Longitudinal assessment of imatinib's effect on the blood-brain barrier after ischemia/reperfusion injury with permeability MRI.

abstract：:There was an error in Fig. 2d. The correct Fig. 2d is shown below. ...

journal_title：Translational stroke research

authors： Yoshimura S,Uchida K,Sakai N,Imamura H,Yamagami H,Tanaka K,Ezura M,Nonaka T,Matsumoto Y,Shibata M,Ohta H,Morimoto M,Fukawa N,Hatano T,Enomoto Y,Takeuchi M,Ota T,Shimizu F,Kimura N,Kamiya Y,Shimamura N,Morimoto T

更新日期：2020-10-22 00:00:00

abstract：:Diabetes significantly increases the risk of stroke and post-stroke mortality. Recurrent hypoglycemia (RH) is common among diabetes patients owing to glucose-lowering therapies. Earlier, we showed that RH in a rat model of insulin-dependent diabetes exacerbates cerebral ischemic damage. Impaired mitochondrial function...

journal_title：Translational stroke research

authors： Shukla V,Fuchs P,Liu A,Cohan CH,Dong C,Wright CB,Perez-Pinzon MA,Dave KR

更新日期：2019-02-01 00:00:00

abstract：:Preconditioning is a paradigm in which sublethal stress-prior to a more injurious insult-induces protection against injury. In the central nervous system (CNS), preconditioning against ischemic stroke is induced by short durations of ischemia, brief seizures, exposure to anesthetics, and other stresses. Increasing evi...

journal_title：Translational stroke research

authors： Bell JD,Cho JE,Giffard RG

更新日期：2017-12-01 00:00:00

abstract：:Impaired cerebral autoregulation and neurovascular coupling (NVC) contribute to delayed cerebral ischemia after subarachnoid hemorrhage (SAH). Retinal vessel analysis (RVA) allows non-invasive assessment of vessel dimension and NVC hereby demonstrating a predictive value in the context of various neurovascular disease...

journal_title：Translational stroke research

authors： Conzen C,Albanna W,Weiss M,Kürten D,Vilser W,Kotliar K,Zäske C,Clusmann H,Schubert GA

更新日期：2018-06-01 00:00:00

abstract：:Hydrocephalus is one of the most common sequelae after aneurysmal subarachnoid hemorrhage (aSAH), and it is a large contributor to the condition's high rates of readmission and mortality. Our objective was to quantify the healthcare resource utilization (HCRU) and health economic burden incurred by the US health syste...

journal_title：Translational stroke research

authors： Adil SM,Liu B,Charalambous LT,Kiyani M,Gramer R,Swisher CB,Verbick LZ,McCabe A,Parente BA,Pagadala P,Lad SP

更新日期：2019-12-01 00:00:00

abstract：:Traumatic brain injury (TBI) affects all age groups in a population and is an injury generating scientific interest not only as an acute event, but also as a complex brain disease with several underlying neurobehavioral and neuropathological characteristics. We review early and long-term alterations after juvenile and...

journal_title：Translational stroke research

authors： Pop V,Badaut J

更新日期：2011-12-01 00:00:00

abstract：:Cerebrovascular disease is a leading cause of death-from-disease and of disability worldwide, affecting some 15 million people. The incidence of stroke or "brain attack" is unlikely to recede for a decade at minimum by most predictions, despite large public health initiatives in stroke prevention. It has been well est...

journal_title：Translational stroke research

authors： Herson PS,Palmateer J,Hurn PD

更新日期：2013-08-01 00:00:00

abstract：:The iron chelator, deferoxamine mesylate (DFO), has shown neuroprotective effects, mediated via suppression of iron-induced hydroxyl radical formation, in various animal models of ischemic and hemorrhagic stroke. Therefore, the objective of this study was to investigate whether DFO can exert similar actions in stroke ...

journal_title：Translational stroke research

authors： Selim M

更新日期：2010-03-01 00:00:00

abstract：:RTL1000 is a partial human MHC molecule coupled to a human myelin peptide. We previously demonstrated that RTL1000 was protective against experimental ischemic stroke in HLA-DR2 transgenic (DR2-Tg) mice. Since thrombolysis with recombinant tissue plasminogen activator (t-PA) is a standard therapy for stroke, we determ...

journal_title：Translational stroke research

authors： Zhu W,Libal NL,Casper A,Bodhankar S,Offner H,Alkayed NJ

更新日期：2014-10-01 00:00:00

abstract：:Early infection after stroke is associated with a poor outcome. We aimed to determine whether delayed infections (up to 76 days post-stroke) are associated with poor outcome at 90 days. Data came from the international Efficacy of Nitric Oxide Stroke (ENOS, ISRCTN99414122) trial. Post hoc data on infections were obtai...

journal_title：Translational stroke research

authors： Learoyd AE,Woodhouse L,Shaw L,Sprigg N,Bereczki D,Berge E,Caso V,Christensen H,Collins R,Czlonkowska A,El Etribi A,Farr TD,Gommans J,Laska AC,Ntaios G,Ozturk S,Pocock SJ,Prasad K,Wardlaw JM,Fone KC,Bath PM,Truem

更新日期：2017-12-01 00:00:00

abstract：:Stroke is a cerebrovascular disorder that affects many people worldwide. Pericytes play an important role in stroke progression and recovery. The sigma-1 receptor (σ-1R) signaling pathway has been suggested as having promising neuroprotective potential in treating stroke; however, whether σ-1R activation regulates per...

journal_title：Translational stroke research

authors： Zhang Y,Zhang X,Wei Q,Leng S,Li C,Han B,Bai Y,Zhang H,Yao H

更新日期：2020-04-01 00:00:00

abstract：:Rodent animal models of stroke are widely used with brain ischemia inducible by various occlusion methods. Permanent or transient occlusion of the distal portion of the middle cerebral artery (MCAO) offers a reproducible model with low mortality rates, and it is the most likely model of choice for mid- and long-term s...

journal_title：Translational stroke research

authors： Rosell A,Agin V,Rahman M,Morancho A,Ali C,Koistinaho J,Wang X,Vivien D,Schwaninger M,Montaner J

更新日期：2013-06-01 00:00:00

abstract：:Poor clinical outcomes despite endovascular therapy (EVT) are common in patients with acute basilar artery occlusion (BAO). We aimed to develop a new angiographic collateral grading system for predicting 90-day functional outcomes of acute BAO after EVT. A prospectively registered consecutive cohort of acute BAO patie...

journal_title：Translational stroke research

authors： Gao F,Tong X,Sun X,Miao Z

更新日期：2020-09-28 00:00:00

abstract：:The incidence of small vessel-type (lacunar) ischemic strokes is greater in African-Americans compared to whites. The chronic inflammatory changes that result from lacunar stroke are poorly understood. To elucidate these changes, we measured serum inflammatory and thrombotic biomarkers in African-Americans at least 6 ...

journal_title：Translational stroke research

authors： Brown CM,Bushnell CD,Samsa GP,Goldstein LB,Colton CA

更新日期：2015-12-01 00:00:00

abstract：:Lifestyle risk factors, inflammation and genetics play a role in the development of atherosclerosis. We therefore studied Fc gamma receptor (FcγR) polymorphisms, interleukin (IL)-10 polymorphisms and other biomarkers related to carotid intima-media thickness (cIMT) in patients with ischemic stroke at a young age. Pati...

journal_title：Translational stroke research

authors： Waje-Andreassen U,Naess H,Thomassen L,Maroy TH,Mazengia KY,Eide GE,Vedeler CA

更新日期：2015-08-01 00:00:00

abstract：:Activation and repression of gene expression are key features of ischemic tolerance. Converging lines of inquiry from several groups suggests that epigenetic proteins may transduce sublethal stresses, including bioenergetic or oxidative stress into durable (2-3 days) changes in gene expression that mediate ischemic to...

journal_title：Translational stroke research

authors： Brand D,Ratan RR

更新日期：2013-02-01 00:00:00

abstract：:This study was aimed to test the hypothesis that human bone marrow stromal cells (hBMSC) expanded in fetal calf serum (FCS)-free, platelet lysate (PL)-containing medium would retain their capacity of migration, survival, and neural differentiation when transplanted into the infarct brain, using serial in vivo magnetic...

journal_title：Translational stroke research

authors： Ito M,Kuroda S,Sugiyama T,Shichinohe H,Takeda Y,Nishio M,Koike T,Houkin K

更新日期：2011-09-01 00:00:00

abstract：:Management of intracranial aneurysms remains controversial. For unruptured aneurysms, many factors should be taken into account before deciding the type of treatment and whether to treat or not. Ruptured aneurysms on the other hand are almost always treated. Still, the question remains what are the indicators that one...

journal_title：Translational stroke research

authors： Zanaty M,Chalouhi N,Tjoumakaris SI,Rosenwasser RH,Jabbour PM

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVE:To elucidate the role of magnesium sulfate in patients with subarachnoid hemorrhagic (SAH) brain injury METHOD:Studies for the meta-analysis were identified from PubMed (1966 to 2009), Embase (1980 to 2009), and two Chinese journals (1989 to 2009). Paper selection was based on randomized controlled trials co...

journal_title：Translational stroke research

authors： Huang B,Khatibi NH,Tong L,Yan P,Xie P,Zhang JH

更新日期：2010-06-01 00:00:00

abstract：:Increasingly, experimental research in subarachnoid hemorrhage (SAH) has investigated early brain injury and the microcirculation. A number of pathophysiological changes occur in the cerebral microvessels after SAH including altered vasoreactivity, vasoconstriction, inflammation, blood-brain barrier impairment, increa...

journal_title：Translational stroke research

authors： Tso MK,Macdonald RL

更新日期：2014-04-01 00:00:00

abstract：:The most deadly form of stroke, intracerebral hemorrhage (ICH) continues to puzzle researchers and produce substantial decrements in the quality of patients' lives. Intensive basic research has devised many agents with putative benefit in mitigating the devastating effects of ICH, but these therapies have been largely...

journal_title：Translational stroke research

authors： Ayer A,Hwang BY,Appelboom G,Connolly ES Jr

更新日期：2012-12-01 00:00:00

abstract：:We reported previously that both a cannabinoid receptor 2 (CB2R) agonist and a cannabinoid receptor 1 (CB1R) antagonist were protective in the treatment of transient middle cerebral artery occlusion/reperfusion injury (MCAO/R) and that they acted in a synergistic manner when administered in combination. The goal of th...

journal_title：Translational stroke research

authors： Zhang M,Mahadevan A,Amere M,Li H,Ganea D,Tuma RF

更新日期：2012-09-01 00:00:00

abstract：:Stroke prevention efforts typically focus on either ischemic or hemorrhagic stroke. This approach is overly simplistic due to the frequent coexistence of ischemic and hemorrhagic cerebrovascular disease. This coexistence, termed "mixed cerebrovascular disease", offers a conceptual framework that appears useful for str...

journal_title：Translational stroke research

authors： Fisher M,Vasilevko V,Cribbs DH

更新日期：2012-07-01 00:00:00

abstract：:Monocytes recruitment from the blood to inflamed tissues following ischemic stroke is an important immune response to wound healing and tissue repair. Mouse monocytes can be endogenously divided into two distinct populations: pro-inflammatory or classical monocytes that express CCR2highCX3CR1low and circulate in blood...

journal_title：Translational stroke research

authors： Park J,Kim JY,Kim YR,Huang M,Chang JY,Sim AY,Jung H,Lee WT,Hyun YM,Lee JE

更新日期：2021-01-06 00:00:00

abstract：:Clinical studies on subarachnoid hemorrhage (SAH) have shown discrepancies between large vessel vasospasm, cerebral perfusion, and clinical outcome. We set out to analyze the contribution of large vessel vasospasm to impaired cerebral perfusion and neurological impairment in a murine model of SAH. SAH was induced in C...

journal_title：Translational stroke research

authors： Neulen A,Meyer S,Kramer A,Pantel T,Kosterhon M,Kunzelmann S,Goetz H,Thal SC

更新日期：2018-07-12 00:00:00

abstract：:This review focuses on assessment of behavioral outcomes following traumatic brain injury in juvenile animal models. In the 15 years since the first publication in this field, the majority of studies have used rats roughly equivalent to human toddlers in terms of brain development. Few studies have tested ages closer ...

journal_title：Translational stroke research

authors： Hartman RE

更新日期：2011-12-01 00:00:00

abstract：:CD8+ T cells are recognized as key players in exacerbation of ischemic stroke; however, the underlying mechanism in modulating the function of CD8+ T cells has not been completely elucidated. Here, we uncovered that FasL enhanced the cytotoxicity of CD8+ T cells to neurons after ischemic stroke. Inactivation of FasL s...

journal_title：Translational stroke research

authors： Fan L,Zhang CJ,Zhu L,Chen J,Zhang Z,Liu P,Cao X,Meng H,Xu Y

更新日期：2020-08-01 00:00:00

abstract：:Despite being a conveniently portable technology for stroke assessment, Transcranial Doppler ultrasound (TCD) remains widely underutilized due to complex training requirements necessary to reliably obtain and interpret cerebral blood flow velocity (CBFV) waveforms. The validation of objective TCD metrics for large ves...

journal_title：Translational stroke research

authors： Thorpe SG,Thibeault CM,Wilk SJ,O'Brien M,Canac N,Ranjbaran M,Devlin C,Devlin T,Hamilton RB

更新日期：2019-10-01 00:00:00

abstract：:Infection is a leading cause of death in patients with stroke; however, the impact of cerebral infarct size or location on infectious outcome is unclear. To examine the effect of infarct size on post-stroke infection, we utilised the intraluminal middle-cerebral artery occlusion (MCAO) mouse model of ischemic stroke a...

journal_title：Translational stroke research

authors： Shim R,Wen SW,Wanrooy BJ,Rank M,Thirugnanachandran T,Ho L,Sepehrizadeh T,de Veer M,Srikanth VK,Ma H,Phan TG,Sobey CG,Wong CHY

更新日期：2020-06-01 00:00:00

abstract：:In clinical trials, assessing efficacy is based on validated scales, and the primary endpoint is usually based on a single scale. The aim of the review is to revisit the concepts and methods to design and analyze studies focused on restoration, recovery and or compensation. These studies are becoming more frequent wit...

journal_title：Translational stroke research

authors： Hommel M,Detante O,Favre I,Touzé E,Jaillard A

更新日期：2016-10-01 00:00:00