Abstract:
:Bone disease in rheumatoid arthritis (RA) is a complex phenomenon where genetic risk factors have been partially evaluated. The system formed by receptor activator for nuclear factor-κB (RANK), receptor activator for nuclear factor-κB ligand (RANKL), and osteoprotegerin (OPG): RANK/RANKL/OPG is a crucial molecular pathway for coupling between osteoblasts and osteoclasts, since OPG is able to inhibit osteoclast differentiation and activation. We aim to evaluate the association between SNPs C950T (rs2073617), C209T (rs3134069), T245G (rs3134070) in the TNFRSF11B (OPG) gene, and osteoporosis in RA. We included 81 women with RA and 52 healthy subjects in a cross-sectional study, genotyped them, and measured bone mineral density (BMD) at the lumbar spine and the femoral neck. Mean age in RA was 50 ± 12 with disease duration of 12 ± 8 years. According to BMD results, 23 (33.3%) were normal and 46 (66.7%) had osteopenia/osteoporosis. We found a higher prevalence of C allele for C950T SNP in RA. Polymorphisms C209T and T245G did not reach statistical significance in allele distribution. Further studies including patients from other regions of Latin America with a multicenter design to increase the sample size are required to confirm our findings and elucidate if C950T SNP could be associated with osteoporosis in RA.
journal_name
J Immunol Resjournal_title
Journal of immunology researchauthors
Zavala-Cerna MG,Moran-Moguel MC,Cornejo-Toledo JA,Gonzalez-Montoya NG,Sanchez-Corona J,Salazar-Paramo M,Nava-Zavala AH,Aguilar-Chavez EA,Alcaraz-Lopez MF,Gonzalez-Sanchez AG,Gonzalez-Lopez L,Gamez-Nava JIdoi
10.1155/2015/376197subject
Has Abstractpub_date
2015-01-01 00:00:00pages
376197eissn
2314-8861issn
2314-7156journal_volume
2015pub_type
杂志文章abstract::Lycium barbarum polysaccharide (LBP) is isolated from the fruit of Chinese herbal Lycium barbarum. Previous studies had demonstrated that LBP could inhibit tumor growth and enhance the immunity in mice. However, the effect of LBP on systemic and local immune responses in vivo, especially on phenotypic and functional c...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2018/3431782
更新日期:2018-06-03 00:00:00
abstract::Objective. It has been shown that podocyte injury represents an important pathological basis that contributes to proteinuria and eventually leads to kidney failure. High glucose (HG) activates macrophage polarization, further exacerbating HG-induced podocyte injury. Our previous study on diabetic nephropathy rats indi...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2020/8263598
更新日期:2020-08-27 00:00:00
abstract::Multiepitope peptide vaccine has some advantages over traditional recombinant protein vaccine due to its easy and fast production and possible inclusion of multiple protective epitopes of pathogens. However, it is usually poorly immunogenic and needs to conjugate to a large carrier protein. Peptides conjugated to a ce...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2020/2074803
更新日期:2020-01-08 00:00:00
abstract::Bone is sensitive to overactive immune responses, which initiate the onset of inflammatory bone disorders, such as rheumatoid arthritis and periodontitis, resulting in a significant systemic inflammatory response. On the other hand, neuroinflammation is strongly implicated in Alzheimer's disease (AD), which can be enh...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2015/471342
更新日期:2015-01-01 00:00:00
abstract::Human respiratory syncytial virus (RSV) is a common and highly contagious viral agent responsible for acute lower respiratory infection in infants. This pathology characterized by mucus hypersecretion and a disturbed T cell immune response is one of the major causes of infant hospitalization for severe bronchiolitis. ...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2017/8734504
更新日期:2017-01-01 00:00:00
abstract::Bullous systemic lupus erythematosus (BSLE) is an autoantibody-mediated vesiculobullous disease in patients with SLE. Autoimmunity in BSLE is characterized by the presence of circulating anti-type VII collagen antibodies. BSLE patients often present with multiple, tense, clear fluid-filled vesicles and bullae overlyin...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2015/167064
更新日期:2015-01-01 00:00:00
abstract::Regulatory T-cells (Tregs) are a very important subtype of lymphocytes when it comes to self-control in the human immunological system. Tregs are decisive not only in the protection against destruction of own tissues by autoimmune immunocompetent cells but also in the immunological answer to developing cancers. On the...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2019/2816498
更新日期:2019-03-03 00:00:00
abstract::Purified protein vaccines often require adjuvants for efficient stimulation of immune responses. There is no licensed mucosal adjuvant on the market to adequately boost the immune response to purified antigens for intranasal applications in humans. Bacterial outer membrane vesicles (OMV) are attractive candidates pote...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2016/3576028
更新日期:2016-01-01 00:00:00
abstract::Reconstitution of the hematopoietic system during immune responses and immunological and neoplastic diseases or upon transplantation depends on the emergent differentiation of hematopoietic stem/progenitor cells within the bone marrow. Although in the last decade the use of dialyzable leukocyte extracts (DLE) as suppo...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2016/4097642
更新日期:2016-01-01 00:00:00
abstract::Molecular dynamics was used to simulate large molecules of the immune system (major histocompatibility complex class I, presented epitope, T-cell receptor, and a CD8 coreceptor.) To characterize the relative orientation and movements of domains local coordinate systems (based on principal component analysis) were gene...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2015/210675
更新日期:2015-01-01 00:00:00
abstract::Macrophages, a kind of innate immune cells, derive from monocytes in circulation and play a crucial role in the innate and adaptive immunity. Under the stimulation of the signals from local microenvironment, macrophages generally tend to differentiate into two main functional phenotypes depending on their high plastic...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2020/8148272
更新日期:2020-07-28 00:00:00
abstract::Toll/IL-1R-domain-containing adaptor-inducing IFN-β (TRIF) is an important adaptor for TLR3- and TLR4-mediated inflammatory signaling pathways. Recent studies have shown that TRIF plays a key role in vessel inflammation and atherosclerosis; however, the precise mechanisms are unclear. We investigated the mechanisms of...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2018/6249085
更新日期:2018-06-07 00:00:00
abstract::Breast cancer is the most common neoplasm diagnosed in women around the world. Checkpoint inhibitors, targeting the programmed death receptor-1 or ligand-1 (PD-1/PD-L1) axis, have dramatically changed the outcome of cancer treatment. These therapies have been recently considered as alternatives for treatment of breast...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2021/6668573
更新日期:2021-01-07 00:00:00
abstract::In organ transplantation, alloantigens are taken up by antigen presenting cells and presented via the indirect pathway to T-cells which in turn can induce allograft rejection. Monitoring of these T-cells is of major importance; however no reliable assay is available to routinely monitor indirect allorecognition. Recen...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2016/4215684
更新日期:2016-01-01 00:00:00
abstract::In vitro differentiation of mesenchymal stromal cells (MSC) into osteocytes (human differentiated osteogenic cells, hDOC) before implantation has been proposed to optimize bone regeneration. However, a deep characterization of the immunological properties of DOC, including their effect on dendritic cell (DC) function,...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2015/526195
更新日期:2015-01-01 00:00:00
abstract::Pregnancy is an immunological enigma where paternal antigens are present at the fetomaternal interface. What regulates the local immunotolerance, which is necessary to prevent rejection of the conceptus, is still under strong investigation. Gamma/delta T cells are believed to play a role in the local regulation of thi...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2019/3836942
更新日期:2019-05-20 00:00:00
abstract::The human leukocyte antigen-G (HLA-G) is considered an immune checkpoint molecule involved in tumor immune evasion. Hypoxia and the metabolic sensor hypoxia-inducible factor 1 (HIF-1) are hallmarks of metastasization, angiogenesis, and intense tumor metabolic activity. The purpose of this review was to examine origina...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2017/4587520
更新日期:2017-01-01 00:00:00
abstract::The bioactive and anti-inflammatory role of human milk components has been recognized; active milk components include soluble forms of Toll-like receptors (TLRs). Preterm babies are more susceptible to infections and may succumb to necrotizing enterocolitis (NEC), a gastrointestinal disease which is exacerbated by an ...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2019/4078671
更新日期:2019-12-04 00:00:00
abstract::Considerable shortages in the supply of available organs continue to plague the field of solid organ transplantation. Despite changes in allocation, as well as the utilization of extended criteria and living donors, the number of patients waiting for organs continues to grow at an alarming pace. Xenotransplantation, c...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2018/6413012
更新日期:2018-03-04 00:00:00
abstract:Objective:This study aimed to investigate the correlation of CD4+/PD-1+ or CD4+/PD-1- tumor-infiltrating lymphocytes with pathological characteristics in breast cancer patients. Methods:A cross-sectional study consecutively recruited 133 patients with invasive ductal breast cancer. The expression of CD4, programmed ce...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2018/5690258
更新日期:2018-07-04 00:00:00
abstract:Aims:This study is aimed at exploring the relation between IL-33 single-nucleotide polymorphisms (SNPs) and the risk of systemic lupus erythematosus (SLE). Methods:SNPStats (online software) was used to test the Hardy-Weinberg equilibrium in controls. Generalized multifactor dimensionality reduction (GMDR) was adopted...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2019/1547578
更新日期:2019-03-11 00:00:00
abstract:OBJECTIVE:To investigate the expression and clinical significance of trans-membrane MerTK (mMer) on circulating CD14+ monocytes/macrophages and soluble MerTK (sMer) levels in plasma in systemic lupus erythematosus (SLE). METHOD:108 SLE patients and 42 healthy controls were recruited in this study. The expression of mM...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2014/431896
更新日期:2014-01-01 00:00:00
abstract::Inflammation plays an essential role in the control of pathogens and in shaping the ensuing adaptive immune responses. Traditionally, innate immunity has been described as a rapid response triggered through generic and nonspecific means that by definition lacks the ability to remember. Recently, it has become clear th...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2018/1467538
更新日期:2018-06-11 00:00:00
abstract::Probiotics are commensal or nonpathogenic microbes that confer beneficial effects on the host through several mechanisms such as competitive exclusion, antibacterial effects, and modulation of immune responses. Some probiotics have been found to regulate immune responses via immune regulatory mechanisms. T regulatory ...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2019/1603758
更新日期:2019-04-16 00:00:00
abstract::Antibody-secreting cells (ASCs) play a fundamental role in humoral immunity. The aberrant function of ASCs is related to a number of disease states, including autoimmune diseases and cancer. Recent insights into activated B cell subsets, including naïve B cell to ASC stages and their resultant cellular disturbances, s...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2020/9518137
更新日期:2020-03-23 00:00:00
abstract::An important function of the immune system is its ability to differentiate between healthy cells in the organism and "foreign" cells, allowing the latest to be attacked and the first ones to be conserved. The most important molecules in this process are considered to be checkpoint inhibitors. This review is focused on...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2018/4625472
更新日期:2018-10-17 00:00:00
abstract::Peroxisome proliferator-activated receptors (PPAR gamma-2) and beta-3-adrenergic receptors (ADRB3) are involved in the risk of hypertension. But their exact role in blood pressure modulation in patients with connective tissue diseases (CTD) is still not well defined. In this study, 104 patients with CTD and 103 gender...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2020/7509608
更新日期:2020-02-03 00:00:00
abstract::The roots of Euphorbia kansui, which belong to the family Euphorbiaceae, have been used as a traditional medicine for the treatment of various diseases such as diabetes, ascites, and leukemia. Recently, it was reported that the methylene chloride fraction of E. kansui radix (EKC) regulated the differentiation of Th17 ...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2017/7052560
更新日期:2017-01-01 00:00:00
abstract::Rheumatoid arthritis (RA) is an inflammatory autoimmune disorder; abnormal T cell immunity plays a critical role in the development of RA. Recently, A20 was identified as a key negative regulator for T cell activation and inflammatory signaling and may be involved in RA pathogenesis. In this study, we analyzed the exp...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2014/492872
更新日期:2014-01-01 00:00:00
abstract::Calcitonin gene-related peptide (CGRP) is a mediator of microglial activation at the transcriptional level. The involvement of the epigenetic mechanism in this process is largely undefined. Histone deacetylase (HDAC)1/2 are considered important epigenetic regulators of gene expression in activated microglia. In this s...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2020/4384696
更新日期:2020-08-04 00:00:00