Abstract：
PURPOSES:To investigate the possible changes in B cell subsets and in B cell expression patterns of lipid rafts (LRs) and F-actin in patients with SLE and whether leflunomide treatment may have effect on these changes. METHODS:The B cell subsets and LRs expression were determined by flow cytometry and confocal microscopy, and F-actin expression was examined by confocal microscopy. RESULTS:CD27(+)IgD(+) B cell subsets were significantly decreased while CD38(+)CD95(+) B cell subsets increased in SLE patients. The LRs levels of B cells were remarkably increased and positively correlated with SLEDAI and anti-dsDNA titer in SLE patients. The expression level of LRs was significantly higher in CD38(+) B cells than CD38(-) B cells and negatively correlated with C3 levels. The increased expression of LRs was associated with reduced expression of F-actin in the B cells from active SLE patients. Furthermore, in vitro treatment of the cells with A771726 reduced the expression level of LRs, attenuated the overaggregation of LRs, and normalized the distribution of F-actin. CONCLUSIONS:There were abnormalities in B cell subsets and LRs and F-actin expression of B cell from SLE patients. Modulation of B cell expression of LRs and F-actin by LEF could be a potential therapeutic target for SLE.
journal_name
J Immunol Resjournal_title
Journal of immunology researchauthors
Dong GF,Zhang X,He DN,Li L,Zhang GFdoi
10.1155/2015/832916subject
Has Abstractpub_date
2015-01-01 00:00:00pages
832916eissn
2314-8861issn
2314-7156journal_volume
2015pub_type
杂志文章abstract：:The age-specific reference values for immunoglobulin (Ig) serum concentrations in European bison (Bison bonasus) are lacking. Identification of immune alterations that accompany normal physiological aging will help assist in development of better monitoring health programs. In the present study, the age-associated cha...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2020/2614317
更新日期：2020-01-23 00:00:00
abstract：OBJECTIVE:To investigate the expression and clinical significance of trans-membrane MerTK (mMer) on circulating CD14+ monocytes/macrophages and soluble MerTK (sMer) levels in plasma in systemic lupus erythematosus (SLE). METHOD:108 SLE patients and 42 healthy controls were recruited in this study. The expression of mM...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2014/431896
更新日期：2014-01-01 00:00:00
abstract：:The present study was aimed at determining the activity of aqueous and methanolic extracts of Tinospora cordifolia (AETC and METC) against Salmonella typhimurium. In vitro anti-Salmonella activity of T. cordifolia was determined through the broth dilution and agar well diffusion assays. The immune-stimulating potentia...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2017/1787803
更新日期：2017-01-01 00:00:00
abstract：:Calcitonin gene-related peptide (CGRP) is a mediator of microglial activation at the transcriptional level. The involvement of the epigenetic mechanism in this process is largely undefined. Histone deacetylase (HDAC)1/2 are considered important epigenetic regulators of gene expression in activated microglia. In this s...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2020/4384696
更新日期：2020-08-04 00:00:00
abstract：:Cationic protein is a cytotoxic protein secreted by eosinophils and takes part in the damage of airway epithelium in asthma. Poly-L-arginine (PLA), a synthetic cationic protein, is widely used to mimic the biological function of the natural cationic protein in vitro. Previous studies demonstrated the damage of the air...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2018/3651743
更新日期：2018-06-14 00:00:00
abstract：:Peroxisome proliferator-activated receptors (PPAR gamma-2) and beta-3-adrenergic receptors (ADRB3) are involved in the risk of hypertension. But their exact role in blood pressure modulation in patients with connective tissue diseases (CTD) is still not well defined. In this study, 104 patients with CTD and 103 gender...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2020/7509608
更新日期：2020-02-03 00:00:00
abstract：:Immune activation plays a significant role in the disease progression of HIV. Microbial products, especially bacterial lipopolysaccharide (LPS), contribute to immune activation. Increasing evidence indicates that T lymphocyte homeostasis disruptions are associated with immune activation. However, the mechanism by whic...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2015/202738
更新日期：2015-01-01 00:00:00
abstract：:Chagas disease, or American trypanosomiasis, which is caused by the protozoan parasite Trypanosoma cruzi, is primarily a vector disease endemic in 21 Latin American countries, including Mexico. Although many vector control programs have been implemented, T. cruzi has not been eradicated. The development of an anti-T. ...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2015/489758
更新日期：2015-01-01 00:00:00
abstract：:In organ transplantation, alloantigens are taken up by antigen presenting cells and presented via the indirect pathway to T-cells which in turn can induce allograft rejection. Monitoring of these T-cells is of major importance; however no reliable assay is available to routinely monitor indirect allorecognition. Recen...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2016/4215684
更新日期：2016-01-01 00:00:00
abstract：:The human leukocyte antigen-G (HLA-G) is considered an immune checkpoint molecule involved in tumor immune evasion. Hypoxia and the metabolic sensor hypoxia-inducible factor 1 (HIF-1) are hallmarks of metastasization, angiogenesis, and intense tumor metabolic activity. The purpose of this review was to examine origina...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2017/4587520
更新日期：2017-01-01 00:00:00
abstract：:Toll-like receptors (TLRs) are known to detect a defined spectrum of microbial structures. However, the knowledge about the specificity of teleost Tlr factors for distinct pathogens is limited so far. We measured baseline expression profiles of 18 tlr genes and associated signaling factors in four immune-relevant tiss...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2015/901015
更新日期：2015-01-01 00:00:00
abstract：:We investigated the characteristics of Chinese SLE patients by analyzing the association between specific autoantibodies and clinical manifestations of 2104 SLE patients from registry data of CSTAR cohort. Significant (P<0.05) associations were found between anti-Sm antibody, anti-rRNP antibody, and malar rash; betwee...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2014/809389
更新日期：2014-01-01 00:00:00
abstract：:Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are life-threatening disease. However, there are only few epidemiologic studies of SJS/TEN from China. To analyze the clinical characteristics, causality, and outcome of treatment for SJS/TEN in China, we reviewed case reports of patients with SJS/TEN f...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2018/4320195
更新日期：2018-02-11 00:00:00
abstract：:Inflammation plays an essential role in the control of pathogens and in shaping the ensuing adaptive immune responses. Traditionally, innate immunity has been described as a rapid response triggered through generic and nonspecific means that by definition lacks the ability to remember. Recently, it has become clear th...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2018/1467538
更新日期：2018-06-11 00:00:00
abstract：:Cutaneous adverse drug reactions are commonly seen in patients with anticancer drug treatment. Anticancer drugs, including chemotherapy, target therapy, and recent immunotherapy causing skin reactions ranging from mild skin rash to life-threatening severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson sy...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2018/5376476
更新日期：2018-01-17 00:00:00
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journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2019/7453236
更新日期：2019-05-29 00:00:00
abstract：:Cutaneous melanoma is a significant immunogenic tumoral model, the most frequently described immune phenomenon being tumor regression, as a result of the interaction of tumoral antigens and stromal microenvironment. We present a retrospective cohort study including 52 cases of melanoma with regression. There were eval...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2020/5416843
更新日期：2020-10-23 00:00:00
abstract：:The predominant distribution of γ δ T cells in the mucosal and epithelial tissues makes these unconventional lymphocytes the "guards" to contact external environment (like allergens) and to contribute to immune surveillance, as well as "vanguards" to participate in initiating mucosal inflammation. Therefore, γ δ T cel...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2014/963484
更新日期：2014-01-01 00:00:00
abstract：:TACI is a membrane receptor of BAFF and APRIL, contributing to the differentiation and survival of normal B cells. Although malignant B cells are also subjected on TACI signaling, there is a remarkable intradisease and interindividual variability of TACI expression in B-cell malignancies. The aim of our study was to e...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2015/478753
更新日期：2015-01-01 00:00:00
abstract：:Immune cell therapy has emerged as a promising approach to treat malignancies that were up until recently only treated on a palliative basis. Chimeric antigen receptor- (CAR-) modified T lymphocytes (T cells) in particular have proven to be very effective for certain hematological malignancies. The production of CAR T...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2019/3616120
更新日期：2019-09-04 00:00:00
abstract：:Objective. It has been shown that podocyte injury represents an important pathological basis that contributes to proteinuria and eventually leads to kidney failure. High glucose (HG) activates macrophage polarization, further exacerbating HG-induced podocyte injury. Our previous study on diabetic nephropathy rats indi...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2020/8263598
更新日期：2020-08-27 00:00:00
abstract：:Mucosal surfaces in the airways and the gastrointestinal tract are critical for the interactions of the host with its environment. Due to their abundance at mucosal tissue sites and their powerful immunomodulatory capacities, the role of innate lymphoid cells (ILCs) and natural killer T (NKT) cells in the maintenance ...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2014/546596
更新日期：2014-01-01 00:00:00
abstract：:Reports suggesting a pathogenic role of autoantibodies directed against glutamic acid decarboxylase 65 (GAD65Abs) in cerebellar ataxias (CAs) are reviewed, and debatable issues such as internalization of antibodies by neurons and roles of epitopes are discussed. GAD65 is one of two enzymes that catalyze the conversion...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2017/2913297
更新日期：2017-01-01 00:00:00
abstract：:In this study we examined changes in the salivary concentrations of immunoglobulin A (sIgA), cortisol (sC), testosterone (sT), and testosterone-to-cortisol ratio (T/C) in 21 competitive swimmers, 11-15 years old, during a week leading to competition as compared to a control (noncompetition) week. No day-to-day changes...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2014/234565
更新日期：2014-01-01 00:00:00
abstract：:Easy access to a vast collection of experimental data on immune epitopes can greatly facilitate the development of therapeutics and vaccines. The Immune Epitope Database and Analysis Resource (IEDB) was developed to provide such a resource as a free service to the biomedical research community. The IEDB contains epito...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2017/5974574
更新日期：2017-01-01 00:00:00
abstract：:Calcium is a ubiquitous intracellular messenger that has a crucial role in determining the proliferation, differentiation, and functions of multipotent mesenchymal stem cells (MSCs). Our study is aimed at elucidating the influence of genetically manipulating Ca2+ release-activated Ca2+ (CRAC) channel-mediated intercel...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2019/7510214
更新日期：2019-02-17 00:00:00
abstract：:Pancreatic ductal adenocarcinoma (PDAC) remains one of the most devastating cancer types despite the improvement of modern medicine. In our present study, we found that dickkopf-related protein 2 (DKK2) shares a higher expression in PDAC compared with adjacent pancreas tissue in tissue microarray. In addition, an elev...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2019/8656282
更新日期：2019-09-08 00:00:00
abstract：:Chemokine (C-X-C motif) ligand (CXCL)10 and other CXCR3 chemokines are involved in the pathogenesis of acute and "chronic hepatitis C virus (HCV) infection" (CHC). Here, we review the scientific literature about HCV and CXCL10. The combination of circulating CXCL10 and single nucleotide polymorphisms (SNPs) in IL-28B ...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2019/5878960
更新日期：2019-08-08 00:00:00
abstract：:Multiepitope peptide vaccine has some advantages over traditional recombinant protein vaccine due to its easy and fast production and possible inclusion of multiple protective epitopes of pathogens. However, it is usually poorly immunogenic and needs to conjugate to a large carrier protein. Peptides conjugated to a ce...
journal_title：Journal of immunology research
pub_type： 杂志文章
doi：10.1155/2020/2074803
更新日期：2020-01-08 00:00:00
abstract：:Recruitment of human NK cells to porcine tissues has been demonstrated in pig organs perfused ex vivo with human blood in the early 1990s. Subsequently, the molecular mechanisms leading to adhesion and cytotoxicity in human NK cell-porcine endothelial cell (pEC) interactions have been elucidated in vitro to identify t...
journal_title：Journal of immunology research
pub_type： 杂志文章,评审
doi：10.1155/2017/4627384
更新日期：2017-01-01 00:00:00
