Abstract:
:Irritant Contact Dermatitis (ICD) is characterized by epidermal hyperplasia and inflammatory cytokine release. IL-6 has been shown to be involved in the pathogenesis of ICD; however, the involvement of the IL-22/IL-22Rα axis and its relation to IL-6 in the inflammatory response following irritant exposure are unknown. Using a chemical model of ICD, it was observed that mice with a keratinocyte-specific knockout of IL-6Rα (IL-6RαΔker) presented with increased inflammation and IL-22Rα and IL-22 protein expression relative to WT following irritant exposure, indicating that IL-6Rα deficiency in epidermal keratinocytes leads to the upregulation of IL-22Rα and its ligand during ICD. Furthermore, it was shown that IL-6 negatively regulates the expression of IL-22Rα on epidermal keratinocytes. This effect is functional as the effects of IL-22 on keratinocyte proliferation and differentiation were markedly reduced when keratinocytes were pretreated with IL-6 prior to IL-22 treatment. These results show that IL-6 modulates the IL-22/IL-22Rα axis in the skin and suggest that this occurrence may be associated with the increased epidermal hyperplasia and exacerbated inflammatory response observed in IL-6RαΔker mice during ICD.
journal_name
J Immunol Resjournal_title
Journal of immunology researchauthors
Frempah B,Luckett-Chastain LR,Gallucci RMdoi
10.1155/2019/6276254subject
Has Abstractpub_date
2019-10-29 00:00:00pages
6276254eissn
2314-8861issn
2314-7156journal_volume
2019pub_type
杂志文章abstract::Mucosal surfaces in the airways and the gastrointestinal tract are critical for the interactions of the host with its environment. Due to their abundance at mucosal tissue sites and their powerful immunomodulatory capacities, the role of innate lymphoid cells (ILCs) and natural killer T (NKT) cells in the maintenance ...
journal_title:Journal of immunology research
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pub_type: 杂志文章,评审
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journal_title:Journal of immunology research
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更新日期:2015-01-01 00:00:00
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journal_title:Journal of immunology research
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pub_type: 杂志文章
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更新日期:2019-02-19 00:00:00