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A brief history of behavioral assessment following experimental traumatic brain injury in juveniles.

Abstract：

:This review focuses on assessment of behavioral outcomes following traumatic brain injury in juvenile animal models. In the 15 years since the first publication in this field, the majority of studies have used rats roughly equivalent to human toddlers in terms of brain development. Few studies have tested ages closer to human neonates, and fewer have assessed ages closer to human adolescents. Closed head impact has been the most commonly used model, causing relatively consistent motor and cognitive deficits. Additionally, closed head impacts of a more severe nature have generally led to behavioral deficits of a more severe nature. Impact models (both closed and open skull) have produced more severe deficits in younger animals than in older animals, similar to patterns observed in juvenile humans with traumatic brain injury. In contrast, the fluid percussion model has produced relatively subtle deficits that did not get worse with a more severe injury and were worse for older animals than younger animals. Most of the studies have looked at relatively short postinjury time points, and none so far have assessed behavior in old adult animals injured as juveniles. The review ends with a discussion of possible directions for future animal research into juvenile traumatic brain injury.

journal_name

Transl Stroke Res

journal_title

Translational stroke research

authors

Hartman RE

doi

10.1007/s12975-011-0132-y

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

433-7

issue

4

eissn

1868-4483

issn

1868-601X

journal_volume

2

pub_type

杂志文章

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