Abstract：
:RTL1000 is a partial human MHC molecule coupled to a human myelin peptide. We previously demonstrated that RTL1000 was protective against experimental ischemic stroke in HLA-DR2 transgenic (DR2-Tg) mice. Since thrombolysis with recombinant tissue plasminogen activator (t-PA) is a standard therapy for stroke, we determined if RTL1000 efficacy is altered when combined with t-PA in experimental stroke. Male DR2-Tg mice underwent 60 min of intraluminal middle cerebral artery occlusion (MCAO). t-PA or vehicle was infused intravenously followed by either a single or four daily subcutaneous injections of RTL1000 or vehicle. Infarct size was measured by 2, 3, 5-triphenyltetrazolium chloride staining at 24 or 96 h of reperfusion. Our data showed that t-PA alone reduced infarct size when measured at 24 h but not at 96 h after MCAO. RTL1000 alone reduced infarct size both at 24 and 96 h after MCAO. Combining RTL1000 with t-PA did not alter its ability to reduce infarct size at either 24 or 96 h after MCAO and provides additional protection in t-PA treated mice at 24 h after ischemic stroke. Taken together, RTL1000 treatment alone improves outcome and provides additional protection in t-PA-treated mice in experimental ischemic stroke.
journal_name
Transl Stroke Resjournal_title
Translational stroke researchauthors
Zhu W,Libal NL,Casper A,Bodhankar S,Offner H,Alkayed NJdoi
10.1007/s12975-014-0348-8subject
Has Abstractpub_date
2014-10-01 00:00:00pages
612-7issue
5eissn
1868-4483issn
1868-601Xjournal_volume
5pub_type
杂志文章abstract：:Neonatal hypoxia-ischemia (HI) is a devastating condition resulting in neuronal cell death and often culminates in neurological deficits. Granulocyte-colony stimulating factor (G-CSF) has been shown to have neuroprotective activity via inhibition of apoptosis and inflammation in various stroke models. Stem cell factor...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-012-0225-2
更新日期：2013-04-01 00:00:00
abstract：:Acute ischemic stroke (AIS) often results in degeneration of the blood-brain barrier (BBB), which can lead to vasogenic edema and an increased risk of intracerebral hemorrhage. Imatinib is an agent that may be able to protect the BBB and reduce the risk of the harmful consequences of BBB degeneration. We sought to mea...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-014-0358-6
更新日期：2015-02-01 00:00:00
abstract：:Ischemic stroke is a devastating neural event as currently no therapies other than physical rehabilitation are available to enhance recovery after stroke. To identify endogenous mediators to repair stroke brain, we performed the expression profiling analysis of transcripts in the mouse photothrombotic stroke brain. Ba...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-015-0401-2
更新日期：2015-08-01 00:00:00
abstract：:Voltage-gated potassium (Kv) channels are widely expressed in the central and peripheral nervous system and are crucial mediators of neuronal excitability. Importantly, these channels also actively participate in cellular and molecular signaling pathways that regulate the life and death of neurons. Injury-mediated inc...
journal_title：Translational stroke research
pub_type： 杂志文章,评审
doi：10.1007/s12975-013-0297-7
更新日期：2014-02-01 00:00:00
abstract：:Aneurysmal subarachnoid hemorrhage comprises of an early phase after the bleeding and a late phase of delayed consequences of the bleeding. The development of delayed injury mechanisms, like the reduction of cerebral blood flow (CBF) due to cerebral vasospasm (CVS), seems mainly to depend on the amount and the duratio...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-015-0392-z
更新日期：2015-06-01 00:00:00
abstract：:Neurogenesis is essential for a good post-stroke outcome. Exogenous stem cells are currently being tested to promote neurogenesis after stroke. Elsewhere, we demonstrated that treatment with the PPARγ agonist pioglitazone (PGZ) before cerebral ischemia induction reduced brain damage and activated survival-related gene...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-017-0577-8
更新日期：2018-06-01 00:00:00
abstract：:The long-term effects of multiple sport-related concussions are currently at the center of debate in the popular press and scientific community. The question, "How many concussions are too many," is frequently asked in the competitive sport environment by parents, athletes, and coaches. While research suggests that a ...
journal_title：Translational stroke research
pub_type： 杂志文章,评审
doi：10.1007/s12975-012-0237-y
更新日期：2013-08-01 00:00:00
abstract：:Cerebrovascular disease is a leading cause of death-from-disease and of disability worldwide, affecting some 15 million people. The incidence of stroke or "brain attack" is unlikely to recede for a decade at minimum by most predictions, despite large public health initiatives in stroke prevention. It has been well est...
journal_title：Translational stroke research
pub_type： 杂志文章,评审
doi：10.1007/s12975-012-0238-x
更新日期：2013-08-01 00:00:00
abstract：:Intracerebral hemorrhage is by far the most destructive form of stroke. Apart from the management in a specialized stroke or neurological intensive care unit (NICU), no specific therapies have been shown to consistently improve outcomes after ICH. Current guidelines endorse early aggressive optimization of physiologic...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-012-0175-8
更新日期：2012-07-01 00:00:00
abstract：:CD8+ T cells are recognized as key players in exacerbation of ischemic stroke; however, the underlying mechanism in modulating the function of CD8+ T cells has not been completely elucidated. Here, we uncovered that FasL enhanced the cytotoxicity of CD8+ T cells to neurons after ischemic stroke. Inactivation of FasL s...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-019-00749-0
更新日期：2020-08-01 00:00:00
abstract：:Management of intracranial aneurysms remains controversial. For unruptured aneurysms, many factors should be taken into account before deciding the type of treatment and whether to treat or not. Ruptured aneurysms on the other hand are almost always treated. Still, the question remains what are the indicators that one...
journal_title：Translational stroke research
pub_type： 杂志文章,评审
doi：10.1007/s12975-013-0311-0
更新日期：2014-04-01 00:00:00
abstract：:Low translational yield for stroke may reflect the focus of discovery science on rodents rather than humans. Just how little is known about human neuronal ischaemic responses is confirmed by systematic review and meta-analysis revealing that data for the most commonly used SH-SY5Y human cells comprises only 84 papers....
journal_title：Translational stroke research
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s12975-018-0620-4
更新日期：2018-12-01 00:00:00
abstract：:Activation and repression of gene expression are key features of ischemic tolerance. Converging lines of inquiry from several groups suggests that epigenetic proteins may transduce sublethal stresses, including bioenergetic or oxidative stress into durable (2-3 days) changes in gene expression that mediate ischemic to...
journal_title：Translational stroke research
pub_type： 杂志文章,评审
doi：10.1007/s12975-012-0235-0
更新日期：2013-02-01 00:00:00
abstract：:Impaired cerebral autoregulation and neurovascular coupling (NVC) contribute to delayed cerebral ischemia after subarachnoid hemorrhage (SAH). Retinal vessel analysis (RVA) allows non-invasive assessment of vessel dimension and NVC hereby demonstrating a predictive value in the context of various neurovascular disease...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-017-0585-8
更新日期：2018-06-01 00:00:00
abstract：:In the original publication of the article, there was a switched order of author names. ...
journal_title：Translational stroke research
pub_type： 杂志文章,已发布勘误
doi：10.1007/s12975-018-0618-y
更新日期：2018-12-01 00:00:00
abstract：:Cerebral blood flow (CBF) is the key factor for identifying progressive hypoperfusion that is indicative of numerous pathological conditions. CBF measurement is beneficial for the management of cerebrovascular disease, head injury, and intracranial neoplasms. Of the various imaging modalities developed to assess CBF, ...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-010-0064-y
更新日期：2011-06-01 00:00:00
abstract：:Preconditioning is a paradigm in which sublethal stress-prior to a more injurious insult-induces protection against injury. In the central nervous system (CNS), preconditioning against ischemic stroke is induced by short durations of ischemia, brief seizures, exposure to anesthetics, and other stresses. Increasing evi...
journal_title：Translational stroke research
pub_type： 杂志文章,评审
doi：10.1007/s12975-017-0547-1
更新日期：2017-12-01 00:00:00
abstract：:Global ischemia following cardiac arrest is characterized by high mortality and significant neurological deficits in long-term survivors. Its mechanisms of neuronal cell death have only partially been elucidated. 12/15-lipoxygenase (12/15-LOX) is a major contributor to delayed neuronal cell death and vascular injury i...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-016-0509-z
更新日期：2017-04-01 00:00:00
abstract：:Acute ischemic stroke affects over 800,000 US adults annually, with hundreds of thousands more experiencing a transient ischemic attack. Emergent evaluation, prompt acute treatment, and identification of stroke or TIA (transient ischemic attack) etiology for specific secondary prevention are critical for decreasing fu...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-017-0537-3
更新日期：2017-05-05 00:00:00
abstract：:Pathophysiological findings of early brain injury in humans have not permitted conclusive determinations. We explored the essence of this phenomenon by taking intraoperative cortical specimens of Hunt-Kosnik grades IV~V (poor-grade) subarachnoid hemorrhages (SAH). From 2013 to 2017, we treated 39 consecutive poor-grad...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-020-00875-0
更新日期：2020-11-27 00:00:00
abstract：:Stroke is a cerebrovascular disorder that affects many people worldwide. Pericytes play an important role in stroke progression and recovery. The sigma-1 receptor (σ-1R) signaling pathway has been suggested as having promising neuroprotective potential in treating stroke; however, whether σ-1R activation regulates per...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-019-00711-0
更新日期：2020-04-01 00:00:00
abstract：:Magnetic resonance imaging (MRI) has dramatically changed our ability to diagnose and treat stroke as well as follow its evolution and response to treatment. Early stroke and ischemia can be visualized using diffusion-weighted imaging that utilizes water diffusion within tissues as a reporter for evolving neuropatholo...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-011-0139-4
更新日期：2012-03-01 00:00:00
abstract：:Cerebral hyperperfusion syndrome (CHS) is a complication that can occur after carotid endarterectomy (CEA), the treatment of choice to decrease the subsequent risk of fatal or disabling stroke for patients with symptomatic severe stenosis of the carotid artery. Because of its rarity and complexity, the mechanism of th...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-017-0605-8
更新日期：2018-10-01 00:00:00
abstract：:Approximately, 16 million strokes occur worldwide each year, causing 6 million deaths and considerable disability, implying an enormous social, individual health, and economic burden. Due to this high incidence, strategies to promote stroke recovery are urgently needed. Research into new therapeutic approaches for str...
journal_title：Translational stroke research
pub_type： 杂志文章,评审
doi：10.1007/s12975-018-0654-7
更新日期：2019-06-01 00:00:00
abstract：:Traumatic brain injury (TBI) affects all age groups in a population and is an injury generating scientific interest not only as an acute event, but also as a complex brain disease with several underlying neurobehavioral and neuropathological characteristics. We review early and long-term alterations after juvenile and...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-011-0126-9
更新日期：2011-12-01 00:00:00
abstract：:Increasing endogenous ciliary neurotrophic factor (CNTF) expression with a pharmacological agent might be beneficial after stroke as CNTF both promotes neurogenesis and, separately, is neuroprotective. P2X7 purinergic receptor inhibition is neuroprotective in rats and increases CNTF release in rat CMT1A Schwann cells....
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-013-0265-2
更新日期：2013-10-01 00:00:00
abstract：:Anticoagulation increases the risk of intracerebral hemorrhage (ICH) in patients with cerebral amyloid angiopathy (CAA), so the management of stroke-risk in patients with both atrial fibrillation (AF) and CAA is controversial. Advances in left atrial appendage closure (LAAC) techniques provide a stroke-risk-reduction ...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-020-00838-5
更新日期：2020-08-07 00:00:00
abstract：:Subarachnoid haemorrhage (SAH) is a devastating disease and a major burden on society. Despite this, pharmacological treatment options are limited. Appropriate animal modelling of SAH is essential for the development of neuroprotective drugs, but experimental SAH often fails to produce widespread neuronal loss, as fre...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-011-0124-y
更新日期：2012-03-01 00:00:00
abstract：BACKGROUND:Admission hyperglycemia impacts ischemic stroke deleteriously but the relative role of acute hyperglycemia (HG) versus diabetes in the pathogenesis of this poor outcome is not clear. PURPOSE:To determine the effect of acute HG on neurovascular outcomes of stroke under control and diabetic conditions. METHO...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-011-0083-3
更新日期：2011-09-01 00:00:00
abstract：:The most deadly form of stroke, intracerebral hemorrhage (ICH) continues to puzzle researchers and produce substantial decrements in the quality of patients' lives. Intensive basic research has devised many agents with putative benefit in mitigating the devastating effects of ICH, but these therapies have been largely...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-012-0207-4
更新日期：2012-12-01 00:00:00
