Abstract:
:Chagas disease, or American trypanosomiasis, which is caused by the protozoan parasite Trypanosoma cruzi, is primarily a vector disease endemic in 21 Latin American countries, including Mexico. Although many vector control programs have been implemented, T. cruzi has not been eradicated. The development of an anti-T. cruzi vaccine for prophylactic and therapeutic purposes may significantly contribute to the transmission control of Chagas disease. Immune protection against experimental infection with T. cruzi has been studied since the second decade of the last century, and many types of immunogens have been used subsequently, such as killed or attenuated parasites and new DNA vaccines. This primary prevention strategy appears feasible, effective, safe, and inexpensive, although problems remain. The objective of this review is to summarize the research efforts about the development of vaccines against Chagas disease worldwide. A thorough literature review was conducted by searching PubMed with the terms "Chagas disease" and "American trypanosomiasis" together with "vaccines" or "immunization". In addition, reports and journals not cited in PubMed were identified. Publications in English, Spanish, and Portuguese were reviewed.
journal_name
J Immunol Resjournal_title
Journal of immunology researchauthors
Rodríguez-Morales O,Monteón-Padilla V,Carrillo-Sánchez SC,Rios-Castro M,Martínez-Cruz M,Carabarin-Lima A,Arce-Fonseca Mdoi
10.1155/2015/489758subject
Has Abstractpub_date
2015-01-01 00:00:00pages
489758eissn
2314-8861issn
2314-7156journal_volume
2015pub_type
杂志文章,评审abstract::Background. Millions of people are infected with hepatitis C virus (HCV) worldwide and 30% spontaneously clear the infection. Reasons for HCV clearance without antiviral treatment are not well understood. Methods. Blood was collected for DNA analysis from patients with chronic HCV infection or evidence of spontaneous ...
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更新日期:2014-01-01 00:00:00
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journal_title:Journal of immunology research
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journal_title:Journal of immunology research
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journal_title:Journal of immunology research
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journal_title:Journal of immunology research
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journal_title:Journal of immunology research
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更新日期:2019-10-29 00:00:00