Abstract:
:Ischemic stroke is a devastating neural event as currently no therapies other than physical rehabilitation are available to enhance recovery after stroke. To identify endogenous mediators to repair stroke brain, we performed the expression profiling analysis of transcripts in the mouse photothrombotic stroke brain. Based on real-time PCR analysis, we found VGF, identified as a nerve growth factor (NGF)-regulated transcript, was induced transcriptionally in stroke brain at 1-7 days after insult. The immunoreactivites of VGF were observed in the neurons around the ischemic core of stroke brain. Experiments with various inhibitors and plasmid transfections indicated that cAMP response element binding protein-mediated complex signaling pathways are possibly implicated in the NGF-mediated VGF expressions in vitro. Furthermore, the over-expression of VGF promoted neurite extensions and conferred protections from ischemic stress in vitro. These findings raise the possibility the application of VGF could be one of the promising therapeutic strategies to enhance recovery after stroke.
journal_name
Transl Stroke Resjournal_title
Translational stroke researchauthors
Sakamoto M,Miyazaki Y,Kitajo K,Yamaguchi Adoi
10.1007/s12975-015-0401-2subject
Has Abstractpub_date
2015-08-01 00:00:00pages
301-8issue
4eissn
1868-4483issn
1868-601Xjournal_volume
6pub_type
杂志文章abstract::Pulmonary complications associated with persistent respiratory muscle weakness, paralysis, and spasticity are among the most important problems faced by patients with spinal cord injury when lack of muscle strength and disorganization of reciprocal respiratory muscle control lead to breathing insufficiency. This revie...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-011-0114-0
更新日期:2011-12-01 00:00:00
abstract::The incidence of small vessel-type (lacunar) ischemic strokes is greater in African-Americans compared to whites. The chronic inflammatory changes that result from lacunar stroke are poorly understood. To elucidate these changes, we measured serum inflammatory and thrombotic biomarkers in African-Americans at least 6 ...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-015-0424-8
更新日期:2015-12-01 00:00:00
abstract::Clinical studies on subarachnoid hemorrhage (SAH) have shown discrepancies between large vessel vasospasm, cerebral perfusion, and clinical outcome. We set out to analyze the contribution of large vessel vasospasm to impaired cerebral perfusion and neurological impairment in a murine model of SAH. SAH was induced in C...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-018-0647-6
更新日期:2018-07-12 00:00:00
abstract::The presence of active developmental angiogenesis and vascular outgrowth in the postnatal brain may differentially affect vascular responses to stroke in newborns and adults, but very little is known about the dynamics of vascular injury and re-growth after stroke during the neonatal period. In this study we used a cl...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-012-0214-5
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:To elucidate the role of magnesium sulfate in patients with subarachnoid hemorrhagic (SAH) brain injury METHOD:Studies for the meta-analysis were identified from PubMed (1966 to 2009), Embase (1980 to 2009), and two Chinese journals (1989 to 2009). Paper selection was based on randomized controlled trials co...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-010-0022-8
更新日期:2010-06-01 00:00:00
abstract::Acute ischemic stroke (AIS) often results in degeneration of the blood-brain barrier (BBB), which can lead to vasogenic edema and an increased risk of intracerebral hemorrhage. Imatinib is an agent that may be able to protect the BBB and reduce the risk of the harmful consequences of BBB degeneration. We sought to mea...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-014-0358-6
更新日期:2015-02-01 00:00:00
abstract::Motor impairment is the most common complication after stroke, and recovery of motor function has been shown to be dependent on the extent of lesion in the ipsilesional corticospinal tract (iCST) and activity within ipsilesional primary and secondary motor cortices. However, work from neuroimaging research has suggest...
journal_title:Translational stroke research
pub_type: 杂志文章,评审
doi:10.1007/s12975-017-0551-5
更新日期:2017-12-01 00:00:00
abstract::Neonatal hypoxia-ischemia (HI) is a devastating condition resulting in neuronal cell death and often culminates in neurological deficits. Granulocyte-colony stimulating factor (G-CSF) has been shown to have neuroprotective activity via inhibition of apoptosis and inflammation in various stroke models. Stem cell factor...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-012-0225-2
更新日期:2013-04-01 00:00:00
abstract::This study was aimed to test the hypothesis that human bone marrow stromal cells (hBMSC) expanded in fetal calf serum (FCS)-free, platelet lysate (PL)-containing medium would retain their capacity of migration, survival, and neural differentiation when transplanted into the infarct brain, using serial in vivo magnetic...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-011-0098-9
更新日期:2011-09-01 00:00:00
abstract::Global ischemia following cardiac arrest is characterized by high mortality and significant neurological deficits in long-term survivors. Its mechanisms of neuronal cell death have only partially been elucidated. 12/15-lipoxygenase (12/15-LOX) is a major contributor to delayed neuronal cell death and vascular injury i...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-016-0509-z
更新日期:2017-04-01 00:00:00
abstract::Monocytes recruitment from the blood to inflamed tissues following ischemic stroke is an important immune response to wound healing and tissue repair. Mouse monocytes can be endogenously divided into two distinct populations: pro-inflammatory or classical monocytes that express CCR2highCX3CR1low and circulate in blood...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-020-00878-x
更新日期:2021-01-06 00:00:00
abstract::Our group recently identified a panel of ten genes whose RNA expression levels in whole blood have utility for detection of stroke. The purpose of this study was to determine the mechanisms by which these genes become differentially expressed during stroke pathology. First, we assessed the transcriptional distribution...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-018-0623-1
更新日期:2019-02-01 00:00:00
abstract::Cerebral hyperperfusion syndrome (CHS) is a complication that can occur after carotid endarterectomy (CEA), the treatment of choice to decrease the subsequent risk of fatal or disabling stroke for patients with symptomatic severe stenosis of the carotid artery. Because of its rarity and complexity, the mechanism of th...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-017-0605-8
更新日期:2018-10-01 00:00:00
abstract::CD8+ T cells are recognized as key players in exacerbation of ischemic stroke; however, the underlying mechanism in modulating the function of CD8+ T cells has not been completely elucidated. Here, we uncovered that FasL enhanced the cytotoxicity of CD8+ T cells to neurons after ischemic stroke. Inactivation of FasL s...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-019-00749-0
更新日期:2020-08-01 00:00:00
abstract::Ischemic stroke contributes to the majority of brain injuries and remains to be a leading cause of death and long-term disability. Despite the devastating pathology and high incidence of disease, there remain only few treatment options (TPA and endovascular procedures), which may be hampered by time-dependent administ...
journal_title:Translational stroke research
pub_type: 杂志文章,评审
doi:10.1007/s12975-013-0319-5
更新日期:2014-02-01 00:00:00
abstract::Magnetic resonance imaging (MRI) has dramatically changed our ability to diagnose and treat stroke as well as follow its evolution and response to treatment. Early stroke and ischemia can be visualized using diffusion-weighted imaging that utilizes water diffusion within tissues as a reporter for evolving neuropatholo...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-011-0139-4
更新日期:2012-03-01 00:00:00
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journal_title:Translational stroke research
pub_type: 杂志文章,评审
doi:10.1007/s12975-012-0234-1
更新日期:2013-06-01 00:00:00
abstract::Systemic docosahexaenoic acid (DHA) has been explored as a clinically feasible protectant in stroke models. However, the mechanism for DHA-afforded neuroprotection remains elusive. Transient middle cerebral artery occlusion (tMCAO) was induced for 1 h. DHA (i.p., 10 mg/kg) was administered immediately after reperfusio...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-018-0662-7
更新日期:2018-12-01 00:00:00
abstract::The COVID-19 pandemic is associated with neurological symptoms and complications including stroke. There is hypercoagulability associated with COVID-19 that is likely a "sepsis-induced coagulopathy" and may predispose to stroke. The SARS-CoV-2 virus binds to angiotensin-converting enzyme 2 (ACE2) present on brain endo...
journal_title:Translational stroke research
pub_type: 信件
doi:10.1007/s12975-020-00818-9
更新日期:2020-06-01 00:00:00
abstract::Intraventricular hemorrhage (IVH), which afflicts thousands of people of all ages every year, frequently results in the development of communicating hydrocephalus. Classically, IVH-induced hydrocephalus has been attributed to reduced resorption of cerebrospinal fluid (CSF) due to dysfunction of arachnoid granulations,...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-011-0070-8
更新日期:2011-06-01 00:00:00
abstract::Despite being a conveniently portable technology for stroke assessment, Transcranial Doppler ultrasound (TCD) remains widely underutilized due to complex training requirements necessary to reliably obtain and interpret cerebral blood flow velocity (CBFV) waveforms. The validation of objective TCD metrics for large ves...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-018-0667-2
更新日期:2019-10-01 00:00:00
abstract::Stroke is a cerebrovascular disorder that affects many people worldwide. Pericytes play an important role in stroke progression and recovery. The sigma-1 receptor (σ-1R) signaling pathway has been suggested as having promising neuroprotective potential in treating stroke; however, whether σ-1R activation regulates per...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-019-00711-0
更新日期:2020-04-01 00:00:00
abstract::Low translational yield for stroke may reflect the focus of discovery science on rodents rather than humans. Just how little is known about human neuronal ischaemic responses is confirmed by systematic review and meta-analysis revealing that data for the most commonly used SH-SY5Y human cells comprises only 84 papers....
journal_title:Translational stroke research
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s12975-018-0620-4
更新日期:2018-12-01 00:00:00
abstract::Pathophysiological findings of early brain injury in humans have not permitted conclusive determinations. We explored the essence of this phenomenon by taking intraoperative cortical specimens of Hunt-Kosnik grades IV~V (poor-grade) subarachnoid hemorrhages (SAH). From 2013 to 2017, we treated 39 consecutive poor-grad...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-020-00875-0
更新日期:2020-11-27 00:00:00
abstract::We reported previously that both a cannabinoid receptor 2 (CB2R) agonist and a cannabinoid receptor 1 (CB1R) antagonist were protective in the treatment of transient middle cerebral artery occlusion/reperfusion injury (MCAO/R) and that they acted in a synergistic manner when administered in combination. The goal of th...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-012-0197-2
更新日期:2012-09-01 00:00:00
abstract::Intracerebral hemorrhage is by far the most destructive form of stroke. Apart from the management in a specialized stroke or neurological intensive care unit (NICU), no specific therapies have been shown to consistently improve outcomes after ICH. Current guidelines endorse early aggressive optimization of physiologic...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-012-0175-8
更新日期:2012-07-01 00:00:00
abstract::Despite ischemic stroke being the fifth leading cause of death in the USA, there are few therapeutic options available. We recently showed that the neuroprotective compound P7C3-A20 reduced brain atrophy, increased neurogenesis, and improved functional recovery when treatment was initiated immediately post-reperfusion...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-017-0565-z
更新日期:2018-04-01 00:00:00
abstract::Quantitative susceptibility mapping (QSM) has been recently introduced as a novel MRI post-processing technique of gradient recalled echo (GRE) data. QSM is useful in depicting both brain anatomy and for detecting abnormalities. Its utility in the context of ischemic stroke has, however, not been extensively character...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-017-0591-x
更新日期:2018-08-01 00:00:00
abstract::Hematoma puncture and subsequent clot lysis with recombinant tissue plasminogen activator (rtPA) emerged as an alternative therapy for spontaneous intracerebral hemorrhage (ICH) and is associated with delayed edema possibly counteracting the beneficial effects of hematoma volume reduction. We hypothesized that immedia...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-012-0188-3
更新日期:2012-07-01 00:00:00
abstract::Early infection after stroke is associated with a poor outcome. We aimed to determine whether delayed infections (up to 76 days post-stroke) are associated with poor outcome at 90 days. Data came from the international Efficacy of Nitric Oxide Stroke (ENOS, ISRCTN99414122) trial. Post hoc data on infections were obtai...
journal_title:Translational stroke research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s12975-017-0553-3
更新日期:2017-12-01 00:00:00