The Epidemiology of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in China.

abstract：:Diabetes mellitus, a metabolic disease characterized by hyperglycemia and poor glucose control, is a risk factor for Mycobacterium tuberculosis (M. tuberculosis) infection and the development of active tuberculosis. To evaluate whether M. tuberculosis infection susceptibility is associated with an intrinsic factor in ...

journal_title：Journal of immunology research

authors： Torres M,Herrera MT,Fabián-San-Miguel G,Gonzalez Y

更新日期：2019-11-14 00:00:00

abstract：OBJECTIVE:To investigate the expression and clinical significance of trans-membrane MerTK (mMer) on circulating CD14+ monocytes/macrophages and soluble MerTK (sMer) levels in plasma in systemic lupus erythematosus (SLE). METHOD:108 SLE patients and 42 healthy controls were recruited in this study. The expression of mM...

journal_title：Journal of immunology research

authors： Zhu H,Sun X,Zhu L,Hu F,Shi L,Li Z,Su Y

更新日期：2014-01-01 00:00:00

abstract：Objective:Several molecules are involved in the pathogenesis of a new bone formation in ankylosing spondylitis (AS). The aim of this study was to evaluate the serum levels of sclerostin in patients with AS as a possible biomarker and to investigate any correlations with radiographic damage, disease activity, and functi...

journal_title：Journal of immunology research

authors： Perrotta FM,Ceccarelli F,Barbati C,Colasanti T,De Socio A,Scriffignano S,Alessandri C,Lubrano E

更新日期：2018-05-02 00:00:00

abstract：:Latent tuberculosis infection (LTBI) is evidence of immunological control of tuberculosis. Dormancy survival regulator (DosR) regulon-encoded proteins may have a role in the maintenance of LTBI. T cell responses to Rv1733c, Rv0081, Rv1735c, and Rv1737c DosR regulon-encoded proteins were found to be most frequent among...

journal_title：Journal of immunology research

authors： Kimuda SG,Nalwoga A,Levin J,Franken KL,Ottenhoff TH,Elliott AM,Cose S,Andia-Biraro I

更新日期：2017-01-01 00:00:00

abstract：:TACI is a membrane receptor of BAFF and APRIL, contributing to the differentiation and survival of normal B cells. Although malignant B cells are also subjected on TACI signaling, there is a remarkable intradisease and interindividual variability of TACI expression in B-cell malignancies. The aim of our study was to e...

journal_title：Journal of immunology research

authors： Mamara A,Germenis AE,Kompoti M,Palassopoulou M,Mandala E,Banti A,Giannakoulas N,Speletas M

更新日期：2015-01-01 00:00:00

abstract：:Many immune-based intestinal disorders, such as ulcerative colitis and Crohn's disease, as well as other illnesses, may have the intestines as an initial cause or aggravator in the development of diseases, even apparently not correlating directly to the intestine. Diabetes, obesity, multiple sclerosis, depression, and...

journal_title：Journal of immunology research

authors： Maranduba CM,De Castro SB,de Souza GT,Rossato C,da Guia FC,Valente MA,Rettore JV,Maranduba CP,de Souza CM,do Carmo AM,Macedo GC,Silva Fde S

更新日期：2015-01-01 00:00:00

abstract：:Although it is known that systemic form of lupus erythematosus (LE) and metabolic syndrome (MetS) are frequently observed together, there are no published reports on MetS in patients with skin-restricted LE. We aimed to compare the frequencies of MetS and its components in discoid LE (DLE) with the non-DLE control gro...

journal_title：Journal of immunology research

authors： Akarsu S,Ozbagcivan O,Semiz F,Aktan S

更新日期：2017-01-01 00:00:00

abstract：Introduction:Understanding the mechanisms underlying the pathogenesis of Sjögren's syndrome (SS) is crucially important in order to be able to discriminate the steps that lead to B cell transformation and promptly identify the patients at risk of lymphomagenesis. The aim of this narrative review is to describe the evid...

journal_title：Journal of immunology research

authors： Talotta R,Sarzi-Puttini P,Atzeni F

更新日期：2019-01-06 00:00:00

abstract：:Mucosal surfaces in the airways and the gastrointestinal tract are critical for the interactions of the host with its environment. Due to their abundance at mucosal tissue sites and their powerful immunomodulatory capacities, the role of innate lymphoid cells (ILCs) and natural killer T (NKT) cells in the maintenance ...

journal_title：Journal of immunology research

authors： Nau D,Altmayer N,Mattner J

更新日期：2014-01-01 00:00:00

abstract：:Background. U65, a self-aggregating peptide scaffold, traps fused protein antigens in yeast cells. Conversion to Yeast Cell Particle (YCP) vaccines by partial removal of surface mannoproteins exposes β-glucan, mediating efficient uptake by antigen-presenting cells (APCs). YCP vaccines are inexpensive, capable of rapid...

journal_title：Journal of immunology research

authors： Tipper DJ,Szomolanyi-Tsuda E

更新日期：2016-01-01 00:00:00

abstract：:C-type lectin domain family 5-member A (CLEC5A) associates with adaptor DAP12 (DNAX activation protein 12) to form receptor complexes involved in inflammatory responses. We postulated a potential role of CLEC5A in the pathogenesis of adult-onset Still's disease (AOSD) and aimed to investigate CLEC5A expression and its...

journal_title：Journal of immunology research

authors： Chen PK,Hsieh SL,Lan JL,Lin CC,Chang SH,Chen DY

更新日期：2020-04-23 00:00:00

abstract：:Differential cell systematic evolution of ligands by exponential enrichment (SELEX) is an in vitro selection method for obtaining molecular recognition elements (MREs) that specifically bind to individual cell types with high affinity. MREs are selected from initial large libraries of different nucleic or amino acids....

journal_title：Journal of immunology research

authors： Williams RM,Sooter LJ

更新日期：2015-01-01 00:00:00

abstract：Background:RNA helicases have various essential functions in basically all aspects of RNA metabolism, not only unwinding RNA but also disturbing the interaction of RNA with proteins. Recently, RNA helicases have been considered potential targets in cancers. So far, there has been no detailed investigation of the biolog...

journal_title：Journal of immunology research

authors： Xu Y,Jiang Q,Liu H,Xiao X,Yang D,Saw PE,Luo B

更新日期：2020-12-30 00:00:00

abstract：PURPOSES:To investigate the possible changes in B cell subsets and in B cell expression patterns of lipid rafts (LRs) and F-actin in patients with SLE and whether leflunomide treatment may have effect on these changes. METHODS:The B cell subsets and LRs expression were determined by flow cytometry and confocal microsc...

journal_title：Journal of immunology research

authors： Dong GF,Zhang X,He DN,Li L,Zhang GF

更新日期：2015-01-01 00:00:00

abstract：Background:Gastrosphere, an enriched cellular population with stem-like properties believed to be responsible for an escape from immune-mediated destruction. Th17 and Treg cells play a major role in gastric cancer; however, their interaction with gastrospheres remained elusive. Method:Peripheral blood mononuclear cell...

journal_title：Journal of immunology research

authors： Rezalotfi A,Solgi G,Ebrahimi M

更新日期：2020-12-23 00:00:00

abstract：:Chagas disease, or American trypanosomiasis, which is caused by the protozoan parasite Trypanosoma cruzi, is primarily a vector disease endemic in 21 Latin American countries, including Mexico. Although many vector control programs have been implemented, T. cruzi has not been eradicated. The development of an anti-T. ...

journal_title：Journal of immunology research

authors： Rodríguez-Morales O,Monteón-Padilla V,Carrillo-Sánchez SC,Rios-Castro M,Martínez-Cruz M,Carabarin-Lima A,Arce-Fonseca M

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Resistant and susceptible mouse strains to experimental autoimmune encephalomyelitis (EAE), an inducible demyelinating experimental disease serving as animal model for multiple sclerosis, have been described. We aimed to explore MHC-independent mechanisms inducing resistance to EAE. METHODS:F...

journal_title：Journal of immunology research

authors： Marín N,Mecha M,Espejo C,Mestre L,Eixarch H,Montalban X,Álvarez-Cermeño JC,Guaza C,Villar LM

更新日期：2014-01-01 00:00:00

abstract：:Probiotics are commensal or nonpathogenic microbes that confer beneficial effects on the host through several mechanisms such as competitive exclusion, antibacterial effects, and modulation of immune responses. Some probiotics have been found to regulate immune responses via immune regulatory mechanisms. T regulatory ...

journal_title：Journal of immunology research

authors： Zeng W,Shen J,Bo T,Peng L,Xu H,Nasser MI,Zhuang Q,Zhao M

更新日期：2019-04-16 00:00:00

abstract：:Breast cancer is the most common neoplasm diagnosed in women around the world. Checkpoint inhibitors, targeting the programmed death receptor-1 or ligand-1 (PD-1/PD-L1) axis, have dramatically changed the outcome of cancer treatment. These therapies have been recently considered as alternatives for treatment of breast...

journal_title：Journal of immunology research

authors： Segovia-Mendoza M,Romero-Garcia S,Lemini C,Prado-Garcia H

更新日期：2021-01-07 00:00:00

abstract：:Bone is sensitive to overactive immune responses, which initiate the onset of inflammatory bone disorders, such as rheumatoid arthritis and periodontitis, resulting in a significant systemic inflammatory response. On the other hand, neuroinflammation is strongly implicated in Alzheimer's disease (AD), which can be enh...

journal_title：Journal of immunology research

authors： Wu Z,Nakanishi H

更新日期：2015-01-01 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP) is a mediator of microglial activation at the transcriptional level. The involvement of the epigenetic mechanism in this process is largely undefined. Histone deacetylase (HDAC)1/2 are considered important epigenetic regulators of gene expression in activated microglia. In this s...

journal_title：Journal of immunology research

authors： Guo X,Chen D,An S,Wang Z

更新日期：2020-08-04 00:00:00

abstract：:RANKL (receptor activator of nuclear factor kappa-β ligand) and OPG (osteoprotegerin) are two proteins involved in bone remodelling. During the active phase of periodontal disease, an imbalance between the ratios of the two elements can be noticed. While the expression of RANKL is elevated compared with that of OPG, t...

journal_title：Journal of immunology research

authors： Teodorescu AC,Martu I,Teslaru S,Kappenberg-Nitescu DC,Goriuc A,Luchian I,Martu MA,Solomon SM,Mârțu S

更新日期：2019-04-28 00:00:00

abstract：:Bacterial vaginosis (BV), the most common genital infection in reproductive-aged women, is associated with increased risk of sexually transmitted infections. Its etiology remains unclear, especially the role of Gardnerella (G.) vaginalis, an anaerobic bacterium characteristic of the BV-alteration of the vaginal ecosys...

journal_title：Journal of immunology research

authors： Bertran T,Brachet P,Vareille-Delarbre M,Falenta J,Dosgilbert A,Vasson MP,Forestier C,Tridon A,Evrard B

更新日期：2016-01-01 00:00:00

abstract：:C-type lectin receptors (CLRs) on antigen-presenting cells (APCs) facilitate uptake of carbohydrate antigens for antigen presentation, modulating the immune response in infection, homeostasis, autoimmunity, allergy, and cancer. In this review, we focus on the role of the macrophage galactose type C-type lectin (MGL) i...

journal_title：Journal of immunology research

authors： Zizzari IG,Napoletano C,Battisti F,Rahimi H,Caponnetto S,Pierelli L,Nuti M,Rughetti A

更新日期：2015-01-01 00:00:00

abstract：:It has been shown that rapamycin is able to significantly increase the expression of FoxP3 and suppress activity in induced Treg (iTreg) cells in vivo and in vitro. CD39 is a newly determined Treg marker that relates to cell suppression. Runx1, a regulator of FoxP3, controls the expression of adenosine deaminase (ADA)...

journal_title：Journal of immunology research

authors： Lu Y,Wang J,Gu J,Lu H,Li X,Qian X,Liu X,Wang X,Zhang F,Lu L

更新日期：2014-01-01 00:00:00

abstract：:Human papillomavirus (HPV) is a small double-stranded DNA virus with tropism for epithelial cells. To this date, over 150 genotypes are known and are classified into two major groups, low-risk and high-risk strains, depending on the ability of the virus to induce malignant transformation. The host's immunity plays a c...

journal_title：Journal of immunology research

authors： Georgescu SR,Mitran CI,Mitran MI,Caruntu C,Sarbu MI,Matei C,Nicolae I,Tocut SM,Popa MI,Tampa M

更新日期：2018-08-27 00:00:00

abstract：:In this study we examined changes in the salivary concentrations of immunoglobulin A (sIgA), cortisol (sC), testosterone (sT), and testosterone-to-cortisol ratio (T/C) in 21 competitive swimmers, 11-15 years old, during a week leading to competition as compared to a control (noncompetition) week. No day-to-day changes...

journal_title：Journal of immunology research

authors： Papadopoulos E,Muir C,Russell C,Timmons BW,Falk B,Klentrou P

更新日期：2014-01-01 00:00:00

abstract：Objective:To evaluate the efficacy and safety of rituximab in multiple sclerosis in a clinical practice setting. Methods:Clinical data for all adult patients with multiple sclerosis (MS) treated with off-label rituximab at a single MS center in Lebanon between March 2008 and April 2017 were retrospectively collected f...

journal_title：Journal of immunology research

authors： Yamout BI,El-Ayoubi NK,Nicolas J,El Kouzi Y,Khoury SJ,Zeineddine MM

更新日期：2018-11-12 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that is characterized by synovial hyperplasia and progressive joint destruction. The activation of RA synovial fibroblasts (SFs), also called fibroblast-like synoviocytes (FLS), contributes significantly to perpetuation of the disease. Genetic and ...

journal_title：Journal of immunology research

authors： Araki Y,Mimura T

更新日期：2016-01-01 00:00:00

abstract：:Reconstitution of the hematopoietic system during immune responses and immunological and neoplastic diseases or upon transplantation depends on the emergent differentiation of hematopoietic stem/progenitor cells within the bone marrow. Although in the last decade the use of dialyzable leukocyte extracts (DLE) as suppo...

journal_title：Journal of immunology research

authors： Ramírez-Ramírez D,Vadillo E,Arriaga-Pizano LA,Mayani H,Estrada-Parra S,Velasco-Velázquez MA,Pérez-Tapia SM,Pelayo R

更新日期：2016-01-01 00:00:00