Abstract:
:Aneurysmal subarachnoid hemorrhage comprises of an early phase after the bleeding and a late phase of delayed consequences of the bleeding. The development of delayed injury mechanisms, like the reduction of cerebral blood flow (CBF) due to cerebral vasospasm (CVS), seems mainly to depend on the amount and the duration of the subarachnoid blood clot. The reduction of CBF may lead to cerebral ischemia and delayed neurological deterioration. The rat double cisterna magna injection model reproduces the time course of the delayed consequences of CVS and imitates the clinical setting more precise than other rodent subarachnoid hemorrhage models. Therefore, the rat double cisterna magna injection model seems to be predisposed to be used to mimick the delayed consequences of subarachnoid hemorrhage. We reviewed the existing literature on this animal model and propose a standard protocol including technical considerations, as well as advantages and limitations of this model.
journal_name
Transl Stroke Resjournal_title
Translational stroke researchauthors
Güresir E,Schuss P,Borger V,Vatter Hdoi
10.1007/s12975-015-0392-zsubject
Has Abstractpub_date
2015-06-01 00:00:00pages
242-51issue
3eissn
1868-4483issn
1868-601Xjournal_volume
6pub_type
杂志文章abstract::Diabetes significantly increases the risk of stroke and post-stroke mortality. Recurrent hypoglycemia (RH) is common among diabetes patients owing to glucose-lowering therapies. Earlier, we showed that RH in a rat model of insulin-dependent diabetes exacerbates cerebral ischemic damage. Impaired mitochondrial function...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-018-0622-2
更新日期:2019-02-01 00:00:00
abstract::Neurogenesis is essential for a good post-stroke outcome. Exogenous stem cells are currently being tested to promote neurogenesis after stroke. Elsewhere, we demonstrated that treatment with the PPARγ agonist pioglitazone (PGZ) before cerebral ischemia induction reduced brain damage and activated survival-related gene...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-017-0577-8
更新日期:2018-06-01 00:00:00
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journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-010-0064-y
更新日期:2011-06-01 00:00:00
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journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-017-0545-3
更新日期:2017-12-01 00:00:00
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journal_title:Translational stroke research
pub_type: 已发布勘误
doi:10.1007/s12975-020-00871-4
更新日期:2020-10-22 00:00:00
abstract::Hydrocephalus is one of the most common sequelae after aneurysmal subarachnoid hemorrhage (aSAH), and it is a large contributor to the condition's high rates of readmission and mortality. Our objective was to quantify the healthcare resource utilization (HCRU) and health economic burden incurred by the US health syste...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-019-00697-9
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Admission hyperglycemia impacts ischemic stroke deleteriously but the relative role of acute hyperglycemia (HG) versus diabetes in the pathogenesis of this poor outcome is not clear. PURPOSE:To determine the effect of acute HG on neurovascular outcomes of stroke under control and diabetic conditions. METHO...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-011-0083-3
更新日期:2011-09-01 00:00:00
abstract::Cerebrovascular disease is a leading cause of death-from-disease and of disability worldwide, affecting some 15 million people. The incidence of stroke or "brain attack" is unlikely to recede for a decade at minimum by most predictions, despite large public health initiatives in stroke prevention. It has been well est...
journal_title:Translational stroke research
pub_type: 杂志文章,评审
doi:10.1007/s12975-012-0238-x
更新日期:2013-08-01 00:00:00
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journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-017-0565-z
更新日期:2018-04-01 00:00:00
abstract::Pathophysiological findings of early brain injury in humans have not permitted conclusive determinations. We explored the essence of this phenomenon by taking intraoperative cortical specimens of Hunt-Kosnik grades IV~V (poor-grade) subarachnoid hemorrhages (SAH). From 2013 to 2017, we treated 39 consecutive poor-grad...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-020-00875-0
更新日期:2020-11-27 00:00:00
abstract::Poor clinical outcomes despite endovascular therapy (EVT) are common in patients with acute basilar artery occlusion (BAO). We aimed to develop a new angiographic collateral grading system for predicting 90-day functional outcomes of acute BAO after EVT. A prospectively registered consecutive cohort of acute BAO patie...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-020-00856-3
更新日期:2020-09-28 00:00:00
abstract::Low translational yield for stroke may reflect the focus of discovery science on rodents rather than humans. Just how little is known about human neuronal ischaemic responses is confirmed by systematic review and meta-analysis revealing that data for the most commonly used SH-SY5Y human cells comprises only 84 papers....
journal_title:Translational stroke research
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s12975-018-0620-4
更新日期:2018-12-01 00:00:00
abstract::Despite being a conveniently portable technology for stroke assessment, Transcranial Doppler ultrasound (TCD) remains widely underutilized due to complex training requirements necessary to reliably obtain and interpret cerebral blood flow velocity (CBFV) waveforms. The validation of objective TCD metrics for large ves...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-018-0667-2
更新日期:2019-10-01 00:00:00
abstract::Previous studies showed that complement activation is associated with poor functional outcome after aneurysmal subarachnoid hemorrhage (SAH). We investigated whether complement activation is underlying brain injury after aneurysmal SAH (n = 7) and if it is an appropriate treatment target. We investigated complement ex...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-019-00757-0
更新日期:2020-08-01 00:00:00
abstract::Motor impairment is the most common complication after stroke, and recovery of motor function has been shown to be dependent on the extent of lesion in the ipsilesional corticospinal tract (iCST) and activity within ipsilesional primary and secondary motor cortices. However, work from neuroimaging research has suggest...
journal_title:Translational stroke research
pub_type: 杂志文章,评审
doi:10.1007/s12975-017-0551-5
更新日期:2017-12-01 00:00:00
abstract::Inflammation is a critical process behind cerebral aneurysm formation and rupture. Tumor necrosis factor alpha (TNF-α) is a key immune modulator that has been implicated in cerebral aneurysm pathophysiology. This may occur through TNF-α-mediated endothelial injury, smooth muscle cell phenotypic modulation, recruitment...
journal_title:Translational stroke research
pub_type: 杂志文章,评审
doi:10.1007/s12975-013-0287-9
更新日期:2014-04-01 00:00:00
abstract::Global ischemia following cardiac arrest is characterized by high mortality and significant neurological deficits in long-term survivors. Its mechanisms of neuronal cell death have only partially been elucidated. 12/15-lipoxygenase (12/15-LOX) is a major contributor to delayed neuronal cell death and vascular injury i...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-016-0509-z
更新日期:2017-04-01 00:00:00
abstract::Silent information regulator 1 (SIRT1) is a NAD+-dependent histone deacetylase that represses gene expression and plays a role in longevity. SIRT1 responds to diverse stress conditions and regulates metabolism in nutrient deficiency conditions; therefore, it is involved in adaptive pathways to better fulfill tissue ne...
journal_title:Translational stroke research
pub_type: 杂志文章,评审
doi:10.1007/s12975-013-0277-y
更新日期:2013-12-01 00:00:00
abstract::Increasingly, experimental research in subarachnoid hemorrhage (SAH) has investigated early brain injury and the microcirculation. A number of pathophysiological changes occur in the cerebral microvessels after SAH including altered vasoreactivity, vasoconstriction, inflammation, blood-brain barrier impairment, increa...
journal_title:Translational stroke research
pub_type: 杂志文章,评审
doi:10.1007/s12975-014-0323-4
更新日期:2014-04-01 00:00:00
abstract::Stroke prevention efforts typically focus on either ischemic or hemorrhagic stroke. This approach is overly simplistic due to the frequent coexistence of ischemic and hemorrhagic cerebrovascular disease. This coexistence, termed "mixed cerebrovascular disease", offers a conceptual framework that appears useful for str...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-012-0185-6
更新日期:2012-07-01 00:00:00
abstract::Stroke is a cerebrovascular disorder that affects many people worldwide. Pericytes play an important role in stroke progression and recovery. The sigma-1 receptor (σ-1R) signaling pathway has been suggested as having promising neuroprotective potential in treating stroke; however, whether σ-1R activation regulates per...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-019-00711-0
更新日期:2020-04-01 00:00:00
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journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-010-0022-8
更新日期:2010-06-01 00:00:00
abstract::This review focuses on assessment of behavioral outcomes following traumatic brain injury in juvenile animal models. In the 15 years since the first publication in this field, the majority of studies have used rats roughly equivalent to human toddlers in terms of brain development. Few studies have tested ages closer ...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-011-0132-y
更新日期:2011-12-01 00:00:00
abstract::Lifestyle risk factors, inflammation and genetics play a role in the development of atherosclerosis. We therefore studied Fc gamma receptor (FcγR) polymorphisms, interleukin (IL)-10 polymorphisms and other biomarkers related to carotid intima-media thickness (cIMT) in patients with ischemic stroke at a young age. Pati...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-015-0403-0
更新日期:2015-08-01 00:00:00
abstract::Intraventricular hemorrhage (IVH), which afflicts thousands of people of all ages every year, frequently results in the development of communicating hydrocephalus. Classically, IVH-induced hydrocephalus has been attributed to reduced resorption of cerebrospinal fluid (CSF) due to dysfunction of arachnoid granulations,...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-011-0070-8
更新日期:2011-06-01 00:00:00
abstract::The most deadly form of stroke, intracerebral hemorrhage (ICH) continues to puzzle researchers and produce substantial decrements in the quality of patients' lives. Intensive basic research has devised many agents with putative benefit in mitigating the devastating effects of ICH, but these therapies have been largely...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-012-0207-4
更新日期:2012-12-01 00:00:00
abstract::Acute ischemic stroke (AIS) often results in degeneration of the blood-brain barrier (BBB), which can lead to vasogenic edema and an increased risk of intracerebral hemorrhage. Imatinib is an agent that may be able to protect the BBB and reduce the risk of the harmful consequences of BBB degeneration. We sought to mea...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-014-0358-6
更新日期:2015-02-01 00:00:00
abstract::The incidence of small vessel-type (lacunar) ischemic strokes is greater in African-Americans compared to whites. The chronic inflammatory changes that result from lacunar stroke are poorly understood. To elucidate these changes, we measured serum inflammatory and thrombotic biomarkers in African-Americans at least 6 ...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-015-0424-8
更新日期:2015-12-01 00:00:00
abstract::Cerebral hyperperfusion syndrome (CHS) is a complication that can occur after carotid endarterectomy (CEA), the treatment of choice to decrease the subsequent risk of fatal or disabling stroke for patients with symptomatic severe stenosis of the carotid artery. Because of its rarity and complexity, the mechanism of th...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-017-0605-8
更新日期:2018-10-01 00:00:00
abstract::Intracerebral hemorrhage is by far the most destructive form of stroke. Apart from the management in a specialized stroke or neurological intensive care unit (NICU), no specific therapies have been shown to consistently improve outcomes after ICH. Current guidelines endorse early aggressive optimization of physiologic...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-012-0175-8
更新日期:2012-07-01 00:00:00