COVID-19-Related Stroke.

abstract：:Cavernous angioma (CA) is a vascular pathology caused by loss of function in one of the 3 CA genes (CCM1, CCM2, and CCM3) that result in rho kinase (ROCK) activation. We investigated a novel ROCK2 selective inhibitor for the ability to reduce brain lesion formation, growth, and maturation. We used genetic methods to e...

journal_title：Translational stroke research

authors： McKerracher L,Shenkar R,Abbinanti M,Cao Y,Peiper A,Liao JK,Lightle R,Moore T,Hobson N,Gallione C,Ruschel J,Koskimäki J,Girard R,Rosen K,Marchuk DA,Awad IA

更新日期：2020-06-01 00:00:00

abstract：:Global ischemia following cardiac arrest is characterized by high mortality and significant neurological deficits in long-term survivors. Its mechanisms of neuronal cell death have only partially been elucidated. 12/15-lipoxygenase (12/15-LOX) is a major contributor to delayed neuronal cell death and vascular injury i...

journal_title：Translational stroke research

authors： Yigitkanli K,Zheng Y,Pekcec A,Lo EH,van Leyen K

更新日期：2017-04-01 00:00:00

abstract：:Intracerebral hemorrhage is by far the most destructive form of stroke. Apart from the management in a specialized stroke or neurological intensive care unit (NICU), no specific therapies have been shown to consistently improve outcomes after ICH. Current guidelines endorse early aggressive optimization of physiologic...

journal_title：Translational stroke research

authors： Rincon F,Mayer SA

更新日期：2012-07-01 00:00:00

abstract：:The incidence of small vessel-type (lacunar) ischemic strokes is greater in African-Americans compared to whites. The chronic inflammatory changes that result from lacunar stroke are poorly understood. To elucidate these changes, we measured serum inflammatory and thrombotic biomarkers in African-Americans at least 6 ...

journal_title：Translational stroke research

authors： Brown CM,Bushnell CD,Samsa GP,Goldstein LB,Colton CA

更新日期：2015-12-01 00:00:00

abstract：:There was an error in Fig. 2d. The correct Fig. 2d is shown below. ...

journal_title：Translational stroke research

authors： Yoshimura S,Uchida K,Sakai N,Imamura H,Yamagami H,Tanaka K,Ezura M,Nonaka T,Matsumoto Y,Shibata M,Ohta H,Morimoto M,Fukawa N,Hatano T,Enomoto Y,Takeuchi M,Ota T,Shimizu F,Kimura N,Kamiya Y,Shimamura N,Morimoto T

更新日期：2020-10-22 00:00:00

abstract：:Aneurysmal subarachnoid hemorrhage comprises of an early phase after the bleeding and a late phase of delayed consequences of the bleeding. The development of delayed injury mechanisms, like the reduction of cerebral blood flow (CBF) due to cerebral vasospasm (CVS), seems mainly to depend on the amount and the duratio...

journal_title：Translational stroke research

authors： Güresir E,Schuss P,Borger V,Vatter H

更新日期：2015-06-01 00:00:00

abstract：:Cerebral blood flow (CBF) is the key factor for identifying progressive hypoperfusion that is indicative of numerous pathological conditions. CBF measurement is beneficial for the management of cerebrovascular disease, head injury, and intracranial neoplasms. Of the various imaging modalities developed to assess CBF, ...

journal_title：Translational stroke research

authors： Mette D,Strunk R,Zuccarello M

更新日期：2011-06-01 00:00:00

abstract：:Management of intracranial aneurysms remains controversial. For unruptured aneurysms, many factors should be taken into account before deciding the type of treatment and whether to treat or not. Ruptured aneurysms on the other hand are almost always treated. Still, the question remains what are the indicators that one...

journal_title：Translational stroke research

authors： Zanaty M,Chalouhi N,Tjoumakaris SI,Rosenwasser RH,Jabbour PM

更新日期：2014-04-01 00:00:00

abstract：:Motor impairment is the most common complication after stroke, and recovery of motor function has been shown to be dependent on the extent of lesion in the ipsilesional corticospinal tract (iCST) and activity within ipsilesional primary and secondary motor cortices. However, work from neuroimaging research has suggest...

journal_title：Translational stroke research

authors： Alawieh A,Tomlinson S,Adkins D,Kautz S,Feng W

更新日期：2017-12-01 00:00:00

abstract：:Anticoagulation increases the risk of intracerebral hemorrhage (ICH) in patients with cerebral amyloid angiopathy (CAA), so the management of stroke-risk in patients with both atrial fibrillation (AF) and CAA is controversial. Advances in left atrial appendage closure (LAAC) techniques provide a stroke-risk-reduction ...

journal_title：Translational stroke research

authors： Schrag M,Mac Grory B,Nackenoff A,Eaton J,Mistry E,Kirshner H,Yaghi S,Ellis CR

更新日期：2020-08-07 00:00:00

abstract：:Increasing endogenous ciliary neurotrophic factor (CNTF) expression with a pharmacological agent might be beneficial after stroke as CNTF both promotes neurogenesis and, separately, is neuroprotective. P2X7 purinergic receptor inhibition is neuroprotective in rats and increases CNTF release in rat CMT1A Schwann cells....

journal_title：Translational stroke research

authors： Kang SS,Keasey MP,Hagg T

更新日期：2013-10-01 00:00:00

abstract：:Polymorphonuclear neutrophils (PMNs) infiltration into brain parenchyma after cerebrovascular accidents is viewed as a key component of secondary brain injury. Interestingly, a recent study of ischemic stroke suggests that after ischemic stroke, PMNs do not enter brain parenchyma and as such may cause no harm to the b...

journal_title：Translational stroke research

authors： Zhao X,Sun G,Zhang H,Ting SM,Song S,Gonzales N,Aronowski J

更新日期：2014-10-01 00:00:00

abstract：:Voltage-gated potassium (Kv) channels are widely expressed in the central and peripheral nervous system and are crucial mediators of neuronal excitability. Importantly, these channels also actively participate in cellular and molecular signaling pathways that regulate the life and death of neurons. Injury-mediated inc...

journal_title：Translational stroke research

authors： Shah NH,Aizenman E

更新日期：2014-02-01 00:00:00

abstract：:Ischemic stroke is a devastating neural event as currently no therapies other than physical rehabilitation are available to enhance recovery after stroke. To identify endogenous mediators to repair stroke brain, we performed the expression profiling analysis of transcripts in the mouse photothrombotic stroke brain. Ba...

journal_title：Translational stroke research

authors： Sakamoto M,Miyazaki Y,Kitajo K,Yamaguchi A

更新日期：2015-08-01 00:00:00

abstract：:Traumatic brain injury (TBI) affects all age groups in a population and is an injury generating scientific interest not only as an acute event, but also as a complex brain disease with several underlying neurobehavioral and neuropathological characteristics. We review early and long-term alterations after juvenile and...

journal_title：Translational stroke research

authors： Pop V,Badaut J

更新日期：2011-12-01 00:00:00

abstract：:This study was aimed to test the hypothesis that human bone marrow stromal cells (hBMSC) expanded in fetal calf serum (FCS)-free, platelet lysate (PL)-containing medium would retain their capacity of migration, survival, and neural differentiation when transplanted into the infarct brain, using serial in vivo magnetic...

journal_title：Translational stroke research

authors： Ito M,Kuroda S,Sugiyama T,Shichinohe H,Takeda Y,Nishio M,Koike T,Houkin K

更新日期：2011-09-01 00:00:00

abstract：:We reported previously that both a cannabinoid receptor 2 (CB2R) agonist and a cannabinoid receptor 1 (CB1R) antagonist were protective in the treatment of transient middle cerebral artery occlusion/reperfusion injury (MCAO/R) and that they acted in a synergistic manner when administered in combination. The goal of th...

journal_title：Translational stroke research

authors： Zhang M,Mahadevan A,Amere M,Li H,Ganea D,Tuma RF

更新日期：2012-09-01 00:00:00

abstract：:In a porcine ischemic stroke model, we sought to compare the acute predicted infarct core volume (PIV) defined by CT perfusion (CTP)-hemodynamic parameters and MR-diffusion-weighted imaging (MR-DWI)/apparent diffusion coefficient (ADC), with the true infarct core volume (TIV) as defined by histology. Ten Duroc-cross p...

journal_title：Translational stroke research

authors： d'Esterre CD,Aviv RI,Morrison L,Fainardi E,Lee TY

更新日期：2015-06-01 00:00:00

abstract：:Pathophysiological findings of early brain injury in humans have not permitted conclusive determinations. We explored the essence of this phenomenon by taking intraoperative cortical specimens of Hunt-Kosnik grades IV~V (poor-grade) subarachnoid hemorrhages (SAH). From 2013 to 2017, we treated 39 consecutive poor-grad...

journal_title：Translational stroke research

authors： Shimamura N,Fumoto T,Naraoka M,Katagai T,Fujiwara N,Katayama K,Kinoshita S,Yanagiya K,Sasaki T,Kurose A,Ohkuma H

更新日期：2020-11-27 00:00:00

abstract：:Approximately, 16 million strokes occur worldwide each year, causing 6 million deaths and considerable disability, implying an enormous social, individual health, and economic burden. Due to this high incidence, strategies to promote stroke recovery are urgently needed. Research into new therapeutic approaches for str...

journal_title：Translational stroke research

authors： Otero-Ortega L,Laso-García F,Gómez-de Frutos M,Fuentes B,Diekhorst L,Díez-Tejedor E,Gutiérrez-Fernández M

更新日期：2019-06-01 00:00:00

abstract：:Although used extensively in stroke research, there is limited knowledge of how 2, 3, 5-triphenyltetrazolium chloride (TTC)-treated rat brain sections are altered and if they can be used for immunohistochemical quantification after staining with TTC. In the present study, we hypothesized that TTC treatment (TTC+) woul...

journal_title：Translational stroke research

authors： Li Z,Bishop N,Chan SL,Cipolla MJ

更新日期：2018-10-01 00:00:00

abstract：:The presence of active developmental angiogenesis and vascular outgrowth in the postnatal brain may differentially affect vascular responses to stroke in newborns and adults, but very little is known about the dynamics of vascular injury and re-growth after stroke during the neonatal period. In this study we used a cl...

journal_title：Translational stroke research

authors： Fernández-López D,Faustino J,Derugin N,Vexler ZS

更新日期：2013-04-01 00:00:00

abstract：:Subarachnoid haemorrhage (SAH) is a devastating disease and a major burden on society. Despite this, pharmacological treatment options are limited. Appropriate animal modelling of SAH is essential for the development of neuroprotective drugs, but experimental SAH often fails to produce widespread neuronal loss, as fre...

journal_title：Translational stroke research

authors： Greenhalgh AD,Rothwell NJ,Allan SM

更新日期：2012-03-01 00:00:00

abstract：:The long-term effects of multiple sport-related concussions are currently at the center of debate in the popular press and scientific community. The question, "How many concussions are too many," is frequently asked in the competitive sport environment by parents, athletes, and coaches. While research suggests that a ...

journal_title：Translational stroke research

authors： Elbin RJ,Covassin T,Henry L,Whalen DJ,Wedge J,Kontos AP

更新日期：2013-08-01 00:00:00

abstract：:An argument for preclinical stroke research to make more use of the permanent middle cerebral artery occlusion (MCAO) model, rather than transient MCAO, is presented. Despite STAIR recommending permanent MCAO as the primary model, preclinical stroke research has not been listened. In 2012, Hossmann reported that 64% o...

journal_title：Translational stroke research

authors： McBride DW,Zhang JH

更新日期：2017-07-17 00:00:00

abstract：:Neonatal hypoxia-ischemia (HI) is a devastating condition resulting in neuronal cell death and often culminates in neurological deficits. Granulocyte-colony stimulating factor (G-CSF) has been shown to have neuroprotective activity via inhibition of apoptosis and inflammation in various stroke models. Stem cell factor...

journal_title：Translational stroke research

authors： Doycheva D,Shih G,Chen H,Applegate R,Zhang JH,Tang J

更新日期：2013-04-01 00:00:00

abstract：:Impaired cerebral autoregulation and neurovascular coupling (NVC) contribute to delayed cerebral ischemia after subarachnoid hemorrhage (SAH). Retinal vessel analysis (RVA) allows non-invasive assessment of vessel dimension and NVC hereby demonstrating a predictive value in the context of various neurovascular disease...

journal_title：Translational stroke research

authors： Conzen C,Albanna W,Weiss M,Kürten D,Vilser W,Kotliar K,Zäske C,Clusmann H,Schubert GA

更新日期：2018-06-01 00:00:00

abstract：:For years, strategies have been proposed to improve translational success in stroke research by improving the quality of animal studies. However, articles that report preclinical intracerebral hemorrhage (ICH) studies continue to lack adequate qualitative and quantitative descriptions of fresh brain tissue collection....

journal_title：Translational stroke research

authors： Chang CF,Cai L,Wang J

更新日期：2015-10-01 00:00:00

abstract：:Previous studies showed that complement activation is associated with poor functional outcome after aneurysmal subarachnoid hemorrhage (SAH). We investigated whether complement activation is underlying brain injury after aneurysmal SAH (n = 7) and if it is an appropriate treatment target. We investigated complement ex...

journal_title：Translational stroke research

authors： van Dijk BJ,Meijers JCM,Kloek AT,Knaup VL,Rinkel GJE,Morgan BP,van der Kamp MJ,Osuka K,Aronica E,Ruigrok YM,van de Beek D,Brouwer M,Pekna M,Hol EM,Vergouwen MDI

更新日期：2020-08-01 00:00:00

abstract：:Diabetes significantly increases the risk of stroke and post-stroke mortality. Recurrent hypoglycemia (RH) is common among diabetes patients owing to glucose-lowering therapies. Earlier, we showed that RH in a rat model of insulin-dependent diabetes exacerbates cerebral ischemic damage. Impaired mitochondrial function...

journal_title：Translational stroke research

authors： Shukla V,Fuchs P,Liu A,Cohan CH,Dong C,Wright CB,Perez-Pinzon MA,Dave KR

更新日期：2019-02-01 00:00:00