Abstract:
:Therapeutic monoclonal antibodies (mAbs) represent a milestone in pharmacological development. Their superiority is based on the combination of high specificity, low toxicity, and long half-life that characterizes biologics. If biologics have Achilles' heel, it is their potential immunogenicity. To better understand the impact of the size of immune complexes of mAbs on anti-drug antibody (ADA) dependent adverse reactions in Macaca fascicularis, we developed an efficient high-throughput size exclusion chromatography- (SEC-) based methodology that enables analysis of the size, size distribution, and ratio of free and ADA-complexed mAb in serum allowing for assessment of formation and clearance of circulating ADA-mAb immune complexes (CIC).
journal_name
J Immunol Resjournal_title
Journal of immunology researchauthors
Boysen M,Schlicksupp L,Dreher I,Loebbert R,Richter Mdoi
10.1155/2016/9096059subject
Has Abstractpub_date
2016-01-01 00:00:00pages
9096059eissn
2314-8861issn
2314-7156journal_volume
2016pub_type
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