新日期：2014-04-01 00:00:00

abstract：:In a porcine ischemic stroke model, we sought to compare the acute predicted infarct core volume (PIV) defined by CT perfusion (CTP)-hemodynamic parameters and MR-diffusion-weighted imaging (MR-DWI)/apparent diffusion coefficient (ADC), with the true infarct core volume (TIV) as defined by histology. Ten Duroc-cross p...

journal_title：Translational stroke research

authors： d'Esterre CD,Aviv RI,Morrison L,Fainardi E,Lee TY

更新日期：2015-06-01 00:00:00

abstract：:Rodent animal models of stroke are widely used with brain ischemia inducible by various occlusion methods. Permanent or transient occlusion of the distal portion of the middle cerebral artery (MCAO) offers a reproducible model with low mortality rates, and it is the most likely model of choice for mid- and long-term s...

journal_title：Translational stroke research

authors： Rosell A,Agin V,Rahman M,Morancho A,Ali C,Koistinaho J,Wang X,Vivien D,Schwaninger M,Montaner J

更新日期：2013-06-01 00:00:00

abstract：:Previous studies showed that complement activation is associated with poor functional outcome after aneurysmal subarachnoid hemorrhage (SAH). We investigated whether complement activation is underlying brain injury after aneurysmal SAH (n = 7) and if it is an appropriate treatment target. We investigated complement ex...

journal_title：Translational stroke research

authors： van Dijk BJ,Meijers JCM,Kloek AT,Knaup VL,Rinkel GJE,Morgan BP,van der Kamp MJ,Osuka K,Aronica E,Ruigrok YM,van de Beek D,Brouwer M,Pekna M,Hol EM,Vergouwen MDI

更新日期：2020-08-01 00:00:00

abstract：:Subarachnoid haemorrhage (SAH) is a devastating disease and a major burden on society. Despite this, pharmacological treatment options are limited. Appropriate animal modelling of SAH is essential for the development of neuroprotective drugs, but experimental SAH often fails to produce widespread neuronal loss, as fre...

journal_title：Translational stroke research

authors： Greenhalgh AD,Rothwell NJ,Allan SM

更新日期：2012-03-01 00:00:00

abstract：:This study was aimed to test the hypothesis that human bone marrow stromal cells (hBMSC) expanded in fetal calf serum (FCS)-free, platelet lysate (PL)-containing medium would retain their capacity of migration, survival, and neural differentiation when transplanted into the infarct brain, using serial in vivo magnetic...

journal_title：Translational stroke research

authors： Ito M,Kuroda S,Sugiyama T,Shichinohe H,Takeda Y,Nishio M,Koike T,Houkin K

更新日期：2011-09-01 00:00:00

abstract：:Intracerebral hemorrhage is by far the most destructive form of stroke. Apart from the management in a specialized stroke or neurological intensive care unit (NICU), no specific therapies have been shown to consistently improve outcomes after ICH. Current guidelines endorse early aggressive optimization of physiologic...

journal_title：Translational stroke research

authors： Rincon F,Mayer SA

更新日期：2012-07-01 00:00:00

abstract：:Magnetic resonance imaging (MRI) has dramatically changed our ability to diagnose and treat stroke as well as follow its evolution and response to treatment. Early stroke and ischemia can be visualized using diffusion-weighted imaging that utilizes water diffusion within tissues as a reporter for evolving neuropatholo...

journal_title：Translational stroke research

authors： Obenaus A,Ashwal S

更新日期：2012-03-01 00:00:00

abstract：:Poor clinical outcomes despite endovascular therapy (EVT) are common in patients with acute basilar artery occlusion (BAO). We aimed to develop a new angiographic collateral grading system for predicting 90-day functional outcomes of acute BAO after EVT. A prospectively registered consecutive cohort of acute BAO patie...

journal_title：Translational stroke research

authors： Gao F,Tong X,Sun X,Miao Z

更新日期：2020-09-28 00:00:00

abstract：:Increasing endogenous ciliary neurotrophic factor (CNTF) expression with a pharmacological agent might be beneficial after stroke as CNTF both promotes neurogenesis and, separately, is neuroprotective. P2X7 purinergic receptor inhibition is neuroprotective in rats and increases CNTF release in rat CMT1A Schwann cells....

journal_title：Translational stroke research

authors： Kang SS,Keasey MP,Hagg T

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Admission hyperglycemia impacts ischemic stroke deleteriously but the relative role of acute hyperglycemia (HG) versus diabetes in the pathogenesis of this poor outcome is not clear. PURPOSE:To determine the effect of acute HG on neurovascular outcomes of stroke under control and diabetic conditions. METHO...

journal_title：Translational stroke research

authors： Elgebaly MM,Ogbi S,Li W,Mezzetti EM,Prakash R,Johnson MH,Bruno A,Fagan SC,Ergul A

更新日期：2011-09-01 00:00:00

abstract：:The iron chelator, deferoxamine mesylate (DFO), has shown neuroprotective effects, mediated via suppression of iron-induced hydroxyl radical formation, in various animal models of ischemic and hemorrhagic stroke. Therefore, the objective of this study was to investigate whether DFO can exert similar actions in stroke ...

journal_title：Translational stroke research

authors： Selim M

更新日期：2010-03-01 00:00:00

abstract：:Our group recently identified a panel of ten genes whose RNA expression levels in whole blood have utility for detection of stroke. The purpose of this study was to determine the mechanisms by which these genes become differentially expressed during stroke pathology. First, we assessed the transcriptional distribution...

journal_title：Translational stroke research

authors： O'Connell GC,Treadway MB,Tennant CS,Lucke-Wold N,Chantler PD,Barr TL

更新日期：2019-02-01 00:00:00

abstract：:Impaired cerebral autoregulation and neurovascular coupling (NVC) contribute to delayed cerebral ischemia after subarachnoid hemorrhage (SAH). Retinal vessel analysis (RVA) allows non-invasive assessment of vessel dimension and NVC hereby demonstrating a predictive value in the context of various neurovascular disease...

journal_title：Translational stroke research

authors： Conzen C,Albanna W,Weiss M,Kürten D,Vilser W,Kotliar K,Zäske C,Clusmann H,Schubert GA

更新日期：2018-06-01 00:00:00

abstract：:Circulating levels of the pro-inflammatory cytokine C-C motif chemokine 11 (CCL11, also known as eotaxin-1) are increased in several animal models of neuroinflammation, including traumatic brain injury and Alzheimer's disease. Increased levels of CCL11 have also been linked to decreased neurogenesis in mice. We hypoth...

journal_title：Translational stroke research

authors： Roy-O'Reilly M,Ritzel RM,Conway SE,Staff I,Fortunato G,McCullough LD

更新日期：2017-12-01 00:00:00

abstract：:Positron emission tomography (PET) is widely used in clinical and animal studies, along with the development of diverse tracers. The biochemical characteristics of PET tracers may help uncover the pathophysiological consequences of cardiac arrest (CA) and ischemic stroke, which include cerebral ischemia and reperfusio...

journal_title：Translational stroke research

authors： Wang Z,Mascarenhas C,Jia X

更新日期：2020-08-01 00:00:00

abstract：:Although used extensively in stroke research, there is limited knowledge of how 2, 3, 5-triphenyltetrazolium chloride (TTC)-treated rat brain sections are altered and if they can be used for immunohistochemical quantification after staining with TTC. In the present study, we hypothesized that TTC treatment (TTC+) woul...

journal_title：Translational stroke research

authors： Li Z,Bishop N,Chan SL,Cipolla MJ

更新日期：2018-10-01 00:00:00

abstract：:Despite ischemic stroke being the fifth leading cause of death in the USA, there are few therapeutic options available. We recently showed that the neuroprotective compound P7C3-A20 reduced brain atrophy, increased neurogenesis, and improved functional recovery when treatment was initiated immediately post-reperfusion...

journal_title：Translational stroke research

authors： Loris ZB,Hynton JR,Pieper AA,Dietrich WD

更新日期：2018-04-01 00:00:00

abstract：:The most deadly form of stroke, intracerebral hemorrhage (ICH) continues to puzzle researchers and produce substantial decrements in the quality of patients' lives. Intensive basic research has devised many agents with putative benefit in mitigating the devastating effects of ICH, but these therapies have been largely...

journal_title：Translational stroke research

authors： Ayer A,Hwang BY,Appelboom G,Connolly ES Jr

更新日期：2012-12-01 00:00:00

abstract：:An argument for preclinical stroke research to make more use of the permanent middle cerebral artery occlusion (MCAO) model, rather than transient MCAO, is presented. Despite STAIR recommending permanent MCAO as the primary model, preclinical stroke research has not been listened. In 2012, Hossmann reported that 64% o...

journal_title：Translational stroke research

authors： McBride DW,Zhang JH

更新日期：2017-07-17 00:00:00

abstract：:Cerebral blood flow (CBF) is the key factor for identifying progressive hypoperfusion that is indicative of numerous pathological conditions. CBF measurement is beneficial for the management of cerebrovascular disease, head injury, and intracranial neoplasms. Of the various imaging modalities developed to assess CBF, ...

journal_title：Translational stroke research

authors： Mette D,Strunk R,Zuccarello M

更新日期：2011-06-01 00:00:00

abstract：:Neonatal hypoxia-ischemia (HI) is a devastating condition resulting in neuronal cell death and often culminates in neurological deficits. Granulocyte-colony stimulating factor (G-CSF) has been shown to have neuroprotective activity via inhibition of apoptosis and inflammation in various stroke models. Stem cell factor...

journal_title：Translational stroke research

authors： Doycheva D,Shih G,Chen H,Applegate R,Zhang JH,Tang J

更新日期：2013-04-01 00:00:00