Abstract:
:Pancreatic ductal adenocarcinoma (PDAC) remains one of the most devastating cancer types despite the improvement of modern medicine. In our present study, we found that dickkopf-related protein 2 (DKK2) shares a higher expression in PDAC compared with adjacent pancreas tissue in tissue microarray. In addition, an elevated expression of DKK2 predicts poorer prognosis of patients and positively correlated with poor tumor differentiation. Multivariate Cox regression analysis was also performed and confirmed that the expression of DKK2 is an independent prognostic factor in PDAC. A high expression of DKK2 correlates with cell migration and epithelial mesenchymal transition based on gene set enrichment analysis (GSEA) while knockdown of DKK2 in PDAC cells resulted in impaired cellular migration. Furthermore, GSEA predicts negative correlation between tumor immunity invasion and DKK2 expression. We then confirmed these results and demonstrated that a higher expression of DKK2 imparts the recruitment of CD8+ T cells. Our work suggested that DKK2 imparts tumor immune evasion and is associated with poor prognosis in pancreatic ductal adenocarcinoma.
journal_name
J Immunol Resjournal_title
Journal of immunology researchauthors
Yang J,Jiang Y,He R,Liu W,Yang M,Tao L,Fu X,Shen Y,Li J,Liu D,Huo Y,Zhang J,Hua R,Zhang Z,Sun Ydoi
10.1155/2019/8656282subject
Has Abstractpub_date
2019-09-08 00:00:00pages
8656282eissn
2314-8861issn
2314-7156journal_volume
2019pub_type
杂志文章abstract::C-type lectin domain family 5-member A (CLEC5A) associates with adaptor DAP12 (DNAX activation protein 12) to form receptor complexes involved in inflammatory responses. We postulated a potential role of CLEC5A in the pathogenesis of adult-onset Still's disease (AOSD) and aimed to investigate CLEC5A expression and its...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2020/9473497
更新日期:2020-04-23 00:00:00
abstract::Objective. It has been shown that podocyte injury represents an important pathological basis that contributes to proteinuria and eventually leads to kidney failure. High glucose (HG) activates macrophage polarization, further exacerbating HG-induced podocyte injury. Our previous study on diabetic nephropathy rats indi...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2020/8263598
更新日期:2020-08-27 00:00:00
abstract::We assessed the immune response against recombinant proteins of two related, albeit functionally different, peroxidoxins from Leishmania donovani: peroxidoxin 1 (LdPxn1) and peroxidoxin 2 (LdPxn2) in BALB/c mice. We also evaluated the effect of coadministration of TLR agonists (CpG ODN and GLA-SE) on the antigen-speci...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2015/348401
更新日期:2015-01-01 00:00:00
abstract::Ischemia/reperfusion injury (IRI) remains a major problem in organ transplantation, which represents the main cause of graft dysfunction posttransplantation. Hepatic IRI is characterized by an excessive inflammatory response within the liver. Mesenchymal stem cells (MSCs) have been shown to be immunomodulatory cells a...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2018/7283703
更新日期:2018-12-03 00:00:00
abstract::The benefits of garlic to health have been proclaimed for centuries; however, only recently have Allium sativum and its derivatives been proposed as promising candidates for maintaining the homeostasis of the immune system. The complex biochemistry of garlic makes it possible for variations in processing to yield diff...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2015/401630
更新日期:2015-01-01 00:00:00
abstract::Calcium is a ubiquitous intracellular messenger that has a crucial role in determining the proliferation, differentiation, and functions of multipotent mesenchymal stem cells (MSCs). Our study is aimed at elucidating the influence of genetically manipulating Ca2+ release-activated Ca2+ (CRAC) channel-mediated intercel...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2019/7510214
更新日期:2019-02-17 00:00:00
abstract::Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are life-threatening disease. However, there are only few epidemiologic studies of SJS/TEN from China. To analyze the clinical characteristics, causality, and outcome of treatment for SJS/TEN in China, we reviewed case reports of patients with SJS/TEN f...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2018/4320195
更新日期:2018-02-11 00:00:00
abstract::In vitro differentiation of mesenchymal stromal cells (MSC) into osteocytes (human differentiated osteogenic cells, hDOC) before implantation has been proposed to optimize bone regeneration. However, a deep characterization of the immunological properties of DOC, including their effect on dendritic cell (DC) function,...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2015/526195
更新日期:2015-01-01 00:00:00
abstract::The gastrointestinal microbiota plays a critical role in nutritional, metabolic, and immune functions in infants and young children and has implications for future lung health status. Understanding the role of intestinal dysbiosis in chronic lung disease progression will provide opportunities to design early intervent...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2017/8450496
更新日期:2017-01-01 00:00:00
abstract::Chloroquine (CQ) and hydroxychloroquine (HCQ) are derivatives of 4-aminoquinoline compounds with over 60 years of safe clinical usage. CQ and HCQ are able to inhibit the production of cytokines such as interleukin- (IL-) 1, IL-2, IL-6, IL-17, and IL-22. Also, CQ and HCQ inhibit the production of interferon- (IFN-) α a...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2020/4582612
更新日期:2020-09-25 00:00:00
abstract::The phenotype and functional properties of antigen-presenting cells (APC), that is, circulating monocytes and generated in vitro macrophages and dendritic cells, were investigated in the patients with pulmonary tuberculosis (TB) differing in lymphocyte reactivity to M. tuberculosis antigens (PPD-reactive versus PPD-an...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2015/793292
更新日期:2015-01-01 00:00:00
abstract:Background and Objectives:Pneumocystis pneumonia (PCP) is a common opportunistic infection in acquired immune deficiency syndrome (AIDS) patients that continues to result in a high mortality rate. To develop a better treatment strategy and improve PCP prognosis, a cohort study was conducted to evaluate the therapeutic ...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2019/8105075
更新日期:2019-12-01 00:00:00
abstract::RANKL (receptor activator of nuclear factor kappa-β ligand) and OPG (osteoprotegerin) are two proteins involved in bone remodelling. During the active phase of periodontal disease, an imbalance between the ratios of the two elements can be noticed. While the expression of RANKL is elevated compared with that of OPG, t...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2019/6195258
更新日期:2019-04-28 00:00:00
abstract::Multiepitope peptide vaccine has some advantages over traditional recombinant protein vaccine due to its easy and fast production and possible inclusion of multiple protective epitopes of pathogens. However, it is usually poorly immunogenic and needs to conjugate to a large carrier protein. Peptides conjugated to a ce...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2020/2074803
更新日期:2020-01-08 00:00:00
abstract::Anti-CD3 antibody has been employed for various immune-mediated disorders. However, whether anti-CD3 administration leads to rapid metabolic alternation has not been well investigated. In the current study, we studied how anti-CD3 treatment affected blood glucose levels in mice. We found that anti-CD3 treatment induce...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2014/326708
更新日期:2014-01-01 00:00:00
abstract::Diabetes mellitus, a metabolic disease characterized by hyperglycemia and poor glucose control, is a risk factor for Mycobacterium tuberculosis (M. tuberculosis) infection and the development of active tuberculosis. To evaluate whether M. tuberculosis infection susceptibility is associated with an intrinsic factor in ...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2019/1462098
更新日期:2019-11-14 00:00:00
abstract::Mesothelin (MSLN) is a 40-kDa cell differentiation-associated glycoprotein appearing with carcinogenesis and is highly expressed in many human cancers, including the majority of pancreatic adenocarcinomas, ovarian cancers, and mesotheliomas, while its expression in normal tissue is limited to mesothelial cells lining ...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2015/268172
更新日期:2015-01-01 00:00:00
abstract::Bronchopulmonary dysplasia (BPD) is a severe complication of the respiratory system associated with preterm birth. Type 2 innate lymphoid cells (ILC2s) play a major role in tissue homeostasis, inflammation, and wound healing. However, the role in BPD remains unclear. The present study showed that ILC2s, interleukin-4 ...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2020/8050186
更新日期:2020-10-31 00:00:00
abstract:Objective:This study aimed to investigate the correlation of CD4+/PD-1+ or CD4+/PD-1- tumor-infiltrating lymphocytes with pathological characteristics in breast cancer patients. Methods:A cross-sectional study consecutively recruited 133 patients with invasive ductal breast cancer. The expression of CD4, programmed ce...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2018/5690258
更新日期:2018-07-04 00:00:00
abstract::We investigated the characteristics of Chinese SLE patients by analyzing the association between specific autoantibodies and clinical manifestations of 2104 SLE patients from registry data of CSTAR cohort. Significant (P<0.05) associations were found between anti-Sm antibody, anti-rRNP antibody, and malar rash; betwee...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2014/809389
更新日期:2014-01-01 00:00:00
abstract::We evaluated the association between anti-cyclic citrullinated peptide antibodies (anti-CCP) and anti-mutated citrullinated vimentin antibodies (anti-MCV) with the presence of extra-articular (ExRA) manifestations in 225 patients with rheumatoid arthritis (RA). Ninety-five patients had ExRA and 130 had no ExRA. There ...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2014/536050
更新日期:2014-01-01 00:00:00
abstract::HLA-G has a relevant role in immune response regulation. The overall structure of the HLA-G coding region has been maintained during the evolution process, in which most of its variable sites are synonymous mutations or coincide with introns, preserving major functional HLA-G properties. The HLA-G promoter region is d...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2014/734068
更新日期:2014-01-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a disease of chronic systemic inflammation (SI). In the present study, we used four datasets to explore whether methylation-derived neutrophil-to-lymphocyte ratio (mdNLR) might be a marker of SI in new onset, untreated, and treated prevalent RA cases and/or a marker of treatment response t...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2018/2624981
更新日期:2018-08-14 00:00:00
abstract:Background:Monocytic myeloid-derived suppressor cells (M-MDSCs) characterized with the phenotype of CD14+HLA-DRlow/- have attracted a lot of attention in the field of human tumor immunology. However, little is known about the roles of M-MDSCs in acute myeloid leukemia (AML) as opposed to their multiple roles in solid t...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2020/7363084
更新日期:2020-12-21 00:00:00
abstract::Mast cells are unique tissue-resident immune cells that secrete a diverse array of biologically active compounds that can stimulate, modulate, or suppress the immune response. Although mounting evidence supports that mast cells are consistently infiltrating tumors, their role as either a driving or an opposite force f...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2018/2584243
更新日期:2018-02-05 00:00:00
abstract::Sepsis has become a major health economic issue, with more patients dying in hospitals due to sepsis related complications compared to breast and colorectal cancer together. Despite extensive research in order to improve outcome in sepsis over the last few decades, results of large multicenter studies were by-and-larg...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2015/510436
更新日期:2015-01-01 00:00:00
abstract::Although it is known that systemic form of lupus erythematosus (LE) and metabolic syndrome (MetS) are frequently observed together, there are no published reports on MetS in patients with skin-restricted LE. We aimed to compare the frequencies of MetS and its components in discoid LE (DLE) with the non-DLE control gro...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2017/3972706
更新日期:2017-01-01 00:00:00
abstract::An important function of the immune system is its ability to differentiate between healthy cells in the organism and "foreign" cells, allowing the latest to be attacked and the first ones to be conserved. The most important molecules in this process are considered to be checkpoint inhibitors. This review is focused on...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2018/4625472
更新日期:2018-10-17 00:00:00
abstract::Pregnancy is an immunological enigma where paternal antigens are present at the fetomaternal interface. What regulates the local immunotolerance, which is necessary to prevent rejection of the conceptus, is still under strong investigation. Gamma/delta T cells are believed to play a role in the local regulation of thi...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2019/3836942
更新日期:2019-05-20 00:00:00
abstract::Diabetic nephropathy (DN) is one of the most serious chronic kidney diseases and the major cause of end-stage renal failure worldwide. The underlying mechanisms of DN are complex and required to be further investigated. Both innate immunity and renin-angiotensin system (RAS) play critical roles in the pathogenesis of ...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2020/6193407
更新日期:2020-04-30 00:00:00