Abstract:
:Poor clinical outcomes despite endovascular therapy (EVT) are common in patients with acute basilar artery occlusion (BAO). We aimed to develop a new angiographic collateral grading system for predicting 90-day functional outcomes of acute BAO after EVT. A prospectively registered consecutive cohort of acute BAO patients treated with EVT in our center during a 6-year period was reviewed. The angiographic collateral grading system for BAO (ACGS-BAO) included 4 grades for poor (grade 1-2), intermediate (grade 3), and good (grade 4) collateral statuses. First, the independent association of ACGS-BAO with 90-day functional independence (mRS ≤ 2), favorable outcome (mRS ≤ 3), and death was evaluated by multivariable logistic regression model; then, the heterogeneity in the effects of ACGS-BAO on 90-day outcomes was explored among the subgroups stratified by age, time window, stroke severity, and etiology. Finally, the interobserver agreement of ACGS-BAO was assessed by weighted kappa statistic. Of 173 patients included in this study, 62 (35.8%), 83 (48.0%), and 36 (20.8%) achieved 90-day functional independence, favorable outcome, and death, respectively. Multivariable logistic analyses showed that ACGS-BAO was independently associated with functional independence (OR = 2.07, 95% CI = 1.05-4.07) and favorable outcome (OR = 1.84, 95% CI = 1.02-3.43) but not related to death (OR = 0.78, 95% CI = 0.37-1.64). Similar effects of ACGS-BAO on 90-day outcomes were seen across all subgroups (P > 0.10 for all interactions). The interobserver agreement of ACGS-BAO was very high (weighted kappa = 0.96, 95% CI = 0.93-0.99). The ACGS-BAO is an angiographic tool with excellent interobserver reliability that can be used to predict the 90-day outcome of acute BAO treated by EVT. Nevertheless, our findings are still needed to be confirmed in a prospective multicenter study before clinical application.
journal_name
Transl Stroke Resjournal_title
Translational stroke researchauthors
Gao F,Tong X,Sun X,Miao Zdoi
10.1007/s12975-020-00856-3subject
Has Abstractpub_date
2020-09-28 00:00:00eissn
1868-4483issn
1868-601Xpii
10.1007/s12975-020-00856-3pub_type
杂志文章abstract::Inflammation is a critical process behind cerebral aneurysm formation and rupture. Tumor necrosis factor alpha (TNF-α) is a key immune modulator that has been implicated in cerebral aneurysm pathophysiology. This may occur through TNF-α-mediated endothelial injury, smooth muscle cell phenotypic modulation, recruitment...
journal_title:Translational stroke research
pub_type: 杂志文章,评审
doi:10.1007/s12975-013-0287-9
更新日期:2014-04-01 00:00:00
abstract::Despite being a conveniently portable technology for stroke assessment, Transcranial Doppler ultrasound (TCD) remains widely underutilized due to complex training requirements necessary to reliably obtain and interpret cerebral blood flow velocity (CBFV) waveforms. The validation of objective TCD metrics for large ves...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-018-0667-2
更新日期:2019-10-01 00:00:00
abstract::Monocytes recruitment from the blood to inflamed tissues following ischemic stroke is an important immune response to wound healing and tissue repair. Mouse monocytes can be endogenously divided into two distinct populations: pro-inflammatory or classical monocytes that express CCR2highCX3CR1low and circulate in blood...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-020-00878-x
更新日期:2021-01-06 00:00:00
abstract::Early infection after stroke is associated with a poor outcome. We aimed to determine whether delayed infections (up to 76 days post-stroke) are associated with poor outcome at 90 days. Data came from the international Efficacy of Nitric Oxide Stroke (ENOS, ISRCTN99414122) trial. Post hoc data on infections were obtai...
journal_title:Translational stroke research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s12975-017-0553-3
更新日期:2017-12-01 00:00:00
abstract::The incidence of small vessel-type (lacunar) ischemic strokes is greater in African-Americans compared to whites. The chronic inflammatory changes that result from lacunar stroke are poorly understood. To elucidate these changes, we measured serum inflammatory and thrombotic biomarkers in African-Americans at least 6 ...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-015-0424-8
更新日期:2015-12-01 00:00:00
abstract::Aneurysmal subarachnoid hemorrhage comprises of an early phase after the bleeding and a late phase of delayed consequences of the bleeding. The development of delayed injury mechanisms, like the reduction of cerebral blood flow (CBF) due to cerebral vasospasm (CVS), seems mainly to depend on the amount and the duratio...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-015-0392-z
更新日期:2015-06-01 00:00:00
abstract::Hydrocephalus is one of the most common sequelae after aneurysmal subarachnoid hemorrhage (aSAH), and it is a large contributor to the condition's high rates of readmission and mortality. Our objective was to quantify the healthcare resource utilization (HCRU) and health economic burden incurred by the US health syste...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-019-00697-9
更新日期:2019-12-01 00:00:00
abstract::This review focuses on assessment of behavioral outcomes following traumatic brain injury in juvenile animal models. In the 15 years since the first publication in this field, the majority of studies have used rats roughly equivalent to human toddlers in terms of brain development. Few studies have tested ages closer ...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-011-0132-y
更新日期:2011-12-01 00:00:00
abstract::Traumatic brain injury (TBI) affects all age groups in a population and is an injury generating scientific interest not only as an acute event, but also as a complex brain disease with several underlying neurobehavioral and neuropathological characteristics. We review early and long-term alterations after juvenile and...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-011-0126-9
更新日期:2011-12-01 00:00:00
abstract::Infection is a leading cause of death in patients with stroke; however, the impact of cerebral infarct size or location on infectious outcome is unclear. To examine the effect of infarct size on post-stroke infection, we utilised the intraluminal middle-cerebral artery occlusion (MCAO) mouse model of ischemic stroke a...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-019-00738-3
更新日期:2020-06-01 00:00:00
abstract::Activation and repression of gene expression are key features of ischemic tolerance. Converging lines of inquiry from several groups suggests that epigenetic proteins may transduce sublethal stresses, including bioenergetic or oxidative stress into durable (2-3 days) changes in gene expression that mediate ischemic to...
journal_title:Translational stroke research
pub_type: 杂志文章,评审
doi:10.1007/s12975-012-0235-0
更新日期:2013-02-01 00:00:00
abstract::Rodent animal models of stroke are widely used with brain ischemia inducible by various occlusion methods. Permanent or transient occlusion of the distal portion of the middle cerebral artery (MCAO) offers a reproducible model with low mortality rates, and it is the most likely model of choice for mid- and long-term s...
journal_title:Translational stroke research
pub_type: 杂志文章,评审
doi:10.1007/s12975-012-0234-1
更新日期:2013-06-01 00:00:00
abstract::Positron emission tomography (PET) is widely used in clinical and animal studies, along with the development of diverse tracers. The biochemical characteristics of PET tracers may help uncover the pathophysiological consequences of cardiac arrest (CA) and ischemic stroke, which include cerebral ischemia and reperfusio...
journal_title:Translational stroke research
pub_type: 杂志文章,评审
doi:10.1007/s12975-019-00765-0
更新日期:2020-08-01 00:00:00
abstract::Inconsistency in outcome parameters for delayed cerebral ischemia (DCI) makes it difficult to compare results between mouse studies, in the same way inconsistency in outcome parameters in human studies has for long obstructed adequate comparison. The absence of an established definition may in part be responsible for ...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-020-00796-y
更新日期:2020-10-01 00:00:00
abstract::Clinical studies on subarachnoid hemorrhage (SAH) have shown discrepancies between large vessel vasospasm, cerebral perfusion, and clinical outcome. We set out to analyze the contribution of large vessel vasospasm to impaired cerebral perfusion and neurological impairment in a murine model of SAH. SAH was induced in C...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-018-0647-6
更新日期:2018-07-12 00:00:00
abstract::The long-term effects of multiple sport-related concussions are currently at the center of debate in the popular press and scientific community. The question, "How many concussions are too many," is frequently asked in the competitive sport environment by parents, athletes, and coaches. While research suggests that a ...
journal_title:Translational stroke research
pub_type: 杂志文章,评审
doi:10.1007/s12975-012-0237-y
更新日期:2013-08-01 00:00:00
abstract::An argument for preclinical stroke research to make more use of the permanent middle cerebral artery occlusion (MCAO) model, rather than transient MCAO, is presented. Despite STAIR recommending permanent MCAO as the primary model, preclinical stroke research has not been listened. In 2012, Hossmann reported that 64% o...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-017-0554-2
更新日期:2017-07-17 00:00:00
abstract::Increasing endogenous ciliary neurotrophic factor (CNTF) expression with a pharmacological agent might be beneficial after stroke as CNTF both promotes neurogenesis and, separately, is neuroprotective. P2X7 purinergic receptor inhibition is neuroprotective in rats and increases CNTF release in rat CMT1A Schwann cells....
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-013-0265-2
更新日期:2013-10-01 00:00:00
abstract::Motor impairment is the most common complication after stroke, and recovery of motor function has been shown to be dependent on the extent of lesion in the ipsilesional corticospinal tract (iCST) and activity within ipsilesional primary and secondary motor cortices. However, work from neuroimaging research has suggest...
journal_title:Translational stroke research
pub_type: 杂志文章,评审
doi:10.1007/s12975-017-0551-5
更新日期:2017-12-01 00:00:00
abstract::Ischemic stroke contributes to the majority of brain injuries and remains to be a leading cause of death and long-term disability. Despite the devastating pathology and high incidence of disease, there remain only few treatment options (TPA and endovascular procedures), which may be hampered by time-dependent administ...
journal_title:Translational stroke research
pub_type: 杂志文章,评审
doi:10.1007/s12975-013-0319-5
更新日期:2014-02-01 00:00:00
abstract::Magnetic resonance imaging (MRI) has dramatically changed our ability to diagnose and treat stroke as well as follow its evolution and response to treatment. Early stroke and ischemia can be visualized using diffusion-weighted imaging that utilizes water diffusion within tissues as a reporter for evolving neuropatholo...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-011-0139-4
更新日期:2012-03-01 00:00:00
abstract::Despite ischemic stroke being the fifth leading cause of death in the USA, there are few therapeutic options available. We recently showed that the neuroprotective compound P7C3-A20 reduced brain atrophy, increased neurogenesis, and improved functional recovery when treatment was initiated immediately post-reperfusion...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-017-0565-z
更新日期:2018-04-01 00:00:00
abstract::There was an error in Fig. 2d. The correct Fig. 2d is shown below. ...
journal_title:Translational stroke research
pub_type: 已发布勘误
doi:10.1007/s12975-020-00871-4
更新日期:2020-10-22 00:00:00
abstract::In a porcine ischemic stroke model, we sought to compare the acute predicted infarct core volume (PIV) defined by CT perfusion (CTP)-hemodynamic parameters and MR-diffusion-weighted imaging (MR-DWI)/apparent diffusion coefficient (ADC), with the true infarct core volume (TIV) as defined by histology. Ten Duroc-cross p...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-015-0394-x
更新日期:2015-06-01 00:00:00
abstract::In the original publication of the article, there was a switched order of author names. ...
journal_title:Translational stroke research
pub_type: 杂志文章,已发布勘误
doi:10.1007/s12975-018-0618-y
更新日期:2018-12-01 00:00:00
abstract::Circulating levels of the pro-inflammatory cytokine C-C motif chemokine 11 (CCL11, also known as eotaxin-1) are increased in several animal models of neuroinflammation, including traumatic brain injury and Alzheimer's disease. Increased levels of CCL11 have also been linked to decreased neurogenesis in mice. We hypoth...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-017-0545-3
更新日期:2017-12-01 00:00:00
abstract::Cerebral hyperperfusion syndrome (CHS) is a complication that can occur after carotid endarterectomy (CEA), the treatment of choice to decrease the subsequent risk of fatal or disabling stroke for patients with symptomatic severe stenosis of the carotid artery. Because of its rarity and complexity, the mechanism of th...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-017-0605-8
更新日期:2018-10-01 00:00:00
abstract::Silent information regulator 1 (SIRT1) is a NAD+-dependent histone deacetylase that represses gene expression and plays a role in longevity. SIRT1 responds to diverse stress conditions and regulates metabolism in nutrient deficiency conditions; therefore, it is involved in adaptive pathways to better fulfill tissue ne...
journal_title:Translational stroke research
pub_type: 杂志文章,评审
doi:10.1007/s12975-013-0277-y
更新日期:2013-12-01 00:00:00
abstract::Impaired cerebral autoregulation and neurovascular coupling (NVC) contribute to delayed cerebral ischemia after subarachnoid hemorrhage (SAH). Retinal vessel analysis (RVA) allows non-invasive assessment of vessel dimension and NVC hereby demonstrating a predictive value in the context of various neurovascular disease...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-017-0585-8
更新日期:2018-06-01 00:00:00
abstract::RTL1000 is a partial human MHC molecule coupled to a human myelin peptide. We previously demonstrated that RTL1000 was protective against experimental ischemic stroke in HLA-DR2 transgenic (DR2-Tg) mice. Since thrombolysis with recombinant tissue plasminogen activator (t-PA) is a standard therapy for stroke, we determ...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-014-0348-8
更新日期:2014-10-01 00:00:00