Abstract：
:Ischemic stroke contributes to the majority of brain injuries and remains to be a leading cause of death and long-term disability. Despite the devastating pathology and high incidence of disease, there remain only few treatment options (TPA and endovascular procedures), which may be hampered by time-dependent administration among a variety of other factors. Promising research of glutamate receptor antagonists has been unsuccessful in clinical trial. But, the mechanism by which glutamate receptors initiate injury by excessive calcium overload has spurred investigation of new and potentially successful candidates for stroke therapy. Acid-sensing ion channels (ASICs) may contribute to poor stroke prognosis due to localized drop in brain pH, resulting in excessive calcium overload, independent of glutamate activation. Accumulating studies targeting ASICs have underscored the importance of understanding inhibition, regulation, desensitization, and trafficking of this channel and its role in disease. This review will discuss potential directions in translational ASIC research for future stroke therapies.
journal_name
Transl Stroke Resjournal_title
Translational stroke researchauthors
O'Bryant Z,Vann KT,Xiong ZGdoi
10.1007/s12975-013-0319-5subject
Has Abstractpub_date
2014-02-01 00:00:00pages
59-68issue
1eissn
1868-4483issn
1868-601Xjournal_volume
5pub_type
杂志文章,评审abstract：:Infection is a leading cause of death in patients with stroke; however, the impact of cerebral infarct size or location on infectious outcome is unclear. To examine the effect of infarct size on post-stroke infection, we utilised the intraluminal middle-cerebral artery occlusion (MCAO) mouse model of ischemic stroke a...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-019-00738-3
更新日期：2020-06-01 00:00:00
abstract：:Activation and repression of gene expression are key features of ischemic tolerance. Converging lines of inquiry from several groups suggests that epigenetic proteins may transduce sublethal stresses, including bioenergetic or oxidative stress into durable (2-3 days) changes in gene expression that mediate ischemic to...
journal_title：Translational stroke research
pub_type： 杂志文章,评审
doi：10.1007/s12975-012-0235-0
更新日期：2013-02-01 00:00:00
abstract：:Global ischemia following cardiac arrest is characterized by high mortality and significant neurological deficits in long-term survivors. Its mechanisms of neuronal cell death have only partially been elucidated. 12/15-lipoxygenase (12/15-LOX) is a major contributor to delayed neuronal cell death and vascular injury i...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-016-0509-z
更新日期：2017-04-01 00:00:00
abstract：:The iron chelator, deferoxamine mesylate (DFO), has shown neuroprotective effects, mediated via suppression of iron-induced hydroxyl radical formation, in various animal models of ischemic and hemorrhagic stroke. Therefore, the objective of this study was to investigate whether DFO can exert similar actions in stroke ...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-009-0001-0
更新日期：2010-03-01 00:00:00
abstract：:Monocytes recruitment from the blood to inflamed tissues following ischemic stroke is an important immune response to wound healing and tissue repair. Mouse monocytes can be endogenously divided into two distinct populations: pro-inflammatory or classical monocytes that express CCR2highCX3CR1low and circulate in blood...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-020-00878-x
更新日期：2021-01-06 00:00:00
abstract：:Cerebral blood flow (CBF) is the key factor for identifying progressive hypoperfusion that is indicative of numerous pathological conditions. CBF measurement is beneficial for the management of cerebrovascular disease, head injury, and intracranial neoplasms. Of the various imaging modalities developed to assess CBF, ...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-010-0064-y
更新日期：2011-06-01 00:00:00
abstract：:For years, strategies have been proposed to improve translational success in stroke research by improving the quality of animal studies. However, articles that report preclinical intracerebral hemorrhage (ICH) studies continue to lack adequate qualitative and quantitative descriptions of fresh brain tissue collection....
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-015-0399-5
更新日期：2015-10-01 00:00:00
abstract：:The incidence of small vessel-type (lacunar) ischemic strokes is greater in African-Americans compared to whites. The chronic inflammatory changes that result from lacunar stroke are poorly understood. To elucidate these changes, we measured serum inflammatory and thrombotic biomarkers in African-Americans at least 6 ...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-015-0424-8
更新日期：2015-12-01 00:00:00
abstract：:Acute ischemic stroke (AIS) often results in degeneration of the blood-brain barrier (BBB), which can lead to vasogenic edema and an increased risk of intracerebral hemorrhage. Imatinib is an agent that may be able to protect the BBB and reduce the risk of the harmful consequences of BBB degeneration. We sought to mea...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-014-0358-6
更新日期：2015-02-01 00:00:00
abstract：:Inflammation is a critical process behind cerebral aneurysm formation and rupture. Tumor necrosis factor alpha (TNF-α) is a key immune modulator that has been implicated in cerebral aneurysm pathophysiology. This may occur through TNF-α-mediated endothelial injury, smooth muscle cell phenotypic modulation, recruitment...
journal_title：Translational stroke research
pub_type： 杂志文章,评审
doi：10.1007/s12975-013-0287-9
更新日期：2014-04-01 00:00:00
abstract：:In the original publication of the article, there was a switched order of author names. ...
journal_title：Translational stroke research
pub_type： 杂志文章,已发布勘误
doi：10.1007/s12975-018-0618-y
更新日期：2018-12-01 00:00:00
abstract：:Lifestyle risk factors, inflammation and genetics play a role in the development of atherosclerosis. We therefore studied Fc gamma receptor (FcγR) polymorphisms, interleukin (IL)-10 polymorphisms and other biomarkers related to carotid intima-media thickness (cIMT) in patients with ischemic stroke at a young age. Pati...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-015-0403-0
更新日期：2015-08-01 00:00:00
abstract：:This study was aimed to test the hypothesis that human bone marrow stromal cells (hBMSC) expanded in fetal calf serum (FCS)-free, platelet lysate (PL)-containing medium would retain their capacity of migration, survival, and neural differentiation when transplanted into the infarct brain, using serial in vivo magnetic...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-011-0098-9
更新日期：2011-09-01 00:00:00
abstract：:Despite ischemic stroke being the fifth leading cause of death in the USA, there are few therapeutic options available. We recently showed that the neuroprotective compound P7C3-A20 reduced brain atrophy, increased neurogenesis, and improved functional recovery when treatment was initiated immediately post-reperfusion...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-017-0565-z
更新日期：2018-04-01 00:00:00
abstract：:Stroke prevention efforts typically focus on either ischemic or hemorrhagic stroke. This approach is overly simplistic due to the frequent coexistence of ischemic and hemorrhagic cerebrovascular disease. This coexistence, termed "mixed cerebrovascular disease", offers a conceptual framework that appears useful for str...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-012-0185-6
更新日期：2012-07-01 00:00:00
abstract：:This study aimed to investigate whether serum lactate dehydrogenase (LDH) levels predicted hematoma expansion and poor outcomes in intracerebral hemorrhage (ICH) patients. The differentially expressed proteins between patients with and without hematoma expansion were screened using proteomic analysis. Then the critica...
journal_title：Translational stroke research
pub_type： 杂志文章,多中心研究
doi：10.1007/s12975-019-0686-7
更新日期：2019-12-01 00:00:00
abstract：:We reported previously that both a cannabinoid receptor 2 (CB2R) agonist and a cannabinoid receptor 1 (CB1R) antagonist were protective in the treatment of transient middle cerebral artery occlusion/reperfusion injury (MCAO/R) and that they acted in a synergistic manner when administered in combination. The goal of th...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-012-0197-2
更新日期：2012-09-01 00:00:00
abstract：:Rodent animal models of stroke are widely used with brain ischemia inducible by various occlusion methods. Permanent or transient occlusion of the distal portion of the middle cerebral artery (MCAO) offers a reproducible model with low mortality rates, and it is the most likely model of choice for mid- and long-term s...
journal_title：Translational stroke research
pub_type： 杂志文章,评审
doi：10.1007/s12975-012-0234-1
更新日期：2013-06-01 00:00:00
abstract：:In clinical trials, assessing efficacy is based on validated scales, and the primary endpoint is usually based on a single scale. The aim of the review is to revisit the concepts and methods to design and analyze studies focused on restoration, recovery and or compensation. These studies are becoming more frequent wit...
journal_title：Translational stroke research
pub_type： 杂志文章,评审
doi：10.1007/s12975-016-0488-0
更新日期：2016-10-01 00:00:00
abstract：:Low translational yield for stroke may reflect the focus of discovery science on rodents rather than humans. Just how little is known about human neuronal ischaemic responses is confirmed by systematic review and meta-analysis revealing that data for the most commonly used SH-SY5Y human cells comprises only 84 papers....
journal_title：Translational stroke research
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s12975-018-0620-4
更新日期：2018-12-01 00:00:00
abstract：:Clinical studies on subarachnoid hemorrhage (SAH) have shown discrepancies between large vessel vasospasm, cerebral perfusion, and clinical outcome. We set out to analyze the contribution of large vessel vasospasm to impaired cerebral perfusion and neurological impairment in a murine model of SAH. SAH was induced in C...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-018-0647-6
更新日期：2018-07-12 00:00:00
abstract：:Polymorphonuclear neutrophils (PMNs) infiltration into brain parenchyma after cerebrovascular accidents is viewed as a key component of secondary brain injury. Interestingly, a recent study of ischemic stroke suggests that after ischemic stroke, PMNs do not enter brain parenchyma and as such may cause no harm to the b...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-014-0341-2
更新日期：2014-10-01 00:00:00
abstract：:The presence of active developmental angiogenesis and vascular outgrowth in the postnatal brain may differentially affect vascular responses to stroke in newborns and adults, but very little is known about the dynamics of vascular injury and re-growth after stroke during the neonatal period. In this study we used a cl...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-012-0214-5
更新日期：2013-04-01 00:00:00
abstract：:RTL1000 is a partial human MHC molecule coupled to a human myelin peptide. We previously demonstrated that RTL1000 was protective against experimental ischemic stroke in HLA-DR2 transgenic (DR2-Tg) mice. Since thrombolysis with recombinant tissue plasminogen activator (t-PA) is a standard therapy for stroke, we determ...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-014-0348-8
更新日期：2014-10-01 00:00:00
abstract：:Traumatic brain injury (TBI) affects all age groups in a population and is an injury generating scientific interest not only as an acute event, but also as a complex brain disease with several underlying neurobehavioral and neuropathological characteristics. We review early and long-term alterations after juvenile and...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-011-0126-9
更新日期：2011-12-01 00:00:00
abstract：:Poor clinical outcomes despite endovascular therapy (EVT) are common in patients with acute basilar artery occlusion (BAO). We aimed to develop a new angiographic collateral grading system for predicting 90-day functional outcomes of acute BAO after EVT. A prospectively registered consecutive cohort of acute BAO patie...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-020-00856-3
更新日期：2020-09-28 00:00:00
abstract：:Voltage-gated potassium (Kv) channels are widely expressed in the central and peripheral nervous system and are crucial mediators of neuronal excitability. Importantly, these channels also actively participate in cellular and molecular signaling pathways that regulate the life and death of neurons. Injury-mediated inc...
journal_title：Translational stroke research
pub_type： 杂志文章,评审
doi：10.1007/s12975-013-0297-7
更新日期：2014-02-01 00:00:00
abstract：:Inconsistency in outcome parameters for delayed cerebral ischemia (DCI) makes it difficult to compare results between mouse studies, in the same way inconsistency in outcome parameters in human studies has for long obstructed adequate comparison. The absence of an established definition may in part be responsible for ...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-020-00796-y
更新日期：2020-10-01 00:00:00
abstract：:Increasingly, experimental research in subarachnoid hemorrhage (SAH) has investigated early brain injury and the microcirculation. A number of pathophysiological changes occur in the cerebral microvessels after SAH including altered vasoreactivity, vasoconstriction, inflammation, blood-brain barrier impairment, increa...
journal_title：Translational stroke research
pub_type： 杂志文章,评审
doi：10.1007/s12975-014-0323-4
更新日期：2014-04-01 00:00:00
abstract：:Pulmonary complications associated with persistent respiratory muscle weakness, paralysis, and spasticity are among the most important problems faced by patients with spinal cord injury when lack of muscle strength and disorganization of reciprocal respiratory muscle control lead to breathing insufficiency. This revie...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-011-0114-0
更新日期：2011-12-01 00:00:00
