In Vitro Selection of Cancer Cell-Specific Molecular Recognition Elements from Amino Acid Libraries.

abstract：:The benefits of garlic to health have been proclaimed for centuries; however, only recently have Allium sativum and its derivatives been proposed as promising candidates for maintaining the homeostasis of the immune system. The complex biochemistry of garlic makes it possible for variations in processing to yield diff...

journal_title：Journal of immunology research

authors： Arreola R,Quintero-Fabián S,López-Roa RI,Flores-Gutiérrez EO,Reyes-Grajeda JP,Carrera-Quintanar L,Ortuño-Sahagún D

更新日期：2015-01-01 00:00:00

abstract：:We recently have proved that excessive fecal DCA caused by high-fat diet may serve as an endogenous danger-associated molecular pattern to activate NLRP3 inflammasome and thus contributes to the development of inflammatory bowel disease (IBD). Moreover, the effect of DCA on inflammasome activation is mainly mediated t...

journal_title：Journal of immunology research

authors： Zhao S,Gong Z,Du X,Tian C,Wang L,Zhou J,Xu C,Chen Y,Cai W,Wu J

更新日期：2018-05-09 00:00:00

abstract：:The age-specific reference values for immunoglobulin (Ig) serum concentrations in European bison (Bison bonasus) are lacking. Identification of immune alterations that accompany normal physiological aging will help assist in development of better monitoring health programs. In the present study, the age-associated cha...

journal_title：Journal of immunology research

authors： Pomorska-Mól M,Krzysiak MK,Larska M,Włodarek J

更新日期：2020-01-23 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) remains one of the most devastating cancer types despite the improvement of modern medicine. In our present study, we found that dickkopf-related protein 2 (DKK2) shares a higher expression in PDAC compared with adjacent pancreas tissue in tissue microarray. In addition, an elev...

journal_title：Journal of immunology research

authors： Yang J,Jiang Y,He R,Liu W,Yang M,Tao L,Fu X,Shen Y,Li J,Liu D,Huo Y,Zhang J,Hua R,Zhang Z,Sun Y

更新日期：2019-09-08 00:00:00

abstract：:Background. U65, a self-aggregating peptide scaffold, traps fused protein antigens in yeast cells. Conversion to Yeast Cell Particle (YCP) vaccines by partial removal of surface mannoproteins exposes β-glucan, mediating efficient uptake by antigen-presenting cells (APCs). YCP vaccines are inexpensive, capable of rapid...

journal_title：Journal of immunology research

authors： Tipper DJ,Szomolanyi-Tsuda E

更新日期：2016-01-01 00:00:00

abstract：:The bioactive and anti-inflammatory role of human milk components has been recognized; active milk components include soluble forms of Toll-like receptors (TLRs). Preterm babies are more susceptible to infections and may succumb to necrotizing enterocolitis (NEC), a gastrointestinal disease which is exacerbated by an ...

journal_title：Journal of immunology research

authors： Cattaneo C,Caramaschi A,Uga E,Braghin M,Cosi G,Peila C,Strozzi MC,Sabatini M,Gazzolo D,Manfredi M,Cavaletto M

更新日期：2019-12-04 00:00:00

abstract：:C-type lectin receptors (CLRs) on antigen-presenting cells (APCs) facilitate uptake of carbohydrate antigens for antigen presentation, modulating the immune response in infection, homeostasis, autoimmunity, allergy, and cancer. In this review, we focus on the role of the macrophage galactose type C-type lectin (MGL) i...

journal_title：Journal of immunology research

authors： Zizzari IG,Napoletano C,Battisti F,Rahimi H,Caponnetto S,Pierelli L,Nuti M,Rughetti A

更新日期：2015-01-01 00:00:00

abstract：Background:RNA helicases have various essential functions in basically all aspects of RNA metabolism, not only unwinding RNA but also disturbing the interaction of RNA with proteins. Recently, RNA helicases have been considered potential targets in cancers. So far, there has been no detailed investigation of the biolog...

journal_title：Journal of immunology research

authors： Xu Y,Jiang Q,Liu H,Xiao X,Yang D,Saw PE,Luo B

更新日期：2020-12-30 00:00:00

abstract：:Antibody-secreting cells (ASCs) play a fundamental role in humoral immunity. The aberrant function of ASCs is related to a number of disease states, including autoimmune diseases and cancer. Recent insights into activated B cell subsets, including naïve B cell to ASC stages and their resultant cellular disturbances, s...

journal_title：Journal of immunology research

authors： Jin W,Luo Z,Yang H

更新日期：2020-03-23 00:00:00

abstract：:T follicular helper cells (TFH) are a subset of recently discovered CD4+ T cells. Their major function is to participate in the formation of germinal centres (GCs) and promote B cell proliferation and differentiation to play important roles in the production of antibodies. Currently, the functions of TFH cells are cle...

journal_title：Journal of immunology research

authors： Zou X,Sun G,Huo F,Chang L,Yang W

更新日期：2018-07-02 00:00:00

abstract：:A myriad of pathogens gain access to the host via the mucosal route; thus, vaccinations that protect against mucosal pathogens are critical. Pathogens such as HIV, HSV, and influenza enter the host at mucosal sites such as the intestinal, urogenital, and respiratory tracts. All currently licensed vaccines mediate prot...

journal_title：Journal of immunology research

authors： Gary EN,Kutzler MA

更新日期：2018-12-13 00:00:00

abstract：:Diabetic retinopathy (DR) is an important cause of vision loss around the world, being the leading cause in the population between 20 and 60 years old. Among patients with DR, diabetic macular edema (DME) is the most frequent cause of vision impairment and represents a significant public health issue. Macular photocoa...

journal_title：Journal of immunology research

authors： Stefanini FR,Badaró E,Falabella P,Koss M,Farah ME,Maia M

更新日期：2014-01-01 00:00:00

abstract：:Accumulating evidence has pointed out that metastasis is the leading cause of death in several malignant tumor, including CRC. During CRC, metastatic capacity is closely correlated with reprogrammed energy metabolism. Mitochondrial Pyruvate Carrier 1 (MPC1), as the carrier of transporting pyruvate into mitochondria, l...

journal_title：Journal of immunology research

authors： Tian GA,Xu CJ,Zhou KX,Zhang ZG,Gu JR,Zhang XL,Wang YH

更新日期：2020-08-19 00:00:00

abstract：:The roots of Euphorbia kansui, which belong to the family Euphorbiaceae, have been used as a traditional medicine for the treatment of various diseases such as diabetes, ascites, and leukemia. Recently, it was reported that the methylene chloride fraction of E. kansui radix (EKC) regulated the differentiation of Th17 ...

journal_title：Journal of immunology research

authors： Kim SJ,Jang YW,Hyung KE,Lee DK,Hyun KH,Park SY,Park ES,Hwang KW

更新日期：2017-01-01 00:00:00

abstract：:Breast cancer is the most common neoplasm diagnosed in women around the world. Checkpoint inhibitors, targeting the programmed death receptor-1 or ligand-1 (PD-1/PD-L1) axis, have dramatically changed the outcome of cancer treatment. These therapies have been recently considered as alternatives for treatment of breast...

journal_title：Journal of immunology research

authors： Segovia-Mendoza M,Romero-Garcia S,Lemini C,Prado-Garcia H

更新日期：2021-01-07 00:00:00

abstract：Background and Objectives:Pneumocystis pneumonia (PCP) is a common opportunistic infection in acquired immune deficiency syndrome (AIDS) patients that continues to result in a high mortality rate. To develop a better treatment strategy and improve PCP prognosis, a cohort study was conducted to evaluate the therapeutic ...

journal_title：Journal of immunology research

authors： Wang M,Lang G,Chen Y,Hu C,Guo Y,Tao R,Dong X,Zhu B

更新日期：2019-12-01 00:00:00

abstract：:Toll-like receptors (TLRs) are known to detect a defined spectrum of microbial structures. However, the knowledge about the specificity of teleost Tlr factors for distinct pathogens is limited so far. We measured baseline expression profiles of 18 tlr genes and associated signaling factors in four immune-relevant tiss...

journal_title：Journal of immunology research

authors： Brietzke A,Korytář T,Jaros J,Köllner B,Goldammer T,Seyfert HM,Rebl A

更新日期：2015-01-01 00:00:00

abstract：:C-type lectin domain family 5-member A (CLEC5A) associates with adaptor DAP12 (DNAX activation protein 12) to form receptor complexes involved in inflammatory responses. We postulated a potential role of CLEC5A in the pathogenesis of adult-onset Still's disease (AOSD) and aimed to investigate CLEC5A expression and its...

journal_title：Journal of immunology research

authors： Chen PK,Hsieh SL,Lan JL,Lin CC,Chang SH,Chen DY

更新日期：2020-04-23 00:00:00

abstract：:Bacterial vaginosis (BV), the most common genital infection in reproductive-aged women, is associated with increased risk of sexually transmitted infections. Its etiology remains unclear, especially the role of Gardnerella (G.) vaginalis, an anaerobic bacterium characteristic of the BV-alteration of the vaginal ecosys...

journal_title：Journal of immunology research

authors： Bertran T,Brachet P,Vareille-Delarbre M,Falenta J,Dosgilbert A,Vasson MP,Forestier C,Tridon A,Evrard B

更新日期：2016-01-01 00:00:00

abstract：:Regulatory T cells (Treg) can show plasticity whereby FOXP3 expression, the master transcription factor for Treg suppressor function, is lost and proinflammatory cytokines are produced. Optimal FOXP3 expression strongly depends on hypomethylation of the FOXP3 gene. 5-Azacytidine (Aza) and its derivative 5-aza-2'-deoxy...

journal_title：Journal of immunology research

authors： Landman S,Cruijsen M,Urbano PCM,Huls G,van Erp PEJ,van Rijssen E,Joosten I,Koenen HJPM

更新日期：2018-04-15 00:00:00

abstract：:Ischemia/reperfusion injury (IRI) remains a major problem in organ transplantation, which represents the main cause of graft dysfunction posttransplantation. Hepatic IRI is characterized by an excessive inflammatory response within the liver. Mesenchymal stem cells (MSCs) have been shown to be immunomodulatory cells a...

journal_title：Journal of immunology research

authors： Li S,Zheng X,Li H,Zheng J,Chen X,Liu W,Tai Y,Zhang Y,Wang G,Yang Y

更新日期：2018-12-03 00:00:00

abstract：Objectives:Both thymic stromal lymphopoietin (TSLP) and dendritic cells (DCs) are involved in many autoimmune diseases, but the potential roles of TSLP and DCs in bullous pemphigoid (BP) have not been clarified. We sought to explore the contributions of TSLP and DCs in patients with BP. Methods:TSLP levels in sera and...

journal_title：Journal of immunology research

authors： Li SZ,Jin XX,Ge XL,Zuo YG,Jin HZ

更新日期：2020-09-24 00:00:00

abstract：:Systemic lupus erythematosus is characterized by dysregulated activation of T and B cells and autoantibodies to nuclear antigens and, in some cases, lipid antigens. Liposomes with nonbilayer phospholipid arrangements induce a disease resembling human lupus in mice, including IgM and IgG antibodies against nonbilayer p...

journal_title：Journal of immunology research

authors： Wong-Baeza C,Tescucano A,Astudillo H,Reséndiz A,Landa C,España L,Serafín-López J,Estrada-García I,Estrada-Parra S,Flores-Romo L,Wong C,Baeza I

更新日期：2015-01-01 00:00:00

abstract：:Gram-negative bacterial sepsis accounts for up to 50% worldwide sepsis that causes hospital mortality. Acute kidney injury (AKI), a common complication of Gram-negative bacterial sepsis, is caused by Toll-like receptor 4 (TLR4) activation. Lipopolysaccharide (LPS) is an endotoxin in Gram-negative bacteria and is recog...

journal_title：Journal of immunology research

authors： Li Q,Wu C,Liu Z,Zhang H,Du Y,Liu Y,Song K,Shi Q,Li R

更新日期：2019-02-19 00:00:00

abstract：Background:Several efforts have been made to find out a valuable marker to assist the diagnosis and differentiation of gangrenous/perforated appendicitis. We aimed to determine the diagnostic capacity of soluble B7H3 (sB7H3) in acute appendicitis (AA) and its accuracy as a predictor of the severity of appendicitis. Me...

journal_title：Journal of immunology research

authors： Du X,Chen Y,Zhu J,Bai Z,Hua J,Li Y,Lv H,Zhang G

更新日期：2020-09-01 00:00:00

abstract：:Easy access to a vast collection of experimental data on immune epitopes can greatly facilitate the development of therapeutics and vaccines. The Immune Epitope Database and Analysis Resource (IEDB) was developed to provide such a resource as a free service to the biomedical research community. The IEDB contains epito...

journal_title：Journal of immunology research

authors： Fleri W,Vaughan K,Salimi N,Vita R,Peters B,Sette A

更新日期：2017-01-01 00:00:00

abstract：:Many immune-based intestinal disorders, such as ulcerative colitis and Crohn's disease, as well as other illnesses, may have the intestines as an initial cause or aggravator in the development of diseases, even apparently not correlating directly to the intestine. Diabetes, obesity, multiple sclerosis, depression, and...

journal_title：Journal of immunology research

authors： Maranduba CM,De Castro SB,de Souza GT,Rossato C,da Guia FC,Valente MA,Rettore JV,Maranduba CP,de Souza CM,do Carmo AM,Macedo GC,Silva Fde S

更新日期：2015-01-01 00:00:00

abstract：:Epstein-Barr virus is a very common human virus that infects 90% of human adults. EBV replicates in epithelial and B cells and causes infectious mononucleosis. EBV infection is also linked to various cancers, including Burkitt's lymphoma and nasopharyngeal carcinomas, and autoimmune diseases such as multiple sclerosis...

journal_title：Journal of immunology research

authors： Alonso-Padilla J,Lafuente EM,Reche PA

更新日期：2017-01-01 00:00:00

abstract：:Schmallenberg virus (SBV), discovered in continental Europe in late 2011, causes mild clinical signs in adult ruminants, including diarrhoea and reduced milk yield. However, fetal infection can lead to severe malformation in newborn offspring. To develop improved reagents for SBV serology, a high-level yeast expressio...

journal_title：Journal of immunology research

authors： Lazutka J,Zvirbliene A,Dalgediene I,Petraityte-Burneikiene R,Spakova A,Sereika V,Lelesius R,Wernike K,Beer M,Sasnauskas K

更新日期：2014-01-01 00:00:00

abstract：:Lycium barbarum polysaccharide (LBP) is isolated from the fruit of Chinese herbal Lycium barbarum. Previous studies had demonstrated that LBP could inhibit tumor growth and enhance the immunity in mice. However, the effect of LBP on systemic and local immune responses in vivo, especially on phenotypic and functional c...

journal_title：Journal of immunology research

authors： Deng X,Luo S,Luo X,Hu M,Ma F,Wang Y,Lai X,Zhou L

更新日期：2018-06-03 00:00:00