Treatment with the PPARγ Agonist Pioglitazone in the Early Post-ischemia Phase Inhibits Pro-inflammatory Responses and Promotes Neurogenesis Via the Activation of Innate- and Bone Marrow-Derived Stem Cells in Rats.

abstract：:Neonatal hypoxia-ischemia (HI) is a devastating condition resulting in neuronal cell death and often culminates in neurological deficits. Granulocyte-colony stimulating factor (G-CSF) has been shown to have neuroprotective activity via inhibition of apoptosis and inflammation in various stroke models. Stem cell factor...

journal_title：Translational stroke research

authors： Doycheva D,Shih G,Chen H,Applegate R,Zhang JH,Tang J

更新日期：2013-04-01 00:00:00

abstract：:Silent information regulator 1 (SIRT1) is a NAD+-dependent histone deacetylase that represses gene expression and plays a role in longevity. SIRT1 responds to diverse stress conditions and regulates metabolism in nutrient deficiency conditions; therefore, it is involved in adaptive pathways to better fulfill tissue ne...

journal_title：Translational stroke research

authors： Petegnief V,Planas AM

更新日期：2013-12-01 00:00:00

abstract：:For years, strategies have been proposed to improve translational success in stroke research by improving the quality of animal studies. However, articles that report preclinical intracerebral hemorrhage (ICH) studies continue to lack adequate qualitative and quantitative descriptions of fresh brain tissue collection....

journal_title：Translational stroke research

authors： Chang CF,Cai L,Wang J

更新日期：2015-10-01 00:00:00

abstract：:In clinical trials, assessing efficacy is based on validated scales, and the primary endpoint is usually based on a single scale. The aim of the review is to revisit the concepts and methods to design and analyze studies focused on restoration, recovery and or compensation. These studies are becoming more frequent wit...

journal_title：Translational stroke research

authors： Hommel M,Detante O,Favre I,Touzé E,Jaillard A

更新日期：2016-10-01 00:00:00

abstract：:Approximately, 16 million strokes occur worldwide each year, causing 6 million deaths and considerable disability, implying an enormous social, individual health, and economic burden. Due to this high incidence, strategies to promote stroke recovery are urgently needed. Research into new therapeutic approaches for str...

journal_title：Translational stroke research

authors： Otero-Ortega L,Laso-García F,Gómez-de Frutos M,Fuentes B,Diekhorst L,Díez-Tejedor E,Gutiérrez-Fernández M

更新日期：2019-06-01 00:00:00

abstract：:Clinical studies on subarachnoid hemorrhage (SAH) have shown discrepancies between large vessel vasospasm, cerebral perfusion, and clinical outcome. We set out to analyze the contribution of large vessel vasospasm to impaired cerebral perfusion and neurological impairment in a murine model of SAH. SAH was induced in C...

journal_title：Translational stroke research

authors： Neulen A,Meyer S,Kramer A,Pantel T,Kosterhon M,Kunzelmann S,Goetz H,Thal SC

更新日期：2018-07-12 00:00:00

abstract：:Traumatic brain injury (TBI) affects all age groups in a population and is an injury generating scientific interest not only as an acute event, but also as a complex brain disease with several underlying neurobehavioral and neuropathological characteristics. We review early and long-term alterations after juvenile and...

journal_title：Translational stroke research

authors： Pop V,Badaut J

更新日期：2011-12-01 00:00:00

abstract：:Our group recently identified a panel of ten genes whose RNA expression levels in whole blood have utility for detection of stroke. The purpose of this study was to determine the mechanisms by which these genes become differentially expressed during stroke pathology. First, we assessed the transcriptional distribution...

journal_title：Translational stroke research

authors： O'Connell GC,Treadway MB,Tennant CS,Lucke-Wold N,Chantler PD,Barr TL

更新日期：2019-02-01 00:00:00

abstract：:Cavernous angioma (CA) is a vascular pathology caused by loss of function in one of the 3 CA genes (CCM1, CCM2, and CCM3) that result in rho kinase (ROCK) activation. We investigated a novel ROCK2 selective inhibitor for the ability to reduce brain lesion formation, growth, and maturation. We used genetic methods to e...

journal_title：Translational stroke research

authors： McKerracher L,Shenkar R,Abbinanti M,Cao Y,Peiper A,Liao JK,Lightle R,Moore T,Hobson N,Gallione C,Ruschel J,Koskimäki J,Girard R,Rosen K,Marchuk DA,Awad IA

更新日期：2020-06-01 00:00:00

abstract：:Monocytes recruitment from the blood to inflamed tissues following ischemic stroke is an important immune response to wound healing and tissue repair. Mouse monocytes can be endogenously divided into two distinct populations: pro-inflammatory or classical monocytes that express CCR2highCX3CR1low and circulate in blood...

journal_title：Translational stroke research

authors： Park J,Kim JY,Kim YR,Huang M,Chang JY,Sim AY,Jung H,Lee WT,Hyun YM,Lee JE

更新日期：2021-01-06 00:00:00

abstract：:The incidence of small vessel-type (lacunar) ischemic strokes is greater in African-Americans compared to whites. The chronic inflammatory changes that result from lacunar stroke are poorly understood. To elucidate these changes, we measured serum inflammatory and thrombotic biomarkers in African-Americans at least 6 ...

journal_title：Translational stroke research

authors： Brown CM,Bushnell CD,Samsa GP,Goldstein LB,Colton CA

更新日期：2015-12-01 00:00:00

abstract：:This review focuses on assessment of behavioral outcomes following traumatic brain injury in juvenile animal models. In the 15 years since the first publication in this field, the majority of studies have used rats roughly equivalent to human toddlers in terms of brain development. Few studies have tested ages closer ...

journal_title：Translational stroke research

authors： Hartman RE

更新日期：2011-12-01 00:00:00

abstract：:Increasingly, experimental research in subarachnoid hemorrhage (SAH) has investigated early brain injury and the microcirculation. A number of pathophysiological changes occur in the cerebral microvessels after SAH including altered vasoreactivity, vasoconstriction, inflammation, blood-brain barrier impairment, increa...

journal_title：Translational stroke research

authors： Tso MK,Macdonald RL

更新日期：2014-04-01 00:00:00

abstract：:Poor clinical outcomes despite endovascular therapy (EVT) are common in patients with acute basilar artery occlusion (BAO). We aimed to develop a new angiographic collateral grading system for predicting 90-day functional outcomes of acute BAO after EVT. A prospectively registered consecutive cohort of acute BAO patie...

journal_title：Translational stroke research

authors： Gao F,Tong X,Sun X,Miao Z

更新日期：2020-09-28 00:00:00

abstract：:Low translational yield for stroke may reflect the focus of discovery science on rodents rather than humans. Just how little is known about human neuronal ischaemic responses is confirmed by systematic review and meta-analysis revealing that data for the most commonly used SH-SY5Y human cells comprises only 84 papers....

journal_title：Translational stroke research

authors： Liu Y,Eaton ED,Wills TE,McCann SK,Antonic A,Howells DW

更新日期：2018-12-01 00:00:00

abstract：:The COVID-19 pandemic is associated with neurological symptoms and complications including stroke. There is hypercoagulability associated with COVID-19 that is likely a "sepsis-induced coagulopathy" and may predispose to stroke. The SARS-CoV-2 virus binds to angiotensin-converting enzyme 2 (ACE2) present on brain endo...

journal_title：Translational stroke research

authors： Hess DC,Eldahshan W,Rutkowski E

更新日期：2020-06-01 00:00:00

abstract：:An argument for preclinical stroke research to make more use of the permanent middle cerebral artery occlusion (MCAO) model, rather than transient MCAO, is presented. Despite STAIR recommending permanent MCAO as the primary model, preclinical stroke research has not been listened. In 2012, Hossmann reported that 64% o...

journal_title：Translational stroke research

authors： McBride DW,Zhang JH

更新日期：2017-07-17 00:00:00

abstract：:Motor impairment is the most common complication after stroke, and recovery of motor function has been shown to be dependent on the extent of lesion in the ipsilesional corticospinal tract (iCST) and activity within ipsilesional primary and secondary motor cortices. However, work from neuroimaging research has suggest...

journal_title：Translational stroke research

authors： Alawieh A,Tomlinson S,Adkins D,Kautz S,Feng W

更新日期：2017-12-01 00:00:00

abstract：:This study aimed to investigate whether serum lactate dehydrogenase (LDH) levels predicted hematoma expansion and poor outcomes in intracerebral hemorrhage (ICH) patients. The differentially expressed proteins between patients with and without hematoma expansion were screened using proteomic analysis. Then the critica...

journal_title：Translational stroke research

authors： Chu H,Huang C,Dong J,Yang X,Xiang J,Dong Q,Tang Y

更新日期：2019-12-01 00:00:00

abstract：:Voltage-gated potassium (Kv) channels are widely expressed in the central and peripheral nervous system and are crucial mediators of neuronal excitability. Importantly, these channels also actively participate in cellular and molecular signaling pathways that regulate the life and death of neurons. Injury-mediated inc...

journal_title：Translational stroke research

authors： Shah NH,Aizenman E

更新日期：2014-02-01 00:00:00

abstract：:Polymorphonuclear neutrophils (PMNs) infiltration into brain parenchyma after cerebrovascular accidents is viewed as a key component of secondary brain injury. Interestingly, a recent study of ischemic stroke suggests that after ischemic stroke, PMNs do not enter brain parenchyma and as such may cause no harm to the b...

journal_title：Translational stroke research

authors： Zhao X,Sun G,Zhang H,Ting SM,Song S,Gonzales N,Aronowski J

更新日期：2014-10-01 00:00:00

abstract：:Inconsistency in outcome parameters for delayed cerebral ischemia (DCI) makes it difficult to compare results between mouse studies, in the same way inconsistency in outcome parameters in human studies has for long obstructed adequate comparison. The absence of an established definition may in part be responsible for ...

journal_title：Translational stroke research

authors： van Lieshout JH,Marbacher S,Muhammad S,Boogaarts HD,Bartels RHMA,Dibué M,Steiger HJ,Hänggi D,Kamp MA

更新日期：2020-10-01 00:00:00

abstract：:Global ischemia following cardiac arrest is characterized by high mortality and significant neurological deficits in long-term survivors. Its mechanisms of neuronal cell death have only partially been elucidated. 12/15-lipoxygenase (12/15-LOX) is a major contributor to delayed neuronal cell death and vascular injury i...

journal_title：Translational stroke research

authors： Yigitkanli K,Zheng Y,Pekcec A,Lo EH,van Leyen K

更新日期：2017-04-01 00:00:00

abstract：:Hematoma puncture and subsequent clot lysis with recombinant tissue plasminogen activator (rtPA) emerged as an alternative therapy for spontaneous intracerebral hemorrhage (ICH) and is associated with delayed edema possibly counteracting the beneficial effects of hematoma volume reduction. We hypothesized that immedia...

journal_title：Translational stroke research

authors： Keric N,Maier GS,Samadani U,Kallenberg K,Dechent P,Brueck W,Heuer J,Rohde V

更新日期：2012-07-01 00:00:00

abstract：:Early infection after stroke is associated with a poor outcome. We aimed to determine whether delayed infections (up to 76 days post-stroke) are associated with poor outcome at 90 days. Data came from the international Efficacy of Nitric Oxide Stroke (ENOS, ISRCTN99414122) trial. Post hoc data on infections were obtai...

journal_title：Translational stroke research

authors： Learoyd AE,Woodhouse L,Shaw L,Sprigg N,Bereczki D,Berge E,Caso V,Christensen H,Collins R,Czlonkowska A,El Etribi A,Farr TD,Gommans J,Laska AC,Ntaios G,Ozturk S,Pocock SJ,Prasad K,Wardlaw JM,Fone KC,Bath PM,Truem

更新日期：2017-12-01 00:00:00

abstract：:Quantitative susceptibility mapping (QSM) has been recently introduced as a novel MRI post-processing technique of gradient recalled echo (GRE) data. QSM is useful in depicting both brain anatomy and for detecting abnormalities. Its utility in the context of ischemic stroke has, however, not been extensively character...

journal_title：Translational stroke research

authors： Vaas M,Deistung A,Reichenbach JR,Keller A,Kipar A,Klohs J

更新日期：2018-08-01 00:00:00

abstract：:There was an error in Fig. 2d. The correct Fig. 2d is shown below. ...

journal_title：Translational stroke research

authors： Yoshimura S,Uchida K,Sakai N,Imamura H,Yamagami H,Tanaka K,Ezura M,Nonaka T,Matsumoto Y,Shibata M,Ohta H,Morimoto M,Fukawa N,Hatano T,Enomoto Y,Takeuchi M,Ota T,Shimizu F,Kimura N,Kamiya Y,Shimamura N,Morimoto T

更新日期：2020-10-22 00:00:00

abstract：:Circulating levels of the pro-inflammatory cytokine C-C motif chemokine 11 (CCL11, also known as eotaxin-1) are increased in several animal models of neuroinflammation, including traumatic brain injury and Alzheimer's disease. Increased levels of CCL11 have also been linked to decreased neurogenesis in mice. We hypoth...

journal_title：Translational stroke research

authors： Roy-O'Reilly M,Ritzel RM,Conway SE,Staff I,Fortunato G,McCullough LD

更新日期：2017-12-01 00:00:00

abstract：:Previous studies showed that complement activation is associated with poor functional outcome after aneurysmal subarachnoid hemorrhage (SAH). We investigated whether complement activation is underlying brain injury after aneurysmal SAH (n = 7) and if it is an appropriate treatment target. We investigated complement ex...

journal_title：Translational stroke research

authors： van Dijk BJ,Meijers JCM,Kloek AT,Knaup VL,Rinkel GJE,Morgan BP,van der Kamp MJ,Osuka K,Aronica E,Ruigrok YM,van de Beek D,Brouwer M,Pekna M,Hol EM,Vergouwen MDI

更新日期：2020-08-01 00:00:00

abstract：:Stroke prevention efforts typically focus on either ischemic or hemorrhagic stroke. This approach is overly simplistic due to the frequent coexistence of ischemic and hemorrhagic cerebrovascular disease. This coexistence, termed "mixed cerebrovascular disease", offers a conceptual framework that appears useful for str...

journal_title：Translational stroke research

authors： Fisher M,Vasilevko V,Cribbs DH

更新日期：2012-07-01 00:00:00