Abstract:
:The aim of this paper is to determine the modulatory effects of Lactobacillus acidophilus on the IL-23/Th17 immune axis in experimental colitis. DSS-induced mouse models of UC were to be saline, hormones, and different concentrations of Lactobacillus acidophilus intervention. The expression of interleukin- (IL-) 17, tumor necrosis factor α (TNFα), IL-23, transforming growth factor β1 (TGFβ1), signal transducer and activator of transcription 3 (STAT3), and phosphorylated (p)-STAT3 was examined by RT-PCR, Western blotting, and immunohistochemical analysis. And the results showed that administration of L. acidophilus suppressed Th17 cell-mediated secretion of proinflammatory cytokine IL-17 through downregulation of IL-23 and TGFβ1 expression and downstream phosphorylation of p-STAT3.
journal_name
J Immunol Resjournal_title
Journal of immunology researchauthors
Chen L,Zou Y,Peng J,Lu F,Yin Y,Li F,Yang Jdoi
10.1155/2015/909514subject
Has Abstractpub_date
2015-01-01 00:00:00pages
909514eissn
2314-8861issn
2314-7156journal_volume
2015pub_type
杂志文章abstract::Background. U65, a self-aggregating peptide scaffold, traps fused protein antigens in yeast cells. Conversion to Yeast Cell Particle (YCP) vaccines by partial removal of surface mannoproteins exposes β-glucan, mediating efficient uptake by antigen-presenting cells (APCs). YCP vaccines are inexpensive, capable of rapid...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2016/2743292
更新日期:2016-01-01 00:00:00
abstract::Extracellular matrix metalloproteases and the fibrinolytic system are important protease systems interacting with each other in charge of remodeling and recycling of tissues. Their role in tumor invasion and metastasis is often discussed. In this study several metalloproteases such as MMP-1, MMP-3, MMP-9, and TIMP-1 t...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2016/8519648
更新日期:2016-01-01 00:00:00
abstract::Tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) gene encodes the A20 protein, an important negative feedback regulator of the nuclear factor kappa-light-chain-enhancer of activated B cell (NF-κB) pathway. A coding TNFAIP3 variant, namely rs2230926, has been previously linked to B cell non-Hodgkin's lymphoma (...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2018/6923213
更新日期:2018-12-19 00:00:00
abstract::Lycium barbarum polysaccharide (LBP) is isolated from the fruit of Chinese herbal Lycium barbarum. Previous studies had demonstrated that LBP could inhibit tumor growth and enhance the immunity in mice. However, the effect of LBP on systemic and local immune responses in vivo, especially on phenotypic and functional c...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2018/3431782
更新日期:2018-06-03 00:00:00
abstract::Antibody-secreting cells (ASCs) play a fundamental role in humoral immunity. The aberrant function of ASCs is related to a number of disease states, including autoimmune diseases and cancer. Recent insights into activated B cell subsets, including naïve B cell to ASC stages and their resultant cellular disturbances, s...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2020/9518137
更新日期:2020-03-23 00:00:00
abstract::Adverse drug reactions (ADRs) remain a common and major problem in healthcare. Severe cutaneous adverse drug reactions (SCARs), such as Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) with mortality rate ranges from 10% to more than 30%, can be life threatening. A number of recent studies demonstrated ...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2017/3186328
更新日期:2017-01-01 00:00:00
abstract::Chemokine (C-X-C motif) ligand (CXCL)10 and other CXCR3 chemokines are involved in the pathogenesis of acute and "chronic hepatitis C virus (HCV) infection" (CHC). Here, we review the scientific literature about HCV and CXCL10. The combination of circulating CXCL10 and single nucleotide polymorphisms (SNPs) in IL-28B ...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2019/5878960
更新日期:2019-08-08 00:00:00
abstract::Malaria continues being a high-impact disease regarding public health worldwide; the WHO report for malaria in 2018 estimated that ~219 million cases occurred in 2017, mostly caused by the parasite Plasmodium falciparum. The disease cost the lives of more than 400,000 people, mainly in Africa. In spite of great effort...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2019/3832513
更新日期:2019-12-30 00:00:00
abstract::Propionibacterium acnes (P. acnes) is a gram-positive anaerobic bacillus present in normal human skin microbiota, which exerts important immunomodulatory effects, when used as heat- or phenol-killed suspensions. We previously demonstrated that heat-killed P. acnes or its soluble polysaccharide (PS), extracted from the...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2015/132083
更新日期:2015-01-01 00:00:00
abstract::The gastrointestinal microbiota plays a critical role in nutritional, metabolic, and immune functions in infants and young children and has implications for future lung health status. Understanding the role of intestinal dysbiosis in chronic lung disease progression will provide opportunities to design early intervent...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2017/8450496
更新日期:2017-01-01 00:00:00
abstract::HLA-G has a relevant role in immune response regulation. The overall structure of the HLA-G coding region has been maintained during the evolution process, in which most of its variable sites are synonymous mutations or coincide with introns, preserving major functional HLA-G properties. The HLA-G promoter region is d...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2014/734068
更新日期:2014-01-01 00:00:00
abstract::Aims. In the present study, we aimed to assess the concentrations of IL-13 and IL-17 in serum of patients with early rheumatoid arthritis (eRA), the investigation of correlation between the concentrations of these cytokines and disease activity score, and the concentration of some autoantibodies and the evaluation of ...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2016/3109135
更新日期:2016-01-01 00:00:00
abstract::Bullous systemic lupus erythematosus (BSLE) is an autoantibody-mediated vesiculobullous disease in patients with SLE. Autoimmunity in BSLE is characterized by the presence of circulating anti-type VII collagen antibodies. BSLE patients often present with multiple, tense, clear fluid-filled vesicles and bullae overlyin...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2015/167064
更新日期:2015-01-01 00:00:00
abstract::Cutaneous melanoma is a significant immunogenic tumoral model, the most frequently described immune phenomenon being tumor regression, as a result of the interaction of tumoral antigens and stromal microenvironment. We present a retrospective cohort study including 52 cases of melanoma with regression. There were eval...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2020/5416843
更新日期:2020-10-23 00:00:00
abstract::Epidemiological studies have demonstrated that interleukin-10 (IL-10) polymorphisms may be associated with the development of Behcet's disease (BD). However, the published results were inconsistent. Therefore, this meta-analysis was conducted to derive a more precise relationship between IL-10 polymorphisms and BD sus...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2020/9382609
更新日期:2020-06-19 00:00:00
abstract:Objective:Safflower has antioxidant and anti-inflammatory activities. The two forms of preparations for safflower which are widely used in China are injection and decoction. The first step of the process for preparing an injection involves extracting safflower with water, which actually yields a decoction. This study i...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2019/1018274
更新日期:2019-05-06 00:00:00
abstract::A novel, simple, and reproducible method for cultivating pathological tissues obtained from human eyes during surgery was developed using viscoelastic material as a tissue adherent to facilitate cell attachment and expansion and calcium imaging of cultured cells challenged by mechanical and acetylcholine (ACh) stimula...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2014/232659
更新日期:2014-01-01 00:00:00
abstract::Type I interferon (IFN-I) plays a critical role in the antitumor immune response. In our previous study, we showed that IFN-I-inducible 2'-5' oligoadenylate synthetase-like 1 (OASL1) negatively regulated IFN-I production upon tumor challenge similar to that of viral infection. Thus, OASL1-deficient (Oasl1-/-) mice wer...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2019/7596786
更新日期:2019-03-31 00:00:00
abstract::Lung cancer is the leading cause of cancer death worldwide due to its late diagnosis and poor outcome. Immunotherapy is becoming more and more encouraging and promising in lung cancer therapy. Myeloid-derived suppressor cells (MDSCs) are the main tumor suppressor factors, and the treatment strategy of targeting MDSCs ...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2018/6319649
更新日期:2018-03-25 00:00:00
abstract::Mesothelin (MSLN) is a 40-kDa cell differentiation-associated glycoprotein appearing with carcinogenesis and is highly expressed in many human cancers, including the majority of pancreatic adenocarcinomas, ovarian cancers, and mesotheliomas, while its expression in normal tissue is limited to mesothelial cells lining ...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2015/268172
更新日期:2015-01-01 00:00:00
abstract::Following fetal or neonatal gene transfer in mice and other species immune tolerance of the transgenic protein is frequently observed; however the underlying mechanisms remain largely undefined. In this study fetal and neonatal BALB/c mice received adenovirus vector to deliver human factor IX (hFIX) cDNA. The long-ter...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2015/397879
更新日期:2015-01-01 00:00:00
abstract::Gram-negative bacterial sepsis accounts for up to 50% worldwide sepsis that causes hospital mortality. Acute kidney injury (AKI), a common complication of Gram-negative bacterial sepsis, is caused by Toll-like receptor 4 (TLR4) activation. Lipopolysaccharide (LPS) is an endotoxin in Gram-negative bacteria and is recog...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2019/3737890
更新日期:2019-02-19 00:00:00
abstract::A myriad of pathogens gain access to the host via the mucosal route; thus, vaccinations that protect against mucosal pathogens are critical. Pathogens such as HIV, HSV, and influenza enter the host at mucosal sites such as the intestinal, urogenital, and respiratory tracts. All currently licensed vaccines mediate prot...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2018/3734207
更新日期:2018-12-13 00:00:00
abstract::Toll-like receptors (TLRs) are known to detect a defined spectrum of microbial structures. However, the knowledge about the specificity of teleost Tlr factors for distinct pathogens is limited so far. We measured baseline expression profiles of 18 tlr genes and associated signaling factors in four immune-relevant tiss...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2015/901015
更新日期:2015-01-01 00:00:00
abstract::Objective. It has been shown that podocyte injury represents an important pathological basis that contributes to proteinuria and eventually leads to kidney failure. High glucose (HG) activates macrophage polarization, further exacerbating HG-induced podocyte injury. Our previous study on diabetic nephropathy rats indi...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2020/8263598
更新日期:2020-08-27 00:00:00
abstract::Bronchopulmonary dysplasia (BPD) is a severe complication of the respiratory system associated with preterm birth. Type 2 innate lymphoid cells (ILC2s) play a major role in tissue homeostasis, inflammation, and wound healing. However, the role in BPD remains unclear. The present study showed that ILC2s, interleukin-4 ...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2020/8050186
更新日期:2020-10-31 00:00:00
abstract::The purpose of this study was to investigate the expression levels of the immune checkpoint proteins, programmed cell death-ligand 1 (PD-L1), B7-H3, B7-H4, and V-domain Ig suppressor of T cell activation (VISTA), as well as the significance thereof, in clear cell carcinoma (CCC) of the cervix (a rare histological subt...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2020/1283632
更新日期:2020-04-03 00:00:00
abstract:Background and Objectives:Pneumocystis pneumonia (PCP) is a common opportunistic infection in acquired immune deficiency syndrome (AIDS) patients that continues to result in a high mortality rate. To develop a better treatment strategy and improve PCP prognosis, a cohort study was conducted to evaluate the therapeutic ...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2019/8105075
更新日期:2019-12-01 00:00:00
abstract:Objective:Systemic lupus erythematosus (SLE) is an autoimmune systemic disease and its pathogenesis has not yet been completely clarified. Patients with SLE show a deranged lipid metabolism, which can contribute to the immunopathogenesis of the disease and to the accelerated atherosclerosis. Resolvin D1 (RvD1), a produ...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2018/5264195
更新日期:2018-10-21 00:00:00
abstract::Collectin-12 (collectin placenta 1, CL-P1, or CL-12) is a newly identified pattern recognition molecule of the innate immune system. Recent evidences show that CL-12 plays important roles not only in innate immune protection against certain clinically important pathogens but also in scavenging of host molecules, leuko...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2019/9164202
更新日期:2019-07-29 00:00:00