Abstract：
:Bone is sensitive to overactive immune responses, which initiate the onset of inflammatory bone disorders, such as rheumatoid arthritis and periodontitis, resulting in a significant systemic inflammatory response. On the other hand, neuroinflammation is strongly implicated in Alzheimer's disease (AD), which can be enhanced by systemic inflammation, such as that due to cardiovascular disease and diabetes. There is growing clinical evidence supporting the concept that rheumatoid arthritis and periodontitis are positively linked to AD, suggesting that inflammatory bone disorders are risk factors for this condition. Recent studies have suggested that leptomeningeal cells play an important role in transducing systemic inflammatory signals to brain-resident microglia. More importantly, senescent-type, but not juvenile-type, microglia provoke neuroinflammation in response to systemic inflammation. Because the prevalence of rheumatoid arthritis and periodontitis increases with age, inflammatory bone disorders may be significant sources of covert systemic inflammation among elderly people. The present review article highlights our current understanding of the link between inflammatory bone disorders and AD with a special focus on microglia aging.
journal_name
J Immunol Resjournal_title
Journal of immunology researchauthors
Wu Z,Nakanishi Hdoi
10.1155/2015/471342subject
Has Abstractpub_date
2015-01-01 00:00:00pages
471342eissn
2314-8861issn
2314-7156journal_volume
2015pub_type
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journal_title：Journal of immunology research
pub_type： 杂志文章,评审
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journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2015/909514
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journal_title：Journal of immunology research
pub_type： 杂志文章
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abstract：:Accumulating evidence has pointed out that metastasis is the leading cause of death in several malignant tumor, including CRC. During CRC, metastatic capacity is closely correlated with reprogrammed energy metabolism. Mitochondrial Pyruvate Carrier 1 (MPC1), as the carrier of transporting pyruvate into mitochondria, l...
journal_title：Journal of immunology research
pub_type： 杂志文章
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journal_title：Journal of immunology research
pub_type： 杂志文章,评审
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更新日期：2020-05-28 00:00:00
abstract：:Latent tuberculosis infection (LTBI) is evidence of immunological control of tuberculosis. Dormancy survival regulator (DosR) regulon-encoded proteins may have a role in the maintenance of LTBI. T cell responses to Rv1733c, Rv0081, Rv1735c, and Rv1737c DosR regulon-encoded proteins were found to be most frequent among...
journal_title：Journal of immunology research
pub_type： 杂志文章
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journal_title：Journal of immunology research
pub_type： 杂志文章
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更新日期：2018-10-08 00:00:00
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journal_title：Journal of immunology research
pub_type： 杂志文章
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journal_title：Journal of immunology research
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更新日期：2020-05-08 00:00:00
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journal_title：Journal of immunology research
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journal_title：Journal of immunology research
pub_type： 杂志文章,评审
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更新日期：2017-01-01 00:00:00
abstract：:Diabetes mellitus, a metabolic disease characterized by hyperglycemia and poor glucose control, is a risk factor for Mycobacterium tuberculosis (M. tuberculosis) infection and the development of active tuberculosis. To evaluate whether M. tuberculosis infection susceptibility is associated with an intrinsic factor in ...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2019/1462098
更新日期：2019-11-14 00:00:00
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journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2020/6261814
更新日期：2020-12-23 00:00:00
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journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2015/478753
更新日期：2015-01-01 00:00:00
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journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2016/2743292
更新日期：2016-01-01 00:00:00
abstract：:HLA-G has a relevant role in immune response regulation. The overall structure of the HLA-G coding region has been maintained during the evolution process, in which most of its variable sites are synonymous mutations or coincide with introns, preserving major functional HLA-G properties. The HLA-G promoter region is d...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2014/734068
更新日期：2014-01-01 00:00:00
abstract：:Epidemiological studies have demonstrated that interleukin-10 (IL-10) polymorphisms may be associated with the development of Behcet's disease (BD). However, the published results were inconsistent. Therefore, this meta-analysis was conducted to derive a more precise relationship between IL-10 polymorphisms and BD sus...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2020/9382609
更新日期：2020-06-19 00:00:00
abstract：:Cutaneous melanoma is a significant immunogenic tumoral model, the most frequently described immune phenomenon being tumor regression, as a result of the interaction of tumoral antigens and stromal microenvironment. We present a retrospective cohort study including 52 cases of melanoma with regression. There were eval...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2020/5416843
更新日期：2020-10-23 00:00:00
abstract：:In organ transplantation, alloantigens are taken up by antigen presenting cells and presented via the indirect pathway to T-cells which in turn can induce allograft rejection. Monitoring of these T-cells is of major importance; however no reliable assay is available to routinely monitor indirect allorecognition. Recen...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2016/4215684
更新日期：2016-01-01 00:00:00
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journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2019/5821589
更新日期：2019-12-23 00:00:00
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journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2017/5974574
更新日期：2017-01-01 00:00:00
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journal_title：Journal of immunology research
pub_type： 杂志文章,meta分析,评审
doi：10.1155/2017/3736201
更新日期：2017-01-01 00:00:00
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journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2018/5038172
更新日期：2018-05-03 00:00:00
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journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2015/983094
更新日期：2015-01-01 00:00:00
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journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2016/6530436
更新日期：2016-01-01 00:00:00
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journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2016/1639720
更新日期：2016-01-01 00:00:00
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journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2018/4892473
更新日期：2018-08-12 00:00:00
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journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2015/108451
更新日期：2015-01-01 00:00:00
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journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2021/6668573
更新日期：2021-01-07 00:00:00
