Abstract:
:A derivative formula, DGBX, which is composed of three herbs (Radix astragali, Radix Angelicae sinensis, and Coptis chinensis Franch), is derived from a famous Chinese herbal formula, Danggui Buxue Tang (DBT) (Radix astragali and Radix Angelicae sinensis). We aimed to investigate the effects of DGBX on the regulation of the balance between proliferation and apoptosis of hematopoietic stem cells (HSCs) due to the aberrant immune response in a mouse model of aplastic anemia (AA). Cyclosporine (CsA), an immunosuppressor, was used as the positive control. Our results indicated that DGBX could downregulate the production of IFNγ in bone marrow cells by interfering with the binding between SLAM and SAP and the expressions of Fyn and T-bet. This herbal formula can also inhibit the activation of Fas-mediated apoptosis, interferon regulatory factor-1-induced JAK/Stat, and eukaryotic initiation factor 2 signaling pathways and thereby induce proliferation and attenuate apoptosis of HSCs. In conclusion, DGBX can relieve the immune-mediated destruction of HSCs, repair hematopoietic failure, and recover the hematopoietic function of HSCs in hematogenesis. Therefore, DGBX can be used in traditional medicine against AA as a complementary and alternative immunosuppressive therapeutic formula.
journal_name
J Immunol Resjournal_title
Journal of immunology researchauthors
Zhou J,Li X,Deng P,Wei Y,Liu J,Chen M,Xu Y,Zhang D,Zhu L,Lou L,Dong B,Jin Q,Chai Ldoi
10.1155/2017/9786972subject
Has Abstractpub_date
2017-01-01 00:00:00pages
9786972eissn
2314-8861issn
2314-7156journal_volume
2017pub_type
杂志文章abstract::C-type lectin receptors (CLRs) on antigen-presenting cells (APCs) facilitate uptake of carbohydrate antigens for antigen presentation, modulating the immune response in infection, homeostasis, autoimmunity, allergy, and cancer. In this review, we focus on the role of the macrophage galactose type C-type lectin (MGL) i...
journal_title:Journal of immunology research
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doi:10.1155/2015/450695
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journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2020/9473497
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abstract::Circulating T follicular helper (cTfh) cells are known to be involved in numerous immune-mediated diseases, but their pathological role in psoriasis is less fully investigated. Herein, we aimed to identify whether cTfh cells contributed to the pathogenesis of psoriasis. The frequency and function of cTfh cells were co...
journal_title:Journal of immunology research
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doi:10.1155/2016/7346030
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abstract::Following fetal or neonatal gene transfer in mice and other species immune tolerance of the transgenic protein is frequently observed; however the underlying mechanisms remain largely undefined. In this study fetal and neonatal BALB/c mice received adenovirus vector to deliver human factor IX (hFIX) cDNA. The long-ter...
journal_title:Journal of immunology research
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abstract::T follicular helper cells (TFH) are a subset of recently discovered CD4+ T cells. Their major function is to participate in the formation of germinal centres (GCs) and promote B cell proliferation and differentiation to play important roles in the production of antibodies. Currently, the functions of TFH cells are cle...
journal_title:Journal of immunology research
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journal_title:Journal of immunology research
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doi:10.1155/2019/7935451
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journal_title:Journal of immunology research
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更新日期:2020-01-23 00:00:00
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journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2018/5690258
更新日期:2018-07-04 00:00:00
abstract::Neuropathic pain (NPP) is intolerable, persistent, and specific type of long-term pain. It is considered to be a direct consequence of pathological changes affecting the somatosensory system and can be debilitating for affected patients. Despite recent progress and growing interest in understanding the pathogenesis of...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2016/6430423
更新日期:2016-01-01 00:00:00
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journal_title:Journal of immunology research
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doi:10.1155/2017/2913297
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journal_title:Journal of immunology research
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doi:10.1155/2018/3861079
更新日期:2018-07-10 00:00:00
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journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2017/1787803
更新日期:2017-01-01 00:00:00
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journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2018/4892473
更新日期:2018-08-12 00:00:00
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journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2020/2670527
更新日期:2020-09-01 00:00:00
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journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2020/4594630
更新日期:2020-09-24 00:00:00
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journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2019/2816498
更新日期:2019-03-03 00:00:00
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journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2020/9680508
更新日期:2020-05-28 00:00:00
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journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2014/809389
更新日期:2014-01-01 00:00:00
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journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2018/7245956
更新日期:2018-09-18 00:00:00
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journal_title:Journal of immunology research
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doi:10.1155/2015/191832
更新日期:2015-01-01 00:00:00
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journal_title:Journal of immunology research
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doi:10.1155/2015/268172
更新日期:2015-01-01 00:00:00
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journal_title:Journal of immunology research
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doi:10.1155/2018/5264195
更新日期:2018-10-21 00:00:00
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journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2015/186586
更新日期:2015-01-01 00:00:00
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journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2020/8263598
更新日期:2020-08-27 00:00:00
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journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2019/6276254
更新日期:2019-10-29 00:00:00
abstract:Objective:Several molecules are involved in the pathogenesis of a new bone formation in ankylosing spondylitis (AS). The aim of this study was to evaluate the serum levels of sclerostin in patients with AS as a possible biomarker and to investigate any correlations with radiographic damage, disease activity, and functi...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2018/9101964
更新日期:2018-05-02 00:00:00
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journal_title:Journal of immunology research
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doi:10.1155/2014/747426
更新日期:2014-01-01 00:00:00
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journal_title:Journal of immunology research
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doi:10.1155/2015/132083
更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1155/2018/1982423
更新日期:2018-04-11 00:00:00
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journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2016/4215684
更新日期:2016-01-01 00:00:00