Abstract:
:Background. Systemic lupus erythematosus (SLE) is an autoimmune disease with great heterogeneity in pathogenesis and clinical symptoms. Rheumatoid factor (RF) is one key indicator for rheumatoid arthritis (RA) while immunoglobulin E (IgE) is associated with type I hypersensitivity. To better categorize SLE subtypes, we determined the dominant cytokines based on familial SLE patients. Methods. RF, IgE, and multiple cytokines (i.e., IL-1β, IL-6, IL-8, IL-10, IL-17, IFN-γ, IP-10, MCP-1, and MIP-1β) were measured in sera of familial SLE patients (n = 3), noninherited SLE patients (n = 108), and healthy controls (n = 80). Results. Three familial SLE patients and 5 noninherited SLE cases are with features of RF+IgE+. These RF+IgE+ SLE patients expressed significantly higher levels of IL-1β and IL-6 than the other SLE patients (P < 0.05). IL-6 correlated with both IgE and IL-1β levels in RF+IgE+ SLE patients (r2 = 0.583, P = 0.027; r2 = 0.847, P = 0.001), and IgE also correlated with IL-1β (r2 = 0.567, P = 0.031). Conclusion. Both IL-1β and IL-6 are highly expressed cytokines in RF+IgE+ SLE subtype which may be related to the pathogenesis of this special SLE subtype and provide accurate treatment strategy by neutralizing IL-1β and IL-6.
journal_name
J Immunol Resjournal_title
Journal of immunology researchauthors
Wu Y,Cai B,Zhang J,Shen B,Huang Z,Tan C,Baan CC,Wang Ldoi
10.1155/2017/5096741subject
Has Abstractpub_date
2017-01-01 00:00:00pages
5096741eissn
2314-8861issn
2314-7156journal_volume
2017pub_type
杂志文章abstract::We evaluated the association between anti-cyclic citrullinated peptide antibodies (anti-CCP) and anti-mutated citrullinated vimentin antibodies (anti-MCV) with the presence of extra-articular (ExRA) manifestations in 225 patients with rheumatoid arthritis (RA). Ninety-five patients had ExRA and 130 had no ExRA. There ...
journal_title:Journal of immunology research
pub_type: 杂志文章
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journal_title:Journal of immunology research
pub_type: 杂志文章
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journal_title:Journal of immunology research
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journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2019/4078671
更新日期:2019-12-04 00:00:00
abstract::Chagas disease, or American trypanosomiasis, which is caused by the protozoan parasite Trypanosoma cruzi, is primarily a vector disease endemic in 21 Latin American countries, including Mexico. Although many vector control programs have been implemented, T. cruzi has not been eradicated. The development of an anti-T. ...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
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abstract::Breast cancer is the most common neoplasm diagnosed in women around the world. Checkpoint inhibitors, targeting the programmed death receptor-1 or ligand-1 (PD-1/PD-L1) axis, have dramatically changed the outcome of cancer treatment. These therapies have been recently considered as alternatives for treatment of breast...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
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journal_title:Journal of immunology research
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journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2015/429439
更新日期:2015-01-01 00:00:00
abstract::Bronchopulmonary dysplasia (BPD) is a severe complication of the respiratory system associated with preterm birth. Type 2 innate lymphoid cells (ILC2s) play a major role in tissue homeostasis, inflammation, and wound healing. However, the role in BPD remains unclear. The present study showed that ILC2s, interleukin-4 ...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2020/8050186
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journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2016/3576028
更新日期:2016-01-01 00:00:00
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journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2014/546596
更新日期:2014-01-01 00:00:00
abstract::It has been shown that rapamycin is able to significantly increase the expression of FoxP3 and suppress activity in induced Treg (iTreg) cells in vivo and in vitro. CD39 is a newly determined Treg marker that relates to cell suppression. Runx1, a regulator of FoxP3, controls the expression of adenosine deaminase (ADA)...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2014/989434
更新日期:2014-01-01 00:00:00
abstract::This work is aimed at investigating the effect of melittin on identified key genes in bladder cancer (BC) and further providing a theoretical basis for BC treatment. GSE35014 downloaded from the Gene Expression Omnibus (GEO) database was used to screen differentially expressed genes (DEGs) in BC cells and control. Res...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2018/5038172
更新日期:2018-05-03 00:00:00
abstract::Body fluids often contain freely circulating nucleic acids, many of which can be exploited as noninvasive tools for the diagnosis of cancer as well as for clinical prognostication. Identifying microRNAs (miRNAs) in subjects' blood with various malignancies means that they can serve as novel biomarkers for prostate can...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2020/5873056
更新日期:2020-05-08 00:00:00
abstract::Differential cell systematic evolution of ligands by exponential enrichment (SELEX) is an in vitro selection method for obtaining molecular recognition elements (MREs) that specifically bind to individual cell types with high affinity. MREs are selected from initial large libraries of different nucleic or amino acids....
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2015/186586
更新日期:2015-01-01 00:00:00
abstract::Bone is sensitive to overactive immune responses, which initiate the onset of inflammatory bone disorders, such as rheumatoid arthritis and periodontitis, resulting in a significant systemic inflammatory response. On the other hand, neuroinflammation is strongly implicated in Alzheimer's disease (AD), which can be enh...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2015/471342
更新日期:2015-01-01 00:00:00
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journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2019/3836942
更新日期:2019-05-20 00:00:00
abstract::A novel, simple, and reproducible method for cultivating pathological tissues obtained from human eyes during surgery was developed using viscoelastic material as a tissue adherent to facilitate cell attachment and expansion and calcium imaging of cultured cells challenged by mechanical and acetylcholine (ACh) stimula...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2014/232659
更新日期:2014-01-01 00:00:00
abstract:Background:Kawasaki disease (KD) is a systemic form of self-limited vasculitis in children less than five years old, and the main complication is coronary artery injury. However, the etiology of KD remains unclear. The IL-1B polymorphisms rs16944 GG and rs1143627 AA and their diplotype GA/GA have been associated with s...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2019/4730507
更新日期:2019-04-09 00:00:00
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journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2018/3861079
更新日期:2018-07-10 00:00:00
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journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2018/9084759
更新日期:2018-11-12 00:00:00
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journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2015/832916
更新日期:2015-01-01 00:00:00
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journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2018/5376476
更新日期:2018-01-17 00:00:00
abstract:Objective:Rheumatoid arthritis (RA) multidrug resistance is associated with P-glycoprotein (P-gp) overexpression. We investigated the effects of methotrexate (MTX) alone and combined with 4-hydroperoxycyclophosphamide (4-HC) on P-gp expression in fibroblast-like synoviocytes (FLSs) from patients with RA and examined th...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2018/3619320
更新日期:2018-02-18 00:00:00
abstract::Mesothelin (MSLN) is a 40-kDa cell differentiation-associated glycoprotein appearing with carcinogenesis and is highly expressed in many human cancers, including the majority of pancreatic adenocarcinomas, ovarian cancers, and mesotheliomas, while its expression in normal tissue is limited to mesothelial cells lining ...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2015/268172
更新日期:2015-01-01 00:00:00
abstract::Bone diseases are associated with great morbidity; thus, the understanding of the mechanisms leading to their development represents a great challenge to improve bone health. Recent reports suggest that a large number of molecules produced by immune cells affect bone cell activity. However, the mechanisms are incomple...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2015/108451
更新日期:2015-01-01 00:00:00
abstract::Cutaneous melanoma is a significant immunogenic tumoral model, the most frequently described immune phenomenon being tumor regression, as a result of the interaction of tumoral antigens and stromal microenvironment. We present a retrospective cohort study including 52 cases of melanoma with regression. There were eval...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2020/5416843
更新日期:2020-10-23 00:00:00
abstract:Objective:Several molecules are involved in the pathogenesis of a new bone formation in ankylosing spondylitis (AS). The aim of this study was to evaluate the serum levels of sclerostin in patients with AS as a possible biomarker and to investigate any correlations with radiographic damage, disease activity, and functi...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2018/9101964
更新日期:2018-05-02 00:00:00
abstract::Anti-CD3 antibody has been employed for various immune-mediated disorders. However, whether anti-CD3 administration leads to rapid metabolic alternation has not been well investigated. In the current study, we studied how anti-CD3 treatment affected blood glucose levels in mice. We found that anti-CD3 treatment induce...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2014/326708
更新日期:2014-01-01 00:00:00
abstract::Accumulating evidence has pointed out that metastasis is the leading cause of death in several malignant tumor, including CRC. During CRC, metastatic capacity is closely correlated with reprogrammed energy metabolism. Mitochondrial Pyruvate Carrier 1 (MPC1), as the carrier of transporting pyruvate into mitochondria, l...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2020/8340329
更新日期:2020-08-19 00:00:00