Amiselimod (MT-1303), a Novel Sphingosine 1-Phosphate Receptor-1 Modulator, Potently Inhibits the Progression of Lupus Nephritis in Two Murine SLE Models.

abstract：:Intestinal inflammation is a harmful condition in fish that can be triggered by the ingestion of soybean meal. Due to the positive costs-benefits ratio of including soybean meal in farmed fish diets, identifying additives with intestinal anti-inflammatory effects could contribute to solving the issues caused by this p...

journal_title：Journal of immunology research

authors： Ulloa PE,Solís CJ,De la Paz JF,Alaurent TG,Caruffo M,Hernández AJ,Dantagnan P,Feijóo CG

更新日期：2016-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a disease of chronic systemic inflammation (SI). In the present study, we used four datasets to explore whether methylation-derived neutrophil-to-lymphocyte ratio (mdNLR) might be a marker of SI in new onset, untreated, and treated prevalent RA cases and/or a marker of treatment response t...

journal_title：Journal of immunology research

authors： Ambatipudi S,Sharp GC,Clarke SLN,Plant D,Tobias JH,Evans DM,Barton A,Relton CL

更新日期：2018-08-14 00:00:00

abstract：:In vitro differentiation of mesenchymal stromal cells (MSC) into osteocytes (human differentiated osteogenic cells, hDOC) before implantation has been proposed to optimize bone regeneration. However, a deep characterization of the immunological properties of DOC, including their effect on dendritic cell (DC) function,...

journal_title：Journal of immunology research

authors： Trabanelli S,La Manna F,Romano M,Salvestrini V,Cavo M,Ciciarello M,Lemoli RM,Curti A

更新日期：2015-01-01 00:00:00

abstract：:Group A streptococcus (GAS) is known to cause a broad spectrum of illness, from pharyngitis and impetigo, to autoimmune sequelae such as rheumatic heart disease, and invasive diseases. It is a significant cause of infectious disease morbidity and mortality worldwide, but no efficacious vaccine is currently available. ...

journal_title：Journal of immunology research

authors： Tsoi SK,Smeesters PR,Frost HR,Licciardi P,Steer AC

更新日期：2015-01-01 00:00:00

abstract：:Dopamine (DA), a neurotransmitter in the central nervous system (CNS), has modulatory functions at the systemic level. The peripheral and central nervous systems have independent dopaminergic system (DAS) that share mechanisms and molecular machinery. In the past century, experimental evidence has accumulated on the p...

journal_title：Journal of immunology research

authors： Arreola R,Alvarez-Herrera S,Pérez-Sánchez G,Becerril-Villanueva E,Cruz-Fuentes C,Flores-Gutierrez EO,Garcés-Alvarez ME,de la Cruz-Aguilera DL,Medina-Rivero E,Hurtado-Alvarado G,Quintero-Fabián S,Pavón L

更新日期：2016-01-01 00:00:00

abstract：:An important function of the immune system is its ability to differentiate between healthy cells in the organism and "foreign" cells, allowing the latest to be attacked and the first ones to be conserved. The most important molecules in this process are considered to be checkpoint inhibitors. This review is focused on...

journal_title：Journal of immunology research

authors： Vajaitu C,Draghici CC,Solomon I,Lisievici CV,Popa AV,Lupu M,Caruntu C,Constantin MM,Voiculescu VM

更新日期：2018-10-17 00:00:00

abstract：:The predominant distribution of γ δ T cells in the mucosal and epithelial tissues makes these unconventional lymphocytes the "guards" to contact external environment (like allergens) and to contribute to immune surveillance, as well as "vanguards" to participate in initiating mucosal inflammation. Therefore, γ δ T cel...

journal_title：Journal of immunology research

authors： Zheng R,Yang Q

更新日期：2014-01-01 00:00:00

abstract：:Calcium is a ubiquitous intracellular messenger that has a crucial role in determining the proliferation, differentiation, and functions of multipotent mesenchymal stem cells (MSCs). Our study is aimed at elucidating the influence of genetically manipulating Ca2+ release-activated Ca2+ (CRAC) channel-mediated intercel...

journal_title：Journal of immunology research

authors： Liu S,Takahashi M,Kiyoi T,Toyama K,Mogi M

更新日期：2019-02-17 00:00:00

abstract：:We recently have proved that excessive fecal DCA caused by high-fat diet may serve as an endogenous danger-associated molecular pattern to activate NLRP3 inflammasome and thus contributes to the development of inflammatory bowel disease (IBD). Moreover, the effect of DCA on inflammasome activation is mainly mediated t...

journal_title：Journal of immunology research

authors： Zhao S,Gong Z,Du X,Tian C,Wang L,Zhou J,Xu C,Chen Y,Cai W,Wu J

更新日期：2018-05-09 00:00:00

abstract：:Schmallenberg virus (SBV), discovered in continental Europe in late 2011, causes mild clinical signs in adult ruminants, including diarrhoea and reduced milk yield. However, fetal infection can lead to severe malformation in newborn offspring. To develop improved reagents for SBV serology, a high-level yeast expressio...

journal_title：Journal of immunology research

authors： Lazutka J,Zvirbliene A,Dalgediene I,Petraityte-Burneikiene R,Spakova A,Sereika V,Lelesius R,Wernike K,Beer M,Sasnauskas K

更新日期：2014-01-01 00:00:00

abstract：Introduction:Understanding the mechanisms underlying the pathogenesis of Sjögren's syndrome (SS) is crucially important in order to be able to discriminate the steps that lead to B cell transformation and promptly identify the patients at risk of lymphomagenesis. The aim of this narrative review is to describe the evid...

journal_title：Journal of immunology research

authors： Talotta R,Sarzi-Puttini P,Atzeni F

更新日期：2019-01-06 00:00:00

abstract：:Therapeutic monoclonal antibodies (mAbs) represent a milestone in pharmacological development. Their superiority is based on the combination of high specificity, low toxicity, and long half-life that characterizes biologics. If biologics have Achilles' heel, it is their potential immunogenicity. To better understand t...

journal_title：Journal of immunology research

authors： Boysen M,Schlicksupp L,Dreher I,Loebbert R,Richter M

更新日期：2016-01-01 00:00:00

abstract：:Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are life-threatening disease. However, there are only few epidemiologic studies of SJS/TEN from China. To analyze the clinical characteristics, causality, and outcome of treatment for SJS/TEN in China, we reviewed case reports of patients with SJS/TEN f...

journal_title：Journal of immunology research

authors： Yang SC,Hu S,Zhang SZ,Huang JW,Zhang J,Ji C,Cheng B

更新日期：2018-02-11 00:00:00

abstract：:Body fluids often contain freely circulating nucleic acids, many of which can be exploited as noninvasive tools for the diagnosis of cancer as well as for clinical prognostication. Identifying microRNAs (miRNAs) in subjects' blood with various malignancies means that they can serve as novel biomarkers for prostate can...

journal_title：Journal of immunology research

authors： Jin W,Fei X,Wang X,Chen F,Song Y

更新日期：2020-05-08 00:00:00

abstract：:Purified protein vaccines often require adjuvants for efficient stimulation of immune responses. There is no licensed mucosal adjuvant on the market to adequately boost the immune response to purified antigens for intranasal applications in humans. Bacterial outer membrane vesicles (OMV) are attractive candidates pote...

journal_title：Journal of immunology research

authors： Pritsch M,Ben-Khaled N,Chaloupka M,Kobold S,Berens-Riha N,Peter A,Liegl G,Schubert S,Hoelscher M,Löscher T,Wieser A

更新日期：2016-01-01 00:00:00

abstract：:Multiepitope peptide vaccine has some advantages over traditional recombinant protein vaccine due to its easy and fast production and possible inclusion of multiple protective epitopes of pathogens. However, it is usually poorly immunogenic and needs to conjugate to a large carrier protein. Peptides conjugated to a ce...

journal_title：Journal of immunology research

authors： Gu Y,Sun X,Huang J,Zhan B,Zhu X

更新日期：2020-01-08 00:00:00

abstract：:Cutaneous melanoma is a significant immunogenic tumoral model, the most frequently described immune phenomenon being tumor regression, as a result of the interaction of tumoral antigens and stromal microenvironment. We present a retrospective cohort study including 52 cases of melanoma with regression. There were eval...

journal_title：Journal of immunology research

authors： Cioplea M,Nichita L,Georgescu D,Sticlaru L,Cioroianu A,Nedelcu R,Turcu G,Rauta A,Mogodici C,Zurac S,Popp C

更新日期：2020-10-23 00:00:00

abstract：:The phenotype and functional properties of antigen-presenting cells (APC), that is, circulating monocytes and generated in vitro macrophages and dendritic cells, were investigated in the patients with pulmonary tuberculosis (TB) differing in lymphocyte reactivity to M. tuberculosis antigens (PPD-reactive versus PPD-an...

journal_title：Journal of immunology research

authors： Sakhno LV,Shevela EY,Tikhonova MA,Nikonov SD,Ostanin AA,Chernykh ER

更新日期：2015-01-01 00:00:00

abstract：:Bone disease in rheumatoid arthritis (RA) is a complex phenomenon where genetic risk factors have been partially evaluated. The system formed by receptor activator for nuclear factor-κB (RANK), receptor activator for nuclear factor-κB ligand (RANKL), and osteoprotegerin (OPG): RANK/RANKL/OPG is a crucial molecular pat...

journal_title：Journal of immunology research

authors： Zavala-Cerna MG,Moran-Moguel MC,Cornejo-Toledo JA,Gonzalez-Montoya NG,Sanchez-Corona J,Salazar-Paramo M,Nava-Zavala AH,Aguilar-Chavez EA,Alcaraz-Lopez MF,Gonzalez-Sanchez AG,Gonzalez-Lopez L,Gamez-Nava JI

更新日期：2015-01-01 00:00:00

abstract：:Pregnancy is an immunological enigma where paternal antigens are present at the fetomaternal interface. What regulates the local immunotolerance, which is necessary to prevent rejection of the conceptus, is still under strong investigation. Gamma/delta T cells are believed to play a role in the local regulation of thi...

journal_title：Journal of immunology research

authors： Nörenberg J,Meggyes M,Jakso P,Miko E,Barakonyi A

更新日期：2019-05-20 00:00:00

abstract：:The rationale for a type 17 signature in the pathogenesis of spondyloarthritis (SpA) has been increasing and being ratified in studies recently. IL-7 is a cytokine whose ability to stimulate IL-17 production in both innate and adaptive immunity cells has made it a promising target not only for a better understanding o...

journal_title：Journal of immunology research

authors： Gonçalves RSG,Duarte ALBP

更新日期：2019-05-29 00:00:00

abstract：:Ischemia/reperfusion injury (IRI) remains a major problem in organ transplantation, which represents the main cause of graft dysfunction posttransplantation. Hepatic IRI is characterized by an excessive inflammatory response within the liver. Mesenchymal stem cells (MSCs) have been shown to be immunomodulatory cells a...

journal_title：Journal of immunology research

authors： Li S,Zheng X,Li H,Zheng J,Chen X,Liu W,Tai Y,Zhang Y,Wang G,Yang Y

更新日期：2018-12-03 00:00:00

abstract：:Toll-like receptors (TLRs) are known to detect a defined spectrum of microbial structures. However, the knowledge about the specificity of teleost Tlr factors for distinct pathogens is limited so far. We measured baseline expression profiles of 18 tlr genes and associated signaling factors in four immune-relevant tiss...

journal_title：Journal of immunology research

authors： Brietzke A,Korytář T,Jaros J,Köllner B,Goldammer T,Seyfert HM,Rebl A

更新日期：2015-01-01 00:00:00

abstract：:Bronchopulmonary dysplasia (BPD) is a severe complication of the respiratory system associated with preterm birth. Type 2 innate lymphoid cells (ILC2s) play a major role in tissue homeostasis, inflammation, and wound healing. However, the role in BPD remains unclear. The present study showed that ILC2s, interleukin-4 ...

journal_title：Journal of immunology research

authors： Mi L,Zhu S,Cai J,Xu S,Xue Z,Lu H

更新日期：2020-10-31 00:00:00

abstract：:We assessed the immune response against recombinant proteins of two related, albeit functionally different, peroxidoxins from Leishmania donovani: peroxidoxin 1 (LdPxn1) and peroxidoxin 2 (LdPxn2) in BALB/c mice. We also evaluated the effect of coadministration of TLR agonists (CpG ODN and GLA-SE) on the antigen-speci...

journal_title：Journal of immunology research

authors： Daifalla NS,Bayih AG,Gedamu L

更新日期：2015-01-01 00:00:00

abstract：:Mast cells are unique tissue-resident immune cells that secrete a diverse array of biologically active compounds that can stimulate, modulate, or suppress the immune response. Although mounting evidence supports that mast cells are consistently infiltrating tumors, their role as either a driving or an opposite force f...

journal_title：Journal of immunology research

authors： Aponte-López A,Fuentes-Pananá EM,Cortes-Muñoz D,Muñoz-Cruz S

更新日期：2018-02-05 00:00:00

abstract：:Immune activation plays a significant role in the disease progression of HIV. Microbial products, especially bacterial lipopolysaccharide (LPS), contribute to immune activation. Increasing evidence indicates that T lymphocyte homeostasis disruptions are associated with immune activation. However, the mechanism by whic...

journal_title：Journal of immunology research

authors： Zhang GH,Wu RD,Zheng HY,Zhang XL,Zhang MX,Tian RR,Liu GM,Pang W,Zheng YT

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Resistant and susceptible mouse strains to experimental autoimmune encephalomyelitis (EAE), an inducible demyelinating experimental disease serving as animal model for multiple sclerosis, have been described. We aimed to explore MHC-independent mechanisms inducing resistance to EAE. METHODS:F...

journal_title：Journal of immunology research

authors： Marín N,Mecha M,Espejo C,Mestre L,Eixarch H,Montalban X,Álvarez-Cermeño JC,Guaza C,Villar LM

更新日期：2014-01-01 00:00:00

abstract：:Aims. In the present study, we aimed to assess the concentrations of IL-13 and IL-17 in serum of patients with early rheumatoid arthritis (eRA), the investigation of correlation between the concentrations of these cytokines and disease activity score, and the concentration of some autoantibodies and the evaluation of ...

journal_title：Journal of immunology research

authors： Siloşi I,Boldeanu MV,Cojocaru M,Biciuşcă V,Pădureanu V,Bogdan M,Badea RG,Avramescu C,Petrescu IO,Petrescu F,Siloşi CA

更新日期：2016-01-01 00:00:00

abstract：:Lycium barbarum polysaccharide (LBP) is isolated from the fruit of Chinese herbal Lycium barbarum. Previous studies had demonstrated that LBP could inhibit tumor growth and enhance the immunity in mice. However, the effect of LBP on systemic and local immune responses in vivo, especially on phenotypic and functional c...

journal_title：Journal of immunology research

authors： Deng X,Luo S,Luo X,Hu M,Ma F,Wang Y,Lai X,Zhou L

更新日期：2018-06-03 00:00:00