The Impact of Psoriasis and Metabolic Syndrome on the Systemic Inflammation and Oxidative Damage to Nucleic Acids.

abstract：:Considerable shortages in the supply of available organs continue to plague the field of solid organ transplantation. Despite changes in allocation, as well as the utilization of extended criteria and living donors, the number of patients waiting for organs continues to grow at an alarming pace. Xenotransplantation, c...

journal_title：Journal of immunology research

authors： Shah JA,Lanaspa MA,Tanabe T,Watanabe H,Johnson RJ,Yamada K

更新日期：2018-03-04 00:00:00

abstract：:Mucosal surfaces in the airways and the gastrointestinal tract are critical for the interactions of the host with its environment. Due to their abundance at mucosal tissue sites and their powerful immunomodulatory capacities, the role of innate lymphoid cells (ILCs) and natural killer T (NKT) cells in the maintenance ...

journal_title：Journal of immunology research

authors： Nau D,Altmayer N,Mattner J

更新日期：2014-01-01 00:00:00

abstract：:Chagas disease, or American trypanosomiasis, which is caused by the protozoan parasite Trypanosoma cruzi, is primarily a vector disease endemic in 21 Latin American countries, including Mexico. Although many vector control programs have been implemented, T. cruzi has not been eradicated. The development of an anti-T. ...

journal_title：Journal of immunology research

authors： Rodríguez-Morales O,Monteón-Padilla V,Carrillo-Sánchez SC,Rios-Castro M,Martínez-Cruz M,Carabarin-Lima A,Arce-Fonseca M

更新日期：2015-01-01 00:00:00

abstract：Objective:This study aimed to investigate the correlation of CD4+/PD-1+ or CD4+/PD-1- tumor-infiltrating lymphocytes with pathological characteristics in breast cancer patients. Methods:A cross-sectional study consecutively recruited 133 patients with invasive ductal breast cancer. The expression of CD4, programmed ce...

journal_title：Journal of immunology research

authors： Zhao YJ,Zhang J,Shi F,Hu ZP,Wu JP,Wu GJ,Wang RB,Zhou Q,Chang H,Li YN,Song QK

更新日期：2018-07-04 00:00:00

abstract：:Multiepitope peptide vaccine has some advantages over traditional recombinant protein vaccine due to its easy and fast production and possible inclusion of multiple protective epitopes of pathogens. However, it is usually poorly immunogenic and needs to conjugate to a large carrier protein. Peptides conjugated to a ce...

journal_title：Journal of immunology research

authors： Gu Y,Sun X,Huang J,Zhan B,Zhu X

更新日期：2020-01-08 00:00:00

abstract：:Rheumatoid arthritis (RA) is an inflammatory autoimmune disorder; abnormal T cell immunity plays a critical role in the development of RA. Recently, A20 was identified as a key negative regulator for T cell activation and inflammatory signaling and may be involved in RA pathogenesis. In this study, we analyzed the exp...

journal_title：Journal of immunology research

authors： Wang X,Zhu L,Liao Z,Zhang F,Xu L,Xu Y,Chen S,Yang L,Zhou Y,Li Y

更新日期：2014-01-01 00:00:00

abstract：:Pregnancy is an immunological enigma where paternal antigens are present at the fetomaternal interface. What regulates the local immunotolerance, which is necessary to prevent rejection of the conceptus, is still under strong investigation. Gamma/delta T cells are believed to play a role in the local regulation of thi...

journal_title：Journal of immunology research

authors： Nörenberg J,Meggyes M,Jakso P,Miko E,Barakonyi A

更新日期：2019-05-20 00:00:00

abstract：:Diabetic nephropathy (DN) is one of the most serious chronic kidney diseases and the major cause of end-stage renal failure worldwide. The underlying mechanisms of DN are complex and required to be further investigated. Both innate immunity and renin-angiotensin system (RAS) play critical roles in the pathogenesis of ...

journal_title：Journal of immunology research

authors： Feng Q,Liu D,Lu Y,Liu Z

更新日期：2020-04-30 00:00:00

abstract：:Collectin-12 (collectin placenta 1, CL-P1, or CL-12) is a newly identified pattern recognition molecule of the innate immune system. Recent evidences show that CL-12 plays important roles not only in innate immune protection against certain clinically important pathogens but also in scavenging of host molecules, leuko...

journal_title：Journal of immunology research

authors： Zhang J,Li A,Yang CQ,Garred P,Ma YJ

更新日期：2019-07-29 00:00:00

abstract：Background:Diagnostic criteria for Sjögren's syndrome (SS) are continually being updated in pursuit of more precise and earlier diagnosis to prevent its complications. Owing to the high rate of false negative traditional serological markers, the need for better serological testing remains. Objective:To investigate the...

journal_title：Journal of immunology research

authors： Karakus S,Baer AN,Akpek EK

更新日期：2019-01-13 00:00:00

abstract：:It has been shown that rapamycin is able to significantly increase the expression of FoxP3 and suppress activity in induced Treg (iTreg) cells in vivo and in vitro. CD39 is a newly determined Treg marker that relates to cell suppression. Runx1, a regulator of FoxP3, controls the expression of adenosine deaminase (ADA)...

journal_title：Journal of immunology research

authors： Lu Y,Wang J,Gu J,Lu H,Li X,Qian X,Liu X,Wang X,Zhang F,Lu L

更新日期：2014-01-01 00:00:00

abstract：:The effects of propolis on blood glucose regulation and the alleviation of various complications caused by diabetes have been widely studied. The main source of propolis in the northern temperate zone is poplar buds. However, there is limited research on the antidiabetic activity of poplar buds. In order to evaluate t...

journal_title：Journal of immunology research

authors： Peng S,Wei P,Lu Q,Liu R,Ding Y,Zhang J

更新日期：2018-09-18 00:00:00

abstract：:Reconstitution of the hematopoietic system during immune responses and immunological and neoplastic diseases or upon transplantation depends on the emergent differentiation of hematopoietic stem/progenitor cells within the bone marrow. Although in the last decade the use of dialyzable leukocyte extracts (DLE) as suppo...

journal_title：Journal of immunology research

authors： Ramírez-Ramírez D,Vadillo E,Arriaga-Pizano LA,Mayani H,Estrada-Parra S,Velasco-Velázquez MA,Pérez-Tapia SM,Pelayo R

更新日期：2016-01-01 00:00:00

abstract：:We assessed the immune response against recombinant proteins of two related, albeit functionally different, peroxidoxins from Leishmania donovani: peroxidoxin 1 (LdPxn1) and peroxidoxin 2 (LdPxn2) in BALB/c mice. We also evaluated the effect of coadministration of TLR agonists (CpG ODN and GLA-SE) on the antigen-speci...

journal_title：Journal of immunology research

authors： Daifalla NS,Bayih AG,Gedamu L

更新日期：2015-01-01 00:00:00

abstract：:Severe aplastic anemia (SAA) is a rare disease characterized by severe pancytopenia and bone marrow failure. Most patients with AA respond to immunosuppressive therapy (IST), usually as antithymocyte globulin (ATG) and cyclosporine (CsA), but some relapse on CsA withdrawal or require long-term administration of CsA to...

journal_title：Journal of immunology research

authors： Ding S,Liang X,Zhang T,Fu R

更新日期：2020-10-17 00:00:00

abstract：:Cutaneous adverse drug reactions are commonly seen in patients with anticancer drug treatment. Anticancer drugs, including chemotherapy, target therapy, and recent immunotherapy causing skin reactions ranging from mild skin rash to life-threatening severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson sy...

journal_title：Journal of immunology research

authors： Ng CY,Chen CB,Wu MY,Wu J,Yang CH,Hui RC,Chang YC,Lu CW

更新日期：2018-01-17 00:00:00

abstract：Background:Kawasaki disease (KD) is a systemic form of self-limited vasculitis in children less than five years old, and the main complication is coronary artery injury. However, the etiology of KD remains unclear. The IL-1B polymorphisms rs16944 GG and rs1143627 AA and their diplotype GA/GA have been associated with s...

journal_title：Journal of immunology research

authors： Fu LY,Qiu X,Deng QL,Huang P,Pi L,Xu Y,Che D,Zhou H,Lu Z,Tan Y,Jiang Z,Zhang L,Liu T,Gu X

更新日期：2019-04-09 00:00:00

abstract：:RANKL (receptor activator of nuclear factor kappa-β ligand) and OPG (osteoprotegerin) are two proteins involved in bone remodelling. During the active phase of periodontal disease, an imbalance between the ratios of the two elements can be noticed. While the expression of RANKL is elevated compared with that of OPG, t...

journal_title：Journal of immunology research

authors： Teodorescu AC,Martu I,Teslaru S,Kappenberg-Nitescu DC,Goriuc A,Luchian I,Martu MA,Solomon SM,Mârțu S

更新日期：2019-04-28 00:00:00

abstract：:Therapeutic monoclonal antibodies (mAbs) represent a milestone in pharmacological development. Their superiority is based on the combination of high specificity, low toxicity, and long half-life that characterizes biologics. If biologics have Achilles' heel, it is their potential immunogenicity. To better understand t...

journal_title：Journal of immunology research

authors： Boysen M,Schlicksupp L,Dreher I,Loebbert R,Richter M

更新日期：2016-01-01 00:00:00

abstract：:Regulatory T-cells (Tregs) are a very important subtype of lymphocytes when it comes to self-control in the human immunological system. Tregs are decisive not only in the protection against destruction of own tissues by autoimmune immunocompetent cells but also in the immunological answer to developing cancers. On the...

journal_title：Journal of immunology research

authors： Niedźwiecki M,Budziło O,Adamkiewicz-Drożyńska E,Pawlik-Gwozdecka D,Zieliński M,Maciejka-Kembłowska L,Szczepański T,Trzonkowski P

更新日期：2019-03-03 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is characterized by deregulated activation of T and B cells, autoantibody production, and consequent formation of immune complexes. Liposomes with nonbilayer phospholipid arrangements (NPA), induced by chlorpromazine, procainamide, or manganese, provoke a disease resembling human lup...

journal_title：Journal of immunology research

authors： Zárate-Neira LÁ,Sánchez-Barbosa S,Pedroza-Torres A,Reséndiz-Mora A,Wong C,Baeza I,Pérez-Plasencia C,Wong-Baeza C

更新日期：2017-01-01 00:00:00

abstract：:Human papillomavirus (HPV) is a small double-stranded DNA virus with tropism for epithelial cells. To this date, over 150 genotypes are known and are classified into two major groups, low-risk and high-risk strains, depending on the ability of the virus to induce malignant transformation. The host's immunity plays a c...

journal_title：Journal of immunology research

authors： Georgescu SR,Mitran CI,Mitran MI,Caruntu C,Sarbu MI,Matei C,Nicolae I,Tocut SM,Popa MI,Tampa M

更新日期：2018-08-27 00:00:00

abstract：:Regulatory T cells (Treg) can show plasticity whereby FOXP3 expression, the master transcription factor for Treg suppressor function, is lost and proinflammatory cytokines are produced. Optimal FOXP3 expression strongly depends on hypomethylation of the FOXP3 gene. 5-Azacytidine (Aza) and its derivative 5-aza-2'-deoxy...

journal_title：Journal of immunology research

authors： Landman S,Cruijsen M,Urbano PCM,Huls G,van Erp PEJ,van Rijssen E,Joosten I,Koenen HJPM

更新日期：2018-04-15 00:00:00

abstract：:Many immune-based intestinal disorders, such as ulcerative colitis and Crohn's disease, as well as other illnesses, may have the intestines as an initial cause or aggravator in the development of diseases, even apparently not correlating directly to the intestine. Diabetes, obesity, multiple sclerosis, depression, and...

journal_title：Journal of immunology research

authors： Maranduba CM,De Castro SB,de Souza GT,Rossato C,da Guia FC,Valente MA,Rettore JV,Maranduba CP,de Souza CM,do Carmo AM,Macedo GC,Silva Fde S

更新日期：2015-01-01 00:00:00

abstract：:Chemokine (C-X-C motif) ligand (CXCL)10 and other CXCR3 chemokines are involved in the pathogenesis of acute and "chronic hepatitis C virus (HCV) infection" (CHC). Here, we review the scientific literature about HCV and CXCL10. The combination of circulating CXCL10 and single nucleotide polymorphisms (SNPs) in IL-28B ...

journal_title：Journal of immunology research

authors： Ferrari SM,Fallahi P,Ruffilli I,Elia G,Ragusa F,Paparo SR,Patrizio A,Mazzi V,Colaci M,Giuggioli D,Ferri C,Antonelli A

更新日期：2019-08-08 00:00:00

abstract：:Bone diseases are associated with great morbidity; thus, the understanding of the mechanisms leading to their development represents a great challenge to improve bone health. Recent reports suggest that a large number of molecules produced by immune cells affect bone cell activity. However, the mechanisms are incomple...

journal_title：Journal of immunology research

authors： Mori G,D'Amelio P,Faccio R,Brunetti G

更新日期：2015-01-01 00:00:00

abstract：:Schmallenberg virus (SBV), discovered in continental Europe in late 2011, causes mild clinical signs in adult ruminants, including diarrhoea and reduced milk yield. However, fetal infection can lead to severe malformation in newborn offspring. To develop improved reagents for SBV serology, a high-level yeast expressio...

journal_title：Journal of immunology research

authors： Lazutka J,Zvirbliene A,Dalgediene I,Petraityte-Burneikiene R,Spakova A,Sereika V,Lelesius R,Wernike K,Beer M,Sasnauskas K

更新日期：2014-01-01 00:00:00

abstract：Background and Aim:The presumed role of the inhibitory receptor LAIR-1 (CD305) in the inflammatory response suggests that it might contribute to the pathophysiology of chronic inflammatory diseases such as liver cirrhosis. We studied the LAIR-1 expression on liver macrophages and blood monocytes related to the progress...

journal_title：Journal of immunology research

authors： Martínez-Esparza M,Ruiz-Alcaraz AJ,Carmona-Martínez V,Fernández-Fernández MD,Antón G,Muñoz-Tornero M,Lencina M,Pagán I,de la Peña J,García-Peñarrubia P

更新日期：2019-03-24 00:00:00

abstract：:The phenotype and functional properties of antigen-presenting cells (APC), that is, circulating monocytes and generated in vitro macrophages and dendritic cells, were investigated in the patients with pulmonary tuberculosis (TB) differing in lymphocyte reactivity to M. tuberculosis antigens (PPD-reactive versus PPD-an...

journal_title：Journal of immunology research

authors： Sakhno LV,Shevela EY,Tikhonova MA,Nikonov SD,Ostanin AA,Chernykh ER

更新日期：2015-01-01 00:00:00

abstract：:Dopamine (DA), a neurotransmitter in the central nervous system (CNS), has modulatory functions at the systemic level. The peripheral and central nervous systems have independent dopaminergic system (DAS) that share mechanisms and molecular machinery. In the past century, experimental evidence has accumulated on the p...

journal_title：Journal of immunology research

authors： Arreola R,Alvarez-Herrera S,Pérez-Sánchez G,Becerril-Villanueva E,Cruz-Fuentes C,Flores-Gutierrez EO,Garcés-Alvarez ME,de la Cruz-Aguilera DL,Medina-Rivero E,Hurtado-Alvarado G,Quintero-Fabián S,Pavón L

更新日期：2016-01-01 00:00:00