High Prevalence of Metabolic Syndrome in Patients with Discoid Lupus Erythematosus: A Cross-Sectional, Case-Control Study.


:Although it is known that systemic form of lupus erythematosus (LE) and metabolic syndrome (MetS) are frequently observed together, there are no published reports on MetS in patients with skin-restricted LE. We aimed to compare the frequencies of MetS and its components in discoid LE (DLE) with the non-DLE control group. Additionally, we intended to determine the differences of sociodemographic and clinical data of the DLE patients with MetS compared to the patients without MetS. This was a cross-sectional, case-control study, including 60 patients with DLE and 82 age- and gender-matched control subjects. In DLE group, the presence of MetS was observed as more frequent (48.3% versus 24.4%, p = 0.003), and hypertriglyceridemia (43.3% versus 22.0%, p = 0.006) and reduced HDL-cholesterol (61.7% versus 23.2%, p < 0.001) among the MetS components were found significantly higher when compared to the control group. DLE patients with MetS were at older age (50.45 ± 11.49 versus 43.06 ± 12.09, p = 0.02), and hypertension, hyperlipidemia/dyslipidemia, and cardiovascular disease histories were observed at a higher ratio when compared to the patients without MetS. Between the DLE patients with and without MetS, no significant difference was observed in terms of clinical characteristics of DLE. Moreover, further large case-control studies with follow-up periods would be required to clearly assess the impact of MetS on the clinical outcomes of DLE.


J Immunol Res


Akarsu S,Ozbagcivan O,Semiz F,Aktan S




Has Abstract


2017-01-01 00:00:00










  • The Epidemiology of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in China.

    abstract::Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are life-threatening disease. However, there are only few epidemiologic studies of SJS/TEN from China. To analyze the clinical characteristics, causality, and outcome of treatment for SJS/TEN in China, we reviewed case reports of patients with SJS/TEN f...

    journal_title:Journal of immunology research

    pub_type: 杂志文章


    authors: Yang SC,Hu S,Zhang SZ,Huang JW,Zhang J,Ji C,Cheng B

    更新日期:2018-02-11 00:00:00

  • Immune Checkpoint Inhibitors to Treat Malignant Lymphomas.

    abstract::Genetic and/or epigenetic changes provide antigen-derived diversity in neoplastic cells. Beside, these cells do not initiate immune response of host organisms. A variety of factors are responsible for the resistant to treatment, including individual variations in patients and somatic cell genetic differences in tumors...

    journal_title:Journal of immunology research

    pub_type: 杂志文章,评审


    authors: Witkowska M,Smolewski P

    更新日期:2018-04-11 00:00:00

  • Genetic Variation in the IL-6 and HLA-DQB1 Genes Is Associated with Spontaneous Clearance of Hepatitis C Virus Infection.

    abstract::Background. Millions of people are infected with hepatitis C virus (HCV) worldwide and 30% spontaneously clear the infection. Reasons for HCV clearance without antiviral treatment are not well understood. Methods. Blood was collected for DNA analysis from patients with chronic HCV infection or evidence of spontaneous ...

    journal_title:Journal of immunology research

    pub_type: 杂志文章


    authors: Waldron PR,Belitskaya-Lévy I,Chary A,Won J,Winters M,Monto A,Ryan J,Lazzeroni LC,Holodniy M

    更新日期:2016-01-01 00:00:00

  • The Effectiveness of Rapamycin Combined with Eltrombopag in Murine Models of Immune-Mediated Bone Marrow Failure.

    abstract::Severe aplastic anemia (SAA) is a rare disease characterized by severe pancytopenia and bone marrow failure. Most patients with AA respond to immunosuppressive therapy (IST), usually as antithymocyte globulin (ATG) and cyclosporine (CsA), but some relapse on CsA withdrawal or require long-term administration of CsA to...

    journal_title:Journal of immunology research

    pub_type: 杂志文章


    authors: Ding S,Liang X,Zhang T,Fu R

    更新日期:2020-10-17 00:00:00

  • Circulating miRNAs as Biomarkers for Prostate Cancer Diagnosis in Subjects with Benign Prostatic Hyperplasia.

    abstract::Body fluids often contain freely circulating nucleic acids, many of which can be exploited as noninvasive tools for the diagnosis of cancer as well as for clinical prognostication. Identifying microRNAs (miRNAs) in subjects' blood with various malignancies means that they can serve as novel biomarkers for prostate can...

    journal_title:Journal of immunology research

    pub_type: 杂志文章


    authors: Jin W,Fei X,Wang X,Chen F,Song Y

    更新日期:2020-05-08 00:00:00

  • IFI16 Expression Is Related to Selected Transcription Factors during B-Cell Differentiation.

    abstract::The interferon-inducible DNA sensor IFI16 is involved in the modulation of cellular survival, proliferation, and differentiation. In the hematopoietic system, IFI16 is consistently expressed in the CD34+ stem cells and in peripheral blood lymphocytes; however, little is known regarding its regulation during maturation...

    journal_title:Journal of immunology research

    pub_type: 杂志文章


    authors: Piccaluga PP,Agostinelli C,Fuligni F,Righi S,Tripodo C,Re MC,Clò A,Miserocchi A,Morini S,Gariglio M,Ferri GG,Rinaldi-Ceroni A,Piccin O,De Andrea M,Pileri SA,Landolfo S,Gibellini D

    更新日期:2015-01-01 00:00:00

  • TNFAIP3 F127C Coding Variation in Greek Primary Sjogren's Syndrome Patients.

    abstract::Tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) gene encodes the A20 protein, an important negative feedback regulator of the nuclear factor kappa-light-chain-enhancer of activated B cell (NF-κB) pathway. A coding TNFAIP3 variant, namely rs2230926, has been previously linked to B cell non-Hodgkin's lymphoma (...

    journal_title:Journal of immunology research

    pub_type: 杂志文章


    authors: Nezos A,Gkioka E,Koutsilieris M,Voulgarelis M,Tzioufas AG,Mavragani CP

    更新日期:2018-12-19 00:00:00

  • Rapamycin regulates iTreg function through CD39 and Runx1 pathways.

    abstract::It has been shown that rapamycin is able to significantly increase the expression of FoxP3 and suppress activity in induced Treg (iTreg) cells in vivo and in vitro. CD39 is a newly determined Treg marker that relates to cell suppression. Runx1, a regulator of FoxP3, controls the expression of adenosine deaminase (ADA)...

    journal_title:Journal of immunology research

    pub_type: 杂志文章


    authors: Lu Y,Wang J,Gu J,Lu H,Li X,Qian X,Liu X,Wang X,Zhang F,Lu L

    更新日期:2014-01-01 00:00:00

  • Anti-VEGF for the management of diabetic macular edema.

    abstract::Diabetic retinopathy (DR) is an important cause of vision loss around the world, being the leading cause in the population between 20 and 60 years old. Among patients with DR, diabetic macular edema (DME) is the most frequent cause of vision impairment and represents a significant public health issue. Macular photocoa...

    journal_title:Journal of immunology research

    pub_type: 杂志文章,评审


    authors: Stefanini FR,Badaró E,Falabella P,Koss M,Farah ME,Maia M

    更新日期:2014-01-01 00:00:00

  • The Intracellular Growth of M. tuberculosis Is More Associated with High Glucose Levels Than with Impaired Responses of Monocytes from T2D Patients.

    abstract::Diabetes mellitus, a metabolic disease characterized by hyperglycemia and poor glucose control, is a risk factor for Mycobacterium tuberculosis (M. tuberculosis) infection and the development of active tuberculosis. To evaluate whether M. tuberculosis infection susceptibility is associated with an intrinsic factor in ...

    journal_title:Journal of immunology research

    pub_type: 杂志文章


    authors: Torres M,Herrera MT,Fabián-San-Miguel G,Gonzalez Y

    更新日期:2019-11-14 00:00:00

  • Dysregulation of miR-155-5p and miR-200-3p and the Anti-Non-Bilayer Phospholipid Arrangement Antibodies Favor the Development of Lupus in Three Novel Murine Lupus Models.

    abstract::Systemic lupus erythematosus (SLE) is characterized by deregulated activation of T and B cells, autoantibody production, and consequent formation of immune complexes. Liposomes with nonbilayer phospholipid arrangements (NPA), induced by chlorpromazine, procainamide, or manganese, provoke a disease resembling human lup...

    journal_title:Journal of immunology research

    pub_type: 杂志文章


    authors: Zárate-Neira LÁ,Sánchez-Barbosa S,Pedroza-Torres A,Reséndiz-Mora A,Wong C,Baeza I,Pérez-Plasencia C,Wong-Baeza C

    更新日期:2017-01-01 00:00:00

  • Inhibition of neutrophil collagenase/MMP-8 and gelatinase B/MMP-9 and protection against endotoxin shock.

    abstract::Endotoxin shock is a life-threatening disorder, associated with the rapid release of neutrophil enzymes, including neutrophil collagenase/matrix metalloproteinase-8 (MMP-8) and gelatinase B/matrix metalloproteinase-9 (MMP-9). After activation, these enzymes cleave extracellular matrix components and cytokines and thus...

    journal_title:Journal of immunology research

    pub_type: 杂志文章


    authors: Qiu Z,Chen J,Xu H,Van den Steen PE,Opdenakker G,Wang M,Hu J

    更新日期:2014-01-01 00:00:00

  • Poly-L-Arginine Induces Apoptosis of NCI-H292 Cells via ERK1/2 Signaling Pathway.

    abstract::Cationic protein is a cytotoxic protein secreted by eosinophils and takes part in the damage of airway epithelium in asthma. Poly-L-arginine (PLA), a synthetic cationic protein, is widely used to mimic the biological function of the natural cationic protein in vitro. Previous studies demonstrated the damage of the air...

    journal_title:Journal of immunology research

    pub_type: 杂志文章


    authors: Wang YN,Zhang LL,Fan XY,Wu SS,Zhang SQ

    更新日期:2018-06-14 00:00:00

  • CD4hiCD8low Double-Positive T Cells Are Associated with Graft Rejection in a Nonhuman Primate Model of Islet Transplantation.

    abstract::Peripheral CD4/CD8 double-positive (DP) T cells are associated with autoimmune disorders, cancer, and viral infection. However, the relationship between organ transplantation and DP T cells is unclear. Here, we examined the functional characteristics of peripheral DP T cells and analyzed their significance with respec...

    journal_title:Journal of immunology research

    pub_type: 杂志文章


    authors: Choi YJ,Park HJ,Park HJ,Jung KC,Lee JI

    更新日期:2018-07-10 00:00:00

  • Safety of Human Papillomavirus 9-Valent Vaccine: A Meta-Analysis of Randomized Trials.

    abstract::Vaccination against human papillomavirus (HPV) has been progressively implemented in most developed countries for approximately 10 years. In order to increase the protection of the vaccines, a 9-valent vaccine (HPV9) was developed, which provides protection against nine types of the virus. Studies evaluating its safet...

    journal_title:Journal of immunology research

    pub_type: 杂志文章,meta分析,评审


    authors: Costa APF,Cobucci RNO,da Silva JM,da Costa Lima PH,Giraldo PC,Gonçalves AK

    更新日期:2017-01-01 00:00:00

  • Clinical Correlations of Novel Autoantibodies in Patients with Dry Eye.

    abstract:Background:Diagnostic criteria for Sjögren's syndrome (SS) are continually being updated in pursuit of more precise and earlier diagnosis to prevent its complications. Owing to the high rate of false negative traditional serological markers, the need for better serological testing remains. Objective:To investigate the...

    journal_title:Journal of immunology research

    pub_type: 杂志文章


    authors: Karakus S,Baer AN,Akpek EK

    更新日期:2019-01-13 00:00:00

  • Elucidating the Pivotal Immunomodulatory and Anti-Inflammatory Potentials of Chloroquine and Hydroxychloroquine.

    abstract::Chloroquine (CQ) and hydroxychloroquine (HCQ) are derivatives of 4-aminoquinoline compounds with over 60 years of safe clinical usage. CQ and HCQ are able to inhibit the production of cytokines such as interleukin- (IL-) 1, IL-2, IL-6, IL-17, and IL-22. Also, CQ and HCQ inhibit the production of interferon- (IFN-) α a...

    journal_title:Journal of immunology research

    pub_type: 杂志文章,评审


    authors: Richard SA,Kampo S,Hechavarria ME,Sackey M,Buunaaim ADB,Kuugbee ED,Anabah TW

    更新日期:2020-09-25 00:00:00

  • Early Differentiation of Human CD11c+NK Cells with γδ T Cell Activation Properties Is Promoted by Dialyzable Leukocyte Extracts.

    abstract::Reconstitution of the hematopoietic system during immune responses and immunological and neoplastic diseases or upon transplantation depends on the emergent differentiation of hematopoietic stem/progenitor cells within the bone marrow. Although in the last decade the use of dialyzable leukocyte extracts (DLE) as suppo...

    journal_title:Journal of immunology research

    pub_type: 杂志文章


    authors: Ramírez-Ramírez D,Vadillo E,Arriaga-Pizano LA,Mayani H,Estrada-Parra S,Velasco-Velázquez MA,Pérez-Tapia SM,Pelayo R

    更新日期:2016-01-01 00:00:00

  • Elevated Expression of C-Type Lectin Domain Family 5-Member A (CLEC5A) and Its Relation to Inflammatory Parameters and Disease Course in Adult-Onset Still's Disease.

    abstract::C-type lectin domain family 5-member A (CLEC5A) associates with adaptor DAP12 (DNAX activation protein 12) to form receptor complexes involved in inflammatory responses. We postulated a potential role of CLEC5A in the pathogenesis of adult-onset Still's disease (AOSD) and aimed to investigate CLEC5A expression and its...

    journal_title:Journal of immunology research

    pub_type: 杂志文章


    authors: Chen PK,Hsieh SL,Lan JL,Lin CC,Chang SH,Chen DY

    更新日期:2020-04-23 00:00:00

  • Transplanted human umbilical cord mesenchymal stem cells facilitate lesion repair in B6.Fas mice.

    abstract:BACKGROUND:Systemic lupus erythematosus (SLE) is a multisystem disease that is characterized by the appearance of serum autoantibodies. No effective treatment for SLE currently exists. METHODS:We used human umbilical cord mesenchymal stem cell (H-UC-MSC) transplantation to treat B6.Fas mice. RESULTS:After four rounds...

    journal_title:Journal of immunology research

    pub_type: 杂志文章


    authors: Ruan GP,Yao X,Yang SJ,Wang JX,Shu F,Li ZA,Liu JF,Pang RQ,Pan XH

    更新日期:2014-01-01 00:00:00

  • Preliminary Evaluation of the Safety and Immunogenicity of an Antimalarial Vaccine Candidate Modified Peptide (IMPIPS) Mixture in a Murine Model.

    abstract::Malaria continues being a high-impact disease regarding public health worldwide; the WHO report for malaria in 2018 estimated that ~219 million cases occurred in 2017, mostly caused by the parasite Plasmodium falciparum. The disease cost the lives of more than 400,000 people, mainly in Africa. In spite of great effort...

    journal_title:Journal of immunology research

    pub_type: 杂志文章


    authors: Lambraño J,Curtidor H,Avendaño C,Díaz-Arévalo D,Roa L,Vanegas M,Patarroyo ME,Patarroyo MA

    更新日期:2019-12-30 00:00:00

  • Immunosuppressive Role of Myeloid-Derived Suppressor Cells and Therapeutic Targeting in Lung Cancer.

    abstract::Lung cancer is the leading cause of cancer death worldwide due to its late diagnosis and poor outcome. Immunotherapy is becoming more and more encouraging and promising in lung cancer therapy. Myeloid-derived suppressor cells (MDSCs) are the main tumor suppressor factors, and the treatment strategy of targeting MDSCs ...

    journal_title:Journal of immunology research

    pub_type: 杂志文章,评审


    authors: Ma J,Xu H,Wang S

    更新日期:2018-03-25 00:00:00

  • Revisiting the molecular mechanism of neurological manifestations in antiphospholipid syndrome: beyond vascular damage.

    abstract::Antiphospholipid syndrome (APS) is a multiorgan disease often affecting the central nervous system (CNS). Typically, neurological manifestations of APS include thrombosis of cerebral vessels leading to stroke and requiring prompt initiation of treatment with antiplatelet drugs or anticoagulant therapy. In these cases,...

    journal_title:Journal of immunology research

    pub_type: 杂志文章,评审


    authors: Carecchio M,Cantello R,Comi C

    更新日期:2014-01-01 00:00:00

  • Safety and Efficacy of Rituximab in Multiple Sclerosis: A Retrospective Observational Study.

    abstract:Objective:To evaluate the efficacy and safety of rituximab in multiple sclerosis in a clinical practice setting. Methods:Clinical data for all adult patients with multiple sclerosis (MS) treated with off-label rituximab at a single MS center in Lebanon between March 2008 and April 2017 were retrospectively collected f...

    journal_title:Journal of immunology research

    pub_type: 杂志文章


    authors: Yamout BI,El-Ayoubi NK,Nicolas J,El Kouzi Y,Khoury SJ,Zeineddine MM

    更新日期:2018-11-12 00:00:00

  • Regulating the Polarization of Macrophages: A Promising Approach to Vascular Dermatosis.

    abstract::Macrophages, a kind of innate immune cells, derive from monocytes in circulation and play a crucial role in the innate and adaptive immunity. Under the stimulation of the signals from local microenvironment, macrophages generally tend to differentiate into two main functional phenotypes depending on their high plastic...

    journal_title:Journal of immunology research

    pub_type: 杂志文章,评审


    authors: Peng H,Xian D,Liu J,Pan S,Tang R,Zhong J

    更新日期:2020-07-28 00:00:00

  • Protective Effects of Thalidomide on High-Glucose-Induced Podocyte Injury through In Vitro Modulation of Macrophage M1/M2 Differentiation.

    abstract::Objective. It has been shown that podocyte injury represents an important pathological basis that contributes to proteinuria and eventually leads to kidney failure. High glucose (HG) activates macrophage polarization, further exacerbating HG-induced podocyte injury. Our previous study on diabetic nephropathy rats indi...

    journal_title:Journal of immunology research

    pub_type: 杂志文章


    authors: Liao H,Li Y,Zhang X,Zhao X,Zheng D,Shen D,Li R

    更新日期:2020-08-27 00:00:00

  • Assessing the Role of DNA Methylation-Derived Neutrophil-to-Lymphocyte Ratio in Rheumatoid Arthritis.

    abstract::Rheumatoid arthritis (RA) is a disease of chronic systemic inflammation (SI). In the present study, we used four datasets to explore whether methylation-derived neutrophil-to-lymphocyte ratio (mdNLR) might be a marker of SI in new onset, untreated, and treated prevalent RA cases and/or a marker of treatment response t...

    journal_title:Journal of immunology research

    pub_type: 杂志文章


    authors: Ambatipudi S,Sharp GC,Clarke SLN,Plant D,Tobias JH,Evans DM,Barton A,Relton CL

    更新日期:2018-08-14 00:00:00

  • Cytokine Profile in Early Infection by Leptospira interrogans in A/J Mice.

    abstract::Leptospirosis is considered a neglected disease with an estimated more than one million cases every year. Since rodents are at the same time the main reservoir and generally asymptomatic to Leptospira infection, understanding why some animal species are resistant and others are susceptible to this infection would shed...

    journal_title:Journal of immunology research

    pub_type: 杂志文章


    authors: Bavia L,de Castro ÍA,Amano MT,da Silva AMG,Vasconcellos SA,Isaac L

    更新日期:2019-10-07 00:00:00

  • Anti-cyclic citrullinated peptide (anti-CCP) and anti-mutated citrullinated vimentin (anti-MCV) relation with extra-articular manifestations in rheumatoid arthritis.

    abstract::We evaluated the association between anti-cyclic citrullinated peptide antibodies (anti-CCP) and anti-mutated citrullinated vimentin antibodies (anti-MCV) with the presence of extra-articular (ExRA) manifestations in 225 patients with rheumatoid arthritis (RA). Ninety-five patients had ExRA and 130 had no ExRA. There ...

    journal_title:Journal of immunology research

    pub_type: 杂志文章


    authors: Gonzalez-Lopez L,Rocha-Muñoz AD,Ponce-Guarneros M,Flores-Chavez A,Salazar-Paramo M,Nava A,Cardona-Muñoz EG,Fajardo-Robledo NS,Zavaleta-Muñiz SA,Garcia-Cobian T,Gamez-Nava JI

    更新日期:2014-01-01 00:00:00

  • MPC1 Deficiency Promotes CRC Liver Metastasis via Facilitating Nuclear Translocation of β-Catenin.

    abstract::Accumulating evidence has pointed out that metastasis is the leading cause of death in several malignant tumor, including CRC. During CRC, metastatic capacity is closely correlated with reprogrammed energy metabolism. Mitochondrial Pyruvate Carrier 1 (MPC1), as the carrier of transporting pyruvate into mitochondria, l...

    journal_title:Journal of immunology research

    pub_type: 杂志文章


    authors: Tian GA,Xu CJ,Zhou KX,Zhang ZG,Gu JR,Zhang XL,Wang YH

    更新日期:2020-08-19 00:00:00