Abstract：
:Intracerebral hemorrhage is a devastating disease. Despite its clinical importance, the pathophysiology of intracerebral hemorrhage is not well understood. Hematoma expansion occurs in a large subset of patients and is a predictor of poor outcomes. Since hematoma growth provides a potential opportunity for therapeutic intervention, a thorough understanding of its biological mechanisms is of key importance. After vessel rupture, an initial hematoma forms. Following this initial phase, accumulating evidence suggests that the mass effect causes secondary vessel rupture, which contributes to the hematoma and may trigger an avalanche of further vessel ruptures. The circumstances under which this occurs and to what extent secondary hemorrhage contributes to final hematoma volume remain unknown, however. To address these questions, a translational approach seems most suitable. Current experimental models include intracranial injections of collagenase or autologous blood. Each has individual strengths and weaknesses in its ability to simulate human intracerebral hemorrhage. The ultimate goal for improved understanding and modeling of the pathophysiology of hematoma expansion is to identify new treatment approaches.
journal_name
Transl Stroke Resjournal_title
Translational stroke researchauthors
Schlunk F,Greenberg SMdoi
10.1007/s12975-015-0410-1subject
Has Abstractpub_date
2015-08-01 00:00:00pages
257-63issue
4eissn
1868-4483issn
1868-601Xjournal_volume
6pub_type
杂志文章,评审abstract：:Anticoagulation increases the risk of intracerebral hemorrhage (ICH) in patients with cerebral amyloid angiopathy (CAA), so the management of stroke-risk in patients with both atrial fibrillation (AF) and CAA is controversial. Advances in left atrial appendage closure (LAAC) techniques provide a stroke-risk-reduction ...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-020-00838-5
更新日期：2020-08-07 00:00:00
abstract：:Impaired cerebral autoregulation and neurovascular coupling (NVC) contribute to delayed cerebral ischemia after subarachnoid hemorrhage (SAH). Retinal vessel analysis (RVA) allows non-invasive assessment of vessel dimension and NVC hereby demonstrating a predictive value in the context of various neurovascular disease...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-017-0585-8
更新日期：2018-06-01 00:00:00
abstract：:Although used extensively in stroke research, there is limited knowledge of how 2, 3, 5-triphenyltetrazolium chloride (TTC)-treated rat brain sections are altered and if they can be used for immunohistochemical quantification after staining with TTC. In the present study, we hypothesized that TTC treatment (TTC+) woul...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-017-0604-9
更新日期：2018-10-01 00:00:00
abstract：:Intracerebral hemorrhage is by far the most destructive form of stroke. Apart from the management in a specialized stroke or neurological intensive care unit (NICU), no specific therapies have been shown to consistently improve outcomes after ICH. Current guidelines endorse early aggressive optimization of physiologic...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-012-0175-8
更新日期：2012-07-01 00:00:00
abstract：:Increasing endogenous ciliary neurotrophic factor (CNTF) expression with a pharmacological agent might be beneficial after stroke as CNTF both promotes neurogenesis and, separately, is neuroprotective. P2X7 purinergic receptor inhibition is neuroprotective in rats and increases CNTF release in rat CMT1A Schwann cells....
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-013-0265-2
更新日期：2013-10-01 00:00:00
abstract：:The COVID-19 pandemic is associated with neurological symptoms and complications including stroke. There is hypercoagulability associated with COVID-19 that is likely a "sepsis-induced coagulopathy" and may predispose to stroke. The SARS-CoV-2 virus binds to angiotensin-converting enzyme 2 (ACE2) present on brain endo...
journal_title：Translational stroke research
pub_type： 信件
doi：10.1007/s12975-020-00818-9
更新日期：2020-06-01 00:00:00
abstract：:Pulmonary complications associated with persistent respiratory muscle weakness, paralysis, and spasticity are among the most important problems faced by patients with spinal cord injury when lack of muscle strength and disorganization of reciprocal respiratory muscle control lead to breathing insufficiency. This revie...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-011-0114-0
更新日期：2011-12-01 00:00:00
abstract：:Acute ischemic stroke affects over 800,000 US adults annually, with hundreds of thousands more experiencing a transient ischemic attack. Emergent evaluation, prompt acute treatment, and identification of stroke or TIA (transient ischemic attack) etiology for specific secondary prevention are critical for decreasing fu...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-017-0537-3
更新日期：2017-05-05 00:00:00
abstract：:Circulating levels of the pro-inflammatory cytokine C-C motif chemokine 11 (CCL11, also known as eotaxin-1) are increased in several animal models of neuroinflammation, including traumatic brain injury and Alzheimer's disease. Increased levels of CCL11 have also been linked to decreased neurogenesis in mice. We hypoth...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-017-0545-3
更新日期：2017-12-01 00:00:00
abstract：:Hydrocephalus is one of the most common sequelae after aneurysmal subarachnoid hemorrhage (aSAH), and it is a large contributor to the condition's high rates of readmission and mortality. Our objective was to quantify the healthcare resource utilization (HCRU) and health economic burden incurred by the US health syste...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-019-00697-9
更新日期：2019-12-01 00:00:00
abstract：:Despite being a conveniently portable technology for stroke assessment, Transcranial Doppler ultrasound (TCD) remains widely underutilized due to complex training requirements necessary to reliably obtain and interpret cerebral blood flow velocity (CBFV) waveforms. The validation of objective TCD metrics for large ves...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-018-0667-2
更新日期：2019-10-01 00:00:00
abstract：:Preconditioning is a paradigm in which sublethal stress-prior to a more injurious insult-induces protection against injury. In the central nervous system (CNS), preconditioning against ischemic stroke is induced by short durations of ischemia, brief seizures, exposure to anesthetics, and other stresses. Increasing evi...
journal_title：Translational stroke research
pub_type： 杂志文章,评审
doi：10.1007/s12975-017-0547-1
更新日期：2017-12-01 00:00:00
abstract：:Global ischemia following cardiac arrest is characterized by high mortality and significant neurological deficits in long-term survivors. Its mechanisms of neuronal cell death have only partially been elucidated. 12/15-lipoxygenase (12/15-LOX) is a major contributor to delayed neuronal cell death and vascular injury i...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-016-0509-z
更新日期：2017-04-01 00:00:00
abstract：:For years, strategies have been proposed to improve translational success in stroke research by improving the quality of animal studies. However, articles that report preclinical intracerebral hemorrhage (ICH) studies continue to lack adequate qualitative and quantitative descriptions of fresh brain tissue collection....
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-015-0399-5
更新日期：2015-10-01 00:00:00
abstract：:Polymorphonuclear neutrophils (PMNs) infiltration into brain parenchyma after cerebrovascular accidents is viewed as a key component of secondary brain injury. Interestingly, a recent study of ischemic stroke suggests that after ischemic stroke, PMNs do not enter brain parenchyma and as such may cause no harm to the b...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-014-0341-2
更新日期：2014-10-01 00:00:00
abstract：:Ischemic stroke is a devastating neural event as currently no therapies other than physical rehabilitation are available to enhance recovery after stroke. To identify endogenous mediators to repair stroke brain, we performed the expression profiling analysis of transcripts in the mouse photothrombotic stroke brain. Ba...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-015-0401-2
更新日期：2015-08-01 00:00:00
abstract：:This study was aimed to test the hypothesis that human bone marrow stromal cells (hBMSC) expanded in fetal calf serum (FCS)-free, platelet lysate (PL)-containing medium would retain their capacity of migration, survival, and neural differentiation when transplanted into the infarct brain, using serial in vivo magnetic...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-011-0098-9
更新日期：2011-09-01 00:00:00
abstract：:Motor impairment is the most common complication after stroke, and recovery of motor function has been shown to be dependent on the extent of lesion in the ipsilesional corticospinal tract (iCST) and activity within ipsilesional primary and secondary motor cortices. However, work from neuroimaging research has suggest...
journal_title：Translational stroke research
pub_type： 杂志文章,评审
doi：10.1007/s12975-017-0551-5
更新日期：2017-12-01 00:00:00
abstract：:There was an error in Fig. 2d. The correct Fig. 2d is shown below. ...
journal_title：Translational stroke research
pub_type： 已发布勘误
doi：10.1007/s12975-020-00871-4
更新日期：2020-10-22 00:00:00
abstract：:Neurogenesis is essential for a good post-stroke outcome. Exogenous stem cells are currently being tested to promote neurogenesis after stroke. Elsewhere, we demonstrated that treatment with the PPARγ agonist pioglitazone (PGZ) before cerebral ischemia induction reduced brain damage and activated survival-related gene...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-017-0577-8
更新日期：2018-06-01 00:00:00
abstract：:In a porcine ischemic stroke model, we sought to compare the acute predicted infarct core volume (PIV) defined by CT perfusion (CTP)-hemodynamic parameters and MR-diffusion-weighted imaging (MR-DWI)/apparent diffusion coefficient (ADC), with the true infarct core volume (TIV) as defined by histology. Ten Duroc-cross p...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-015-0394-x
更新日期：2015-06-01 00:00:00
abstract：:Activation and repression of gene expression are key features of ischemic tolerance. Converging lines of inquiry from several groups suggests that epigenetic proteins may transduce sublethal stresses, including bioenergetic or oxidative stress into durable (2-3 days) changes in gene expression that mediate ischemic to...
journal_title：Translational stroke research
pub_type： 杂志文章,评审
doi：10.1007/s12975-012-0235-0
更新日期：2013-02-01 00:00:00
abstract：:This study aimed to investigate whether serum lactate dehydrogenase (LDH) levels predicted hematoma expansion and poor outcomes in intracerebral hemorrhage (ICH) patients. The differentially expressed proteins between patients with and without hematoma expansion were screened using proteomic analysis. Then the critica...
journal_title：Translational stroke research
pub_type： 杂志文章,多中心研究
doi：10.1007/s12975-019-0686-7
更新日期：2019-12-01 00:00:00
abstract：:Despite ischemic stroke being the fifth leading cause of death in the USA, there are few therapeutic options available. We recently showed that the neuroprotective compound P7C3-A20 reduced brain atrophy, increased neurogenesis, and improved functional recovery when treatment was initiated immediately post-reperfusion...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-017-0565-z
更新日期：2018-04-01 00:00:00
abstract：:Inconsistency in outcome parameters for delayed cerebral ischemia (DCI) makes it difficult to compare results between mouse studies, in the same way inconsistency in outcome parameters in human studies has for long obstructed adequate comparison. The absence of an established definition may in part be responsible for ...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-020-00796-y
更新日期：2020-10-01 00:00:00
abstract：:Cerebrovascular disease is a leading cause of death-from-disease and of disability worldwide, affecting some 15 million people. The incidence of stroke or "brain attack" is unlikely to recede for a decade at minimum by most predictions, despite large public health initiatives in stroke prevention. It has been well est...
journal_title：Translational stroke research
pub_type： 杂志文章,评审
doi：10.1007/s12975-012-0238-x
更新日期：2013-08-01 00:00:00
abstract：:Poor clinical outcomes despite endovascular therapy (EVT) are common in patients with acute basilar artery occlusion (BAO). We aimed to develop a new angiographic collateral grading system for predicting 90-day functional outcomes of acute BAO after EVT. A prospectively registered consecutive cohort of acute BAO patie...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-020-00856-3
更新日期：2020-09-28 00:00:00
abstract：:Cavernous angioma (CA) is a vascular pathology caused by loss of function in one of the 3 CA genes (CCM1, CCM2, and CCM3) that result in rho kinase (ROCK) activation. We investigated a novel ROCK2 selective inhibitor for the ability to reduce brain lesion formation, growth, and maturation. We used genetic methods to e...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-019-00725-8
更新日期：2020-06-01 00:00:00
abstract：:CD8+ T cells are recognized as key players in exacerbation of ischemic stroke; however, the underlying mechanism in modulating the function of CD8+ T cells has not been completely elucidated. Here, we uncovered that FasL enhanced the cytotoxicity of CD8+ T cells to neurons after ischemic stroke. Inactivation of FasL s...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-019-00749-0
更新日期：2020-08-01 00:00:00
abstract：:The long-term effects of multiple sport-related concussions are currently at the center of debate in the popular press and scientific community. The question, "How many concussions are too many," is frequently asked in the competitive sport environment by parents, athletes, and coaches. While research suggests that a ...
journal_title：Translational stroke research
pub_type： 杂志文章,评审
doi：10.1007/s12975-012-0237-y
更新日期：2013-08-01 00:00:00
