Abstract:
:The benefits of garlic to health have been proclaimed for centuries; however, only recently have Allium sativum and its derivatives been proposed as promising candidates for maintaining the homeostasis of the immune system. The complex biochemistry of garlic makes it possible for variations in processing to yield different preparations with differences in final composition and compound proportion. In this review, we assess the most recent experimental results, which indicate that garlic appears to enhance the functioning of the immune system by stimulating certain cell types, such as macrophages, lymphocytes, natural killer (NK) cells, dendritic cells, and eosinophils, by mechanisms including modulation of cytokine secretion, immunoglobulin production, phagocytosis, and macrophage activation. Finally, because immune dysfunction plays an important role in the development and progress of several diseases, we critically examined immunoregulation by garlic extracts and compounds isolated, which can contribute to the treatment and prevention of pathologies such as obesity, metabolic syndrome, cardiovascular disorders, gastric ulcer, and even cancer. We concluded that A. sativum modulates cytokine secretion and that such modulation may provide a mechanism of action for many of their therapeutic effects.
journal_name
J Immunol Resjournal_title
Journal of immunology researchauthors
Arreola R,Quintero-Fabián S,López-Roa RI,Flores-Gutiérrez EO,Reyes-Grajeda JP,Carrera-Quintanar L,Ortuño-Sahagún Ddoi
10.1155/2015/401630subject
Has Abstractpub_date
2015-01-01 00:00:00pages
401630eissn
2314-8861issn
2314-7156journal_volume
2015pub_type
杂志文章,评审abstract::C-type lectin receptors (CLRs) on antigen-presenting cells (APCs) facilitate uptake of carbohydrate antigens for antigen presentation, modulating the immune response in infection, homeostasis, autoimmunity, allergy, and cancer. In this review, we focus on the role of the macrophage galactose type C-type lectin (MGL) i...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
abstract::Multiepitope peptide vaccine has some advantages over traditional recombinant protein vaccine due to its easy and fast production and possible inclusion of multiple protective epitopes of pathogens. However, it is usually poorly immunogenic and needs to conjugate to a large carrier protein. Peptides conjugated to a ce...
journal_title:Journal of immunology research
pub_type: 杂志文章
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更新日期:2020-01-08 00:00:00
abstract::Bronchopulmonary dysplasia (BPD) is a severe complication of the respiratory system associated with preterm birth. Type 2 innate lymphoid cells (ILC2s) play a major role in tissue homeostasis, inflammation, and wound healing. However, the role in BPD remains unclear. The present study showed that ILC2s, interleukin-4 ...
journal_title:Journal of immunology research
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更新日期:2020-10-31 00:00:00
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journal_title:Journal of immunology research
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journal_title:Journal of immunology research
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更新日期:2019-10-07 00:00:00
abstract::Rheumatoid arthritis (RA) is an inflammatory autoimmune disorder; abnormal T cell immunity plays a critical role in the development of RA. Recently, A20 was identified as a key negative regulator for T cell activation and inflammatory signaling and may be involved in RA pathogenesis. In this study, we analyzed the exp...
journal_title:Journal of immunology research
pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
abstract:Objective:To evaluate the efficacy and safety of rituximab in multiple sclerosis in a clinical practice setting. Methods:Clinical data for all adult patients with multiple sclerosis (MS) treated with off-label rituximab at a single MS center in Lebanon between March 2008 and April 2017 were retrospectively collected f...
journal_title:Journal of immunology research
pub_type: 杂志文章
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更新日期:2018-11-12 00:00:00
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journal_title:Journal of immunology research
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doi:10.1155/2018/3861079
更新日期:2018-07-10 00:00:00
abstract::Intestinal inflammation is a harmful condition in fish that can be triggered by the ingestion of soybean meal. Due to the positive costs-benefits ratio of including soybean meal in farmed fish diets, identifying additives with intestinal anti-inflammatory effects could contribute to solving the issues caused by this p...
journal_title:Journal of immunology research
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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更新日期:2019-01-06 00:00:00
abstract::Reconstitution of the hematopoietic system during immune responses and immunological and neoplastic diseases or upon transplantation depends on the emergent differentiation of hematopoietic stem/progenitor cells within the bone marrow. Although in the last decade the use of dialyzable leukocyte extracts (DLE) as suppo...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2016/4097642
更新日期:2016-01-01 00:00:00
abstract::Amiselimod (MT-1303) is a novel and selective sphingosine 1-phosphate receptor-1 (S1P1) modulator with a more favorable cardiac safety profile than other S1P1 receptor modulators. In this study, we evaluated the effects of MT-1303 on the progression of lupus nephritis in two well-known murine systemic lupus erythemato...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2019/5821589
更新日期:2019-12-23 00:00:00
abstract::Chagas disease, or American trypanosomiasis, which is caused by the protozoan parasite Trypanosoma cruzi, is primarily a vector disease endemic in 21 Latin American countries, including Mexico. Although many vector control programs have been implemented, T. cruzi has not been eradicated. The development of an anti-T. ...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2015/376197
更新日期:2015-01-01 00:00:00
abstract::Epidemiological studies have demonstrated that interleukin-10 (IL-10) polymorphisms may be associated with the development of Behcet's disease (BD). However, the published results were inconsistent. Therefore, this meta-analysis was conducted to derive a more precise relationship between IL-10 polymorphisms and BD sus...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2020/9382609
更新日期:2020-06-19 00:00:00
abstract::Neuropathic pain (NPP) is intolerable, persistent, and specific type of long-term pain. It is considered to be a direct consequence of pathological changes affecting the somatosensory system and can be debilitating for affected patients. Despite recent progress and growing interest in understanding the pathogenesis of...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2016/6430423
更新日期:2016-01-01 00:00:00
abstract::A myriad of pathogens gain access to the host via the mucosal route; thus, vaccinations that protect against mucosal pathogens are critical. Pathogens such as HIV, HSV, and influenza enter the host at mucosal sites such as the intestinal, urogenital, and respiratory tracts. All currently licensed vaccines mediate prot...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2018/3734207
更新日期:2018-12-13 00:00:00
abstract::Type I interferon (IFN-I) plays a critical role in the antitumor immune response. In our previous study, we showed that IFN-I-inducible 2'-5' oligoadenylate synthetase-like 1 (OASL1) negatively regulated IFN-I production upon tumor challenge similar to that of viral infection. Thus, OASL1-deficient (Oasl1-/-) mice wer...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2019/7596786
更新日期:2019-03-31 00:00:00
abstract::Considerable shortages in the supply of available organs continue to plague the field of solid organ transplantation. Despite changes in allocation, as well as the utilization of extended criteria and living donors, the number of patients waiting for organs continues to grow at an alarming pace. Xenotransplantation, c...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2018/6413012
更新日期:2018-03-04 00:00:00
abstract::Antiphospholipid syndrome (APS) is characterized by development of venous and/or arterial thrombosis and pregnancy morbidity. Biological criteria are the persistent presence of lupus anticoagulant (LA) and/or anti-cardiolipin (aCL) and/or anti-B2GP1 autoantibodies' positivity. The assays' performances are of crucial i...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2015/983094
更新日期:2015-01-01 00:00:00
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journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2015/931574
更新日期:2015-01-01 00:00:00
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journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2016/6530436
更新日期:2016-01-01 00:00:00
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journal_title:Journal of immunology research
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更新日期:2019-04-16 00:00:00
abstract::Regulatory T cells (Treg) can show plasticity whereby FOXP3 expression, the master transcription factor for Treg suppressor function, is lost and proinflammatory cytokines are produced. Optimal FOXP3 expression strongly depends on hypomethylation of the FOXP3 gene. 5-Azacytidine (Aza) and its derivative 5-aza-2'-deoxy...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2018/4973964
更新日期:2018-04-15 00:00:00
abstract::Inflammation plays an essential role in the control of pathogens and in shaping the ensuing adaptive immune responses. Traditionally, innate immunity has been described as a rapid response triggered through generic and nonspecific means that by definition lacks the ability to remember. Recently, it has become clear th...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2018/1467538
更新日期:2018-06-11 00:00:00
abstract::C-type lectin domain family 5-member A (CLEC5A) associates with adaptor DAP12 (DNAX activation protein 12) to form receptor complexes involved in inflammatory responses. We postulated a potential role of CLEC5A in the pathogenesis of adult-onset Still's disease (AOSD) and aimed to investigate CLEC5A expression and its...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2020/9473497
更新日期:2020-04-23 00:00:00
abstract::Bone is sensitive to overactive immune responses, which initiate the onset of inflammatory bone disorders, such as rheumatoid arthritis and periodontitis, resulting in a significant systemic inflammatory response. On the other hand, neuroinflammation is strongly implicated in Alzheimer's disease (AD), which can be enh...
journal_title:Journal of immunology research
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更新日期:2015-01-01 00:00:00
abstract::Cutaneous adverse drug reactions are commonly seen in patients with anticancer drug treatment. Anticancer drugs, including chemotherapy, target therapy, and recent immunotherapy causing skin reactions ranging from mild skin rash to life-threatening severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson sy...
journal_title:Journal of immunology research
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更新日期:2018-01-17 00:00:00
abstract::Propionibacterium acnes (P. acnes) is a gram-positive anaerobic bacillus present in normal human skin microbiota, which exerts important immunomodulatory effects, when used as heat- or phenol-killed suspensions. We previously demonstrated that heat-killed P. acnes or its soluble polysaccharide (PS), extracted from the...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2015/132083
更新日期:2015-01-01 00:00:00
abstract:Background and Objectives:Pneumocystis pneumonia (PCP) is a common opportunistic infection in acquired immune deficiency syndrome (AIDS) patients that continues to result in a high mortality rate. To develop a better treatment strategy and improve PCP prognosis, a cohort study was conducted to evaluate the therapeutic ...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2019/8105075
更新日期:2019-12-01 00:00:00