Abstract:
:Although cancer immunotherapy has shown significant promise in mediating efficacious responses, it remains encumbered by tumor heterogeneity, loss of tumor-specific antigen targets, and the regulatory milieu both regionally and systemically. Cross talk between the innate and adaptive immune response may be requisite to polarize sustained antigen specific immunity. Cancer vaccines can serve as an essential fulcrum in initiating innate immunity while molding and sustaining adaptive immunity. Although peptide vaccines have shown tepid responses in a therapeutic setting with poor correlates for immune activity, RNA vaccines activate innate immune responses and have shown promising effects in preclinical and clinical studies based on enhanced DC migration. While the mechanistic insights behind the interplay between innate and adaptive immunity may be unique to the immunotherapeutic being investigated, understanding this dynamic is important to coordinate the different arms of the immune response in a focused response against cancer antigens.
journal_name
J Immunol Resjournal_title
Journal of immunology researchauthors
Sayour EJ,Mitchell DAdoi
10.1155/2017/3145742subject
Has Abstractpub_date
2017-01-01 00:00:00pages
3145742eissn
2314-8861issn
2314-7156journal_volume
2017pub_type
杂志文章,评审abstract::Primary Sjogren's syndrome (pSS) is a chronic autoimmune disease. The aim of the study was to establish whether in patients with pSS without central nervous system (CNS) involvement, the function of the central portion of the sensory pathway can be challenged. In 33 patients with pSS without clinical features of CNS d...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2018/8174340
更新日期:2018-04-05 00:00:00
abstract::The roots of Euphorbia kansui, which belong to the family Euphorbiaceae, have been used as a traditional medicine for the treatment of various diseases such as diabetes, ascites, and leukemia. Recently, it was reported that the methylene chloride fraction of E. kansui radix (EKC) regulated the differentiation of Th17 ...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2017/7052560
更新日期:2017-01-01 00:00:00
abstract:Objective:Rheumatoid arthritis (RA) multidrug resistance is associated with P-glycoprotein (P-gp) overexpression. We investigated the effects of methotrexate (MTX) alone and combined with 4-hydroperoxycyclophosphamide (4-HC) on P-gp expression in fibroblast-like synoviocytes (FLSs) from patients with RA and examined th...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2018/3619320
更新日期:2018-02-18 00:00:00
abstract::Adverse drug reactions (ADRs) remain a common and major problem in healthcare. Severe cutaneous adverse drug reactions (SCARs), such as Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) with mortality rate ranges from 10% to more than 30%, can be life threatening. A number of recent studies demonstrated ...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2017/3186328
更新日期:2017-01-01 00:00:00
abstract::T-cell mediated drug hypersensitivity reactions may range from mild rash to severe fatal reactions. Among them, drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS), Stevens-Johnson syndrome/ toxic epidermal necrolysis (SJS/TEN), are some of the most life-threa...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2014/565320
更新日期:2014-01-01 00:00:00
abstract::Amiselimod (MT-1303) is a novel and selective sphingosine 1-phosphate receptor-1 (S1P1) modulator with a more favorable cardiac safety profile than other S1P1 receptor modulators. In this study, we evaluated the effects of MT-1303 on the progression of lupus nephritis in two well-known murine systemic lupus erythemato...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2019/5821589
更新日期:2019-12-23 00:00:00
abstract::Diabetic retinopathy (DR) is an important cause of vision loss around the world, being the leading cause in the population between 20 and 60 years old. Among patients with DR, diabetic macular edema (DME) is the most frequent cause of vision impairment and represents a significant public health issue. Macular photocoa...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2014/632307
更新日期:2014-01-01 00:00:00
abstract::Reconstitution of the hematopoietic system during immune responses and immunological and neoplastic diseases or upon transplantation depends on the emergent differentiation of hematopoietic stem/progenitor cells within the bone marrow. Although in the last decade the use of dialyzable leukocyte extracts (DLE) as suppo...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2016/4097642
更新日期:2016-01-01 00:00:00
abstract::Irritant Contact Dermatitis (ICD) is characterized by epidermal hyperplasia and inflammatory cytokine release. IL-6 has been shown to be involved in the pathogenesis of ICD; however, the involvement of the IL-22/IL-22Rα axis and its relation to IL-6 in the inflammatory response following irritant exposure are unknown....
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2019/6276254
更新日期:2019-10-29 00:00:00
abstract::Lung cancer is the leading cause of cancer death worldwide due to its late diagnosis and poor outcome. Immunotherapy is becoming more and more encouraging and promising in lung cancer therapy. Myeloid-derived suppressor cells (MDSCs) are the main tumor suppressor factors, and the treatment strategy of targeting MDSCs ...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2018/6319649
更新日期:2018-03-25 00:00:00
abstract:Background:RNA helicases have various essential functions in basically all aspects of RNA metabolism, not only unwinding RNA but also disturbing the interaction of RNA with proteins. Recently, RNA helicases have been considered potential targets in cancers. So far, there has been no detailed investigation of the biolog...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2020/8835393
更新日期:2020-12-30 00:00:00
abstract::In vitro differentiation of mesenchymal stromal cells (MSC) into osteocytes (human differentiated osteogenic cells, hDOC) before implantation has been proposed to optimize bone regeneration. However, a deep characterization of the immunological properties of DOC, including their effect on dendritic cell (DC) function,...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2015/526195
更新日期:2015-01-01 00:00:00
abstract::Cationic protein is a cytotoxic protein secreted by eosinophils and takes part in the damage of airway epithelium in asthma. Poly-L-arginine (PLA), a synthetic cationic protein, is widely used to mimic the biological function of the natural cationic protein in vitro. Previous studies demonstrated the damage of the air...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2018/3651743
更新日期:2018-06-14 00:00:00
abstract::Macrophages, a kind of innate immune cells, derive from monocytes in circulation and play a crucial role in the innate and adaptive immunity. Under the stimulation of the signals from local microenvironment, macrophages generally tend to differentiate into two main functional phenotypes depending on their high plastic...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2020/8148272
更新日期:2020-07-28 00:00:00
abstract::Chloroquine (CQ) and hydroxychloroquine (HCQ) are derivatives of 4-aminoquinoline compounds with over 60 years of safe clinical usage. CQ and HCQ are able to inhibit the production of cytokines such as interleukin- (IL-) 1, IL-2, IL-6, IL-17, and IL-22. Also, CQ and HCQ inhibit the production of interferon- (IFN-) α a...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2020/4582612
更新日期:2020-09-25 00:00:00
abstract::Multiepitope peptide vaccine has some advantages over traditional recombinant protein vaccine due to its easy and fast production and possible inclusion of multiple protective epitopes of pathogens. However, it is usually poorly immunogenic and needs to conjugate to a large carrier protein. Peptides conjugated to a ce...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2020/2074803
更新日期:2020-01-08 00:00:00
abstract::Leptospirosis is considered a neglected disease with an estimated more than one million cases every year. Since rodents are at the same time the main reservoir and generally asymptomatic to Leptospira infection, understanding why some animal species are resistant and others are susceptible to this infection would shed...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2019/1892508
更新日期:2019-10-07 00:00:00
abstract::Neuropathic pain (NPP) is intolerable, persistent, and specific type of long-term pain. It is considered to be a direct consequence of pathological changes affecting the somatosensory system and can be debilitating for affected patients. Despite recent progress and growing interest in understanding the pathogenesis of...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2016/6430423
更新日期:2016-01-01 00:00:00
abstract::Epidemiological studies have demonstrated that interleukin-10 (IL-10) polymorphisms may be associated with the development of Behcet's disease (BD). However, the published results were inconsistent. Therefore, this meta-analysis was conducted to derive a more precise relationship between IL-10 polymorphisms and BD sus...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2020/9382609
更新日期:2020-06-19 00:00:00
abstract::Reduning injection is a traditional Chinese medicine injection which has multiple functions such as clearing heat, dispelling wind, and detoxification. Although Reduning injection was widely utilized, reports of its allergenicity emerged one after another. However, there is little research on its allergenic substances...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2016/4895672
更新日期:2016-01-01 00:00:00
abstract::Oropouche virus (OROV) is an emerging pathogen which causes Oropouche fever and meningitis in humans. Several outbreaks of OROV in South America, especially in Brazil, have changed its status as an emerging disease, but no vaccine or specific drug target is available yet. Our approach was to identify the epitope-based...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2018/6718083
更新日期:2018-10-08 00:00:00
abstract::A novel, simple, and reproducible method for cultivating pathological tissues obtained from human eyes during surgery was developed using viscoelastic material as a tissue adherent to facilitate cell attachment and expansion and calcium imaging of cultured cells challenged by mechanical and acetylcholine (ACh) stimula...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2014/232659
更新日期:2014-01-01 00:00:00
abstract::Regulatory T-cells (Tregs) are a very important subtype of lymphocytes when it comes to self-control in the human immunological system. Tregs are decisive not only in the protection against destruction of own tissues by autoimmune immunocompetent cells but also in the immunological answer to developing cancers. On the...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2019/2816498
更新日期:2019-03-03 00:00:00
abstract::We recently have proved that excessive fecal DCA caused by high-fat diet may serve as an endogenous danger-associated molecular pattern to activate NLRP3 inflammasome and thus contributes to the development of inflammatory bowel disease (IBD). Moreover, the effect of DCA on inflammasome activation is mainly mediated t...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2018/2481418
更新日期:2018-05-09 00:00:00
abstract::Following fetal or neonatal gene transfer in mice and other species immune tolerance of the transgenic protein is frequently observed; however the underlying mechanisms remain largely undefined. In this study fetal and neonatal BALB/c mice received adenovirus vector to deliver human factor IX (hFIX) cDNA. The long-ter...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2015/397879
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Systemic lupus erythematosus (SLE) is a multisystem disease that is characterized by the appearance of serum autoantibodies. No effective treatment for SLE currently exists. METHODS:We used human umbilical cord mesenchymal stem cell (H-UC-MSC) transplantation to treat B6.Fas mice. RESULTS:After four rounds...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2014/530501
更新日期:2014-01-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that is characterized by synovial hyperplasia and progressive joint destruction. The activation of RA synovial fibroblasts (SFs), also called fibroblast-like synoviocytes (FLS), contributes significantly to perpetuation of the disease. Genetic and ...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2016/6290682
更新日期:2016-01-01 00:00:00
abstract::Recruitment of human NK cells to porcine tissues has been demonstrated in pig organs perfused ex vivo with human blood in the early 1990s. Subsequently, the molecular mechanisms leading to adhesion and cytotoxicity in human NK cell-porcine endothelial cell (pEC) interactions have been elucidated in vitro to identify t...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2017/4627384
更新日期:2017-01-01 00:00:00
abstract::Cutaneous melanoma is a significant immunogenic tumoral model, the most frequently described immune phenomenon being tumor regression, as a result of the interaction of tumoral antigens and stromal microenvironment. We present a retrospective cohort study including 52 cases of melanoma with regression. There were eval...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2020/5416843
更新日期:2020-10-23 00:00:00
abstract:Background:Gastrosphere, an enriched cellular population with stem-like properties believed to be responsible for an escape from immune-mediated destruction. Th17 and Treg cells play a major role in gastric cancer; however, their interaction with gastrospheres remained elusive. Method:Peripheral blood mononuclear cell...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2020/6261814
更新日期:2020-12-23 00:00:00