Treatment of Bullous Systemic Lupus Erythematosus.

abstract：:Lung cancer is the leading cause of cancer death worldwide due to its late diagnosis and poor outcome. Immunotherapy is becoming more and more encouraging and promising in lung cancer therapy. Myeloid-derived suppressor cells (MDSCs) are the main tumor suppressor factors, and the treatment strategy of targeting MDSCs ...

journal_title：Journal of immunology research

authors： Ma J,Xu H,Wang S

更新日期：2018-03-25 00:00:00

abstract：:Pregnancy is an immunological enigma where paternal antigens are present at the fetomaternal interface. What regulates the local immunotolerance, which is necessary to prevent rejection of the conceptus, is still under strong investigation. Gamma/delta T cells are believed to play a role in the local regulation of thi...

journal_title：Journal of immunology research

authors： Nörenberg J,Meggyes M,Jakso P,Miko E,Barakonyi A

更新日期：2019-05-20 00:00:00

abstract：:Regulatory T-cells (Tregs) are a very important subtype of lymphocytes when it comes to self-control in the human immunological system. Tregs are decisive not only in the protection against destruction of own tissues by autoimmune immunocompetent cells but also in the immunological answer to developing cancers. On the...

journal_title：Journal of immunology research

authors： Niedźwiecki M,Budziło O,Adamkiewicz-Drożyńska E,Pawlik-Gwozdecka D,Zieliński M,Maciejka-Kembłowska L,Szczepański T,Trzonkowski P

更新日期：2019-03-03 00:00:00

abstract：:Multiepitope peptide vaccine has some advantages over traditional recombinant protein vaccine due to its easy and fast production and possible inclusion of multiple protective epitopes of pathogens. However, it is usually poorly immunogenic and needs to conjugate to a large carrier protein. Peptides conjugated to a ce...

journal_title：Journal of immunology research

authors： Gu Y,Sun X,Huang J,Zhan B,Zhu X

更新日期：2020-01-08 00:00:00

abstract：:Background. Millions of people are infected with hepatitis C virus (HCV) worldwide and 30% spontaneously clear the infection. Reasons for HCV clearance without antiviral treatment are not well understood. Methods. Blood was collected for DNA analysis from patients with chronic HCV infection or evidence of spontaneous ...

journal_title：Journal of immunology research

authors： Waldron PR,Belitskaya-Lévy I,Chary A,Won J,Winters M,Monto A,Ryan J,Lazzeroni LC,Holodniy M

更新日期：2016-01-01 00:00:00

abstract：:We investigated cytokine production and expression of degranulation marker CD107a after different strategies of hepatitis B virus (HBV) vaccination in human immunodeficiency virus-infected individuals, which were three doses of 20 μg (standard dose group), four doses of 20 μg (four doses group), or four doses of 40 μg...

journal_title：Journal of immunology research

authors： Chawansuntati K,Chaiklang K,Chaiwarith R,Praparattanapan J,Supparatpinyo K,Wipasa J

更新日期：2018-02-27 00:00:00

abstract：Introduction:Understanding the mechanisms underlying the pathogenesis of Sjögren's syndrome (SS) is crucially important in order to be able to discriminate the steps that lead to B cell transformation and promptly identify the patients at risk of lymphomagenesis. The aim of this narrative review is to describe the evid...

journal_title：Journal of immunology research

authors： Talotta R,Sarzi-Puttini P,Atzeni F

更新日期：2019-01-06 00:00:00

abstract：:Chloroquine (CQ) and hydroxychloroquine (HCQ) are derivatives of 4-aminoquinoline compounds with over 60 years of safe clinical usage. CQ and HCQ are able to inhibit the production of cytokines such as interleukin- (IL-) 1, IL-2, IL-6, IL-17, and IL-22. Also, CQ and HCQ inhibit the production of interferon- (IFN-) α a...

journal_title：Journal of immunology research

authors： Richard SA,Kampo S,Hechavarria ME,Sackey M,Buunaaim ADB,Kuugbee ED,Anabah TW

更新日期：2020-09-25 00:00:00

abstract：:RANKL (receptor activator of nuclear factor kappa-β ligand) and OPG (osteoprotegerin) are two proteins involved in bone remodelling. During the active phase of periodontal disease, an imbalance between the ratios of the two elements can be noticed. While the expression of RANKL is elevated compared with that of OPG, t...

journal_title：Journal of immunology research

authors： Teodorescu AC,Martu I,Teslaru S,Kappenberg-Nitescu DC,Goriuc A,Luchian I,Martu MA,Solomon SM,Mârțu S

更新日期：2019-04-28 00:00:00

abstract：:Aims. In the present study, we aimed to assess the concentrations of IL-13 and IL-17 in serum of patients with early rheumatoid arthritis (eRA), the investigation of correlation between the concentrations of these cytokines and disease activity score, and the concentration of some autoantibodies and the evaluation of ...

journal_title：Journal of immunology research

authors： Siloşi I,Boldeanu MV,Cojocaru M,Biciuşcă V,Pădureanu V,Bogdan M,Badea RG,Avramescu C,Petrescu IO,Petrescu F,Siloşi CA

更新日期：2016-01-01 00:00:00

abstract：:Circulating T follicular helper (cTfh) cells are known to be involved in numerous immune-mediated diseases, but their pathological role in psoriasis is less fully investigated. Herein, we aimed to identify whether cTfh cells contributed to the pathogenesis of psoriasis. The frequency and function of cTfh cells were co...

journal_title：Journal of immunology research

authors： Wang Y,Wang L,Yang H,Yuan W,Ren J,Bai Y

更新日期：2016-01-01 00:00:00

abstract：Objective:Several molecules are involved in the pathogenesis of a new bone formation in ankylosing spondylitis (AS). The aim of this study was to evaluate the serum levels of sclerostin in patients with AS as a possible biomarker and to investigate any correlations with radiographic damage, disease activity, and functi...

journal_title：Journal of immunology research

authors： Perrotta FM,Ceccarelli F,Barbati C,Colasanti T,De Socio A,Scriffignano S,Alessandri C,Lubrano E

更新日期：2018-05-02 00:00:00

abstract：:The predominant distribution of γ δ T cells in the mucosal and epithelial tissues makes these unconventional lymphocytes the "guards" to contact external environment (like allergens) and to contribute to immune surveillance, as well as "vanguards" to participate in initiating mucosal inflammation. Therefore, γ δ T cel...

journal_title：Journal of immunology research

authors： Zheng R,Yang Q

更新日期：2014-01-01 00:00:00

abstract：:The aim of this paper is to determine the modulatory effects of Lactobacillus acidophilus on the IL-23/Th17 immune axis in experimental colitis. DSS-induced mouse models of UC were to be saline, hormones, and different concentrations of Lactobacillus acidophilus intervention. The expression of interleukin- (IL-) 17, t...

journal_title：Journal of immunology research

authors： Chen L,Zou Y,Peng J,Lu F,Yin Y,Li F,Yang J

更新日期：2015-01-01 00:00:00

abstract：:Cutaneous melanoma is a significant immunogenic tumoral model, the most frequently described immune phenomenon being tumor regression, as a result of the interaction of tumoral antigens and stromal microenvironment. We present a retrospective cohort study including 52 cases of melanoma with regression. There were eval...

journal_title：Journal of immunology research

authors： Cioplea M,Nichita L,Georgescu D,Sticlaru L,Cioroianu A,Nedelcu R,Turcu G,Rauta A,Mogodici C,Zurac S,Popp C

更新日期：2020-10-23 00:00:00

abstract：:Therapeutic monoclonal antibodies (mAbs) represent a milestone in pharmacological development. Their superiority is based on the combination of high specificity, low toxicity, and long half-life that characterizes biologics. If biologics have Achilles' heel, it is their potential immunogenicity. To better understand t...

journal_title：Journal of immunology research

authors： Boysen M,Schlicksupp L,Dreher I,Loebbert R,Richter M

更新日期：2016-01-01 00:00:00

abstract：:Extracellular matrix metalloproteases and the fibrinolytic system are important protease systems interacting with each other in charge of remodeling and recycling of tissues. Their role in tumor invasion and metastasis is often discussed. In this study several metalloproteases such as MMP-1, MMP-3, MMP-9, and TIMP-1 t...

journal_title：Journal of immunology research

authors： Barajas-Castañeda LM,Cortés-Gutiérrez E,García-Rodríguez FM,Campos-Rodríguez R,Lara-Padilla E,Enríquez-Rincón F,Castro-Mussot ME,Figueroa-Arredondo P

更新日期：2016-01-01 00:00:00

abstract：:Gram-negative bacterial sepsis accounts for up to 50% worldwide sepsis that causes hospital mortality. Acute kidney injury (AKI), a common complication of Gram-negative bacterial sepsis, is caused by Toll-like receptor 4 (TLR4) activation. Lipopolysaccharide (LPS) is an endotoxin in Gram-negative bacteria and is recog...

journal_title：Journal of immunology research

authors： Li Q,Wu C,Liu Z,Zhang H,Du Y,Liu Y,Song K,Shi Q,Li R

更新日期：2019-02-19 00:00:00

abstract：:A myriad of pathogens gain access to the host via the mucosal route; thus, vaccinations that protect against mucosal pathogens are critical. Pathogens such as HIV, HSV, and influenza enter the host at mucosal sites such as the intestinal, urogenital, and respiratory tracts. All currently licensed vaccines mediate prot...

journal_title：Journal of immunology research

authors： Gary EN,Kutzler MA

更新日期：2018-12-13 00:00:00

abstract：:The benefits of garlic to health have been proclaimed for centuries; however, only recently have Allium sativum and its derivatives been proposed as promising candidates for maintaining the homeostasis of the immune system. The complex biochemistry of garlic makes it possible for variations in processing to yield diff...

journal_title：Journal of immunology research

authors： Arreola R,Quintero-Fabián S,López-Roa RI,Flores-Gutiérrez EO,Reyes-Grajeda JP,Carrera-Quintanar L,Ortuño-Sahagún D

更新日期：2015-01-01 00:00:00

abstract：:Oropouche virus (OROV) is an emerging pathogen which causes Oropouche fever and meningitis in humans. Several outbreaks of OROV in South America, especially in Brazil, have changed its status as an emerging disease, but no vaccine or specific drug target is available yet. Our approach was to identify the epitope-based...

journal_title：Journal of immunology research

authors： Adhikari UK,Tayebi M,Rahman MM

更新日期：2018-10-08 00:00:00

abstract：Objective:This study aimed to investigate the correlation of CD4+/PD-1+ or CD4+/PD-1- tumor-infiltrating lymphocytes with pathological characteristics in breast cancer patients. Methods:A cross-sectional study consecutively recruited 133 patients with invasive ductal breast cancer. The expression of CD4, programmed ce...

journal_title：Journal of immunology research

authors： Zhao YJ,Zhang J,Shi F,Hu ZP,Wu JP,Wu GJ,Wang RB,Zhou Q,Chang H,Li YN,Song QK

更新日期：2018-07-04 00:00:00

abstract：:Inflammation plays an essential role in the control of pathogens and in shaping the ensuing adaptive immune responses. Traditionally, innate immunity has been described as a rapid response triggered through generic and nonspecific means that by definition lacks the ability to remember. Recently, it has become clear th...

journal_title：Journal of immunology research

authors： Cronkite DA,Strutt TM

更新日期：2018-06-11 00:00:00

abstract：:Leptospirosis is considered a neglected disease with an estimated more than one million cases every year. Since rodents are at the same time the main reservoir and generally asymptomatic to Leptospira infection, understanding why some animal species are resistant and others are susceptible to this infection would shed...

journal_title：Journal of immunology research

authors： Bavia L,de Castro ÍA,Amano MT,da Silva AMG,Vasconcellos SA,Isaac L

更新日期：2019-10-07 00:00:00

abstract：:Irritant Contact Dermatitis (ICD) is characterized by epidermal hyperplasia and inflammatory cytokine release. IL-6 has been shown to be involved in the pathogenesis of ICD; however, the involvement of the IL-22/IL-22Rα axis and its relation to IL-6 in the inflammatory response following irritant exposure are unknown....

journal_title：Journal of immunology research

authors： Frempah B,Luckett-Chastain LR,Gallucci RM

更新日期：2019-10-29 00:00:00

abstract：:Purified protein vaccines often require adjuvants for efficient stimulation of immune responses. There is no licensed mucosal adjuvant on the market to adequately boost the immune response to purified antigens for intranasal applications in humans. Bacterial outer membrane vesicles (OMV) are attractive candidates pote...

journal_title：Journal of immunology research

authors： Pritsch M,Ben-Khaled N,Chaloupka M,Kobold S,Berens-Riha N,Peter A,Liegl G,Schubert S,Hoelscher M,Löscher T,Wieser A

更新日期：2016-01-01 00:00:00

abstract：:A derivative formula, DGBX, which is composed of three herbs (Radix astragali, Radix Angelicae sinensis, and Coptis chinensis Franch), is derived from a famous Chinese herbal formula, Danggui Buxue Tang (DBT) (Radix astragali and Radix Angelicae sinensis). We aimed to investigate the effects of DGBX on the regulation ...

journal_title：Journal of immunology research

authors： Zhou J,Li X,Deng P,Wei Y,Liu J,Chen M,Xu Y,Zhang D,Zhu L,Lou L,Dong B,Jin Q,Chai L

更新日期：2017-01-01 00:00:00

abstract：:Toll/IL-1R-domain-containing adaptor-inducing IFN-β (TRIF) is an important adaptor for TLR3- and TLR4-mediated inflammatory signaling pathways. Recent studies have shown that TRIF plays a key role in vessel inflammation and atherosclerosis; however, the precise mechanisms are unclear. We investigated the mechanisms of...

journal_title：Journal of immunology research

authors： Wu Y,Ye J,Guo R,Liang X,Yang L

更新日期：2018-06-07 00:00:00

abstract：:Reduning injection is a traditional Chinese medicine injection which has multiple functions such as clearing heat, dispelling wind, and detoxification. Although Reduning injection was widely utilized, reports of its allergenicity emerged one after another. However, there is little research on its allergenic substances...

journal_title：Journal of immunology research

authors： Wang F,Li CY,Zheng YF,Li HY,Xiao W,Peng GP

更新日期：2016-01-01 00:00:00

abstract：:Antiphospholipid syndrome (APS) is characterized by development of venous and/or arterial thrombosis and pregnancy morbidity. Biological criteria are the persistent presence of lupus anticoagulant (LA) and/or anti-cardiolipin (aCL) and/or anti-B2GP1 autoantibodies' positivity. The assays' performances are of crucial i...

journal_title：Journal of immunology research

authors： Sénant M,Rostane H,Fernani-Oukil F,Hosking F,Bellery F,Courchinoux A,Tartour E,Darnige L,Dragon-Durey MA

更新日期：2015-01-01 00:00:00