Abstract：
:Circulating T follicular helper (cTfh) cells are known to be involved in numerous immune-mediated diseases, but their pathological role in psoriasis is less fully investigated. Herein, we aimed to identify whether cTfh cells contributed to the pathogenesis of psoriasis. The frequency and function of cTfh cells were compared between patients with psoriasis vulgaris and healthy controls, and the infiltration of Tfh cells was detected between lesional and nonlesional skin tissues of psoriasis patients. Moreover, the dynamic change of cTfh cells before and after acitretin treatment was evaluated. Our results showed both increased frequency and activation (indicated by higher expression of ICOS, PD-1, HLA-DR, and Ki-67 and increased production of IL-21, IL-17, and IFN-γ) of cTfh cells in psoriasis patients. Compared with nonlesional skin tissues of psoriasis patients, the number of infiltrated Tfh cells was significantly increased in psoriasis lesions. In addition, positive correlations between the percentage of cTfh, functional markers on cTfh cells in peripheral blood and disease severity were noted. Furthermore, the frequency of cTfh cells and the levels of cytokines secreted by cTfh cells were all significantly decreased after 1-month treatment.
journal_name
J Immunol Resjournal_title
Journal of immunology researchauthors
Wang Y,Wang L,Yang H,Yuan W,Ren J,Bai Ydoi
10.1155/2016/7346030subject
Has Abstractpub_date
2016-01-01 00:00:00pages
7346030eissn
2314-8861issn
2314-7156journal_volume
2016pub_type
杂志文章abstract：Background and Aim:The presumed role of the inhibitory receptor LAIR-1 (CD305) in the inflammatory response suggests that it might contribute to the pathophysiology of chronic inflammatory diseases such as liver cirrhosis. We studied the LAIR-1 expression on liver macrophages and blood monocytes related to the progress...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2019/2974753
更新日期：2019-03-24 00:00:00
abstract：:Rheumatoid arthritis (RA) is an inflammatory autoimmune disorder; abnormal T cell immunity plays a critical role in the development of RA. Recently, A20 was identified as a key negative regulator for T cell activation and inflammatory signaling and may be involved in RA pathogenesis. In this study, we analyzed the exp...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2014/492872
更新日期：2014-01-01 00:00:00
abstract：:Molecular dynamics was used to simulate large molecules of the immune system (major histocompatibility complex class I, presented epitope, T-cell receptor, and a CD8 coreceptor.) To characterize the relative orientation and movements of domains local coordinate systems (based on principal component analysis) were gene...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2015/210675
更新日期：2015-01-01 00:00:00
abstract：:Cationic protein is a cytotoxic protein secreted by eosinophils and takes part in the damage of airway epithelium in asthma. Poly-L-arginine (PLA), a synthetic cationic protein, is widely used to mimic the biological function of the natural cationic protein in vitro. Previous studies demonstrated the damage of the air...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2018/3651743
更新日期：2018-06-14 00:00:00
abstract：:Aims. In the present study, we aimed to assess the concentrations of IL-13 and IL-17 in serum of patients with early rheumatoid arthritis (eRA), the investigation of correlation between the concentrations of these cytokines and disease activity score, and the concentration of some autoantibodies and the evaluation of ...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2016/3109135
更新日期：2016-01-01 00:00:00
abstract：:Propionibacterium acnes (P. acnes) is a gram-positive anaerobic bacillus present in normal human skin microbiota, which exerts important immunomodulatory effects, when used as heat- or phenol-killed suspensions. We previously demonstrated that heat-killed P. acnes or its soluble polysaccharide (PS), extracted from the...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2015/132083
更新日期：2015-01-01 00:00:00
abstract：:Genetic and/or epigenetic changes provide antigen-derived diversity in neoplastic cells. Beside, these cells do not initiate immune response of host organisms. A variety of factors are responsible for the resistant to treatment, including individual variations in patients and somatic cell genetic differences in tumors...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2018/1982423
更新日期：2018-04-11 00:00:00
abstract：:Evidences show that purinergic signaling is involved in processes associated with health and disease, including noncommunicable, neurological, and degenerative diseases. These diseases strike from children to elderly and are generally characterized by progressive deterioration of cells, eventually leading to tissue or...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2018/4892473
更新日期：2018-08-12 00:00:00
abstract：:Collectin-12 (collectin placenta 1, CL-P1, or CL-12) is a newly identified pattern recognition molecule of the innate immune system. Recent evidences show that CL-12 plays important roles not only in innate immune protection against certain clinically important pathogens but also in scavenging of host molecules, leuko...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2019/9164202
更新日期：2019-07-29 00:00:00
abstract：:The effects of propolis on blood glucose regulation and the alleviation of various complications caused by diabetes have been widely studied. The main source of propolis in the northern temperate zone is poplar buds. However, there is limited research on the antidiabetic activity of poplar buds. In order to evaluate t...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2018/7245956
更新日期：2018-09-18 00:00:00
abstract：:Bacterial vaginosis (BV), the most common genital infection in reproductive-aged women, is associated with increased risk of sexually transmitted infections. Its etiology remains unclear, especially the role of Gardnerella (G.) vaginalis, an anaerobic bacterium characteristic of the BV-alteration of the vaginal ecosys...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2016/9747480
更新日期：2016-01-01 00:00:00
abstract：:We investigated the characteristics of Chinese SLE patients by analyzing the association between specific autoantibodies and clinical manifestations of 2104 SLE patients from registry data of CSTAR cohort. Significant (P<0.05) associations were found between anti-Sm antibody, anti-rRNP antibody, and malar rash; betwee...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2014/809389
更新日期：2014-01-01 00:00:00
abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that is characterized by synovial hyperplasia and progressive joint destruction. The activation of RA synovial fibroblasts (SFs), also called fibroblast-like synoviocytes (FLS), contributes significantly to perpetuation of the disease. Genetic and ...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2016/6290682
更新日期：2016-01-01 00:00:00
abstract：Objective:Rheumatoid arthritis (RA) multidrug resistance is associated with P-glycoprotein (P-gp) overexpression. We investigated the effects of methotrexate (MTX) alone and combined with 4-hydroperoxycyclophosphamide (4-HC) on P-gp expression in fibroblast-like synoviocytes (FLSs) from patients with RA and examined th...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2018/3619320
更新日期：2018-02-18 00:00:00
abstract：:Purified protein vaccines often require adjuvants for efficient stimulation of immune responses. There is no licensed mucosal adjuvant on the market to adequately boost the immune response to purified antigens for intranasal applications in humans. Bacterial outer membrane vesicles (OMV) are attractive candidates pote...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2016/3576028
更新日期：2016-01-01 00:00:00
abstract：:Human respiratory syncytial virus (RSV) is a common and highly contagious viral agent responsible for acute lower respiratory infection in infants. This pathology characterized by mucus hypersecretion and a disturbed T cell immune response is one of the major causes of infant hospitalization for severe bronchiolitis. ...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2017/8734504
更新日期：2017-01-01 00:00:00
abstract：:Leptospirosis is considered a neglected disease with an estimated more than one million cases every year. Since rodents are at the same time the main reservoir and generally asymptomatic to Leptospira infection, understanding why some animal species are resistant and others are susceptible to this infection would shed...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2019/1892508
更新日期：2019-10-07 00:00:00
abstract：:Type I interferon (IFN-I) plays a critical role in the antitumor immune response. In our previous study, we showed that IFN-I-inducible 2'-5' oligoadenylate synthetase-like 1 (OASL1) negatively regulated IFN-I production upon tumor challenge similar to that of viral infection. Thus, OASL1-deficient (Oasl1-/-) mice wer...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2019/7596786
更新日期：2019-03-31 00:00:00
abstract：:Neuropathic pain (NPP) is intolerable, persistent, and specific type of long-term pain. It is considered to be a direct consequence of pathological changes affecting the somatosensory system and can be debilitating for affected patients. Despite recent progress and growing interest in understanding the pathogenesis of...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2016/6430423
更新日期：2016-01-01 00:00:00
abstract：:Cutaneous melanoma is a significant immunogenic tumoral model, the most frequently described immune phenomenon being tumor regression, as a result of the interaction of tumoral antigens and stromal microenvironment. We present a retrospective cohort study including 52 cases of melanoma with regression. There were eval...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2020/5416843
更新日期：2020-10-23 00:00:00
abstract：:Adverse drug reactions (ADRs) remain a common and major problem in healthcare. Severe cutaneous adverse drug reactions (SCARs), such as Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) with mortality rate ranges from 10% to more than 30%, can be life threatening. A number of recent studies demonstrated ...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2017/3186328
更新日期：2017-01-01 00:00:00
abstract：:Bone is sensitive to overactive immune responses, which initiate the onset of inflammatory bone disorders, such as rheumatoid arthritis and periodontitis, resulting in a significant systemic inflammatory response. On the other hand, neuroinflammation is strongly implicated in Alzheimer's disease (AD), which can be enh...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2015/471342
更新日期：2015-01-01 00:00:00
abstract：:An important function of the immune system is its ability to differentiate between healthy cells in the organism and "foreign" cells, allowing the latest to be attacked and the first ones to be conserved. The most important molecules in this process are considered to be checkpoint inhibitors. This review is focused on...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2018/4625472
更新日期：2018-10-17 00:00:00
abstract：:In vitro differentiation of mesenchymal stromal cells (MSC) into osteocytes (human differentiated osteogenic cells, hDOC) before implantation has been proposed to optimize bone regeneration. However, a deep characterization of the immunological properties of DOC, including their effect on dendritic cell (DC) function,...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2015/526195
更新日期：2015-01-01 00:00:00
abstract：:T follicular helper cells (TFH) are a subset of recently discovered CD4+ T cells. Their major function is to participate in the formation of germinal centres (GCs) and promote B cell proliferation and differentiation to play important roles in the production of antibodies. Currently, the functions of TFH cells are cle...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2018/7281453
更新日期：2018-07-02 00:00:00
abstract：:The bioactive and anti-inflammatory role of human milk components has been recognized; active milk components include soluble forms of Toll-like receptors (TLRs). Preterm babies are more susceptible to infections and may succumb to necrotizing enterocolitis (NEC), a gastrointestinal disease which is exacerbated by an ...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2019/4078671
更新日期：2019-12-04 00:00:00
abstract：:Group A streptococcus (GAS) is known to cause a broad spectrum of illness, from pharyngitis and impetigo, to autoimmune sequelae such as rheumatic heart disease, and invasive diseases. It is a significant cause of infectious disease morbidity and mortality worldwide, but no efficacious vaccine is currently available. ...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2015/167089
更新日期：2015-01-01 00:00:00
abstract：:Irritant Contact Dermatitis (ICD) is characterized by epidermal hyperplasia and inflammatory cytokine release. IL-6 has been shown to be involved in the pathogenesis of ICD; however, the involvement of the IL-22/IL-22Rα axis and its relation to IL-6 in the inflammatory response following irritant exposure are unknown....
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2019/6276254
更新日期：2019-10-29 00:00:00
abstract：:A novel, simple, and reproducible method for cultivating pathological tissues obtained from human eyes during surgery was developed using viscoelastic material as a tissue adherent to facilitate cell attachment and expansion and calcium imaging of cultured cells challenged by mechanical and acetylcholine (ACh) stimula...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2014/232659
更新日期：2014-01-01 00:00:00
abstract：:The human leukocyte antigen-G (HLA-G) is considered an immune checkpoint molecule involved in tumor immune evasion. Hypoxia and the metabolic sensor hypoxia-inducible factor 1 (HIF-1) are hallmarks of metastasization, angiogenesis, and intense tumor metabolic activity. The purpose of this review was to examine origina...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2017/4587520
更新日期：2017-01-01 00:00:00
