The role of the γ δ T cell in allergic diseases.

abstract：:Adverse drug reactions (ADRs) remain a common and major problem in healthcare. Severe cutaneous adverse drug reactions (SCARs), such as Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) with mortality rate ranges from 10% to more than 30%, can be life threatening. A number of recent studies demonstrated ...

journal_title：Journal of immunology research

authors： Fan WL,Shiao MS,Hui RC,Su SC,Wang CW,Chang YC,Chung WH

更新日期：2017-01-01 00:00:00

abstract：:Collectin-12 (collectin placenta 1, CL-P1, or CL-12) is a newly identified pattern recognition molecule of the innate immune system. Recent evidences show that CL-12 plays important roles not only in innate immune protection against certain clinically important pathogens but also in scavenging of host molecules, leuko...

journal_title：Journal of immunology research

authors： Zhang J,Li A,Yang CQ,Garred P,Ma YJ

更新日期：2019-07-29 00:00:00

abstract：:C-type lectin domain family 5-member A (CLEC5A) associates with adaptor DAP12 (DNAX activation protein 12) to form receptor complexes involved in inflammatory responses. We postulated a potential role of CLEC5A in the pathogenesis of adult-onset Still's disease (AOSD) and aimed to investigate CLEC5A expression and its...

journal_title：Journal of immunology research

authors： Chen PK,Hsieh SL,Lan JL,Lin CC,Chang SH,Chen DY

更新日期：2020-04-23 00:00:00

abstract：Objective:To evaluate the efficacy and safety of rituximab in multiple sclerosis in a clinical practice setting. Methods:Clinical data for all adult patients with multiple sclerosis (MS) treated with off-label rituximab at a single MS center in Lebanon between March 2008 and April 2017 were retrospectively collected f...

journal_title：Journal of immunology research

authors： Yamout BI,El-Ayoubi NK,Nicolas J,El Kouzi Y,Khoury SJ,Zeineddine MM

更新日期：2018-11-12 00:00:00

abstract：:Group A streptococcus (GAS) is known to cause a broad spectrum of illness, from pharyngitis and impetigo, to autoimmune sequelae such as rheumatic heart disease, and invasive diseases. It is a significant cause of infectious disease morbidity and mortality worldwide, but no efficacious vaccine is currently available. ...

journal_title：Journal of immunology research

authors： Tsoi SK,Smeesters PR,Frost HR,Licciardi P,Steer AC

更新日期：2015-01-01 00:00:00

abstract：:Regulatory T-cells (Tregs) are a very important subtype of lymphocytes when it comes to self-control in the human immunological system. Tregs are decisive not only in the protection against destruction of own tissues by autoimmune immunocompetent cells but also in the immunological answer to developing cancers. On the...

journal_title：Journal of immunology research

authors： Niedźwiecki M,Budziło O,Adamkiewicz-Drożyńska E,Pawlik-Gwozdecka D,Zieliński M,Maciejka-Kembłowska L,Szczepański T,Trzonkowski P

更新日期：2019-03-03 00:00:00

abstract：:Following fetal or neonatal gene transfer in mice and other species immune tolerance of the transgenic protein is frequently observed; however the underlying mechanisms remain largely undefined. In this study fetal and neonatal BALB/c mice received adenovirus vector to deliver human factor IX (hFIX) cDNA. The long-ter...

journal_title：Journal of immunology research

authors： Nivsarkar MS,Buckley SM,Parker AL,Perocheau D,McKay TR,Rahim AA,Howe SJ,Waddington SN

更新日期：2015-01-01 00:00:00

abstract：:The gastrointestinal microbiota plays a critical role in nutritional, metabolic, and immune functions in infants and young children and has implications for future lung health status. Understanding the role of intestinal dysbiosis in chronic lung disease progression will provide opportunities to design early intervent...

journal_title：Journal of immunology research

authors： Ranucci G,Buccigrossi V,de Freitas MB,Guarino A,Giannattasio A

更新日期：2017-01-01 00:00:00

abstract：:Calcium is a ubiquitous intracellular messenger that has a crucial role in determining the proliferation, differentiation, and functions of multipotent mesenchymal stem cells (MSCs). Our study is aimed at elucidating the influence of genetically manipulating Ca2+ release-activated Ca2+ (CRAC) channel-mediated intercel...

journal_title：Journal of immunology research

authors： Liu S,Takahashi M,Kiyoi T,Toyama K,Mogi M

更新日期：2019-02-17 00:00:00

abstract：:Schmallenberg virus (SBV), discovered in continental Europe in late 2011, causes mild clinical signs in adult ruminants, including diarrhoea and reduced milk yield. However, fetal infection can lead to severe malformation in newborn offspring. To develop improved reagents for SBV serology, a high-level yeast expressio...

journal_title：Journal of immunology research

authors： Lazutka J,Zvirbliene A,Dalgediene I,Petraityte-Burneikiene R,Spakova A,Sereika V,Lelesius R,Wernike K,Beer M,Sasnauskas K

更新日期：2014-01-01 00:00:00

abstract：:In vitro differentiation of mesenchymal stromal cells (MSC) into osteocytes (human differentiated osteogenic cells, hDOC) before implantation has been proposed to optimize bone regeneration. However, a deep characterization of the immunological properties of DOC, including their effect on dendritic cell (DC) function,...

journal_title：Journal of immunology research

authors： Trabanelli S,La Manna F,Romano M,Salvestrini V,Cavo M,Ciciarello M,Lemoli RM,Curti A

更新日期：2015-01-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) remains one of the most devastating cancer types despite the improvement of modern medicine. In our present study, we found that dickkopf-related protein 2 (DKK2) shares a higher expression in PDAC compared with adjacent pancreas tissue in tissue microarray. In addition, an elev...

journal_title：Journal of immunology research

authors： Yang J,Jiang Y,He R,Liu W,Yang M,Tao L,Fu X,Shen Y,Li J,Liu D,Huo Y,Zhang J,Hua R,Zhang Z,Sun Y

更新日期：2019-09-08 00:00:00

abstract：:Neuropathic pain (NPP) is intolerable, persistent, and specific type of long-term pain. It is considered to be a direct consequence of pathological changes affecting the somatosensory system and can be debilitating for affected patients. Despite recent progress and growing interest in understanding the pathogenesis of...

journal_title：Journal of immunology research

authors： Wan W,Cao L,Khanabdali R,Kalionis B,Tai X,Xia S

更新日期：2016-01-01 00:00:00

abstract：:A derivative formula, DGBX, which is composed of three herbs (Radix astragali, Radix Angelicae sinensis, and Coptis chinensis Franch), is derived from a famous Chinese herbal formula, Danggui Buxue Tang (DBT) (Radix astragali and Radix Angelicae sinensis). We aimed to investigate the effects of DGBX on the regulation ...

journal_title：Journal of immunology research

authors： Zhou J,Li X,Deng P,Wei Y,Liu J,Chen M,Xu Y,Zhang D,Zhu L,Lou L,Dong B,Jin Q,Chai L

更新日期：2017-01-01 00:00:00

abstract：:Phosphotyrosine phosphatases (PTPs) constitute a complex family of enzymes that control the balance of intracellular phosphorylation levels to allow cell responses while avoiding the development of diseases. Despite the relevance of CD4 T cell polarisation and effector function in human autoimmune diseases, the expres...

journal_title：Journal of immunology research

authors： Castro-Sánchez P,Ramirez-Munoz R,Roda-Navarro P

更新日期：2017-01-01 00:00:00

abstract：:Mast cells are unique tissue-resident immune cells that secrete a diverse array of biologically active compounds that can stimulate, modulate, or suppress the immune response. Although mounting evidence supports that mast cells are consistently infiltrating tumors, their role as either a driving or an opposite force f...

journal_title：Journal of immunology research

authors： Aponte-López A,Fuentes-Pananá EM,Cortes-Muñoz D,Muñoz-Cruz S

更新日期：2018-02-05 00:00:00

abstract：:The aim of this paper is to determine the modulatory effects of Lactobacillus acidophilus on the IL-23/Th17 immune axis in experimental colitis. DSS-induced mouse models of UC were to be saline, hormones, and different concentrations of Lactobacillus acidophilus intervention. The expression of interleukin- (IL-) 17, t...

journal_title：Journal of immunology research

authors： Chen L,Zou Y,Peng J,Lu F,Yin Y,Li F,Yang J

更新日期：2015-01-01 00:00:00

abstract：:Bacterial vaginosis (BV), the most common genital infection in reproductive-aged women, is associated with increased risk of sexually transmitted infections. Its etiology remains unclear, especially the role of Gardnerella (G.) vaginalis, an anaerobic bacterium characteristic of the BV-alteration of the vaginal ecosys...

journal_title：Journal of immunology research

authors： Bertran T,Brachet P,Vareille-Delarbre M,Falenta J,Dosgilbert A,Vasson MP,Forestier C,Tridon A,Evrard B

更新日期：2016-01-01 00:00:00

abstract：Background and Objectives:Pneumocystis pneumonia (PCP) is a common opportunistic infection in acquired immune deficiency syndrome (AIDS) patients that continues to result in a high mortality rate. To develop a better treatment strategy and improve PCP prognosis, a cohort study was conducted to evaluate the therapeutic ...

journal_title：Journal of immunology research

authors： Wang M,Lang G,Chen Y,Hu C,Guo Y,Tao R,Dong X,Zhu B

更新日期：2019-12-01 00:00:00

abstract：:Although cancer immunotherapy has shown significant promise in mediating efficacious responses, it remains encumbered by tumor heterogeneity, loss of tumor-specific antigen targets, and the regulatory milieu both regionally and systemically. Cross talk between the innate and adaptive immune response may be requisite t...

journal_title：Journal of immunology research

authors： Sayour EJ,Mitchell DA

更新日期：2017-01-01 00:00:00

abstract：:Cationic protein is a cytotoxic protein secreted by eosinophils and takes part in the damage of airway epithelium in asthma. Poly-L-arginine (PLA), a synthetic cationic protein, is widely used to mimic the biological function of the natural cationic protein in vitro. Previous studies demonstrated the damage of the air...

journal_title：Journal of immunology research

authors： Wang YN,Zhang LL,Fan XY,Wu SS,Zhang SQ

更新日期：2018-06-14 00:00:00

abstract：:In this study we examined changes in the salivary concentrations of immunoglobulin A (sIgA), cortisol (sC), testosterone (sT), and testosterone-to-cortisol ratio (T/C) in 21 competitive swimmers, 11-15 years old, during a week leading to competition as compared to a control (noncompetition) week. No day-to-day changes...

journal_title：Journal of immunology research

authors： Papadopoulos E,Muir C,Russell C,Timmons BW,Falk B,Klentrou P

更新日期：2014-01-01 00:00:00

abstract：:Differential cell systematic evolution of ligands by exponential enrichment (SELEX) is an in vitro selection method for obtaining molecular recognition elements (MREs) that specifically bind to individual cell types with high affinity. MREs are selected from initial large libraries of different nucleic or amino acids....

journal_title：Journal of immunology research

authors： Williams RM,Sooter LJ

更新日期：2015-01-01 00:00:00

abstract：:A novel, simple, and reproducible method for cultivating pathological tissues obtained from human eyes during surgery was developed using viscoelastic material as a tissue adherent to facilitate cell attachment and expansion and calcium imaging of cultured cells challenged by mechanical and acetylcholine (ACh) stimula...

journal_title：Journal of immunology research

authors： Andjelic S,Lumi X,Veréb Z,Josifovska N,Facskó A,Hawlina M,Petrovski G

更新日期：2014-01-01 00:00:00

abstract：Background:RNA helicases have various essential functions in basically all aspects of RNA metabolism, not only unwinding RNA but also disturbing the interaction of RNA with proteins. Recently, RNA helicases have been considered potential targets in cancers. So far, there has been no detailed investigation of the biolog...

journal_title：Journal of immunology research

authors： Xu Y,Jiang Q,Liu H,Xiao X,Yang D,Saw PE,Luo B

更新日期：2020-12-30 00:00:00

abstract：PURPOSES:To investigate the possible changes in B cell subsets and in B cell expression patterns of lipid rafts (LRs) and F-actin in patients with SLE and whether leflunomide treatment may have effect on these changes. METHODS:The B cell subsets and LRs expression were determined by flow cytometry and confocal microsc...

journal_title：Journal of immunology research

authors： Dong GF,Zhang X,He DN,Li L,Zhang GF

更新日期：2015-01-01 00:00:00

abstract：:It has been shown that rapamycin is able to significantly increase the expression of FoxP3 and suppress activity in induced Treg (iTreg) cells in vivo and in vitro. CD39 is a newly determined Treg marker that relates to cell suppression. Runx1, a regulator of FoxP3, controls the expression of adenosine deaminase (ADA)...

journal_title：Journal of immunology research

authors： Lu Y,Wang J,Gu J,Lu H,Li X,Qian X,Liu X,Wang X,Zhang F,Lu L

更新日期：2014-01-01 00:00:00

abstract：:Lycium barbarum polysaccharide (LBP) is isolated from the fruit of Chinese herbal Lycium barbarum. Previous studies had demonstrated that LBP could inhibit tumor growth and enhance the immunity in mice. However, the effect of LBP on systemic and local immune responses in vivo, especially on phenotypic and functional c...

journal_title：Journal of immunology research

authors： Deng X,Luo S,Luo X,Hu M,Ma F,Wang Y,Lai X,Zhou L

更新日期：2018-06-03 00:00:00

abstract：:HLA-G has a relevant role in immune response regulation. The overall structure of the HLA-G coding region has been maintained during the evolution process, in which most of its variable sites are synonymous mutations or coincide with introns, preserving major functional HLA-G properties. The HLA-G promoter region is d...

journal_title：Journal of immunology research

authors： Castelli EC,Veiga-Castelli LC,Yaghi L,Moreau P,Donadi EA

更新日期：2014-01-01 00:00:00

abstract：:Pregnancy is an immunological enigma where paternal antigens are present at the fetomaternal interface. What regulates the local immunotolerance, which is necessary to prevent rejection of the conceptus, is still under strong investigation. Gamma/delta T cells are believed to play a role in the local regulation of thi...

journal_title：Journal of immunology research

authors： Nörenberg J,Meggyes M,Jakso P,Miko E,Barakonyi A

更新日期：2019-05-20 00:00:00