The Interplay of Renin-Angiotensin System and Toll-Like Receptor 4 in the Inflammation of Diabetic Nephropathy.

abstract：:A derivative formula, DGBX, which is composed of three herbs (Radix astragali, Radix Angelicae sinensis, and Coptis chinensis Franch), is derived from a famous Chinese herbal formula, Danggui Buxue Tang (DBT) (Radix astragali and Radix Angelicae sinensis). We aimed to investigate the effects of DGBX on the regulation ...

journal_title：Journal of immunology research

authors： Zhou J,Li X,Deng P,Wei Y,Liu J,Chen M,Xu Y,Zhang D,Zhu L,Lou L,Dong B,Jin Q,Chai L

更新日期：2017-01-01 00:00:00

abstract：:TACI is a membrane receptor of BAFF and APRIL, contributing to the differentiation and survival of normal B cells. Although malignant B cells are also subjected on TACI signaling, there is a remarkable intradisease and interindividual variability of TACI expression in B-cell malignancies. The aim of our study was to e...

journal_title：Journal of immunology research

authors： Mamara A,Germenis AE,Kompoti M,Palassopoulou M,Mandala E,Banti A,Giannakoulas N,Speletas M

更新日期：2015-01-01 00:00:00

abstract：:Neuropathic pain (NPP) is intolerable, persistent, and specific type of long-term pain. It is considered to be a direct consequence of pathological changes affecting the somatosensory system and can be debilitating for affected patients. Despite recent progress and growing interest in understanding the pathogenesis of...

journal_title：Journal of immunology research

authors： Wan W,Cao L,Khanabdali R,Kalionis B,Tai X,Xia S

更新日期：2016-01-01 00:00:00

abstract：:We evaluated the association between anti-cyclic citrullinated peptide antibodies (anti-CCP) and anti-mutated citrullinated vimentin antibodies (anti-MCV) with the presence of extra-articular (ExRA) manifestations in 225 patients with rheumatoid arthritis (RA). Ninety-five patients had ExRA and 130 had no ExRA. There ...

journal_title：Journal of immunology research

authors： Gonzalez-Lopez L,Rocha-Muñoz AD,Ponce-Guarneros M,Flores-Chavez A,Salazar-Paramo M,Nava A,Cardona-Muñoz EG,Fajardo-Robledo NS,Zavaleta-Muñiz SA,Garcia-Cobian T,Gamez-Nava JI

更新日期：2014-01-01 00:00:00

abstract：:C-type lectin receptors (CLRs) on antigen-presenting cells (APCs) facilitate uptake of carbohydrate antigens for antigen presentation, modulating the immune response in infection, homeostasis, autoimmunity, allergy, and cancer. In this review, we focus on the role of the macrophage galactose type C-type lectin (MGL) i...

journal_title：Journal of immunology research

authors： Zizzari IG,Napoletano C,Battisti F,Rahimi H,Caponnetto S,Pierelli L,Nuti M,Rughetti A

更新日期：2015-01-01 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP) is a mediator of microglial activation at the transcriptional level. The involvement of the epigenetic mechanism in this process is largely undefined. Histone deacetylase (HDAC)1/2 are considered important epigenetic regulators of gene expression in activated microglia. In this s...

journal_title：Journal of immunology research

authors： Guo X,Chen D,An S,Wang Z

更新日期：2020-08-04 00:00:00

abstract：:Pregnancy is an immunological enigma where paternal antigens are present at the fetomaternal interface. What regulates the local immunotolerance, which is necessary to prevent rejection of the conceptus, is still under strong investigation. Gamma/delta T cells are believed to play a role in the local regulation of thi...

journal_title：Journal of immunology research

authors： Nörenberg J,Meggyes M,Jakso P,Miko E,Barakonyi A

更新日期：2019-05-20 00:00:00

abstract：:The aim of this paper is to determine the modulatory effects of Lactobacillus acidophilus on the IL-23/Th17 immune axis in experimental colitis. DSS-induced mouse models of UC were to be saline, hormones, and different concentrations of Lactobacillus acidophilus intervention. The expression of interleukin- (IL-) 17, t...

journal_title：Journal of immunology research

authors： Chen L,Zou Y,Peng J,Lu F,Yin Y,Li F,Yang J

更新日期：2015-01-01 00:00:00

abstract：:Ischemia/reperfusion injury (IRI) remains a major problem in organ transplantation, which represents the main cause of graft dysfunction posttransplantation. Hepatic IRI is characterized by an excessive inflammatory response within the liver. Mesenchymal stem cells (MSCs) have been shown to be immunomodulatory cells a...

journal_title：Journal of immunology research

authors： Li S,Zheng X,Li H,Zheng J,Chen X,Liu W,Tai Y,Zhang Y,Wang G,Yang Y

更新日期：2018-12-03 00:00:00

abstract：:Although it is known that systemic form of lupus erythematosus (LE) and metabolic syndrome (MetS) are frequently observed together, there are no published reports on MetS in patients with skin-restricted LE. We aimed to compare the frequencies of MetS and its components in discoid LE (DLE) with the non-DLE control gro...

journal_title：Journal of immunology research

authors： Akarsu S,Ozbagcivan O,Semiz F,Aktan S

更新日期：2017-01-01 00:00:00

abstract：:Reduning injection is a traditional Chinese medicine injection which has multiple functions such as clearing heat, dispelling wind, and detoxification. Although Reduning injection was widely utilized, reports of its allergenicity emerged one after another. However, there is little research on its allergenic substances...

journal_title：Journal of immunology research

authors： Wang F,Li CY,Zheng YF,Li HY,Xiao W,Peng GP

更新日期：2016-01-01 00:00:00

abstract：:Extracellular matrix metalloproteases and the fibrinolytic system are important protease systems interacting with each other in charge of remodeling and recycling of tissues. Their role in tumor invasion and metastasis is often discussed. In this study several metalloproteases such as MMP-1, MMP-3, MMP-9, and TIMP-1 t...

journal_title：Journal of immunology research

authors： Barajas-Castañeda LM,Cortés-Gutiérrez E,García-Rodríguez FM,Campos-Rodríguez R,Lara-Padilla E,Enríquez-Rincón F,Castro-Mussot ME,Figueroa-Arredondo P

更新日期：2016-01-01 00:00:00

abstract：:Gram-negative bacterial sepsis accounts for up to 50% worldwide sepsis that causes hospital mortality. Acute kidney injury (AKI), a common complication of Gram-negative bacterial sepsis, is caused by Toll-like receptor 4 (TLR4) activation. Lipopolysaccharide (LPS) is an endotoxin in Gram-negative bacteria and is recog...

journal_title：Journal of immunology research

authors： Li Q,Wu C,Liu Z,Zhang H,Du Y,Liu Y,Song K,Shi Q,Li R

更新日期：2019-02-19 00:00:00

abstract：:Bone disease in rheumatoid arthritis (RA) is a complex phenomenon where genetic risk factors have been partially evaluated. The system formed by receptor activator for nuclear factor-κB (RANK), receptor activator for nuclear factor-κB ligand (RANKL), and osteoprotegerin (OPG): RANK/RANKL/OPG is a crucial molecular pat...

journal_title：Journal of immunology research

authors： Zavala-Cerna MG,Moran-Moguel MC,Cornejo-Toledo JA,Gonzalez-Montoya NG,Sanchez-Corona J,Salazar-Paramo M,Nava-Zavala AH,Aguilar-Chavez EA,Alcaraz-Lopez MF,Gonzalez-Sanchez AG,Gonzalez-Lopez L,Gamez-Nava JI

更新日期：2015-01-01 00:00:00

abstract：:We investigated the characteristics of Chinese SLE patients by analyzing the association between specific autoantibodies and clinical manifestations of 2104 SLE patients from registry data of CSTAR cohort. Significant (P<0.05) associations were found between anti-Sm antibody, anti-rRNP antibody, and malar rash; betwee...

journal_title：Journal of immunology research

authors： Li J,Leng X,Li Z,Ye Z,Li C,Li X,Zhu P,Wang Z,Zheng Y,Li X,Zhang M,Tian XP,Li M,Zhao J,Zhang FC,Zhao Y,Zeng X

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Systemic lupus erythematosus (SLE) is a multisystem disease that is characterized by the appearance of serum autoantibodies. No effective treatment for SLE currently exists. METHODS:We used human umbilical cord mesenchymal stem cell (H-UC-MSC) transplantation to treat B6.Fas mice. RESULTS:After four rounds...

journal_title：Journal of immunology research

authors： Ruan GP,Yao X,Yang SJ,Wang JX,Shu F,Li ZA,Liu JF,Pang RQ,Pan XH

更新日期：2014-01-01 00:00:00

abstract：Background:Diagnostic criteria for Sjögren's syndrome (SS) are continually being updated in pursuit of more precise and earlier diagnosis to prevent its complications. Owing to the high rate of false negative traditional serological markers, the need for better serological testing remains. Objective:To investigate the...

journal_title：Journal of immunology research

authors： Karakus S,Baer AN,Akpek EK

更新日期：2019-01-13 00:00:00

abstract：:Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are life-threatening disease. However, there are only few epidemiologic studies of SJS/TEN from China. To analyze the clinical characteristics, causality, and outcome of treatment for SJS/TEN in China, we reviewed case reports of patients with SJS/TEN f...

journal_title：Journal of immunology research

authors： Yang SC,Hu S,Zhang SZ,Huang JW,Zhang J,Ji C,Cheng B

更新日期：2018-02-11 00:00:00

abstract：:We investigated cytokine production and expression of degranulation marker CD107a after different strategies of hepatitis B virus (HBV) vaccination in human immunodeficiency virus-infected individuals, which were three doses of 20 μg (standard dose group), four doses of 20 μg (four doses group), or four doses of 40 μg...

journal_title：Journal of immunology research

authors： Chawansuntati K,Chaiklang K,Chaiwarith R,Praparattanapan J,Supparatpinyo K,Wipasa J

更新日期：2018-02-27 00:00:00

abstract：Background and Aim:The presumed role of the inhibitory receptor LAIR-1 (CD305) in the inflammatory response suggests that it might contribute to the pathophysiology of chronic inflammatory diseases such as liver cirrhosis. We studied the LAIR-1 expression on liver macrophages and blood monocytes related to the progress...

journal_title：Journal of immunology research

authors： Martínez-Esparza M,Ruiz-Alcaraz AJ,Carmona-Martínez V,Fernández-Fernández MD,Antón G,Muñoz-Tornero M,Lencina M,Pagán I,de la Peña J,García-Peñarrubia P

更新日期：2019-03-24 00:00:00

abstract：Objectives:Both thymic stromal lymphopoietin (TSLP) and dendritic cells (DCs) are involved in many autoimmune diseases, but the potential roles of TSLP and DCs in bullous pemphigoid (BP) have not been clarified. We sought to explore the contributions of TSLP and DCs in patients with BP. Methods:TSLP levels in sera and...

journal_title：Journal of immunology research

authors： Li SZ,Jin XX,Ge XL,Zuo YG,Jin HZ

更新日期：2020-09-24 00:00:00

abstract：:Inflammation plays an essential role in the control of pathogens and in shaping the ensuing adaptive immune responses. Traditionally, innate immunity has been described as a rapid response triggered through generic and nonspecific means that by definition lacks the ability to remember. Recently, it has become clear th...

journal_title：Journal of immunology research

authors： Cronkite DA,Strutt TM

更新日期：2018-06-11 00:00:00

abstract：:Therapeutic monoclonal antibodies (mAbs) represent a milestone in pharmacological development. Their superiority is based on the combination of high specificity, low toxicity, and long half-life that characterizes biologics. If biologics have Achilles' heel, it is their potential immunogenicity. To better understand t...

journal_title：Journal of immunology research

authors： Boysen M,Schlicksupp L,Dreher I,Loebbert R,Richter M

更新日期：2016-01-01 00:00:00

abstract：:Severe aplastic anemia (SAA) is a rare disease characterized by severe pancytopenia and bone marrow failure. Most patients with AA respond to immunosuppressive therapy (IST), usually as antithymocyte globulin (ATG) and cyclosporine (CsA), but some relapse on CsA withdrawal or require long-term administration of CsA to...

journal_title：Journal of immunology research

authors： Ding S,Liang X,Zhang T,Fu R

更新日期：2020-10-17 00:00:00

abstract：Background and Objectives:Pneumocystis pneumonia (PCP) is a common opportunistic infection in acquired immune deficiency syndrome (AIDS) patients that continues to result in a high mortality rate. To develop a better treatment strategy and improve PCP prognosis, a cohort study was conducted to evaluate the therapeutic ...

journal_title：Journal of immunology research

authors： Wang M,Lang G,Chen Y,Hu C,Guo Y,Tao R,Dong X,Zhu B

更新日期：2019-12-01 00:00:00

abstract：Objective:Systemic lupus erythematosus (SLE) is an autoimmune systemic disease and its pathogenesis has not yet been completely clarified. Patients with SLE show a deranged lipid metabolism, which can contribute to the immunopathogenesis of the disease and to the accelerated atherosclerosis. Resolvin D1 (RvD1), a produ...

journal_title：Journal of immunology research

authors： Navarini L,Bisogno T,Margiotta DPE,Piccoli A,Angeletti S,Laudisio A,Ciccozzi M,Afeltra A,Maccarrone M

更新日期：2018-10-21 00:00:00

abstract：Objective:Rheumatoid arthritis (RA) multidrug resistance is associated with P-glycoprotein (P-gp) overexpression. We investigated the effects of methotrexate (MTX) alone and combined with 4-hydroperoxycyclophosphamide (4-HC) on P-gp expression in fibroblast-like synoviocytes (FLSs) from patients with RA and examined th...

journal_title：Journal of immunology research

authors： Qin K,Chen K,Zhao W,Zhao X,Luo J,Wang Q,Gao C,Li X,Wang C

更新日期：2018-02-18 00:00:00

abstract：:Vaccination against human papillomavirus (HPV) has been progressively implemented in most developed countries for approximately 10 years. In order to increase the protection of the vaccines, a 9-valent vaccine (HPV9) was developed, which provides protection against nine types of the virus. Studies evaluating its safet...

journal_title：Journal of immunology research

authors： Costa APF,Cobucci RNO,da Silva JM,da Costa Lima PH,Giraldo PC,Gonçalves AK

更新日期：2017-01-01 00:00:00

abstract：:The benefits of garlic to health have been proclaimed for centuries; however, only recently have Allium sativum and its derivatives been proposed as promising candidates for maintaining the homeostasis of the immune system. The complex biochemistry of garlic makes it possible for variations in processing to yield diff...

journal_title：Journal of immunology research

authors： Arreola R,Quintero-Fabián S,López-Roa RI,Flores-Gutiérrez EO,Reyes-Grajeda JP,Carrera-Quintanar L,Ortuño-Sahagún D

更新日期：2015-01-01 00:00:00

abstract：:Systemic lupus erythematosus is characterized by dysregulated activation of T and B cells and autoantibodies to nuclear antigens and, in some cases, lipid antigens. Liposomes with nonbilayer phospholipid arrangements induce a disease resembling human lupus in mice, including IgM and IgG antibodies against nonbilayer p...

journal_title：Journal of immunology research

authors： Wong-Baeza C,Tescucano A,Astudillo H,Reséndiz A,Landa C,España L,Serafín-López J,Estrada-García I,Estrada-Parra S,Flores-Romo L,Wong C,Baeza I

更新日期：2015-01-01 00:00:00