High Prevalence of Metabolic Syndrome in Patients with Discoid Lupus Erythematosus: A Cross-Sectional, Case-Control Study.

abstract：:Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are life-threatening disease. However, there are only few epidemiologic studies of SJS/TEN from China. To analyze the clinical characteristics, causality, and outcome of treatment for SJS/TEN in China, we reviewed case reports of patients with SJS/TEN f...

journal_title：Journal of immunology research

authors： Yang SC,Hu S,Zhang SZ,Huang JW,Zhang J,Ji C,Cheng B

更新日期：2018-02-11 00:00:00

abstract：:Genetic and/or epigenetic changes provide antigen-derived diversity in neoplastic cells. Beside, these cells do not initiate immune response of host organisms. A variety of factors are responsible for the resistant to treatment, including individual variations in patients and somatic cell genetic differences in tumors...

journal_title：Journal of immunology research

authors： Witkowska M,Smolewski P

更新日期：2018-04-11 00:00:00

abstract：:Background. Millions of people are infected with hepatitis C virus (HCV) worldwide and 30% spontaneously clear the infection. Reasons for HCV clearance without antiviral treatment are not well understood. Methods. Blood was collected for DNA analysis from patients with chronic HCV infection or evidence of spontaneous ...

journal_title：Journal of immunology research

authors： Waldron PR,Belitskaya-Lévy I,Chary A,Won J,Winters M,Monto A,Ryan J,Lazzeroni LC,Holodniy M

更新日期：2016-01-01 00:00:00

abstract：:Severe aplastic anemia (SAA) is a rare disease characterized by severe pancytopenia and bone marrow failure. Most patients with AA respond to immunosuppressive therapy (IST), usually as antithymocyte globulin (ATG) and cyclosporine (CsA), but some relapse on CsA withdrawal or require long-term administration of CsA to...

journal_title：Journal of immunology research

authors： Ding S,Liang X,Zhang T,Fu R

更新日期：2020-10-17 00:00:00

abstract：:Body fluids often contain freely circulating nucleic acids, many of which can be exploited as noninvasive tools for the diagnosis of cancer as well as for clinical prognostication. Identifying microRNAs (miRNAs) in subjects' blood with various malignancies means that they can serve as novel biomarkers for prostate can...

journal_title：Journal of immunology research

authors： Jin W,Fei X,Wang X,Chen F,Song Y

更新日期：2020-05-08 00:00:00

abstract：:The interferon-inducible DNA sensor IFI16 is involved in the modulation of cellular survival, proliferation, and differentiation. In the hematopoietic system, IFI16 is consistently expressed in the CD34+ stem cells and in peripheral blood lymphocytes; however, little is known regarding its regulation during maturation...

journal_title：Journal of immunology research

authors： Piccaluga PP,Agostinelli C,Fuligni F,Righi S,Tripodo C,Re MC,Clò A,Miserocchi A,Morini S,Gariglio M,Ferri GG,Rinaldi-Ceroni A,Piccin O,De Andrea M,Pileri SA,Landolfo S,Gibellini D

更新日期：2015-01-01 00:00:00

abstract：:Tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) gene encodes the A20 protein, an important negative feedback regulator of the nuclear factor kappa-light-chain-enhancer of activated B cell (NF-κB) pathway. A coding TNFAIP3 variant, namely rs2230926, has been previously linked to B cell non-Hodgkin's lymphoma (...

journal_title：Journal of immunology research

authors： Nezos A,Gkioka E,Koutsilieris M,Voulgarelis M,Tzioufas AG,Mavragani CP

更新日期：2018-12-19 00:00:00

abstract：:It has been shown that rapamycin is able to significantly increase the expression of FoxP3 and suppress activity in induced Treg (iTreg) cells in vivo and in vitro. CD39 is a newly determined Treg marker that relates to cell suppression. Runx1, a regulator of FoxP3, controls the expression of adenosine deaminase (ADA)...

journal_title：Journal of immunology research

authors： Lu Y,Wang J,Gu J,Lu H,Li X,Qian X,Liu X,Wang X,Zhang F,Lu L

更新日期：2014-01-01 00:00:00

abstract：:Diabetic retinopathy (DR) is an important cause of vision loss around the world, being the leading cause in the population between 20 and 60 years old. Among patients with DR, diabetic macular edema (DME) is the most frequent cause of vision impairment and represents a significant public health issue. Macular photocoa...

journal_title：Journal of immunology research

authors： Stefanini FR,Badaró E,Falabella P,Koss M,Farah ME,Maia M

更新日期：2014-01-01 00:00:00

abstract：:Diabetes mellitus, a metabolic disease characterized by hyperglycemia and poor glucose control, is a risk factor for Mycobacterium tuberculosis (M. tuberculosis) infection and the development of active tuberculosis. To evaluate whether M. tuberculosis infection susceptibility is associated with an intrinsic factor in ...

journal_title：Journal of immunology research

authors： Torres M,Herrera MT,Fabián-San-Miguel G,Gonzalez Y

更新日期：2019-11-14 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is characterized by deregulated activation of T and B cells, autoantibody production, and consequent formation of immune complexes. Liposomes with nonbilayer phospholipid arrangements (NPA), induced by chlorpromazine, procainamide, or manganese, provoke a disease resembling human lup...

journal_title：Journal of immunology research

authors： Zárate-Neira LÁ,Sánchez-Barbosa S,Pedroza-Torres A,Reséndiz-Mora A,Wong C,Baeza I,Pérez-Plasencia C,Wong-Baeza C

更新日期：2017-01-01 00:00:00

abstract：:Endotoxin shock is a life-threatening disorder, associated with the rapid release of neutrophil enzymes, including neutrophil collagenase/matrix metalloproteinase-8 (MMP-8) and gelatinase B/matrix metalloproteinase-9 (MMP-9). After activation, these enzymes cleave extracellular matrix components and cytokines and thus...

journal_title：Journal of immunology research

authors： Qiu Z,Chen J,Xu H,Van den Steen PE,Opdenakker G,Wang M,Hu J

更新日期：2014-01-01 00:00:00

abstract：:Cationic protein is a cytotoxic protein secreted by eosinophils and takes part in the damage of airway epithelium in asthma. Poly-L-arginine (PLA), a synthetic cationic protein, is widely used to mimic the biological function of the natural cationic protein in vitro. Previous studies demonstrated the damage of the air...

journal_title：Journal of immunology research

authors： Wang YN,Zhang LL,Fan XY,Wu SS,Zhang SQ

更新日期：2018-06-14 00:00:00

abstract：:Peripheral CD4/CD8 double-positive (DP) T cells are associated with autoimmune disorders, cancer, and viral infection. However, the relationship between organ transplantation and DP T cells is unclear. Here, we examined the functional characteristics of peripheral DP T cells and analyzed their significance with respec...

journal_title：Journal of immunology research

authors： Choi YJ,Park HJ,Park HJ,Jung KC,Lee JI

更新日期：2018-07-10 00:00:00

abstract：:Vaccination against human papillomavirus (HPV) has been progressively implemented in most developed countries for approximately 10 years. In order to increase the protection of the vaccines, a 9-valent vaccine (HPV9) was developed, which provides protection against nine types of the virus. Studies evaluating its safet...

journal_title：Journal of immunology research

authors： Costa APF,Cobucci RNO,da Silva JM,da Costa Lima PH,Giraldo PC,Gonçalves AK

更新日期：2017-01-01 00:00:00

abstract：Background:Diagnostic criteria for Sjögren's syndrome (SS) are continually being updated in pursuit of more precise and earlier diagnosis to prevent its complications. Owing to the high rate of false negative traditional serological markers, the need for better serological testing remains. Objective:To investigate the...

journal_title：Journal of immunology research

authors： Karakus S,Baer AN,Akpek EK

更新日期：2019-01-13 00:00:00

abstract：:Chloroquine (CQ) and hydroxychloroquine (HCQ) are derivatives of 4-aminoquinoline compounds with over 60 years of safe clinical usage. CQ and HCQ are able to inhibit the production of cytokines such as interleukin- (IL-) 1, IL-2, IL-6, IL-17, and IL-22. Also, CQ and HCQ inhibit the production of interferon- (IFN-) α a...

journal_title：Journal of immunology research

authors： Richard SA,Kampo S,Hechavarria ME,Sackey M,Buunaaim ADB,Kuugbee ED,Anabah TW

更新日期：2020-09-25 00:00:00

abstract：:Reconstitution of the hematopoietic system during immune responses and immunological and neoplastic diseases or upon transplantation depends on the emergent differentiation of hematopoietic stem/progenitor cells within the bone marrow. Although in the last decade the use of dialyzable leukocyte extracts (DLE) as suppo...

journal_title：Journal of immunology research

authors： Ramírez-Ramírez D,Vadillo E,Arriaga-Pizano LA,Mayani H,Estrada-Parra S,Velasco-Velázquez MA,Pérez-Tapia SM,Pelayo R

更新日期：2016-01-01 00:00:00

abstract：:C-type lectin domain family 5-member A (CLEC5A) associates with adaptor DAP12 (DNAX activation protein 12) to form receptor complexes involved in inflammatory responses. We postulated a potential role of CLEC5A in the pathogenesis of adult-onset Still's disease (AOSD) and aimed to investigate CLEC5A expression and its...

journal_title：Journal of immunology research

authors： Chen PK,Hsieh SL,Lan JL,Lin CC,Chang SH,Chen DY

更新日期：2020-04-23 00:00:00

abstract：BACKGROUND:Systemic lupus erythematosus (SLE) is a multisystem disease that is characterized by the appearance of serum autoantibodies. No effective treatment for SLE currently exists. METHODS:We used human umbilical cord mesenchymal stem cell (H-UC-MSC) transplantation to treat B6.Fas mice. RESULTS:After four rounds...

journal_title：Journal of immunology research

authors： Ruan GP,Yao X,Yang SJ,Wang JX,Shu F,Li ZA,Liu JF,Pang RQ,Pan XH

更新日期：2014-01-01 00:00:00

abstract：:Malaria continues being a high-impact disease regarding public health worldwide; the WHO report for malaria in 2018 estimated that ~219 million cases occurred in 2017, mostly caused by the parasite Plasmodium falciparum. The disease cost the lives of more than 400,000 people, mainly in Africa. In spite of great effort...

journal_title：Journal of immunology research

authors： Lambraño J,Curtidor H,Avendaño C,Díaz-Arévalo D,Roa L,Vanegas M,Patarroyo ME,Patarroyo MA

更新日期：2019-12-30 00:00:00

abstract：:Lung cancer is the leading cause of cancer death worldwide due to its late diagnosis and poor outcome. Immunotherapy is becoming more and more encouraging and promising in lung cancer therapy. Myeloid-derived suppressor cells (MDSCs) are the main tumor suppressor factors, and the treatment strategy of targeting MDSCs ...

journal_title：Journal of immunology research

authors： Ma J,Xu H,Wang S

更新日期：2018-03-25 00:00:00

abstract：:Antiphospholipid syndrome (APS) is a multiorgan disease often affecting the central nervous system (CNS). Typically, neurological manifestations of APS include thrombosis of cerebral vessels leading to stroke and requiring prompt initiation of treatment with antiplatelet drugs or anticoagulant therapy. In these cases,...

journal_title：Journal of immunology research

authors： Carecchio M,Cantello R,Comi C

更新日期：2014-01-01 00:00:00

abstract：Objective:To evaluate the efficacy and safety of rituximab in multiple sclerosis in a clinical practice setting. Methods:Clinical data for all adult patients with multiple sclerosis (MS) treated with off-label rituximab at a single MS center in Lebanon between March 2008 and April 2017 were retrospectively collected f...

journal_title：Journal of immunology research

authors： Yamout BI,El-Ayoubi NK,Nicolas J,El Kouzi Y,Khoury SJ,Zeineddine MM

更新日期：2018-11-12 00:00:00

abstract：:Macrophages, a kind of innate immune cells, derive from monocytes in circulation and play a crucial role in the innate and adaptive immunity. Under the stimulation of the signals from local microenvironment, macrophages generally tend to differentiate into two main functional phenotypes depending on their high plastic...

journal_title：Journal of immunology research

authors： Peng H,Xian D,Liu J,Pan S,Tang R,Zhong J

更新日期：2020-07-28 00:00:00

abstract：:Objective. It has been shown that podocyte injury represents an important pathological basis that contributes to proteinuria and eventually leads to kidney failure. High glucose (HG) activates macrophage polarization, further exacerbating HG-induced podocyte injury. Our previous study on diabetic nephropathy rats indi...

journal_title：Journal of immunology research

authors： Liao H,Li Y,Zhang X,Zhao X,Zheng D,Shen D,Li R

更新日期：2020-08-27 00:00:00

abstract：:Rheumatoid arthritis (RA) is a disease of chronic systemic inflammation (SI). In the present study, we used four datasets to explore whether methylation-derived neutrophil-to-lymphocyte ratio (mdNLR) might be a marker of SI in new onset, untreated, and treated prevalent RA cases and/or a marker of treatment response t...

journal_title：Journal of immunology research

authors： Ambatipudi S,Sharp GC,Clarke SLN,Plant D,Tobias JH,Evans DM,Barton A,Relton CL

更新日期：2018-08-14 00:00:00

abstract：:Leptospirosis is considered a neglected disease with an estimated more than one million cases every year. Since rodents are at the same time the main reservoir and generally asymptomatic to Leptospira infection, understanding why some animal species are resistant and others are susceptible to this infection would shed...

journal_title：Journal of immunology research

authors： Bavia L,de Castro ÍA,Amano MT,da Silva AMG,Vasconcellos SA,Isaac L

更新日期：2019-10-07 00:00:00

abstract：:We evaluated the association between anti-cyclic citrullinated peptide antibodies (anti-CCP) and anti-mutated citrullinated vimentin antibodies (anti-MCV) with the presence of extra-articular (ExRA) manifestations in 225 patients with rheumatoid arthritis (RA). Ninety-five patients had ExRA and 130 had no ExRA. There ...

journal_title：Journal of immunology research

authors： Gonzalez-Lopez L,Rocha-Muñoz AD,Ponce-Guarneros M,Flores-Chavez A,Salazar-Paramo M,Nava A,Cardona-Muñoz EG,Fajardo-Robledo NS,Zavaleta-Muñiz SA,Garcia-Cobian T,Gamez-Nava JI

更新日期：2014-01-01 00:00:00

abstract：:Accumulating evidence has pointed out that metastasis is the leading cause of death in several malignant tumor, including CRC. During CRC, metastatic capacity is closely correlated with reprogrammed energy metabolism. Mitochondrial Pyruvate Carrier 1 (MPC1), as the carrier of transporting pyruvate into mitochondria, l...

journal_title：Journal of immunology research

authors： Tian GA,Xu CJ,Zhou KX,Zhang ZG,Gu JR,Zhang XL,Wang YH

更新日期：2020-08-19 00:00:00