Hypoxic Modulation of HLA-G Expression through the Metabolic Sensor HIF-1 in Human Cancer Cells.

abstract：OBJECTIVE:To investigate the expression and clinical significance of trans-membrane MerTK (mMer) on circulating CD14+ monocytes/macrophages and soluble MerTK (sMer) levels in plasma in systemic lupus erythematosus (SLE). METHOD:108 SLE patients and 42 healthy controls were recruited in this study. The expression of mM...

journal_title：Journal of immunology research

authors： Zhu H,Sun X,Zhu L,Hu F,Shi L,Li Z,Su Y

更新日期：2014-01-01 00:00:00

abstract：:Breast cancer is the most common neoplasm diagnosed in women around the world. Checkpoint inhibitors, targeting the programmed death receptor-1 or ligand-1 (PD-1/PD-L1) axis, have dramatically changed the outcome of cancer treatment. These therapies have been recently considered as alternatives for treatment of breast...

journal_title：Journal of immunology research

authors： Segovia-Mendoza M,Romero-Garcia S,Lemini C,Prado-Garcia H

更新日期：2021-01-07 00:00:00

abstract：:An important function of the immune system is its ability to differentiate between healthy cells in the organism and "foreign" cells, allowing the latest to be attacked and the first ones to be conserved. The most important molecules in this process are considered to be checkpoint inhibitors. This review is focused on...

journal_title：Journal of immunology research

authors： Vajaitu C,Draghici CC,Solomon I,Lisievici CV,Popa AV,Lupu M,Caruntu C,Constantin MM,Voiculescu VM

更新日期：2018-10-17 00:00:00

abstract：:Rheumatoid arthritis (RA) is a disease of chronic systemic inflammation (SI). In the present study, we used four datasets to explore whether methylation-derived neutrophil-to-lymphocyte ratio (mdNLR) might be a marker of SI in new onset, untreated, and treated prevalent RA cases and/or a marker of treatment response t...

journal_title：Journal of immunology research

authors： Ambatipudi S,Sharp GC,Clarke SLN,Plant D,Tobias JH,Evans DM,Barton A,Relton CL

更新日期：2018-08-14 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPAR gamma-2) and beta-3-adrenergic receptors (ADRB3) are involved in the risk of hypertension. But their exact role in blood pressure modulation in patients with connective tissue diseases (CTD) is still not well defined. In this study, 104 patients with CTD and 103 gender...

journal_title：Journal of immunology research

authors： Grygiel-Górniak B,Ziółkowska-Suchanek I,Kaczmarek E,Puszczewicz M,Rozwadowska N

更新日期：2020-02-03 00:00:00

abstract：:Chagas disease, or American trypanosomiasis, which is caused by the protozoan parasite Trypanosoma cruzi, is primarily a vector disease endemic in 21 Latin American countries, including Mexico. Although many vector control programs have been implemented, T. cruzi has not been eradicated. The development of an anti-T. ...

journal_title：Journal of immunology research

authors： Rodríguez-Morales O,Monteón-Padilla V,Carrillo-Sánchez SC,Rios-Castro M,Martínez-Cruz M,Carabarin-Lima A,Arce-Fonseca M

更新日期：2015-01-01 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP) is a mediator of microglial activation at the transcriptional level. The involvement of the epigenetic mechanism in this process is largely undefined. Histone deacetylase (HDAC)1/2 are considered important epigenetic regulators of gene expression in activated microglia. In this s...

journal_title：Journal of immunology research

authors： Guo X,Chen D,An S,Wang Z

更新日期：2020-08-04 00:00:00

abstract：:Collectin-12 (collectin placenta 1, CL-P1, or CL-12) is a newly identified pattern recognition molecule of the innate immune system. Recent evidences show that CL-12 plays important roles not only in innate immune protection against certain clinically important pathogens but also in scavenging of host molecules, leuko...

journal_title：Journal of immunology research

authors： Zhang J,Li A,Yang CQ,Garred P,Ma YJ

更新日期：2019-07-29 00:00:00

abstract：Objective:Safflower has antioxidant and anti-inflammatory activities. The two forms of preparations for safflower which are widely used in China are injection and decoction. The first step of the process for preparing an injection involves extracting safflower with water, which actually yields a decoction. This study i...

journal_title：Journal of immunology research

authors： Liao H,Li Y,Zhai X,Zheng B,Banbury L,Zhao X,Li R

更新日期：2019-05-06 00:00:00

abstract：:Body fluids often contain freely circulating nucleic acids, many of which can be exploited as noninvasive tools for the diagnosis of cancer as well as for clinical prognostication. Identifying microRNAs (miRNAs) in subjects' blood with various malignancies means that they can serve as novel biomarkers for prostate can...

journal_title：Journal of immunology research

authors： Jin W,Fei X,Wang X,Chen F,Song Y

更新日期：2020-05-08 00:00:00

abstract：:Extracellular matrix metalloproteases and the fibrinolytic system are important protease systems interacting with each other in charge of remodeling and recycling of tissues. Their role in tumor invasion and metastasis is often discussed. In this study several metalloproteases such as MMP-1, MMP-3, MMP-9, and TIMP-1 t...

journal_title：Journal of immunology research

authors： Barajas-Castañeda LM,Cortés-Gutiérrez E,García-Rodríguez FM,Campos-Rodríguez R,Lara-Padilla E,Enríquez-Rincón F,Castro-Mussot ME,Figueroa-Arredondo P

更新日期：2016-01-01 00:00:00

abstract：:Bacterial vaginosis (BV), the most common genital infection in reproductive-aged women, is associated with increased risk of sexually transmitted infections. Its etiology remains unclear, especially the role of Gardnerella (G.) vaginalis, an anaerobic bacterium characteristic of the BV-alteration of the vaginal ecosys...

journal_title：Journal of immunology research

authors： Bertran T,Brachet P,Vareille-Delarbre M,Falenta J,Dosgilbert A,Vasson MP,Forestier C,Tridon A,Evrard B

更新日期：2016-01-01 00:00:00

abstract：:Considerable shortages in the supply of available organs continue to plague the field of solid organ transplantation. Despite changes in allocation, as well as the utilization of extended criteria and living donors, the number of patients waiting for organs continues to grow at an alarming pace. Xenotransplantation, c...

journal_title：Journal of immunology research

authors： Shah JA,Lanaspa MA,Tanabe T,Watanabe H,Johnson RJ,Yamada K

更新日期：2018-03-04 00:00:00

abstract：:Neuropathic pain (NPP) is intolerable, persistent, and specific type of long-term pain. It is considered to be a direct consequence of pathological changes affecting the somatosensory system and can be debilitating for affected patients. Despite recent progress and growing interest in understanding the pathogenesis of...

journal_title：Journal of immunology research

authors： Wan W,Cao L,Khanabdali R,Kalionis B,Tai X,Xia S

更新日期：2016-01-01 00:00:00

abstract：Background:Diagnostic criteria for Sjögren's syndrome (SS) are continually being updated in pursuit of more precise and earlier diagnosis to prevent its complications. Owing to the high rate of false negative traditional serological markers, the need for better serological testing remains. Objective:To investigate the...

journal_title：Journal of immunology research

authors： Karakus S,Baer AN,Akpek EK

更新日期：2019-01-13 00:00:00

abstract：:Peripheral CD4/CD8 double-positive (DP) T cells are associated with autoimmune disorders, cancer, and viral infection. However, the relationship between organ transplantation and DP T cells is unclear. Here, we examined the functional characteristics of peripheral DP T cells and analyzed their significance with respec...

journal_title：Journal of immunology research

authors： Choi YJ,Park HJ,Park HJ,Jung KC,Lee JI

更新日期：2018-07-10 00:00:00

abstract：:In this study we examined changes in the salivary concentrations of immunoglobulin A (sIgA), cortisol (sC), testosterone (sT), and testosterone-to-cortisol ratio (T/C) in 21 competitive swimmers, 11-15 years old, during a week leading to competition as compared to a control (noncompetition) week. No day-to-day changes...

journal_title：Journal of immunology research

authors： Papadopoulos E,Muir C,Russell C,Timmons BW,Falk B,Klentrou P

更新日期：2014-01-01 00:00:00

abstract：:HLA-G has a relevant role in immune response regulation. The overall structure of the HLA-G coding region has been maintained during the evolution process, in which most of its variable sites are synonymous mutations or coincide with introns, preserving major functional HLA-G properties. The HLA-G promoter region is d...

journal_title：Journal of immunology research

authors： Castelli EC,Veiga-Castelli LC,Yaghi L,Moreau P,Donadi EA

更新日期：2014-01-01 00:00:00

abstract：:Intestinal inflammation is a harmful condition in fish that can be triggered by the ingestion of soybean meal. Due to the positive costs-benefits ratio of including soybean meal in farmed fish diets, identifying additives with intestinal anti-inflammatory effects could contribute to solving the issues caused by this p...

journal_title：Journal of immunology research

authors： Ulloa PE,Solís CJ,De la Paz JF,Alaurent TG,Caruffo M,Hernández AJ,Dantagnan P,Feijóo CG

更新日期：2016-01-01 00:00:00

abstract：:Sepsis has become a major health economic issue, with more patients dying in hospitals due to sepsis related complications compared to breast and colorectal cancer together. Despite extensive research in order to improve outcome in sepsis over the last few decades, results of large multicenter studies were by-and-larg...

journal_title：Journal of immunology research

authors： László I,Trásy D,Molnár Z,Fazakas J

更新日期：2015-01-01 00:00:00

abstract：:Primary Sjogren's syndrome (pSS) is a chronic autoimmune disease. The aim of the study was to establish whether in patients with pSS without central nervous system (CNS) involvement, the function of the central portion of the sensory pathway can be challenged. In 33 patients with pSS without clinical features of CNS d...

journal_title：Journal of immunology research

authors： Dziadkowiak E,Sebastian A,Wieczorek M,Kusińska E,Waliszewska-Prosół M,Wiland P,Ejma M

更新日期：2018-04-05 00:00:00

abstract：:C-type lectin domain family 5-member A (CLEC5A) associates with adaptor DAP12 (DNAX activation protein 12) to form receptor complexes involved in inflammatory responses. We postulated a potential role of CLEC5A in the pathogenesis of adult-onset Still's disease (AOSD) and aimed to investigate CLEC5A expression and its...

journal_title：Journal of immunology research

authors： Chen PK,Hsieh SL,Lan JL,Lin CC,Chang SH,Chen DY

更新日期：2020-04-23 00:00:00

abstract：Objectives:Both thymic stromal lymphopoietin (TSLP) and dendritic cells (DCs) are involved in many autoimmune diseases, but the potential roles of TSLP and DCs in bullous pemphigoid (BP) have not been clarified. We sought to explore the contributions of TSLP and DCs in patients with BP. Methods:TSLP levels in sera and...

journal_title：Journal of immunology research

authors： Li SZ,Jin XX,Ge XL,Zuo YG,Jin HZ

更新日期：2020-09-24 00:00:00

abstract：:Diabetic nephropathy (DN) is one of the most serious chronic kidney diseases and the major cause of end-stage renal failure worldwide. The underlying mechanisms of DN are complex and required to be further investigated. Both innate immunity and renin-angiotensin system (RAS) play critical roles in the pathogenesis of ...

journal_title：Journal of immunology research

authors： Feng Q,Liu D,Lu Y,Liu Z

更新日期：2020-04-30 00:00:00

abstract：:Multiepitope peptide vaccine has some advantages over traditional recombinant protein vaccine due to its easy and fast production and possible inclusion of multiple protective epitopes of pathogens. However, it is usually poorly immunogenic and needs to conjugate to a large carrier protein. Peptides conjugated to a ce...

journal_title：Journal of immunology research

authors： Gu Y,Sun X,Huang J,Zhan B,Zhu X

更新日期：2020-01-08 00:00:00

abstract：Background and Aim:The presumed role of the inhibitory receptor LAIR-1 (CD305) in the inflammatory response suggests that it might contribute to the pathophysiology of chronic inflammatory diseases such as liver cirrhosis. We studied the LAIR-1 expression on liver macrophages and blood monocytes related to the progress...

journal_title：Journal of immunology research

authors： Martínez-Esparza M,Ruiz-Alcaraz AJ,Carmona-Martínez V,Fernández-Fernández MD,Antón G,Muñoz-Tornero M,Lencina M,Pagán I,de la Peña J,García-Peñarrubia P

更新日期：2019-03-24 00:00:00

abstract：:Leptospirosis is considered a neglected disease with an estimated more than one million cases every year. Since rodents are at the same time the main reservoir and generally asymptomatic to Leptospira infection, understanding why some animal species are resistant and others are susceptible to this infection would shed...

journal_title：Journal of immunology research

authors： Bavia L,de Castro ÍA,Amano MT,da Silva AMG,Vasconcellos SA,Isaac L

更新日期：2019-10-07 00:00:00

abstract：:Human papillomavirus (HPV) is a small double-stranded DNA virus with tropism for epithelial cells. To this date, over 150 genotypes are known and are classified into two major groups, low-risk and high-risk strains, depending on the ability of the virus to induce malignant transformation. The host's immunity plays a c...

journal_title：Journal of immunology research

authors： Georgescu SR,Mitran CI,Mitran MI,Caruntu C,Sarbu MI,Matei C,Nicolae I,Tocut SM,Popa MI,Tampa M

更新日期：2018-08-27 00:00:00

abstract：Aims:This study is aimed at exploring the relation between IL-33 single-nucleotide polymorphisms (SNPs) and the risk of systemic lupus erythematosus (SLE). Methods:SNPStats (online software) was used to test the Hardy-Weinberg equilibrium in controls. Generalized multifactor dimensionality reduction (GMDR) was adopted...

journal_title：Journal of immunology research

authors： Zhu X,Xie L,Qin H,Liang J,Yang Y,Xu J,Zhang T

更新日期：2019-03-11 00:00:00

abstract：:Calcium is a ubiquitous intracellular messenger that has a crucial role in determining the proliferation, differentiation, and functions of multipotent mesenchymal stem cells (MSCs). Our study is aimed at elucidating the influence of genetically manipulating Ca2+ release-activated Ca2+ (CRAC) channel-mediated intercel...

journal_title：Journal of immunology research

authors： Liu S,Takahashi M,Kiyoi T,Toyama K,Mogi M

更新日期：2019-02-17 00:00:00