Abstract：
:Clinical studies on subarachnoid hemorrhage (SAH) have shown discrepancies between large vessel vasospasm, cerebral perfusion, and clinical outcome. We set out to analyze the contribution of large vessel vasospasm to impaired cerebral perfusion and neurological impairment in a murine model of SAH. SAH was induced in C57BL/6 mice by endovascular filament perforation. Vasospasm was analyzed with microcomputed tomography, cortical perfusion by laser SPECKLE contrast imaging, and functional impairment with a quantitative neuroscore. SAH animals developed large vessel vasospasm, as shown by significantly lower vessel volumes of a 2.5-mm segment of the left middle cerebral artery (MCA) (SAH 5.6 ± 0.6 nL, sham 8.3 ± 0.5 nL, p < 0.01). Induction of SAH significantly reduced cerebral perfusion of the corresponding left MCA territory compared to values before SAH, which only recovered partly (SAH vs. sham, 15 min 35.7 ± 3.1 vs. 101.4 ± 10.2%, p < 0.01; 3 h, 85.0 ± 8.6 vs. 121.9 ± 13.4, p < 0.05; 24 h, 75.3 ± 4.6 vs. 110.6 ± 11.4%, p < 0.01; 72 h, 81.8 ± 4.8 vs. 108.5 ± 14.5%, n.s.). MCA vessel volume did not correlate significantly with MCA perfusion after 72 h (r = 0.34, p = 0.25). Perfusion correlated moderately with neuroscore (24 h: r = - 0.58, p < 0.05; 72 h: r = - 0.44, p = 0.14). There was no significant correlation between vessel volume and neuroscore after 72 h (r = - 0.21, p = 0.50). In the murine SAH model, cerebral hypoperfusion occurs independently of large vessel vasospasm. Neurological outcome is associated with cortical hypoperfusion rather than large vessel vasospasm.
journal_name
Transl Stroke Resjournal_title
Translational stroke researchauthors
Neulen A,Meyer S,Kramer A,Pantel T,Kosterhon M,Kunzelmann S,Goetz H,Thal SCdoi
10.1007/s12975-018-0647-6subject
Has Abstractpub_date
2018-07-12 00:00:00eissn
1868-4483issn
1868-601Xpii
10.1007/s12975-018-0647-6pub_type
杂志文章abstract：:Neonatal hypoxia-ischemia (HI) is a devastating condition resulting in neuronal cell death and often culminates in neurological deficits. Granulocyte-colony stimulating factor (G-CSF) has been shown to have neuroprotective activity via inhibition of apoptosis and inflammation in various stroke models. Stem cell factor...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-012-0225-2
更新日期：2013-04-01 00:00:00
abstract：:Intraventricular hemorrhage (IVH), which afflicts thousands of people of all ages every year, frequently results in the development of communicating hydrocephalus. Classically, IVH-induced hydrocephalus has been attributed to reduced resorption of cerebrospinal fluid (CSF) due to dysfunction of arachnoid granulations,...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-011-0070-8
更新日期：2011-06-01 00:00:00
abstract：:In clinical trials, assessing efficacy is based on validated scales, and the primary endpoint is usually based on a single scale. The aim of the review is to revisit the concepts and methods to design and analyze studies focused on restoration, recovery and or compensation. These studies are becoming more frequent wit...
journal_title：Translational stroke research
pub_type： 杂志文章,评审
doi：10.1007/s12975-016-0488-0
更新日期：2016-10-01 00:00:00
abstract：:Inconsistency in outcome parameters for delayed cerebral ischemia (DCI) makes it difficult to compare results between mouse studies, in the same way inconsistency in outcome parameters in human studies has for long obstructed adequate comparison. The absence of an established definition may in part be responsible for ...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-020-00796-y
更新日期：2020-10-01 00:00:00
abstract：:An argument for preclinical stroke research to make more use of the permanent middle cerebral artery occlusion (MCAO) model, rather than transient MCAO, is presented. Despite STAIR recommending permanent MCAO as the primary model, preclinical stroke research has not been listened. In 2012, Hossmann reported that 64% o...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-017-0554-2
更新日期：2017-07-17 00:00:00
abstract：:Motor impairment is the most common complication after stroke, and recovery of motor function has been shown to be dependent on the extent of lesion in the ipsilesional corticospinal tract (iCST) and activity within ipsilesional primary and secondary motor cortices. However, work from neuroimaging research has suggest...
journal_title：Translational stroke research
pub_type： 杂志文章,评审
doi：10.1007/s12975-017-0551-5
更新日期：2017-12-01 00:00:00
abstract：:Stroke prevention efforts typically focus on either ischemic or hemorrhagic stroke. This approach is overly simplistic due to the frequent coexistence of ischemic and hemorrhagic cerebrovascular disease. This coexistence, termed "mixed cerebrovascular disease", offers a conceptual framework that appears useful for str...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-012-0185-6
更新日期：2012-07-01 00:00:00
abstract：:Pathophysiological findings of early brain injury in humans have not permitted conclusive determinations. We explored the essence of this phenomenon by taking intraoperative cortical specimens of Hunt-Kosnik grades IV~V (poor-grade) subarachnoid hemorrhages (SAH). From 2013 to 2017, we treated 39 consecutive poor-grad...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-020-00875-0
更新日期：2020-11-27 00:00:00
abstract：:Preconditioning is a paradigm in which sublethal stress-prior to a more injurious insult-induces protection against injury. In the central nervous system (CNS), preconditioning against ischemic stroke is induced by short durations of ischemia, brief seizures, exposure to anesthetics, and other stresses. Increasing evi...
journal_title：Translational stroke research
pub_type： 杂志文章,评审
doi：10.1007/s12975-017-0547-1
更新日期：2017-12-01 00:00:00
abstract：:Global ischemia following cardiac arrest is characterized by high mortality and significant neurological deficits in long-term survivors. Its mechanisms of neuronal cell death have only partially been elucidated. 12/15-lipoxygenase (12/15-LOX) is a major contributor to delayed neuronal cell death and vascular injury i...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-016-0509-z
更新日期：2017-04-01 00:00:00
abstract：:The iron chelator, deferoxamine mesylate (DFO), has shown neuroprotective effects, mediated via suppression of iron-induced hydroxyl radical formation, in various animal models of ischemic and hemorrhagic stroke. Therefore, the objective of this study was to investigate whether DFO can exert similar actions in stroke ...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-009-0001-0
更新日期：2010-03-01 00:00:00
abstract：:Monocytes recruitment from the blood to inflamed tissues following ischemic stroke is an important immune response to wound healing and tissue repair. Mouse monocytes can be endogenously divided into two distinct populations: pro-inflammatory or classical monocytes that express CCR2highCX3CR1low and circulate in blood...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-020-00878-x
更新日期：2021-01-06 00:00:00
abstract：:Impaired cerebral autoregulation and neurovascular coupling (NVC) contribute to delayed cerebral ischemia after subarachnoid hemorrhage (SAH). Retinal vessel analysis (RVA) allows non-invasive assessment of vessel dimension and NVC hereby demonstrating a predictive value in the context of various neurovascular disease...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-017-0585-8
更新日期：2018-06-01 00:00:00
abstract：:In the original publication of the article, there was a switched order of author names. ...
journal_title：Translational stroke research
pub_type： 杂志文章,已发布勘误
doi：10.1007/s12975-018-0618-y
更新日期：2018-12-01 00:00:00
abstract：:The presence of active developmental angiogenesis and vascular outgrowth in the postnatal brain may differentially affect vascular responses to stroke in newborns and adults, but very little is known about the dynamics of vascular injury and re-growth after stroke during the neonatal period. In this study we used a cl...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-012-0214-5
更新日期：2013-04-01 00:00:00
abstract：:Stroke is a cerebrovascular disorder that affects many people worldwide. Pericytes play an important role in stroke progression and recovery. The sigma-1 receptor (σ-1R) signaling pathway has been suggested as having promising neuroprotective potential in treating stroke; however, whether σ-1R activation regulates per...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-019-00711-0
更新日期：2020-04-01 00:00:00
abstract：:Low translational yield for stroke may reflect the focus of discovery science on rodents rather than humans. Just how little is known about human neuronal ischaemic responses is confirmed by systematic review and meta-analysis revealing that data for the most commonly used SH-SY5Y human cells comprises only 84 papers....
journal_title：Translational stroke research
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s12975-018-0620-4
更新日期：2018-12-01 00:00:00
abstract：:Hematoma puncture and subsequent clot lysis with recombinant tissue plasminogen activator (rtPA) emerged as an alternative therapy for spontaneous intracerebral hemorrhage (ICH) and is associated with delayed edema possibly counteracting the beneficial effects of hematoma volume reduction. We hypothesized that immedia...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-012-0188-3
更新日期：2012-07-01 00:00:00
abstract：:The long-term effects of multiple sport-related concussions are currently at the center of debate in the popular press and scientific community. The question, "How many concussions are too many," is frequently asked in the competitive sport environment by parents, athletes, and coaches. While research suggests that a ...
journal_title：Translational stroke research
pub_type： 杂志文章,评审
doi：10.1007/s12975-012-0237-y
更新日期：2013-08-01 00:00:00
abstract：:Magnetic resonance imaging (MRI) has dramatically changed our ability to diagnose and treat stroke as well as follow its evolution and response to treatment. Early stroke and ischemia can be visualized using diffusion-weighted imaging that utilizes water diffusion within tissues as a reporter for evolving neuropatholo...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-011-0139-4
更新日期：2012-03-01 00:00:00
abstract：:Subarachnoid haemorrhage (SAH) is a devastating disease and a major burden on society. Despite this, pharmacological treatment options are limited. Appropriate animal modelling of SAH is essential for the development of neuroprotective drugs, but experimental SAH often fails to produce widespread neuronal loss, as fre...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-011-0124-y
更新日期：2012-03-01 00:00:00
abstract：:Anticoagulation increases the risk of intracerebral hemorrhage (ICH) in patients with cerebral amyloid angiopathy (CAA), so the management of stroke-risk in patients with both atrial fibrillation (AF) and CAA is controversial. Advances in left atrial appendage closure (LAAC) techniques provide a stroke-risk-reduction ...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-020-00838-5
更新日期：2020-08-07 00:00:00
abstract：:Silent information regulator 1 (SIRT1) is a NAD+-dependent histone deacetylase that represses gene expression and plays a role in longevity. SIRT1 responds to diverse stress conditions and regulates metabolism in nutrient deficiency conditions; therefore, it is involved in adaptive pathways to better fulfill tissue ne...
journal_title：Translational stroke research
pub_type： 杂志文章,评审
doi：10.1007/s12975-013-0277-y
更新日期：2013-12-01 00:00:00
abstract：:CD8+ T cells are recognized as key players in exacerbation of ischemic stroke; however, the underlying mechanism in modulating the function of CD8+ T cells has not been completely elucidated. Here, we uncovered that FasL enhanced the cytotoxicity of CD8+ T cells to neurons after ischemic stroke. Inactivation of FasL s...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-019-00749-0
更新日期：2020-08-01 00:00:00
abstract：:Traumatic brain injury (TBI) affects all age groups in a population and is an injury generating scientific interest not only as an acute event, but also as a complex brain disease with several underlying neurobehavioral and neuropathological characteristics. We review early and long-term alterations after juvenile and...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-011-0126-9
更新日期：2011-12-01 00:00:00
abstract：:Lifestyle risk factors, inflammation and genetics play a role in the development of atherosclerosis. We therefore studied Fc gamma receptor (FcγR) polymorphisms, interleukin (IL)-10 polymorphisms and other biomarkers related to carotid intima-media thickness (cIMT) in patients with ischemic stroke at a young age. Pati...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-015-0403-0
更新日期：2015-08-01 00:00:00
abstract：:Voltage-gated potassium (Kv) channels are widely expressed in the central and peripheral nervous system and are crucial mediators of neuronal excitability. Importantly, these channels also actively participate in cellular and molecular signaling pathways that regulate the life and death of neurons. Injury-mediated inc...
journal_title：Translational stroke research
pub_type： 杂志文章,评审
doi：10.1007/s12975-013-0297-7
更新日期：2014-02-01 00:00:00
abstract：:In a porcine ischemic stroke model, we sought to compare the acute predicted infarct core volume (PIV) defined by CT perfusion (CTP)-hemodynamic parameters and MR-diffusion-weighted imaging (MR-DWI)/apparent diffusion coefficient (ADC), with the true infarct core volume (TIV) as defined by histology. Ten Duroc-cross p...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-015-0394-x
更新日期：2015-06-01 00:00:00
abstract：BACKGROUND:Admission hyperglycemia impacts ischemic stroke deleteriously but the relative role of acute hyperglycemia (HG) versus diabetes in the pathogenesis of this poor outcome is not clear. PURPOSE:To determine the effect of acute HG on neurovascular outcomes of stroke under control and diabetic conditions. METHO...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-011-0083-3
更新日期：2011-09-01 00:00:00
abstract：:Noninvasive magnetic resonance (MR) methods have been explored to provide quantitative measurements of cerebral blood flow (CBF), oxygen extraction fraction (OEF), and oxygen metabolic index (OMI = CBF × OEF). In this study, we sought to evaluate whether MR measured OEF, CBF, and OMI can consistently detect the expect...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-011-0142-9
更新日期：2012-06-01 00:00:00
