Abstract:
:Neuropathic pain (NPP) is intolerable, persistent, and specific type of long-term pain. It is considered to be a direct consequence of pathological changes affecting the somatosensory system and can be debilitating for affected patients. Despite recent progress and growing interest in understanding the pathogenesis of the disease, NPP still presents a major diagnostic and therapeutic challenge. High mobility group box 1 (HMGB1) mediates inflammatory and immune reactions in nervous system and emerging evidence reveals that HMGB1 plays an essential role in neuroinflammation through receptors such as Toll-like receptors (TLR), receptor for advanced glycation end products (RAGE), C-X-X motif chemokines receptor 4 (CXCR4), and N-methyl-D-aspartate (NMDA) receptor. In this review, we present evidence from studies that address the role of HMGB1 in NPP. First, we review studies aimed at determining the role of HMGB1 in NPP and discuss the possible mechanisms underlying HMGB1-mediated NPP progression where receptors for HMGB1 are involved. Then we review studies that address HMGB1 as a potential therapeutic target for NPP.
journal_name
J Immunol Resjournal_title
Journal of immunology researchauthors
Wan W,Cao L,Khanabdali R,Kalionis B,Tai X,Xia Sdoi
10.1155/2016/6430423subject
Has Abstractpub_date
2016-01-01 00:00:00pages
6430423eissn
2314-8861issn
2314-7156journal_volume
2016pub_type
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doi:10.1155/2018/6413012
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doi:10.1155/2017/9786972
更新日期:2017-01-01 00:00:00
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journal_title:Journal of immunology research
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更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2018-12-13 00:00:00