Lipopolysaccharide Increases Immune Activation and Alters T Cell Homeostasis in SHIVB'WHU Chronically Infected Chinese Rhesus Macaque.

abstract：:Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are life-threatening disease. However, there are only few epidemiologic studies of SJS/TEN from China. To analyze the clinical characteristics, causality, and outcome of treatment for SJS/TEN in China, we reviewed case reports of patients with SJS/TEN f...

journal_title：Journal of immunology research

authors： Yang SC,Hu S,Zhang SZ,Huang JW,Zhang J,Ji C,Cheng B

更新日期：2018-02-11 00:00:00

abstract：Background:Gastrosphere, an enriched cellular population with stem-like properties believed to be responsible for an escape from immune-mediated destruction. Th17 and Treg cells play a major role in gastric cancer; however, their interaction with gastrospheres remained elusive. Method:Peripheral blood mononuclear cell...

journal_title：Journal of immunology research

authors： Rezalotfi A,Solgi G,Ebrahimi M

更新日期：2020-12-23 00:00:00

abstract：:This work is aimed at investigating the effect of melittin on identified key genes in bladder cancer (BC) and further providing a theoretical basis for BC treatment. GSE35014 downloaded from the Gene Expression Omnibus (GEO) database was used to screen differentially expressed genes (DEGs) in BC cells and control. Res...

journal_title：Journal of immunology research

authors： Jin Z,Yao J,Xie N,Cai L,Qi S,Zhang Z,Li B

更新日期：2018-05-03 00:00:00

abstract：:Probiotics are commensal or nonpathogenic microbes that confer beneficial effects on the host through several mechanisms such as competitive exclusion, antibacterial effects, and modulation of immune responses. Some probiotics have been found to regulate immune responses via immune regulatory mechanisms. T regulatory ...

journal_title：Journal of immunology research

authors： Zeng W,Shen J,Bo T,Peng L,Xu H,Nasser MI,Zhuang Q,Zhao M

更新日期：2019-04-16 00:00:00

abstract：:Toll-like receptors (TLRs) are known to detect a defined spectrum of microbial structures. However, the knowledge about the specificity of teleost Tlr factors for distinct pathogens is limited so far. We measured baseline expression profiles of 18 tlr genes and associated signaling factors in four immune-relevant tiss...

journal_title：Journal of immunology research

authors： Brietzke A,Korytář T,Jaros J,Köllner B,Goldammer T,Seyfert HM,Rebl A

更新日期：2015-01-01 00:00:00

abstract：Background:RNA helicases have various essential functions in basically all aspects of RNA metabolism, not only unwinding RNA but also disturbing the interaction of RNA with proteins. Recently, RNA helicases have been considered potential targets in cancers. So far, there has been no detailed investigation of the biolog...

journal_title：Journal of immunology research

authors： Xu Y,Jiang Q,Liu H,Xiao X,Yang D,Saw PE,Luo B

更新日期：2020-12-30 00:00:00

abstract：:Irritant Contact Dermatitis (ICD) is characterized by epidermal hyperplasia and inflammatory cytokine release. IL-6 has been shown to be involved in the pathogenesis of ICD; however, the involvement of the IL-22/IL-22Rα axis and its relation to IL-6 in the inflammatory response following irritant exposure are unknown....

journal_title：Journal of immunology research

authors： Frempah B,Luckett-Chastain LR,Gallucci RM

更新日期：2019-10-29 00:00:00

abstract：:In organ transplantation, alloantigens are taken up by antigen presenting cells and presented via the indirect pathway to T-cells which in turn can induce allograft rejection. Monitoring of these T-cells is of major importance; however no reliable assay is available to routinely monitor indirect allorecognition. Recen...

journal_title：Journal of immunology research

authors： Breman E,Ruben JM,Franken KL,Heemskerk MH,Roelen DL,Claas FH,van Kooten C

更新日期：2016-01-01 00:00:00

abstract：:T-cell mediated drug hypersensitivity reactions may range from mild rash to severe fatal reactions. Among them, drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS), Stevens-Johnson syndrome/ toxic epidermal necrolysis (SJS/TEN), are some of the most life-threa...

journal_title：Journal of immunology research

authors： Cheng CY,Su SC,Chen CH,Chen WL,Deng ST,Chung WH

更新日期：2014-01-01 00:00:00

abstract：:Although cancer immunotherapy has shown significant promise in mediating efficacious responses, it remains encumbered by tumor heterogeneity, loss of tumor-specific antigen targets, and the regulatory milieu both regionally and systemically. Cross talk between the innate and adaptive immune response may be requisite t...

journal_title：Journal of immunology research

authors： Sayour EJ,Mitchell DA

更新日期：2017-01-01 00:00:00

abstract：:Candida albicans is a fungus that is an opportunistic pathogen of humans. Normally, C. albicans exists as a harmless commensal and does not trigger inflammatory responses by resident macrophages in skin mucosa, which may be caused by a tolerance of skin macrophage to C. albicans. IL-34 is a recently discovered cytokin...

journal_title：Journal of immunology research

authors： Xu R,Sun HF,Williams DW,Jones AV,Al-Hussaini A,Song B,Wei XQ

更新日期：2015-01-01 00:00:00

abstract：:The benefits of garlic to health have been proclaimed for centuries; however, only recently have Allium sativum and its derivatives been proposed as promising candidates for maintaining the homeostasis of the immune system. The complex biochemistry of garlic makes it possible for variations in processing to yield diff...

journal_title：Journal of immunology research

authors： Arreola R,Quintero-Fabián S,López-Roa RI,Flores-Gutiérrez EO,Reyes-Grajeda JP,Carrera-Quintanar L,Ortuño-Sahagún D

更新日期：2015-01-01 00:00:00

abstract：PURPOSES:To investigate the possible changes in B cell subsets and in B cell expression patterns of lipid rafts (LRs) and F-actin in patients with SLE and whether leflunomide treatment may have effect on these changes. METHODS:The B cell subsets and LRs expression were determined by flow cytometry and confocal microsc...

journal_title：Journal of immunology research

authors： Dong GF,Zhang X,He DN,Li L,Zhang GF

更新日期：2015-01-01 00:00:00

abstract：:We assessed the immune response against recombinant proteins of two related, albeit functionally different, peroxidoxins from Leishmania donovani: peroxidoxin 1 (LdPxn1) and peroxidoxin 2 (LdPxn2) in BALB/c mice. We also evaluated the effect of coadministration of TLR agonists (CpG ODN and GLA-SE) on the antigen-speci...

journal_title：Journal of immunology research

authors： Daifalla NS,Bayih AG,Gedamu L

更新日期：2015-01-01 00:00:00

abstract：:Mucosal surfaces in the airways and the gastrointestinal tract are critical for the interactions of the host with its environment. Due to their abundance at mucosal tissue sites and their powerful immunomodulatory capacities, the role of innate lymphoid cells (ILCs) and natural killer T (NKT) cells in the maintenance ...

journal_title：Journal of immunology research

authors： Nau D,Altmayer N,Mattner J

更新日期：2014-01-01 00:00:00

abstract：:The aim of this paper is to determine the modulatory effects of Lactobacillus acidophilus on the IL-23/Th17 immune axis in experimental colitis. DSS-induced mouse models of UC were to be saline, hormones, and different concentrations of Lactobacillus acidophilus intervention. The expression of interleukin- (IL-) 17, t...

journal_title：Journal of immunology research

authors： Chen L,Zou Y,Peng J,Lu F,Yin Y,Li F,Yang J

更新日期：2015-01-01 00:00:00

abstract：:C-type lectin domain family 5-member A (CLEC5A) associates with adaptor DAP12 (DNAX activation protein 12) to form receptor complexes involved in inflammatory responses. We postulated a potential role of CLEC5A in the pathogenesis of adult-onset Still's disease (AOSD) and aimed to investigate CLEC5A expression and its...

journal_title：Journal of immunology research

authors： Chen PK,Hsieh SL,Lan JL,Lin CC,Chang SH,Chen DY

更新日期：2020-04-23 00:00:00

abstract：:In vitro differentiation of mesenchymal stromal cells (MSC) into osteocytes (human differentiated osteogenic cells, hDOC) before implantation has been proposed to optimize bone regeneration. However, a deep characterization of the immunological properties of DOC, including their effect on dendritic cell (DC) function,...

journal_title：Journal of immunology research

authors： Trabanelli S,La Manna F,Romano M,Salvestrini V,Cavo M,Ciciarello M,Lemoli RM,Curti A

更新日期：2015-01-01 00:00:00

abstract：Objectives:Both thymic stromal lymphopoietin (TSLP) and dendritic cells (DCs) are involved in many autoimmune diseases, but the potential roles of TSLP and DCs in bullous pemphigoid (BP) have not been clarified. We sought to explore the contributions of TSLP and DCs in patients with BP. Methods:TSLP levels in sera and...

journal_title：Journal of immunology research

authors： Li SZ,Jin XX,Ge XL,Zuo YG,Jin HZ

更新日期：2020-09-24 00:00:00

abstract：:Circulating T follicular helper (cTfh) cells are known to be involved in numerous immune-mediated diseases, but their pathological role in psoriasis is less fully investigated. Herein, we aimed to identify whether cTfh cells contributed to the pathogenesis of psoriasis. The frequency and function of cTfh cells were co...

journal_title：Journal of immunology research

authors： Wang Y,Wang L,Yang H,Yuan W,Ren J,Bai Y

更新日期：2016-01-01 00:00:00

abstract：:Toll/IL-1R-domain-containing adaptor-inducing IFN-β (TRIF) is an important adaptor for TLR3- and TLR4-mediated inflammatory signaling pathways. Recent studies have shown that TRIF plays a key role in vessel inflammation and atherosclerosis; however, the precise mechanisms are unclear. We investigated the mechanisms of...

journal_title：Journal of immunology research

authors： Wu Y,Ye J,Guo R,Liang X,Yang L

更新日期：2018-06-07 00:00:00

abstract：:Severe aplastic anemia (SAA) is a rare disease characterized by severe pancytopenia and bone marrow failure. Most patients with AA respond to immunosuppressive therapy (IST), usually as antithymocyte globulin (ATG) and cyclosporine (CsA), but some relapse on CsA withdrawal or require long-term administration of CsA to...

journal_title：Journal of immunology research

authors： Ding S,Liang X,Zhang T,Fu R

更新日期：2020-10-17 00:00:00

abstract：:Vaccination against human papillomavirus (HPV) has been progressively implemented in most developed countries for approximately 10 years. In order to increase the protection of the vaccines, a 9-valent vaccine (HPV9) was developed, which provides protection against nine types of the virus. Studies evaluating its safet...

journal_title：Journal of immunology research

authors： Costa APF,Cobucci RNO,da Silva JM,da Costa Lima PH,Giraldo PC,Gonçalves AK

更新日期：2017-01-01 00:00:00

abstract：:Gram-negative bacterial sepsis accounts for up to 50% worldwide sepsis that causes hospital mortality. Acute kidney injury (AKI), a common complication of Gram-negative bacterial sepsis, is caused by Toll-like receptor 4 (TLR4) activation. Lipopolysaccharide (LPS) is an endotoxin in Gram-negative bacteria and is recog...

journal_title：Journal of immunology research

authors： Li Q,Wu C,Liu Z,Zhang H,Du Y,Liu Y,Song K,Shi Q,Li R

更新日期：2019-02-19 00:00:00

abstract：:Diabetic nephropathy (DN) is one of the most serious chronic kidney diseases and the major cause of end-stage renal failure worldwide. The underlying mechanisms of DN are complex and required to be further investigated. Both innate immunity and renin-angiotensin system (RAS) play critical roles in the pathogenesis of ...

journal_title：Journal of immunology research

authors： Feng Q,Liu D,Lu Y,Liu Z

更新日期：2020-04-30 00:00:00

abstract：:Background. Systemic lupus erythematosus (SLE) is an autoimmune disease with great heterogeneity in pathogenesis and clinical symptoms. Rheumatoid factor (RF) is one key indicator for rheumatoid arthritis (RA) while immunoglobulin E (IgE) is associated with type I hypersensitivity. To better categorize SLE subtypes, w...

journal_title：Journal of immunology research

authors： Wu Y,Cai B,Zhang J,Shen B,Huang Z,Tan C,Baan CC,Wang L

更新日期：2017-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a disease of chronic systemic inflammation (SI). In the present study, we used four datasets to explore whether methylation-derived neutrophil-to-lymphocyte ratio (mdNLR) might be a marker of SI in new onset, untreated, and treated prevalent RA cases and/or a marker of treatment response t...

journal_title：Journal of immunology research

authors： Ambatipudi S,Sharp GC,Clarke SLN,Plant D,Tobias JH,Evans DM,Barton A,Relton CL

更新日期：2018-08-14 00:00:00

abstract：:Following fetal or neonatal gene transfer in mice and other species immune tolerance of the transgenic protein is frequently observed; however the underlying mechanisms remain largely undefined. In this study fetal and neonatal BALB/c mice received adenovirus vector to deliver human factor IX (hFIX) cDNA. The long-ter...

journal_title：Journal of immunology research

authors： Nivsarkar MS,Buckley SM,Parker AL,Perocheau D,McKay TR,Rahim AA,Howe SJ,Waddington SN

更新日期：2015-01-01 00:00:00

abstract：:The gastrointestinal microbiota plays a critical role in nutritional, metabolic, and immune functions in infants and young children and has implications for future lung health status. Understanding the role of intestinal dysbiosis in chronic lung disease progression will provide opportunities to design early intervent...

journal_title：Journal of immunology research

authors： Ranucci G,Buccigrossi V,de Freitas MB,Guarino A,Giannattasio A

更新日期：2017-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is characterized by deregulated activation of T and B cells, autoantibody production, and consequent formation of immune complexes. Liposomes with nonbilayer phospholipid arrangements (NPA), induced by chlorpromazine, procainamide, or manganese, provoke a disease resembling human lup...

journal_title：Journal of immunology research

authors： Zárate-Neira LÁ,Sánchez-Barbosa S,Pedroza-Torres A,Reséndiz-Mora A,Wong C,Baeza I,Pérez-Plasencia C,Wong-Baeza C

更新日期：2017-01-01 00:00:00