Abstract:
:Diabetes significantly increases the risk of stroke and post-stroke mortality. Recurrent hypoglycemia (RH) is common among diabetes patients owing to glucose-lowering therapies. Earlier, we showed that RH in a rat model of insulin-dependent diabetes exacerbates cerebral ischemic damage. Impaired mitochondrial function has been implicated as a central player in the development of cerebral ischemic damage. Hypoglycemia is also known to affect mitochondrial functioning. The present study tested the hypothesis that prior exposure of insulin-treated diabetic (ITD) rats to RH exacerbates brain damage via enhanced post-ischemic mitochondrial dysfunction. In a rat model of streptozotocin-induced diabetes, we evaluated post-ischemic mitochondrial function in RH-exposed ITD rats. Rats were exposed to five episodes of moderate hypoglycemia prior to the induction of cerebral ischemia. We also evaluated the impact of RH, both alone and in combination with cerebral ischemia, on cognitive function using the Barnes circular platform maze test. We observed that RH exposure to ITD rats leads to increased cerebral ischemic damage and decreased mitochondrial complex I activity. Exposure of ITD rats to RH impaired spatial learning and memory. Our results demonstrate that RH exposure to ITD rats potentially increases post-ischemic damage via enhanced post-ischemic mitochondrial dysfunction.
journal_name
Transl Stroke Resjournal_title
Translational stroke researchauthors
Shukla V,Fuchs P,Liu A,Cohan CH,Dong C,Wright CB,Perez-Pinzon MA,Dave KRdoi
10.1007/s12975-018-0622-2subject
Has Abstractpub_date
2019-02-01 00:00:00pages
78-90issue
1eissn
1868-4483issn
1868-601Xpii
10.1007/s12975-018-0622-2journal_volume
10pub_type
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journal_title:Translational stroke research
pub_type: 信件
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更新日期:2020-06-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Translational stroke research
pub_type: 杂志文章
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journal_title:Translational stroke research
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更新日期:2010-03-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2019-12-01 00:00:00
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