Abstract:
:A novel, simple, and reproducible method for cultivating pathological tissues obtained from human eyes during surgery was developed using viscoelastic material as a tissue adherent to facilitate cell attachment and expansion and calcium imaging of cultured cells challenged by mechanical and acetylcholine (ACh) stimulation as well as inflammatory studies. Anterior lens capsule-lens epithelial cells (aLC-LECs) from cataract surgery and proliferative diabetic retinopathy (PDR) fibrovascular epiretinal membranes (fvERMs) from human eyes were used in the study. We hereby show calcium signaling in aLC-LECs by mechanical and acetylcholine (ACh) stimulation and indicate presence of ACh receptors in these cells. Furthermore, an ex vivo study model was established for measuring the inflammatory response in fvERMs and aLC-LECs upon TNFα treatment.
journal_name
J Immunol Resjournal_title
Journal of immunology researchauthors
Andjelic S,Lumi X,Veréb Z,Josifovska N,Facskó A,Hawlina M,Petrovski Gdoi
10.1155/2014/232659subject
Has Abstractpub_date
2014-01-01 00:00:00pages
232659eissn
2314-8861issn
2314-7156journal_volume
2014pub_type
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journal_title:Journal of immunology research
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