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FOXP3 in Melanoma with Regression: Between Tumoral Expression and Regulatory T Cell Upregulation.

Abstract：

:Cutaneous melanoma is a significant immunogenic tumoral model, the most frequently described immune phenomenon being tumor regression, as a result of the interaction of tumoral antigens and stromal microenvironment. We present a retrospective cohort study including 52 cases of melanoma with regression. There were evaluated correlations of the most important prognostic factors (Breslow depth and mitotic index) with FOXP3 expression in tumor cells and with the presence of regulatory T cells and dendritic cells in the tumoral stroma. FOXP3 expression in tumor cells seems an independent factor of poor prognosis in melanoma, while regression areas are characterized by a high number of dendritic cells and a low number of regulatory T cells. FOXP3 is probably a useful therapeutical target in melanoma, since inhibition of FOXP3-positive tumor clones and of regulatory T cells could eliminate the ability of tumor cells to escape the immune defense of the host.

journal_name

J Immunol Res

journal_title

Journal of immunology research

authors

Cioplea M,Nichita L,Georgescu D,Sticlaru L,Cioroianu A,Nedelcu R,Turcu G,Rauta A,Mogodici C,Zurac S,Popp C

doi

10.1155/2020/5416843

subject

Has Abstract

pub_date

2020-10-23 00:00:00

pages

5416843

eissn

2314-8861

issn

2314-7156

journal_volume

2020

pub_type

杂志文章,评审

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