Abstract:
:Genetic and/or epigenetic changes provide antigen-derived diversity in neoplastic cells. Beside, these cells do not initiate immune response of host organisms. A variety of factors are responsible for the resistant to treatment, including individual variations in patients and somatic cell genetic differences in tumors, even those from the same tissue of origin. Immune system is controlled by several controlling mechanisms. Recently, a significant progress in hematologic treatment has been made; however, majority of diseases still remain incurable. Immunotherapy with checkpoint inhibitors has emerged as promising modality of antitumor treatment, showing marked response to several antigens, including cytotoxic T lymphocyte-associate protein-4 (CTLA-4) or programmed cell death 1 receptor (PD-1). In this review, we demonstrate actual knowledge on immune checkpoint function and its impact on development of new modality of antineoplastic treatment, using, for example, anti-CTLA-4 or PD-1/PD1 ligand (PD-L1) monoclonal antibodies in malignant lymphomas.
journal_name
J Immunol Resjournal_title
Journal of immunology researchauthors
Witkowska M,Smolewski Pdoi
10.1155/2018/1982423subject
Has Abstractpub_date
2018-04-11 00:00:00pages
1982423eissn
2314-8861issn
2314-7156journal_volume
2018pub_type
杂志文章,评审abstract::Anti-CD3 antibody has been employed for various immune-mediated disorders. However, whether anti-CD3 administration leads to rapid metabolic alternation has not been well investigated. In the current study, we studied how anti-CD3 treatment affected blood glucose levels in mice. We found that anti-CD3 treatment induce...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2014/326708
更新日期:2014-01-01 00:00:00
abstract::Lycium barbarum polysaccharide (LBP) is isolated from the fruit of Chinese herbal Lycium barbarum. Previous studies had demonstrated that LBP could inhibit tumor growth and enhance the immunity in mice. However, the effect of LBP on systemic and local immune responses in vivo, especially on phenotypic and functional c...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2018/3431782
更新日期:2018-06-03 00:00:00
abstract::Calcitonin gene-related peptide (CGRP) is a mediator of microglial activation at the transcriptional level. The involvement of the epigenetic mechanism in this process is largely undefined. Histone deacetylase (HDAC)1/2 are considered important epigenetic regulators of gene expression in activated microglia. In this s...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2020/4384696
更新日期:2020-08-04 00:00:00
abstract::Human respiratory syncytial virus (RSV) is a common and highly contagious viral agent responsible for acute lower respiratory infection in infants. This pathology characterized by mucus hypersecretion and a disturbed T cell immune response is one of the major causes of infant hospitalization for severe bronchiolitis. ...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2017/8734504
更新日期:2017-01-01 00:00:00
abstract::Circulating T follicular helper (cTfh) cells are known to be involved in numerous immune-mediated diseases, but their pathological role in psoriasis is less fully investigated. Herein, we aimed to identify whether cTfh cells contributed to the pathogenesis of psoriasis. The frequency and function of cTfh cells were co...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2016/7346030
更新日期:2016-01-01 00:00:00
abstract::Group A streptococcus (GAS) is known to cause a broad spectrum of illness, from pharyngitis and impetigo, to autoimmune sequelae such as rheumatic heart disease, and invasive diseases. It is a significant cause of infectious disease morbidity and mortality worldwide, but no efficacious vaccine is currently available. ...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2015/167089
更新日期:2015-01-01 00:00:00
abstract:Background:Kawasaki disease (KD) is a systemic form of self-limited vasculitis in children less than five years old, and the main complication is coronary artery injury. However, the etiology of KD remains unclear. The IL-1B polymorphisms rs16944 GG and rs1143627 AA and their diplotype GA/GA have been associated with s...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2019/4730507
更新日期:2019-04-09 00:00:00
abstract::Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that is characterized by synovial hyperplasia and progressive joint destruction. The activation of RA synovial fibroblasts (SFs), also called fibroblast-like synoviocytes (FLS), contributes significantly to perpetuation of the disease. Genetic and ...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2016/6290682
更新日期:2016-01-01 00:00:00
abstract::Severe aplastic anemia (SAA) is a rare disease characterized by severe pancytopenia and bone marrow failure. Most patients with AA respond to immunosuppressive therapy (IST), usually as antithymocyte globulin (ATG) and cyclosporine (CsA), but some relapse on CsA withdrawal or require long-term administration of CsA to...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2020/1798795
更新日期:2020-10-17 00:00:00
abstract::Considerable shortages in the supply of available organs continue to plague the field of solid organ transplantation. Despite changes in allocation, as well as the utilization of extended criteria and living donors, the number of patients waiting for organs continues to grow at an alarming pace. Xenotransplantation, c...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2018/6413012
更新日期:2018-03-04 00:00:00
abstract::The roots of Euphorbia kansui, which belong to the family Euphorbiaceae, have been used as a traditional medicine for the treatment of various diseases such as diabetes, ascites, and leukemia. Recently, it was reported that the methylene chloride fraction of E. kansui radix (EKC) regulated the differentiation of Th17 ...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2017/7052560
更新日期:2017-01-01 00:00:00
abstract::The aim of this paper is to determine the modulatory effects of Lactobacillus acidophilus on the IL-23/Th17 immune axis in experimental colitis. DSS-induced mouse models of UC were to be saline, hormones, and different concentrations of Lactobacillus acidophilus intervention. The expression of interleukin- (IL-) 17, t...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2015/909514
更新日期:2015-01-01 00:00:00
abstract::Evidences show that purinergic signaling is involved in processes associated with health and disease, including noncommunicable, neurological, and degenerative diseases. These diseases strike from children to elderly and are generally characterized by progressive deterioration of cells, eventually leading to tissue or...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2018/4892473
更新日期:2018-08-12 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Resistant and susceptible mouse strains to experimental autoimmune encephalomyelitis (EAE), an inducible demyelinating experimental disease serving as animal model for multiple sclerosis, have been described. We aimed to explore MHC-independent mechanisms inducing resistance to EAE. METHODS:F...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2014/156380
更新日期:2014-01-01 00:00:00
abstract::We evaluated the association between anti-cyclic citrullinated peptide antibodies (anti-CCP) and anti-mutated citrullinated vimentin antibodies (anti-MCV) with the presence of extra-articular (ExRA) manifestations in 225 patients with rheumatoid arthritis (RA). Ninety-five patients had ExRA and 130 had no ExRA. There ...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2014/536050
更新日期:2014-01-01 00:00:00
abstract::Dendritic cells (DCs) are major immune components, and depending on how these cells are modulated, the protective host immune response changes drastically. Trypanosoma cruzi is a parasite with high genetic variability and modulates DCs by interfering with their capacity for antigen recognition, migration, and maturati...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2014/962047
更新日期:2014-01-01 00:00:00
abstract::Many immune-based intestinal disorders, such as ulcerative colitis and Crohn's disease, as well as other illnesses, may have the intestines as an initial cause or aggravator in the development of diseases, even apparently not correlating directly to the intestine. Diabetes, obesity, multiple sclerosis, depression, and...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2015/931574
更新日期:2015-01-01 00:00:00
abstract:Aims:This study is aimed at exploring the relation between IL-33 single-nucleotide polymorphisms (SNPs) and the risk of systemic lupus erythematosus (SLE). Methods:SNPStats (online software) was used to test the Hardy-Weinberg equilibrium in controls. Generalized multifactor dimensionality reduction (GMDR) was adopted...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2019/1547578
更新日期:2019-03-11 00:00:00
abstract::Chagas disease, or American trypanosomiasis, which is caused by the protozoan parasite Trypanosoma cruzi, is primarily a vector disease endemic in 21 Latin American countries, including Mexico. Although many vector control programs have been implemented, T. cruzi has not been eradicated. The development of an anti-T. ...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2015/489758
更新日期:2015-01-01 00:00:00
abstract::The purpose of this study was to investigate the expression levels of the immune checkpoint proteins, programmed cell death-ligand 1 (PD-L1), B7-H3, B7-H4, and V-domain Ig suppressor of T cell activation (VISTA), as well as the significance thereof, in clear cell carcinoma (CCC) of the cervix (a rare histological subt...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2020/1283632
更新日期:2020-04-03 00:00:00
abstract::Purified protein vaccines often require adjuvants for efficient stimulation of immune responses. There is no licensed mucosal adjuvant on the market to adequately boost the immune response to purified antigens for intranasal applications in humans. Bacterial outer membrane vesicles (OMV) are attractive candidates pote...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2016/3576028
更新日期:2016-01-01 00:00:00
abstract::T follicular helper cells (TFH) are a subset of recently discovered CD4+ T cells. Their major function is to participate in the formation of germinal centres (GCs) and promote B cell proliferation and differentiation to play important roles in the production of antibodies. Currently, the functions of TFH cells are cle...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2018/7281453
更新日期:2018-07-02 00:00:00
abstract::Calcium is a ubiquitous intracellular messenger that has a crucial role in determining the proliferation, differentiation, and functions of multipotent mesenchymal stem cells (MSCs). Our study is aimed at elucidating the influence of genetically manipulating Ca2+ release-activated Ca2+ (CRAC) channel-mediated intercel...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2019/7510214
更新日期:2019-02-17 00:00:00
abstract::Mesothelin (MSLN) is a 40-kDa cell differentiation-associated glycoprotein appearing with carcinogenesis and is highly expressed in many human cancers, including the majority of pancreatic adenocarcinomas, ovarian cancers, and mesotheliomas, while its expression in normal tissue is limited to mesothelial cells lining ...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2015/268172
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Systemic lupus erythematosus (SLE) is a multisystem disease that is characterized by the appearance of serum autoantibodies. No effective treatment for SLE currently exists. METHODS:We used human umbilical cord mesenchymal stem cell (H-UC-MSC) transplantation to treat B6.Fas mice. RESULTS:After four rounds...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2014/530501
更新日期:2014-01-01 00:00:00
abstract:Background:Psoriasis is a chronic systemic inflammatory disease associated with a wide range of comorbidities, including metabolic syndrome (MetS). Serum calprotectin, ANGPTL8, and oxidative damage to nucleic acids might be associated with both diseases. The presented study describes the influence of psoriasis and MetS...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2020/7352637
更新日期:2020-05-20 00:00:00
abstract:Introduction:Understanding the mechanisms underlying the pathogenesis of Sjögren's syndrome (SS) is crucially important in order to be able to discriminate the steps that lead to B cell transformation and promptly identify the patients at risk of lymphomagenesis. The aim of this narrative review is to describe the evid...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2019/8567364
更新日期:2019-01-06 00:00:00
abstract::Diabetic nephropathy (DN) is one of the most serious chronic kidney diseases and the major cause of end-stage renal failure worldwide. The underlying mechanisms of DN are complex and required to be further investigated. Both innate immunity and renin-angiotensin system (RAS) play critical roles in the pathogenesis of ...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2020/6193407
更新日期:2020-04-30 00:00:00
abstract::Leptospirosis is considered a neglected disease with an estimated more than one million cases every year. Since rodents are at the same time the main reservoir and generally asymptomatic to Leptospira infection, understanding why some animal species are resistant and others are susceptible to this infection would shed...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2019/1892508
更新日期:2019-10-07 00:00:00
abstract::The predominant distribution of γ δ T cells in the mucosal and epithelial tissues makes these unconventional lymphocytes the "guards" to contact external environment (like allergens) and to contribute to immune surveillance, as well as "vanguards" to participate in initiating mucosal inflammation. Therefore, γ δ T cel...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2014/963484
更新日期:2014-01-01 00:00:00