Abstract:
:For years, strategies have been proposed to improve translational success in stroke research by improving the quality of animal studies. However, articles that report preclinical intracerebral hemorrhage (ICH) studies continue to lack adequate qualitative and quantitative descriptions of fresh brain tissue collection. They also tend to lack transparency about animal model quality. We conducted a systematic review of 82 ICH research articles to determine the level of detail reported for brain tissue collection. We found that only 24 (29 %) reported the volume, weight, or thickness of tissue collected and a specific description of the anatomical location. Thus, up to 71 % of preclinical ICH research articles did not properly define how fresh specimens were collected for biochemical measurements. Such omissions may impede reproducibility of results between laboratories. Although existing criteria have improved the quality of preclinical stroke studies, ICH researchers need to identify specific guidelines and strategies to avoid pitfalls, minimize bias, and increase reproducibility in this field.
journal_name
Transl Stroke Resjournal_title
Translational stroke researchauthors
Chang CF,Cai L,Wang Jdoi
10.1007/s12975-015-0399-5subject
Has Abstractpub_date
2015-10-01 00:00:00pages
384-9issue
5eissn
1868-4483issn
1868-601Xjournal_volume
6pub_type
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journal_title:Translational stroke research
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Translational stroke research
pub_type: 信件
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journal_title:Translational stroke research
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Translational stroke research
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2014-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s12975-016-0509-z
更新日期:2017-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-10-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2020-10-22 00:00:00
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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journal_title:Translational stroke research
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pub_type: 杂志文章,评审
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journal_title:Translational stroke research
pub_type: 杂志文章
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