Abstract：
:Intraventricular hemorrhage (IVH), which afflicts thousands of people of all ages every year, frequently results in the development of communicating hydrocephalus. Classically, IVH-induced hydrocephalus has been attributed to reduced resorption of cerebrospinal fluid (CSF) due to dysfunction of arachnoid granulations, but this explanation may be incomplete. We hypothesized that IVH would cause inflammation of the choroid plexus and of the ependymal lining of the ventricles, resulting in dysfunction of these barrier cells. Barrier dysfunction, in turn, would be expected to cause an increase in production of abnormal protein-rich CSF and transependymal migration of CSF. We tested this hypothesis using a rat model of IVH, in which 160 μl of autologous blood was infused into the lateral ventricle, resulting in a twofold increase in ventricular size 48 h later. In this model, we found significant activation of nuclear factor κB (NF-κB) signaling by the CSF barrier cells of the choroid plexus and ependymal lining. Moreover, these inflammatory changes were associated with abnormal uptake of serum-derived IgG by the barrier cells, a phenomenon closely linked to abnormal permeability of the blood-brain barrier. We conclude that inflammation marked by NF-κB signaling is a prominent feature after IVH and may account for certain pathophysiological sequelae associated with IVH.
journal_name
Transl Stroke Resjournal_title
Translational stroke researchauthors
Simard PF,Tosun C,Melnichenko L,Ivanova S,Gerzanich V,Simard JMdoi
10.1007/s12975-011-0070-8subject
Has Abstractpub_date
2011-06-01 00:00:00pages
227-31issue
2eissn
1868-4483issn
1868-601Xjournal_volume
2pub_type
杂志文章abstract：:Hematoma puncture and subsequent clot lysis with recombinant tissue plasminogen activator (rtPA) emerged as an alternative therapy for spontaneous intracerebral hemorrhage (ICH) and is associated with delayed edema possibly counteracting the beneficial effects of hematoma volume reduction. We hypothesized that immedia...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-012-0188-3
更新日期：2012-07-01 00:00:00
abstract：:Lifestyle risk factors, inflammation and genetics play a role in the development of atherosclerosis. We therefore studied Fc gamma receptor (FcγR) polymorphisms, interleukin (IL)-10 polymorphisms and other biomarkers related to carotid intima-media thickness (cIMT) in patients with ischemic stroke at a young age. Pati...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-015-0403-0
更新日期：2015-08-01 00:00:00
abstract：:The most deadly form of stroke, intracerebral hemorrhage (ICH) continues to puzzle researchers and produce substantial decrements in the quality of patients' lives. Intensive basic research has devised many agents with putative benefit in mitigating the devastating effects of ICH, but these therapies have been largely...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-012-0207-4
更新日期：2012-12-01 00:00:00
abstract：:Despite being a conveniently portable technology for stroke assessment, Transcranial Doppler ultrasound (TCD) remains widely underutilized due to complex training requirements necessary to reliably obtain and interpret cerebral blood flow velocity (CBFV) waveforms. The validation of objective TCD metrics for large ves...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-018-0667-2
更新日期：2019-10-01 00:00:00
abstract：:Intracerebral hemorrhage is a devastating disease. Despite its clinical importance, the pathophysiology of intracerebral hemorrhage is not well understood. Hematoma expansion occurs in a large subset of patients and is a predictor of poor outcomes. Since hematoma growth provides a potential opportunity for therapeutic...
journal_title：Translational stroke research
pub_type： 杂志文章,评审
doi：10.1007/s12975-015-0410-1
更新日期：2015-08-01 00:00:00
abstract：:Neurogenesis is essential for a good post-stroke outcome. Exogenous stem cells are currently being tested to promote neurogenesis after stroke. Elsewhere, we demonstrated that treatment with the PPARγ agonist pioglitazone (PGZ) before cerebral ischemia induction reduced brain damage and activated survival-related gene...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-017-0577-8
更新日期：2018-06-01 00:00:00
abstract：:The presence of active developmental angiogenesis and vascular outgrowth in the postnatal brain may differentially affect vascular responses to stroke in newborns and adults, but very little is known about the dynamics of vascular injury and re-growth after stroke during the neonatal period. In this study we used a cl...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-012-0214-5
更新日期：2013-04-01 00:00:00
abstract：:In a porcine ischemic stroke model, we sought to compare the acute predicted infarct core volume (PIV) defined by CT perfusion (CTP)-hemodynamic parameters and MR-diffusion-weighted imaging (MR-DWI)/apparent diffusion coefficient (ADC), with the true infarct core volume (TIV) as defined by histology. Ten Duroc-cross p...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-015-0394-x
更新日期：2015-06-01 00:00:00
abstract：:Traumatic brain injury (TBI) affects all age groups in a population and is an injury generating scientific interest not only as an acute event, but also as a complex brain disease with several underlying neurobehavioral and neuropathological characteristics. We review early and long-term alterations after juvenile and...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-011-0126-9
更新日期：2011-12-01 00:00:00
abstract：:The COVID-19 pandemic is associated with neurological symptoms and complications including stroke. There is hypercoagulability associated with COVID-19 that is likely a "sepsis-induced coagulopathy" and may predispose to stroke. The SARS-CoV-2 virus binds to angiotensin-converting enzyme 2 (ACE2) present on brain endo...
journal_title：Translational stroke research
pub_type： 信件
doi：10.1007/s12975-020-00818-9
更新日期：2020-06-01 00:00:00
abstract：:Low translational yield for stroke may reflect the focus of discovery science on rodents rather than humans. Just how little is known about human neuronal ischaemic responses is confirmed by systematic review and meta-analysis revealing that data for the most commonly used SH-SY5Y human cells comprises only 84 papers....
journal_title：Translational stroke research
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s12975-018-0620-4
更新日期：2018-12-01 00:00:00
abstract：:Previous studies showed that complement activation is associated with poor functional outcome after aneurysmal subarachnoid hemorrhage (SAH). We investigated whether complement activation is underlying brain injury after aneurysmal SAH (n = 7) and if it is an appropriate treatment target. We investigated complement ex...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-019-00757-0
更新日期：2020-08-01 00:00:00
abstract：:There was an error in Fig. 2d. The correct Fig. 2d is shown below. ...
journal_title：Translational stroke research
pub_type： 已发布勘误
doi：10.1007/s12975-020-00871-4
更新日期：2020-10-22 00:00:00
abstract：:Preconditioning is a paradigm in which sublethal stress-prior to a more injurious insult-induces protection against injury. In the central nervous system (CNS), preconditioning against ischemic stroke is induced by short durations of ischemia, brief seizures, exposure to anesthetics, and other stresses. Increasing evi...
journal_title：Translational stroke research
pub_type： 杂志文章,评审
doi：10.1007/s12975-017-0547-1
更新日期：2017-12-01 00:00:00
abstract：:Inconsistency in outcome parameters for delayed cerebral ischemia (DCI) makes it difficult to compare results between mouse studies, in the same way inconsistency in outcome parameters in human studies has for long obstructed adequate comparison. The absence of an established definition may in part be responsible for ...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-020-00796-y
更新日期：2020-10-01 00:00:00
abstract：:Subarachnoid haemorrhage (SAH) is a devastating disease and a major burden on society. Despite this, pharmacological treatment options are limited. Appropriate animal modelling of SAH is essential for the development of neuroprotective drugs, but experimental SAH often fails to produce widespread neuronal loss, as fre...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-011-0124-y
更新日期：2012-03-01 00:00:00
abstract：:Cerebral blood flow (CBF) is the key factor for identifying progressive hypoperfusion that is indicative of numerous pathological conditions. CBF measurement is beneficial for the management of cerebrovascular disease, head injury, and intracranial neoplasms. Of the various imaging modalities developed to assess CBF, ...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-010-0064-y
更新日期：2011-06-01 00:00:00
abstract：:Neonatal hypoxia-ischemia (HI) is a devastating condition resulting in neuronal cell death and often culminates in neurological deficits. Granulocyte-colony stimulating factor (G-CSF) has been shown to have neuroprotective activity via inhibition of apoptosis and inflammation in various stroke models. Stem cell factor...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-012-0225-2
更新日期：2013-04-01 00:00:00
abstract：:Magnetic resonance imaging (MRI) has dramatically changed our ability to diagnose and treat stroke as well as follow its evolution and response to treatment. Early stroke and ischemia can be visualized using diffusion-weighted imaging that utilizes water diffusion within tissues as a reporter for evolving neuropatholo...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-011-0139-4
更新日期：2012-03-01 00:00:00
abstract：:Poor clinical outcomes despite endovascular therapy (EVT) are common in patients with acute basilar artery occlusion (BAO). We aimed to develop a new angiographic collateral grading system for predicting 90-day functional outcomes of acute BAO after EVT. A prospectively registered consecutive cohort of acute BAO patie...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-020-00856-3
更新日期：2020-09-28 00:00:00
abstract：:Voltage-gated potassium (Kv) channels are widely expressed in the central and peripheral nervous system and are crucial mediators of neuronal excitability. Importantly, these channels also actively participate in cellular and molecular signaling pathways that regulate the life and death of neurons. Injury-mediated inc...
journal_title：Translational stroke research
pub_type： 杂志文章,评审
doi：10.1007/s12975-013-0297-7
更新日期：2014-02-01 00:00:00
abstract：:Circulating levels of the pro-inflammatory cytokine C-C motif chemokine 11 (CCL11, also known as eotaxin-1) are increased in several animal models of neuroinflammation, including traumatic brain injury and Alzheimer's disease. Increased levels of CCL11 have also been linked to decreased neurogenesis in mice. We hypoth...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-017-0545-3
更新日期：2017-12-01 00:00:00
abstract：:Global ischemia following cardiac arrest is characterized by high mortality and significant neurological deficits in long-term survivors. Its mechanisms of neuronal cell death have only partially been elucidated. 12/15-lipoxygenase (12/15-LOX) is a major contributor to delayed neuronal cell death and vascular injury i...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-016-0509-z
更新日期：2017-04-01 00:00:00
abstract：:Acute ischemic stroke (AIS) often results in degeneration of the blood-brain barrier (BBB), which can lead to vasogenic edema and an increased risk of intracerebral hemorrhage. Imatinib is an agent that may be able to protect the BBB and reduce the risk of the harmful consequences of BBB degeneration. We sought to mea...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-014-0358-6
更新日期：2015-02-01 00:00:00
abstract：:Ischemic stroke contributes to the majority of brain injuries and remains to be a leading cause of death and long-term disability. Despite the devastating pathology and high incidence of disease, there remain only few treatment options (TPA and endovascular procedures), which may be hampered by time-dependent administ...
journal_title：Translational stroke research
pub_type： 杂志文章,评审
doi：10.1007/s12975-013-0319-5
更新日期：2014-02-01 00:00:00
abstract：:Aneurysmal subarachnoid hemorrhage comprises of an early phase after the bleeding and a late phase of delayed consequences of the bleeding. The development of delayed injury mechanisms, like the reduction of cerebral blood flow (CBF) due to cerebral vasospasm (CVS), seems mainly to depend on the amount and the duratio...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-015-0392-z
更新日期：2015-06-01 00:00:00
abstract：:Hydrocephalus is one of the most common sequelae after aneurysmal subarachnoid hemorrhage (aSAH), and it is a large contributor to the condition's high rates of readmission and mortality. Our objective was to quantify the healthcare resource utilization (HCRU) and health economic burden incurred by the US health syste...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-019-00697-9
更新日期：2019-12-01 00:00:00
abstract：OBJECTIVE:To elucidate the role of magnesium sulfate in patients with subarachnoid hemorrhagic (SAH) brain injury METHOD:Studies for the meta-analysis were identified from PubMed (1966 to 2009), Embase (1980 to 2009), and two Chinese journals (1989 to 2009). Paper selection was based on randomized controlled trials co...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-010-0022-8
更新日期：2010-06-01 00:00:00
abstract：:For years, strategies have been proposed to improve translational success in stroke research by improving the quality of animal studies. However, articles that report preclinical intracerebral hemorrhage (ICH) studies continue to lack adequate qualitative and quantitative descriptions of fresh brain tissue collection....
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-015-0399-5
更新日期：2015-10-01 00:00:00
abstract：:Diabetes significantly increases the risk of stroke and post-stroke mortality. Recurrent hypoglycemia (RH) is common among diabetes patients owing to glucose-lowering therapies. Earlier, we showed that RH in a rat model of insulin-dependent diabetes exacerbates cerebral ischemic damage. Impaired mitochondrial function...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-018-0622-2
更新日期：2019-02-01 00:00:00
