Abstract:
:Polymorphonuclear neutrophils (PMNs) infiltration into brain parenchyma after cerebrovascular accidents is viewed as a key component of secondary brain injury. Interestingly, a recent study of ischemic stroke suggests that after ischemic stroke, PMNs do not enter brain parenchyma and as such may cause no harm to the brain. Thus, the present study was designed to determine PMNs' behavior after intracerebral hemorrhage (ICH). Using the autologous blood injection model of ICH in rats and immunohistochemistry for PMNs and vascular components, we evaluated the temporal and spatial PMNs distribution in the ICH-affected brain. We found that, similar to ischemia, there is a robust increase in presence of PMNs in the ICH-injured tissue that lasts for at least 1 to 2 weeks. However, in contrast to what was suggested for ischemia, besides PMNs that stay in association with the vasculature, after ICH, we found abundance of intraparenchymal PMNs (with no obvious association with vessels) in the ICH core and hematoma border, especially between 1 and 7 days after the ictus. Interestingly, the increased presence of intraparenchymal PMNs after ICH coincided with the massive loss of microvascular integrity, suggesting vascular disruption as a potential cause of PMNs presence in the brain parenchyma. Our study indicates that in contrast to ischemic stroke, after ICH, PMNs target not only vascular compartment but also brain parenchyma in the affected brain. As such, it is possible that the pathogenic role and therapeutic implications of targeting PMNs after ICH could be different from these after ischemic stroke. Our work suggests the needs for more studies addressing the role of PMNs in ICH.
journal_name
Transl Stroke Resjournal_title
Translational stroke researchauthors
Zhao X,Sun G,Zhang H,Ting SM,Song S,Gonzales N,Aronowski Jdoi
10.1007/s12975-014-0341-2subject
Has Abstractpub_date
2014-10-01 00:00:00pages
554-61issue
5eissn
1868-4483issn
1868-601Xjournal_volume
5pub_type
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journal_title:Translational stroke research
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更新日期:2020-11-27 00:00:00
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journal_title:Translational stroke research
pub_type: 杂志文章
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更新日期:2020-06-01 00:00:00
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journal_title:Translational stroke research
pub_type: 杂志文章,评审
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journal_title:Translational stroke research
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journal_title:Translational stroke research
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pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
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