Slight Pro-Inflammatory Immunomodulation Properties of Dendritic Cells by Gardnerella vaginalis: The "Invisible Man" of Bacterial Vaginosis?

abstract：:Leptospirosis is considered a neglected disease with an estimated more than one million cases every year. Since rodents are at the same time the main reservoir and generally asymptomatic to Leptospira infection, understanding why some animal species are resistant and others are susceptible to this infection would shed...

journal_title：Journal of immunology research

authors： Bavia L,de Castro ÍA,Amano MT,da Silva AMG,Vasconcellos SA,Isaac L

更新日期：2019-10-07 00:00:00

abstract：:Adverse drug reactions (ADRs) remain a common and major problem in healthcare. Severe cutaneous adverse drug reactions (SCARs), such as Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) with mortality rate ranges from 10% to more than 30%, can be life threatening. A number of recent studies demonstrated ...

journal_title：Journal of immunology research

authors： Fan WL,Shiao MS,Hui RC,Su SC,Wang CW,Chang YC,Chung WH

更新日期：2017-01-01 00:00:00

abstract：:Peripheral CD4/CD8 double-positive (DP) T cells are associated with autoimmune disorders, cancer, and viral infection. However, the relationship between organ transplantation and DP T cells is unclear. Here, we examined the functional characteristics of peripheral DP T cells and analyzed their significance with respec...

journal_title：Journal of immunology research

authors： Choi YJ,Park HJ,Park HJ,Jung KC,Lee JI

更新日期：2018-07-10 00:00:00

abstract：:Cutaneous melanoma is a significant immunogenic tumoral model, the most frequently described immune phenomenon being tumor regression, as a result of the interaction of tumoral antigens and stromal microenvironment. We present a retrospective cohort study including 52 cases of melanoma with regression. There were eval...

journal_title：Journal of immunology research

authors： Cioplea M,Nichita L,Georgescu D,Sticlaru L,Cioroianu A,Nedelcu R,Turcu G,Rauta A,Mogodici C,Zurac S,Popp C

更新日期：2020-10-23 00:00:00

abstract：:Malaria continues being a high-impact disease regarding public health worldwide; the WHO report for malaria in 2018 estimated that ~219 million cases occurred in 2017, mostly caused by the parasite Plasmodium falciparum. The disease cost the lives of more than 400,000 people, mainly in Africa. In spite of great effort...

journal_title：Journal of immunology research

authors： Lambraño J,Curtidor H,Avendaño C,Díaz-Arévalo D,Roa L,Vanegas M,Patarroyo ME,Patarroyo MA

更新日期：2019-12-30 00:00:00

abstract：Aims:This study is aimed at exploring the relation between IL-33 single-nucleotide polymorphisms (SNPs) and the risk of systemic lupus erythematosus (SLE). Methods:SNPStats (online software) was used to test the Hardy-Weinberg equilibrium in controls. Generalized multifactor dimensionality reduction (GMDR) was adopted...

journal_title：Journal of immunology research

authors： Zhu X,Xie L,Qin H,Liang J,Yang Y,Xu J,Zhang T

更新日期：2019-03-11 00:00:00

abstract：:We assessed the immune response against recombinant proteins of two related, albeit functionally different, peroxidoxins from Leishmania donovani: peroxidoxin 1 (LdPxn1) and peroxidoxin 2 (LdPxn2) in BALB/c mice. We also evaluated the effect of coadministration of TLR agonists (CpG ODN and GLA-SE) on the antigen-speci...

journal_title：Journal of immunology research

authors： Daifalla NS,Bayih AG,Gedamu L

更新日期：2015-01-01 00:00:00

abstract：:Reduning injection is a traditional Chinese medicine injection which has multiple functions such as clearing heat, dispelling wind, and detoxification. Although Reduning injection was widely utilized, reports of its allergenicity emerged one after another. However, there is little research on its allergenic substances...

journal_title：Journal of immunology research

authors： Wang F,Li CY,Zheng YF,Li HY,Xiao W,Peng GP

更新日期：2016-01-01 00:00:00

abstract：Background:Gastrosphere, an enriched cellular population with stem-like properties believed to be responsible for an escape from immune-mediated destruction. Th17 and Treg cells play a major role in gastric cancer; however, their interaction with gastrospheres remained elusive. Method:Peripheral blood mononuclear cell...

journal_title：Journal of immunology research

authors： Rezalotfi A,Solgi G,Ebrahimi M

更新日期：2020-12-23 00:00:00

abstract：OBJECTIVE:To investigate the expression and clinical significance of trans-membrane MerTK (mMer) on circulating CD14+ monocytes/macrophages and soluble MerTK (sMer) levels in plasma in systemic lupus erythematosus (SLE). METHOD:108 SLE patients and 42 healthy controls were recruited in this study. The expression of mM...

journal_title：Journal of immunology research

authors： Zhu H,Sun X,Zhu L,Hu F,Shi L,Li Z,Su Y

更新日期：2014-01-01 00:00:00

abstract：:Chemokine (C-X-C motif) ligand (CXCL)10 and other CXCR3 chemokines are involved in the pathogenesis of acute and "chronic hepatitis C virus (HCV) infection" (CHC). Here, we review the scientific literature about HCV and CXCL10. The combination of circulating CXCL10 and single nucleotide polymorphisms (SNPs) in IL-28B ...

journal_title：Journal of immunology research

authors： Ferrari SM,Fallahi P,Ruffilli I,Elia G,Ragusa F,Paparo SR,Patrizio A,Mazzi V,Colaci M,Giuggioli D,Ferri C,Antonelli A

更新日期：2019-08-08 00:00:00

abstract：:Severe aplastic anemia (SAA) is a rare disease characterized by severe pancytopenia and bone marrow failure. Most patients with AA respond to immunosuppressive therapy (IST), usually as antithymocyte globulin (ATG) and cyclosporine (CsA), but some relapse on CsA withdrawal or require long-term administration of CsA to...

journal_title：Journal of immunology research

authors： Ding S,Liang X,Zhang T,Fu R

更新日期：2020-10-17 00:00:00

abstract：:Background. Systemic lupus erythematosus (SLE) is an autoimmune disease with great heterogeneity in pathogenesis and clinical symptoms. Rheumatoid factor (RF) is one key indicator for rheumatoid arthritis (RA) while immunoglobulin E (IgE) is associated with type I hypersensitivity. To better categorize SLE subtypes, w...

journal_title：Journal of immunology research

authors： Wu Y,Cai B,Zhang J,Shen B,Huang Z,Tan C,Baan CC,Wang L

更新日期：2017-01-01 00:00:00

abstract：:Regulatory T cells (Treg) can show plasticity whereby FOXP3 expression, the master transcription factor for Treg suppressor function, is lost and proinflammatory cytokines are produced. Optimal FOXP3 expression strongly depends on hypomethylation of the FOXP3 gene. 5-Azacytidine (Aza) and its derivative 5-aza-2'-deoxy...

journal_title：Journal of immunology research

authors： Landman S,Cruijsen M,Urbano PCM,Huls G,van Erp PEJ,van Rijssen E,Joosten I,Koenen HJPM

更新日期：2018-04-15 00:00:00

abstract：:We investigated cytokine production and expression of degranulation marker CD107a after different strategies of hepatitis B virus (HBV) vaccination in human immunodeficiency virus-infected individuals, which were three doses of 20 μg (standard dose group), four doses of 20 μg (four doses group), or four doses of 40 μg...

journal_title：Journal of immunology research

authors： Chawansuntati K,Chaiklang K,Chaiwarith R,Praparattanapan J,Supparatpinyo K,Wipasa J

更新日期：2018-02-27 00:00:00

abstract：:Cationic protein is a cytotoxic protein secreted by eosinophils and takes part in the damage of airway epithelium in asthma. Poly-L-arginine (PLA), a synthetic cationic protein, is widely used to mimic the biological function of the natural cationic protein in vitro. Previous studies demonstrated the damage of the air...

journal_title：Journal of immunology research

authors： Wang YN,Zhang LL,Fan XY,Wu SS,Zhang SQ

更新日期：2018-06-14 00:00:00

abstract：:Epstein-Barr virus is a very common human virus that infects 90% of human adults. EBV replicates in epithelial and B cells and causes infectious mononucleosis. EBV infection is also linked to various cancers, including Burkitt's lymphoma and nasopharyngeal carcinomas, and autoimmune diseases such as multiple sclerosis...

journal_title：Journal of immunology research

authors： Alonso-Padilla J,Lafuente EM,Reche PA

更新日期：2017-01-01 00:00:00

abstract：:In organ transplantation, alloantigens are taken up by antigen presenting cells and presented via the indirect pathway to T-cells which in turn can induce allograft rejection. Monitoring of these T-cells is of major importance; however no reliable assay is available to routinely monitor indirect allorecognition. Recen...

journal_title：Journal of immunology research

authors： Breman E,Ruben JM,Franken KL,Heemskerk MH,Roelen DL,Claas FH,van Kooten C

更新日期：2016-01-01 00:00:00

abstract：:Epidemiological studies have demonstrated that interleukin-10 (IL-10) polymorphisms may be associated with the development of Behcet's disease (BD). However, the published results were inconsistent. Therefore, this meta-analysis was conducted to derive a more precise relationship between IL-10 polymorphisms and BD sus...

journal_title：Journal of immunology research

authors： Li XF,Huang ZZ,Hu YY,Niu YM,Cai JW

更新日期：2020-06-19 00:00:00

abstract：:Easy access to a vast collection of experimental data on immune epitopes can greatly facilitate the development of therapeutics and vaccines. The Immune Epitope Database and Analysis Resource (IEDB) was developed to provide such a resource as a free service to the biomedical research community. The IEDB contains epito...

journal_title：Journal of immunology research

authors： Fleri W,Vaughan K,Salimi N,Vita R,Peters B,Sette A

更新日期：2017-01-01 00:00:00

abstract：Introduction:Understanding the mechanisms underlying the pathogenesis of Sjögren's syndrome (SS) is crucially important in order to be able to discriminate the steps that lead to B cell transformation and promptly identify the patients at risk of lymphomagenesis. The aim of this narrative review is to describe the evid...

journal_title：Journal of immunology research

authors： Talotta R,Sarzi-Puttini P,Atzeni F

更新日期：2019-01-06 00:00:00

abstract：Background:Several efforts have been made to find out a valuable marker to assist the diagnosis and differentiation of gangrenous/perforated appendicitis. We aimed to determine the diagnostic capacity of soluble B7H3 (sB7H3) in acute appendicitis (AA) and its accuracy as a predictor of the severity of appendicitis. Me...

journal_title：Journal of immunology research

authors： Du X,Chen Y,Zhu J,Bai Z,Hua J,Li Y,Lv H,Zhang G

更新日期：2020-09-01 00:00:00

abstract：:The purpose of this study was to investigate the expression levels of the immune checkpoint proteins, programmed cell death-ligand 1 (PD-L1), B7-H3, B7-H4, and V-domain Ig suppressor of T cell activation (VISTA), as well as the significance thereof, in clear cell carcinoma (CCC) of the cervix (a rare histological subt...

journal_title：Journal of immunology research

authors： Zong L,Zhang Q,Zhou Y,Kong Y,Yu S,Chen J,Zhang Y,Xiang Y

更新日期：2020-04-03 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is characterized by deregulated activation of T and B cells, autoantibody production, and consequent formation of immune complexes. Liposomes with nonbilayer phospholipid arrangements (NPA), induced by chlorpromazine, procainamide, or manganese, provoke a disease resembling human lup...

journal_title：Journal of immunology research

authors： Zárate-Neira LÁ,Sánchez-Barbosa S,Pedroza-Torres A,Reséndiz-Mora A,Wong C,Baeza I,Pérez-Plasencia C,Wong-Baeza C

更新日期：2017-01-01 00:00:00

abstract：:We investigated the characteristics of Chinese SLE patients by analyzing the association between specific autoantibodies and clinical manifestations of 2104 SLE patients from registry data of CSTAR cohort. Significant (P<0.05) associations were found between anti-Sm antibody, anti-rRNP antibody, and malar rash; betwee...

journal_title：Journal of immunology research

authors： Li J,Leng X,Li Z,Ye Z,Li C,Li X,Zhu P,Wang Z,Zheng Y,Li X,Zhang M,Tian XP,Li M,Zhao J,Zhang FC,Zhao Y,Zeng X

更新日期：2014-01-01 00:00:00

abstract：:Propionibacterium acnes (P. acnes) is a gram-positive anaerobic bacillus present in normal human skin microbiota, which exerts important immunomodulatory effects, when used as heat- or phenol-killed suspensions. We previously demonstrated that heat-killed P. acnes or its soluble polysaccharide (PS), extracted from the...

journal_title：Journal of immunology research

authors： Squaiella-Baptistão CC,Teixeira D,Mussalem JS,Ishimura ME,Longo-Maugéri IM

更新日期：2015-01-01 00:00:00

abstract：:The rationale for a type 17 signature in the pathogenesis of spondyloarthritis (SpA) has been increasing and being ratified in studies recently. IL-7 is a cytokine whose ability to stimulate IL-17 production in both innate and adaptive immunity cells has made it a promising target not only for a better understanding o...

journal_title：Journal of immunology research

authors： Gonçalves RSG,Duarte ALBP

更新日期：2019-05-29 00:00:00

abstract：:Oropouche virus (OROV) is an emerging pathogen which causes Oropouche fever and meningitis in humans. Several outbreaks of OROV in South America, especially in Brazil, have changed its status as an emerging disease, but no vaccine or specific drug target is available yet. Our approach was to identify the epitope-based...

journal_title：Journal of immunology research

authors： Adhikari UK,Tayebi M,Rahman MM

更新日期：2018-10-08 00:00:00

abstract：:Cutaneous adverse drug reactions are commonly seen in patients with anticancer drug treatment. Anticancer drugs, including chemotherapy, target therapy, and recent immunotherapy causing skin reactions ranging from mild skin rash to life-threatening severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson sy...

journal_title：Journal of immunology research

authors： Ng CY,Chen CB,Wu MY,Wu J,Yang CH,Hui RC,Chang YC,Lu CW

更新日期：2018-01-17 00:00:00

abstract：:In this study we examined changes in the salivary concentrations of immunoglobulin A (sIgA), cortisol (sC), testosterone (sT), and testosterone-to-cortisol ratio (T/C) in 21 competitive swimmers, 11-15 years old, during a week leading to competition as compared to a control (noncompetition) week. No day-to-day changes...

journal_title：Journal of immunology research

authors： Papadopoulos E,Muir C,Russell C,Timmons BW,Falk B,Klentrou P

更新日期：2014-01-01 00:00:00