Abstract:
:Bronchopulmonary dysplasia (BPD) is a severe complication of the respiratory system associated with preterm birth. Type 2 innate lymphoid cells (ILC2s) play a major role in tissue homeostasis, inflammation, and wound healing. However, the role in BPD remains unclear. The present study showed that ILC2s, interleukin-4 (IL-4), IL-13, and anti-inflammatory (M2) macrophages increased significantly in BPD mice as compared to the control mice. Administration with recombinant mouse IL-33 amplified the above phenomena and aggravated the alveolar structural disorder and functional injury in mice subjected to BPD, and the opposite was true with anti-ST2 antibody. In addition, the depletion of ILC2s in BPD mice with anti-CD90.2 antibody substantially abolished the destructive effect on BPD. In the treatment of BPD with dexamethasone, the number of ILC2s and M2 macrophages and levels of IL-4 and IL-13 decreased with remission as compared to the control group. This study identified a major destructive role of the ILC2s in BPD that could be attenuated as a therapeutic strategy.
journal_name
J Immunol Resjournal_title
Journal of immunology researchauthors
Mi L,Zhu S,Cai J,Xu S,Xue Z,Lu Hdoi
10.1155/2020/8050186subject
Has Abstractpub_date
2020-10-31 00:00:00pages
8050186eissn
2314-8861issn
2314-7156journal_volume
2020pub_type
杂志文章abstract::Systemic lupus erythematosus (SLE) is characterized by deregulated activation of T and B cells, autoantibody production, and consequent formation of immune complexes. Liposomes with nonbilayer phospholipid arrangements (NPA), induced by chlorpromazine, procainamide, or manganese, provoke a disease resembling human lup...
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更新日期:2020-10-23 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-09-24 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Journal of immunology research
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journal_title:Journal of immunology research
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pub_type: 杂志文章
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更新日期:2019-03-11 00:00:00
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journal_title:Journal of immunology research
pub_type: 杂志文章,评审
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journal_title:Journal of immunology research
pub_type: 杂志文章
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journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2015/832916
更新日期:2015-01-01 00:00:00