Tissue-Resident Type 2 Innate Lymphoid Cells Arrest Alveolarization in Bronchopulmonary Dysplasia.

Abstract:

:Bronchopulmonary dysplasia (BPD) is a severe complication of the respiratory system associated with preterm birth. Type 2 innate lymphoid cells (ILC2s) play a major role in tissue homeostasis, inflammation, and wound healing. However, the role in BPD remains unclear. The present study showed that ILC2s, interleukin-4 (IL-4), IL-13, and anti-inflammatory (M2) macrophages increased significantly in BPD mice as compared to the control mice. Administration with recombinant mouse IL-33 amplified the above phenomena and aggravated the alveolar structural disorder and functional injury in mice subjected to BPD, and the opposite was true with anti-ST2 antibody. In addition, the depletion of ILC2s in BPD mice with anti-CD90.2 antibody substantially abolished the destructive effect on BPD. In the treatment of BPD with dexamethasone, the number of ILC2s and M2 macrophages and levels of IL-4 and IL-13 decreased with remission as compared to the control group. This study identified a major destructive role of the ILC2s in BPD that could be attenuated as a therapeutic strategy.

journal_name

J Immunol Res

authors

Mi L,Zhu S,Cai J,Xu S,Xue Z,Lu H

doi

10.1155/2020/8050186

subject

Has Abstract

pub_date

2020-10-31 00:00:00

pages

8050186

eissn

2314-8861

issn

2314-7156

journal_volume

2020

pub_type

杂志文章
  • Dysregulation of miR-155-5p and miR-200-3p and the Anti-Non-Bilayer Phospholipid Arrangement Antibodies Favor the Development of Lupus in Three Novel Murine Lupus Models.

    abstract::Systemic lupus erythematosus (SLE) is characterized by deregulated activation of T and B cells, autoantibody production, and consequent formation of immune complexes. Liposomes with nonbilayer phospholipid arrangements (NPA), induced by chlorpromazine, procainamide, or manganese, provoke a disease resembling human lup...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2017/8751642

    authors: Zárate-Neira LÁ,Sánchez-Barbosa S,Pedroza-Torres A,Reséndiz-Mora A,Wong C,Baeza I,Pérez-Plasencia C,Wong-Baeza C

    更新日期:2017-01-01 00:00:00

  • Genetic Background of Hypertension in Connective Tissue Diseases.

    abstract::Peroxisome proliferator-activated receptors (PPAR gamma-2) and beta-3-adrenergic receptors (ADRB3) are involved in the risk of hypertension. But their exact role in blood pressure modulation in patients with connective tissue diseases (CTD) is still not well defined. In this study, 104 patients with CTD and 103 gender...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2020/7509608

    authors: Grygiel-Górniak B,Ziółkowska-Suchanek I,Kaczmarek E,Puszczewicz M,Rozwadowska N

    更新日期:2020-02-03 00:00:00

  • SEC Based Method for Size Determination of Immune Complexes of Therapeutic Antibodies in Animal Matrix.

    abstract::Therapeutic monoclonal antibodies (mAbs) represent a milestone in pharmacological development. Their superiority is based on the combination of high specificity, low toxicity, and long half-life that characterizes biologics. If biologics have Achilles' heel, it is their potential immunogenicity. To better understand t...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2016/9096059

    authors: Boysen M,Schlicksupp L,Dreher I,Loebbert R,Richter M

    更新日期:2016-01-01 00:00:00

  • Clinical Correlations of Novel Autoantibodies in Patients with Dry Eye.

    abstract:Background:Diagnostic criteria for Sjögren's syndrome (SS) are continually being updated in pursuit of more precise and earlier diagnosis to prevent its complications. Owing to the high rate of false negative traditional serological markers, the need for better serological testing remains. Objective:To investigate the...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2019/7935451

    authors: Karakus S,Baer AN,Akpek EK

    更新日期:2019-01-13 00:00:00

  • A novel PET imaging using ⁶⁴Cu-labeled monoclonal antibody against mesothelin commonly expressed on cancer cells.

    abstract::Mesothelin (MSLN) is a 40-kDa cell differentiation-associated glycoprotein appearing with carcinogenesis and is highly expressed in many human cancers, including the majority of pancreatic adenocarcinomas, ovarian cancers, and mesotheliomas, while its expression in normal tissue is limited to mesothelial cells lining ...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2015/268172

    authors: Kobayashi K,Sasaki T,Takenaka F,Yakushiji H,Fujii Y,Kishi Y,Kita S,Shen L,Kumon H,Matsuura E

    更新日期:2015-01-01 00:00:00

  • The IL-1B Gene Polymorphisms rs16944 and rs1143627 Contribute to an Increased Risk of Coronary Artery Lesions in Southern Chinese Children with Kawasaki Disease.

    abstract:Background:Kawasaki disease (KD) is a systemic form of self-limited vasculitis in children less than five years old, and the main complication is coronary artery injury. However, the etiology of KD remains unclear. The IL-1B polymorphisms rs16944 GG and rs1143627 AA and their diplotype GA/GA have been associated with s...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2019/4730507

    authors: Fu LY,Qiu X,Deng QL,Huang P,Pi L,Xu Y,Che D,Zhou H,Lu Z,Tan Y,Jiang Z,Zhang L,Liu T,Gu X

    更新日期:2019-04-09 00:00:00

  • Therapeutic Effects of Methanol Extract from Euphorbia kansui Radix on Imiquimod-Induced Psoriasis.

    abstract::The roots of Euphorbia kansui, which belong to the family Euphorbiaceae, have been used as a traditional medicine for the treatment of various diseases such as diabetes, ascites, and leukemia. Recently, it was reported that the methylene chloride fraction of E. kansui radix (EKC) regulated the differentiation of Th17 ...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2017/7052560

    authors: Kim SJ,Jang YW,Hyung KE,Lee DK,Hyun KH,Park SY,Park ES,Hwang KW

    更新日期:2017-01-01 00:00:00

  • IL-6 Negatively Regulates IL-22Rα Expression on Epidermal Keratinocytes: Implications for Irritant Contact Dermatitis.

    abstract::Irritant Contact Dermatitis (ICD) is characterized by epidermal hyperplasia and inflammatory cytokine release. IL-6 has been shown to be involved in the pathogenesis of ICD; however, the involvement of the IL-22/IL-22Rα axis and its relation to IL-6 in the inflammatory response following irritant exposure are unknown....

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2019/6276254

    authors: Frempah B,Luckett-Chastain LR,Gallucci RM

    更新日期:2019-10-29 00:00:00

  • Melittin Constrains the Expression of Identified Key Genes Associated with Bladder Cancer.

    abstract::This work is aimed at investigating the effect of melittin on identified key genes in bladder cancer (BC) and further providing a theoretical basis for BC treatment. GSE35014 downloaded from the Gene Expression Omnibus (GEO) database was used to screen differentially expressed genes (DEGs) in BC cells and control. Res...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2018/5038172

    authors: Jin Z,Yao J,Xie N,Cai L,Qi S,Zhang Z,Li B

    更新日期:2018-05-03 00:00:00

  • Gastrospheres as a Model of Gastric Cancer Stem Cells Skew Th17/Treg Balance toward Antitumor Th17 Cells.

    abstract:Background:Gastrosphere, an enriched cellular population with stem-like properties believed to be responsible for an escape from immune-mediated destruction. Th17 and Treg cells play a major role in gastric cancer; however, their interaction with gastrospheres remained elusive. Method:Peripheral blood mononuclear cell...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2020/6261814

    authors: Rezalotfi A,Solgi G,Ebrahimi M

    更新日期:2020-12-23 00:00:00

  • Enhanced Antitumor Immune Response in 2'-5' Oligoadenylate Synthetase-Like 1- (OASL1-) Deficient Mice upon Cisplatin Chemotherapy and Radiotherapy.

    abstract::Type I interferon (IFN-I) plays a critical role in the antitumor immune response. In our previous study, we showed that IFN-I-inducible 2'-5' oligoadenylate synthetase-like 1 (OASL1) negatively regulated IFN-I production upon tumor challenge similar to that of viral infection. Thus, OASL1-deficient (Oasl1-/-) mice wer...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2019/7596786

    authors: Sim CK,Lee JH,Baek IJ,Lee SW,Lee MS

    更新日期:2019-03-31 00:00:00

  • Immunosuppressive Role of Myeloid-Derived Suppressor Cells and Therapeutic Targeting in Lung Cancer.

    abstract::Lung cancer is the leading cause of cancer death worldwide due to its late diagnosis and poor outcome. Immunotherapy is becoming more and more encouraging and promising in lung cancer therapy. Myeloid-derived suppressor cells (MDSCs) are the main tumor suppressor factors, and the treatment strategy of targeting MDSCs ...

    journal_title:Journal of immunology research

    pub_type: 杂志文章,评审

    doi:10.1155/2018/6319649

    authors: Ma J,Xu H,Wang S

    更新日期:2018-03-25 00:00:00

  • A Multiple Antigen Peptide Vaccine Containing CD4+ T Cell Epitopes Enhances Humoral Immunity against Trichinella spiralis Infection in Mice.

    abstract::Multiepitope peptide vaccine has some advantages over traditional recombinant protein vaccine due to its easy and fast production and possible inclusion of multiple protective epitopes of pathogens. However, it is usually poorly immunogenic and needs to conjugate to a large carrier protein. Peptides conjugated to a ce...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2020/2074803

    authors: Gu Y,Sun X,Huang J,Zhan B,Zhu X

    更新日期:2020-01-08 00:00:00

  • Immune-Stimulatory and Therapeutic Activity of Tinospora cordifolia: Double-Edged Sword against Salmonellosis.

    abstract::The present study was aimed at determining the activity of aqueous and methanolic extracts of Tinospora cordifolia (AETC and METC) against Salmonella typhimurium. In vitro anti-Salmonella activity of T. cordifolia was determined through the broth dilution and agar well diffusion assays. The immune-stimulating potentia...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2017/1787803

    authors: Alsuhaibani S,Khan MA

    更新日期:2017-01-01 00:00:00

  • FOXP3 in Melanoma with Regression: Between Tumoral Expression and Regulatory T Cell Upregulation.

    abstract::Cutaneous melanoma is a significant immunogenic tumoral model, the most frequently described immune phenomenon being tumor regression, as a result of the interaction of tumoral antigens and stromal microenvironment. We present a retrospective cohort study including 52 cases of melanoma with regression. There were eval...

    journal_title:Journal of immunology research

    pub_type: 杂志文章,评审

    doi:10.1155/2020/5416843

    authors: Cioplea M,Nichita L,Georgescu D,Sticlaru L,Cioroianu A,Nedelcu R,Turcu G,Rauta A,Mogodici C,Zurac S,Popp C

    更新日期:2020-10-23 00:00:00

  • Transcriptional and posttranscriptional regulations of the HLA-G gene.

    abstract::HLA-G has a relevant role in immune response regulation. The overall structure of the HLA-G coding region has been maintained during the evolution process, in which most of its variable sites are synonymous mutations or coincide with introns, preserving major functional HLA-G properties. The HLA-G promoter region is d...

    journal_title:Journal of immunology research

    pub_type: 杂志文章,评审

    doi:10.1155/2014/734068

    authors: Castelli EC,Veiga-Castelli LC,Yaghi L,Moreau P,Donadi EA

    更新日期:2014-01-01 00:00:00

  • The Role of NK Cells in Pig-to-Human Xenotransplantation.

    abstract::Recruitment of human NK cells to porcine tissues has been demonstrated in pig organs perfused ex vivo with human blood in the early 1990s. Subsequently, the molecular mechanisms leading to adhesion and cytotoxicity in human NK cell-porcine endothelial cell (pEC) interactions have been elucidated in vitro to identify t...

    journal_title:Journal of immunology research

    pub_type: 杂志文章,评审

    doi:10.1155/2017/4627384

    authors: Puga Yung G,Schneider MKJ,Seebach JD

    更新日期:2017-01-01 00:00:00

  • Thymic Stromal Lymphopoietin Is Implicated in the Pathogenesis of Bullous Pemphigoid by Dendritic Cells.

    abstract:Objectives:Both thymic stromal lymphopoietin (TSLP) and dendritic cells (DCs) are involved in many autoimmune diseases, but the potential roles of TSLP and DCs in bullous pemphigoid (BP) have not been clarified. We sought to explore the contributions of TSLP and DCs in patients with BP. Methods:TSLP levels in sera and...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2020/4594630

    authors: Li SZ,Jin XX,Ge XL,Zuo YG,Jin HZ

    更新日期:2020-09-24 00:00:00

  • Elucidating the Pivotal Immunomodulatory and Anti-Inflammatory Potentials of Chloroquine and Hydroxychloroquine.

    abstract::Chloroquine (CQ) and hydroxychloroquine (HCQ) are derivatives of 4-aminoquinoline compounds with over 60 years of safe clinical usage. CQ and HCQ are able to inhibit the production of cytokines such as interleukin- (IL-) 1, IL-2, IL-6, IL-17, and IL-22. Also, CQ and HCQ inhibit the production of interferon- (IFN-) α a...

    journal_title:Journal of immunology research

    pub_type: 杂志文章,评审

    doi:10.1155/2020/4582612

    authors: Richard SA,Kampo S,Hechavarria ME,Sackey M,Buunaaim ADB,Kuugbee ED,Anabah TW

    更新日期:2020-09-25 00:00:00

  • The Emerging Role of HMGB1 in Neuropathic Pain: A Potential Therapeutic Target for Neuroinflammation.

    abstract::Neuropathic pain (NPP) is intolerable, persistent, and specific type of long-term pain. It is considered to be a direct consequence of pathological changes affecting the somatosensory system and can be debilitating for affected patients. Despite recent progress and growing interest in understanding the pathogenesis of...

    journal_title:Journal of immunology research

    pub_type: 杂志文章,评审

    doi:10.1155/2016/6430423

    authors: Wan W,Cao L,Khanabdali R,Kalionis B,Tai X,Xia S

    更新日期:2016-01-01 00:00:00

  • Bone-immune cell crosstalk: bone diseases.

    abstract::Bone diseases are associated with great morbidity; thus, the understanding of the mechanisms leading to their development represents a great challenge to improve bone health. Recent reports suggest that a large number of molecules produced by immune cells affect bone cell activity. However, the mechanisms are incomple...

    journal_title:Journal of immunology research

    pub_type: 杂志文章,评审

    doi:10.1155/2015/108451

    authors: Mori G,D'Amelio P,Faccio R,Brunetti G

    更新日期:2015-01-01 00:00:00

  • Regulatory lymphocytes are key factors in MHC-independent resistance to EAE.

    abstract:BACKGROUND AND OBJECTIVES:Resistant and susceptible mouse strains to experimental autoimmune encephalomyelitis (EAE), an inducible demyelinating experimental disease serving as animal model for multiple sclerosis, have been described. We aimed to explore MHC-independent mechanisms inducing resistance to EAE. METHODS:F...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2014/156380

    authors: Marín N,Mecha M,Espejo C,Mestre L,Eixarch H,Montalban X,Álvarez-Cermeño JC,Guaza C,Villar LM

    更新日期:2014-01-01 00:00:00

  • Human Gene Expression in Uncomplicated Plasmodium falciparum Malaria.

    abstract::To examine human gene expression during uncomplicated P. falciparum malaria, we obtained three samples (acute illness, treatment, and recovery) from 10 subjects and utilized each subject's recovery sample as their baseline. At the time of acute illness (day 1), subjects had upregulation of innate immune response, cyto...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2015/162639

    authors: Colborn JM,Ylöstalo JH,Koita OA,Cissé OH,Krogstad DJ

    更新日期:2015-01-01 00:00:00

  • Analysis of Toll-Like Receptors in Human Milk: Detection of Membrane-Bound and Soluble Forms.

    abstract::The bioactive and anti-inflammatory role of human milk components has been recognized; active milk components include soluble forms of Toll-like receptors (TLRs). Preterm babies are more susceptible to infections and may succumb to necrotizing enterocolitis (NEC), a gastrointestinal disease which is exacerbated by an ...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2019/4078671

    authors: Cattaneo C,Caramaschi A,Uga E,Braghin M,Cosi G,Peila C,Strozzi MC,Sabatini M,Gazzolo D,Manfredi M,Cavaletto M

    更新日期:2019-12-04 00:00:00

  • Sepsis: From Pathophysiology to Individualized Patient Care.

    abstract::Sepsis has become a major health economic issue, with more patients dying in hospitals due to sepsis related complications compared to breast and colorectal cancer together. Despite extensive research in order to improve outcome in sepsis over the last few decades, results of large multicenter studies were by-and-larg...

    journal_title:Journal of immunology research

    pub_type: 杂志文章,评审

    doi:10.1155/2015/510436

    authors: László I,Trásy D,Molnár Z,Fazakas J

    更新日期:2015-01-01 00:00:00

  • Interaction between IL-33 Gene Polymorphisms and Current Smoking with Susceptibility to Systemic Lupus Erythematosus.

    abstract:Aims:This study is aimed at exploring the relation between IL-33 single-nucleotide polymorphisms (SNPs) and the risk of systemic lupus erythematosus (SLE). Methods:SNPStats (online software) was used to test the Hardy-Weinberg equilibrium in controls. Generalized multifactor dimensionality reduction (GMDR) was adopted...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2019/1547578

    authors: Zhu X,Xie L,Qin H,Liang J,Yang Y,Xu J,Zhang T

    更新日期:2019-03-11 00:00:00

  • New Insights in the Pathogenesis of HPV Infection and the Associated Carcinogenic Processes: The Role of Chronic Inflammation and Oxidative Stress.

    abstract::Human papillomavirus (HPV) is a small double-stranded DNA virus with tropism for epithelial cells. To this date, over 150 genotypes are known and are classified into two major groups, low-risk and high-risk strains, depending on the ability of the virus to induce malignant transformation. The host's immunity plays a c...

    journal_title:Journal of immunology research

    pub_type: 杂志文章,评审

    doi:10.1155/2018/5315816

    authors: Georgescu SR,Mitran CI,Mitran MI,Caruntu C,Sarbu MI,Matei C,Nicolae I,Tocut SM,Popa MI,Tampa M

    更新日期:2018-08-27 00:00:00

  • Serum Sclerostin as a Possible Biomarker in Ankylosing Spondylitis: A Case-Control Study.

    abstract:Objective:Several molecules are involved in the pathogenesis of a new bone formation in ankylosing spondylitis (AS). The aim of this study was to evaluate the serum levels of sclerostin in patients with AS as a possible biomarker and to investigate any correlations with radiographic damage, disease activity, and functi...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2018/9101964

    authors: Perrotta FM,Ceccarelli F,Barbati C,Colasanti T,De Socio A,Scriffignano S,Alessandri C,Lubrano E

    更新日期:2018-05-02 00:00:00

  • Generation of recombinant Schmallenberg virus nucleocapsid protein in yeast and development of virus-specific monoclonal antibodies.

    abstract::Schmallenberg virus (SBV), discovered in continental Europe in late 2011, causes mild clinical signs in adult ruminants, including diarrhoea and reduced milk yield. However, fetal infection can lead to severe malformation in newborn offspring. To develop improved reagents for SBV serology, a high-level yeast expressio...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2014/160316

    authors: Lazutka J,Zvirbliene A,Dalgediene I,Petraityte-Burneikiene R,Spakova A,Sereika V,Lelesius R,Wernike K,Beer M,Sasnauskas K

    更新日期:2014-01-01 00:00:00

  • Effect of Leflunomide on the Abnormal Expression of Lipid Rafts and F-Actin in B Lymphocytes from Patients with Systemic Lupus Erythematosus.

    abstract:PURPOSES:To investigate the possible changes in B cell subsets and in B cell expression patterns of lipid rafts (LRs) and F-actin in patients with SLE and whether leflunomide treatment may have effect on these changes. METHODS:The B cell subsets and LRs expression were determined by flow cytometry and confocal microsc...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2015/832916

    authors: Dong GF,Zhang X,He DN,Li L,Zhang GF

    更新日期:2015-01-01 00:00:00