Validity of bone marrow stromal cell expansion by animal serum-free medium for cell transplantation therapy of cerebral infarct in rats-a serial MRI study.

abstract：:Pathophysiological findings of early brain injury in humans have not permitted conclusive determinations. We explored the essence of this phenomenon by taking intraoperative cortical specimens of Hunt-Kosnik grades IV~V (poor-grade) subarachnoid hemorrhages (SAH). From 2013 to 2017, we treated 39 consecutive poor-grad...

journal_title：Translational stroke research

authors： Shimamura N,Fumoto T,Naraoka M,Katagai T,Fujiwara N,Katayama K,Kinoshita S,Yanagiya K,Sasaki T,Kurose A,Ohkuma H

更新日期：2020-11-27 00:00:00

abstract：:Stroke is a cerebrovascular disorder that affects many people worldwide. Pericytes play an important role in stroke progression and recovery. The sigma-1 receptor (σ-1R) signaling pathway has been suggested as having promising neuroprotective potential in treating stroke; however, whether σ-1R activation regulates per...

journal_title：Translational stroke research

authors： Zhang Y,Zhang X,Wei Q,Leng S,Li C,Han B,Bai Y,Zhang H,Yao H

更新日期：2020-04-01 00:00:00

abstract：:Ischemic stroke contributes to the majority of brain injuries and remains to be a leading cause of death and long-term disability. Despite the devastating pathology and high incidence of disease, there remain only few treatment options (TPA and endovascular procedures), which may be hampered by time-dependent administ...

journal_title：Translational stroke research

authors： O'Bryant Z,Vann KT,Xiong ZG

更新日期：2014-02-01 00:00:00

abstract：:Management of intracranial aneurysms remains controversial. For unruptured aneurysms, many factors should be taken into account before deciding the type of treatment and whether to treat or not. Ruptured aneurysms on the other hand are almost always treated. Still, the question remains what are the indicators that one...

journal_title：Translational stroke research

authors： Zanaty M,Chalouhi N,Tjoumakaris SI,Rosenwasser RH,Jabbour PM

更新日期：2014-04-01 00:00:00

abstract：:The iron chelator, deferoxamine mesylate (DFO), has shown neuroprotective effects, mediated via suppression of iron-induced hydroxyl radical formation, in various animal models of ischemic and hemorrhagic stroke. Therefore, the objective of this study was to investigate whether DFO can exert similar actions in stroke ...

journal_title：Translational stroke research

authors： Selim M

更新日期：2010-03-01 00:00:00

abstract：:Cerebral hyperperfusion syndrome (CHS) is a complication that can occur after carotid endarterectomy (CEA), the treatment of choice to decrease the subsequent risk of fatal or disabling stroke for patients with symptomatic severe stenosis of the carotid artery. Because of its rarity and complexity, the mechanism of th...

journal_title：Translational stroke research

authors： Xiao Y,Rivaz H,Kasuya H,Yokosako S,Mindru C,Teitelbaum J,Sirhan D,Sinclair D,Angle M,Lo BWY

更新日期：2018-10-01 00:00:00

abstract：:Polymorphonuclear neutrophils (PMNs) infiltration into brain parenchyma after cerebrovascular accidents is viewed as a key component of secondary brain injury. Interestingly, a recent study of ischemic stroke suggests that after ischemic stroke, PMNs do not enter brain parenchyma and as such may cause no harm to the b...

journal_title：Translational stroke research

authors： Zhao X,Sun G,Zhang H,Ting SM,Song S,Gonzales N,Aronowski J

更新日期：2014-10-01 00:00:00

abstract：:Silent information regulator 1 (SIRT1) is a NAD+-dependent histone deacetylase that represses gene expression and plays a role in longevity. SIRT1 responds to diverse stress conditions and regulates metabolism in nutrient deficiency conditions; therefore, it is involved in adaptive pathways to better fulfill tissue ne...

journal_title：Translational stroke research

authors： Petegnief V,Planas AM

更新日期：2013-12-01 00:00:00

abstract：:Our group recently identified a panel of ten genes whose RNA expression levels in whole blood have utility for detection of stroke. The purpose of this study was to determine the mechanisms by which these genes become differentially expressed during stroke pathology. First, we assessed the transcriptional distribution...

journal_title：Translational stroke research

authors： O'Connell GC,Treadway MB,Tennant CS,Lucke-Wold N,Chantler PD,Barr TL

更新日期：2019-02-01 00:00:00

abstract：:In clinical trials, assessing efficacy is based on validated scales, and the primary endpoint is usually based on a single scale. The aim of the review is to revisit the concepts and methods to design and analyze studies focused on restoration, recovery and or compensation. These studies are becoming more frequent wit...

journal_title：Translational stroke research

authors： Hommel M,Detante O,Favre I,Touzé E,Jaillard A

更新日期：2016-10-01 00:00:00

abstract：:Cerebral blood flow (CBF) is the key factor for identifying progressive hypoperfusion that is indicative of numerous pathological conditions. CBF measurement is beneficial for the management of cerebrovascular disease, head injury, and intracranial neoplasms. Of the various imaging modalities developed to assess CBF, ...

journal_title：Translational stroke research

authors： Mette D,Strunk R,Zuccarello M

更新日期：2011-06-01 00:00:00

abstract：:This review focuses on assessment of behavioral outcomes following traumatic brain injury in juvenile animal models. In the 15 years since the first publication in this field, the majority of studies have used rats roughly equivalent to human toddlers in terms of brain development. Few studies have tested ages closer ...

journal_title：Translational stroke research

authors： Hartman RE

更新日期：2011-12-01 00:00:00

abstract：:Infection is a leading cause of death in patients with stroke; however, the impact of cerebral infarct size or location on infectious outcome is unclear. To examine the effect of infarct size on post-stroke infection, we utilised the intraluminal middle-cerebral artery occlusion (MCAO) mouse model of ischemic stroke a...

journal_title：Translational stroke research

authors： Shim R,Wen SW,Wanrooy BJ,Rank M,Thirugnanachandran T,Ho L,Sepehrizadeh T,de Veer M,Srikanth VK,Ma H,Phan TG,Sobey CG,Wong CHY

更新日期：2020-06-01 00:00:00

abstract：:Activation and repression of gene expression are key features of ischemic tolerance. Converging lines of inquiry from several groups suggests that epigenetic proteins may transduce sublethal stresses, including bioenergetic or oxidative stress into durable (2-3 days) changes in gene expression that mediate ischemic to...

journal_title：Translational stroke research

authors： Brand D,Ratan RR

更新日期：2013-02-01 00:00:00

abstract：:Despite being a conveniently portable technology for stroke assessment, Transcranial Doppler ultrasound (TCD) remains widely underutilized due to complex training requirements necessary to reliably obtain and interpret cerebral blood flow velocity (CBFV) waveforms. The validation of objective TCD metrics for large ves...

journal_title：Translational stroke research

authors： Thorpe SG,Thibeault CM,Wilk SJ,O'Brien M,Canac N,Ranjbaran M,Devlin C,Devlin T,Hamilton RB

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:To elucidate the role of magnesium sulfate in patients with subarachnoid hemorrhagic (SAH) brain injury METHOD:Studies for the meta-analysis were identified from PubMed (1966 to 2009), Embase (1980 to 2009), and two Chinese journals (1989 to 2009). Paper selection was based on randomized controlled trials co...

journal_title：Translational stroke research

authors： Huang B,Khatibi NH,Tong L,Yan P,Xie P,Zhang JH

更新日期：2010-06-01 00:00:00

abstract：:Acute ischemic stroke (AIS) often results in degeneration of the blood-brain barrier (BBB), which can lead to vasogenic edema and an increased risk of intracerebral hemorrhage. Imatinib is an agent that may be able to protect the BBB and reduce the risk of the harmful consequences of BBB degeneration. We sought to mea...

journal_title：Translational stroke research

authors： Merali Z,Leung J,Mikulis D,Silver F,Kassner A

更新日期：2015-02-01 00:00:00

abstract：:Anticoagulation increases the risk of intracerebral hemorrhage (ICH) in patients with cerebral amyloid angiopathy (CAA), so the management of stroke-risk in patients with both atrial fibrillation (AF) and CAA is controversial. Advances in left atrial appendage closure (LAAC) techniques provide a stroke-risk-reduction ...

journal_title：Translational stroke research

authors： Schrag M,Mac Grory B,Nackenoff A,Eaton J,Mistry E,Kirshner H,Yaghi S,Ellis CR

更新日期：2020-08-07 00:00:00

abstract：:The COVID-19 pandemic is associated with neurological symptoms and complications including stroke. There is hypercoagulability associated with COVID-19 that is likely a "sepsis-induced coagulopathy" and may predispose to stroke. The SARS-CoV-2 virus binds to angiotensin-converting enzyme 2 (ACE2) present on brain endo...

journal_title：Translational stroke research

authors： Hess DC,Eldahshan W,Rutkowski E

更新日期：2020-06-01 00:00:00

abstract：:Clinical studies on subarachnoid hemorrhage (SAH) have shown discrepancies between large vessel vasospasm, cerebral perfusion, and clinical outcome. We set out to analyze the contribution of large vessel vasospasm to impaired cerebral perfusion and neurological impairment in a murine model of SAH. SAH was induced in C...

journal_title：Translational stroke research

authors： Neulen A,Meyer S,Kramer A,Pantel T,Kosterhon M,Kunzelmann S,Goetz H,Thal SC

更新日期：2018-07-12 00:00:00

abstract：:The long-term effects of multiple sport-related concussions are currently at the center of debate in the popular press and scientific community. The question, "How many concussions are too many," is frequently asked in the competitive sport environment by parents, athletes, and coaches. While research suggests that a ...

journal_title：Translational stroke research

authors： Elbin RJ,Covassin T,Henry L,Whalen DJ,Wedge J,Kontos AP

更新日期：2013-08-01 00:00:00

abstract：:Intracerebral hemorrhage is a devastating disease. Despite its clinical importance, the pathophysiology of intracerebral hemorrhage is not well understood. Hematoma expansion occurs in a large subset of patients and is a predictor of poor outcomes. Since hematoma growth provides a potential opportunity for therapeutic...

journal_title：Translational stroke research

authors： Schlunk F,Greenberg SM

更新日期：2015-08-01 00:00:00

abstract：:Poor clinical outcomes despite endovascular therapy (EVT) are common in patients with acute basilar artery occlusion (BAO). We aimed to develop a new angiographic collateral grading system for predicting 90-day functional outcomes of acute BAO after EVT. A prospectively registered consecutive cohort of acute BAO patie...

journal_title：Translational stroke research

authors： Gao F,Tong X,Sun X,Miao Z

更新日期：2020-09-28 00:00:00

abstract：:Despite ischemic stroke being the fifth leading cause of death in the USA, there are few therapeutic options available. We recently showed that the neuroprotective compound P7C3-A20 reduced brain atrophy, increased neurogenesis, and improved functional recovery when treatment was initiated immediately post-reperfusion...

journal_title：Translational stroke research

authors： Loris ZB,Hynton JR,Pieper AA,Dietrich WD

更新日期：2018-04-01 00:00:00

abstract：:Increasingly, experimental research in subarachnoid hemorrhage (SAH) has investigated early brain injury and the microcirculation. A number of pathophysiological changes occur in the cerebral microvessels after SAH including altered vasoreactivity, vasoconstriction, inflammation, blood-brain barrier impairment, increa...

journal_title：Translational stroke research

authors： Tso MK,Macdonald RL

更新日期：2014-04-01 00:00:00

abstract：:In the original publication of the article, there was a switched order of author names. ...

journal_title：Translational stroke research

authors： Dorňák T,Král M,Sedláčková Z,Šaňák D,Čecháková E,Divišová P,Zapletalová J,Kaňovský P

更新日期：2018-12-01 00:00:00

abstract：:The most deadly form of stroke, intracerebral hemorrhage (ICH) continues to puzzle researchers and produce substantial decrements in the quality of patients' lives. Intensive basic research has devised many agents with putative benefit in mitigating the devastating effects of ICH, but these therapies have been largely...

journal_title：Translational stroke research

authors： Ayer A,Hwang BY,Appelboom G,Connolly ES Jr

更新日期：2012-12-01 00:00:00

abstract：:Magnetic resonance imaging (MRI) has dramatically changed our ability to diagnose and treat stroke as well as follow its evolution and response to treatment. Early stroke and ischemia can be visualized using diffusion-weighted imaging that utilizes water diffusion within tissues as a reporter for evolving neuropatholo...

journal_title：Translational stroke research

authors： Obenaus A,Ashwal S

更新日期：2012-03-01 00:00:00

abstract：:Cerebrovascular disease is a leading cause of death-from-disease and of disability worldwide, affecting some 15 million people. The incidence of stroke or "brain attack" is unlikely to recede for a decade at minimum by most predictions, despite large public health initiatives in stroke prevention. It has been well est...

journal_title：Translational stroke research

authors： Herson PS,Palmateer J,Hurn PD

更新日期：2013-08-01 00:00:00

abstract：:Global ischemia following cardiac arrest is characterized by high mortality and significant neurological deficits in long-term survivors. Its mechanisms of neuronal cell death have only partially been elucidated. 12/15-lipoxygenase (12/15-LOX) is a major contributor to delayed neuronal cell death and vascular injury i...

journal_title：Translational stroke research

authors： Yigitkanli K,Zheng Y,Pekcec A,Lo EH,van Leyen K

更新日期：2017-04-01 00:00:00