Abstract：
:Chemokine (C-X-C motif) ligand (CXCL)10 and other CXCR3 chemokines are involved in the pathogenesis of acute and "chronic hepatitis C virus (HCV) infection" (CHC). Here, we review the scientific literature about HCV and CXCL10. The combination of circulating CXCL10 and single nucleotide polymorphisms (SNPs) in IL-28B can identify patients with acute HCV infection most likely to undergo spontaneous HCV clearance and those in need of early antiviral therapy. In CHC, the HCV and intrahepatic interferon- (IFN-) γ drive a raised CXCL10 expression by sinusoidal endothelium and hepatocytes, thereby inducing the recruitment of CXCR3-expressing T cells into the liver; thus, CXCL10 plays an important role in the development of necroinflammation and fibrosis. Increased CXCL10 was significantly associated with the presence of active vasculitis in HCV-associated cryoglobulinemia, or with autoimmune thyroiditis in CHC. Pretreatment CXCL10 levels are predictive of early virological response and sustained virological response (SVR) to IFN-α and ribavirin and may be useful in the evaluation of candidates for therapy. The occurrence of SNPs adjacent to IL-28B (rs12979860, rs12980275, and rs8099917), and CXCL10 below 150 pg/mL, independently predicted the first phase viral decline and rapid virological response, which in turn independently predicted SVR. Directly acting antiviral agents-mediated clearance of HCV is associated with the loss of intrahepatic immune activation by IFN-α, associated by decreased levels of CXCL10. In conclusion, CXCL10 is an important marker of HCV clearance and successful therapy in CHC patients. Whether CXCL10 is a novel therapeutic target in CHC will be evaluated.
journal_name
J Immunol Resjournal_title
Journal of immunology researchauthors
Ferrari SM,Fallahi P,Ruffilli I,Elia G,Ragusa F,Paparo SR,Patrizio A,Mazzi V,Colaci M,Giuggioli D,Ferri C,Antonelli Adoi
10.1155/2019/5878960subject
Has Abstractpub_date
2019-08-08 00:00:00pages
5878960eissn
2314-8861issn
2314-7156journal_volume
2019pub_type
杂志文章,评审abstract：:We recently have proved that excessive fecal DCA caused by high-fat diet may serve as an endogenous danger-associated molecular pattern to activate NLRP3 inflammasome and thus contributes to the development of inflammatory bowel disease (IBD). Moreover, the effect of DCA on inflammasome activation is mainly mediated t...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2018/2481418
更新日期：2018-05-09 00:00:00
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journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2017/3145742
更新日期：2017-01-01 00:00:00
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journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2015/202738
更新日期：2015-01-01 00:00:00
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journal_title：Journal of immunology research
pub_type： 杂志文章,评审
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更新日期：2018-04-11 00:00:00
abstract：:Body fluids often contain freely circulating nucleic acids, many of which can be exploited as noninvasive tools for the diagnosis of cancer as well as for clinical prognostication. Identifying microRNAs (miRNAs) in subjects' blood with various malignancies means that they can serve as novel biomarkers for prostate can...
journal_title：Journal of immunology research
pub_type： 杂志文章
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journal_title：Journal of immunology research
pub_type： 杂志文章
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journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2018/9101964
更新日期：2018-05-02 00:00:00
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journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2014/989434
更新日期：2014-01-01 00:00:00
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journal_title：Journal of immunology research
pub_type： 杂志文章
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journal_title：Journal of immunology research
pub_type： 杂志文章
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更新日期：2017-01-01 00:00:00
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journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2017/5974574
更新日期：2017-01-01 00:00:00
abstract：Background:Psoriasis is a chronic systemic inflammatory disease associated with a wide range of comorbidities, including metabolic syndrome (MetS). Serum calprotectin, ANGPTL8, and oxidative damage to nucleic acids might be associated with both diseases. The presented study describes the influence of psoriasis and MetS...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2020/7352637
更新日期：2020-05-20 00:00:00
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journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2016/4097642
更新日期：2016-01-01 00:00:00
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journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2018/6319649
更新日期：2018-03-25 00:00:00
abstract：:Diabetic retinopathy (DR) is an important cause of vision loss around the world, being the leading cause in the population between 20 and 60 years old. Among patients with DR, diabetic macular edema (DME) is the most frequent cause of vision impairment and represents a significant public health issue. Macular photocoa...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2014/632307
更新日期：2014-01-01 00:00:00
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journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2019/1462098
更新日期：2019-11-14 00:00:00
abstract：:Bronchopulmonary dysplasia (BPD) is a severe complication of the respiratory system associated with preterm birth. Type 2 innate lymphoid cells (ILC2s) play a major role in tissue homeostasis, inflammation, and wound healing. However, the role in BPD remains unclear. The present study showed that ILC2s, interleukin-4 ...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2020/8050186
更新日期：2020-10-31 00:00:00
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journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2018/8174340
更新日期：2018-04-05 00:00:00
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journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2020/8263598
更新日期：2020-08-27 00:00:00
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journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2019/1018274
更新日期：2019-05-06 00:00:00
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journal_title：Journal of immunology research
pub_type： 杂志文章
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journal_title：Journal of immunology research
pub_type： 杂志文章,随机对照试验
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journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2016/1639720
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abstract：:Lycium barbarum polysaccharide (LBP) is isolated from the fruit of Chinese herbal Lycium barbarum. Previous studies had demonstrated that LBP could inhibit tumor growth and enhance the immunity in mice. However, the effect of LBP on systemic and local immune responses in vivo, especially on phenotypic and functional c...
journal_title：Journal of immunology research
pub_type： 杂志文章
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更新日期：2018-06-03 00:00:00
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journal_title：Journal of immunology research
pub_type： 杂志文章,评审
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更新日期：2015-01-01 00:00:00
abstract：:Collectin-12 (collectin placenta 1, CL-P1, or CL-12) is a newly identified pattern recognition molecule of the innate immune system. Recent evidences show that CL-12 plays important roles not only in innate immune protection against certain clinically important pathogens but also in scavenging of host molecules, leuko...
journal_title：Journal of immunology research
pub_type： 杂志文章
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更新日期：2019-07-29 00:00:00
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journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2016/2743292
更新日期：2016-01-01 00:00:00
abstract：:Differential cell systematic evolution of ligands by exponential enrichment (SELEX) is an in vitro selection method for obtaining molecular recognition elements (MREs) that specifically bind to individual cell types with high affinity. MREs are selected from initial large libraries of different nucleic or amino acids....
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2015/186586
更新日期：2015-01-01 00:00:00
abstract：:Vaccination against human papillomavirus (HPV) has been progressively implemented in most developed countries for approximately 10 years. In order to increase the protection of the vaccines, a 9-valent vaccine (HPV9) was developed, which provides protection against nine types of the virus. Studies evaluating its safet...
journal_title：Journal of immunology research
pub_type： 杂志文章,meta分析,评审
doi：10.1155/2017/3736201
更新日期：2017-01-01 00:00:00
abstract：:Reduning injection is a traditional Chinese medicine injection which has multiple functions such as clearing heat, dispelling wind, and detoxification. Although Reduning injection was widely utilized, reports of its allergenicity emerged one after another. However, there is little research on its allergenic substances...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2016/4895672
更新日期：2016-01-01 00:00:00
