Cutting Edge: Probiotics and Fecal Microbiota Transplantation in Immunomodulation.

Abstract:

:Probiotics are commensal or nonpathogenic microbes that confer beneficial effects on the host through several mechanisms such as competitive exclusion, antibacterial effects, and modulation of immune responses. Some probiotics have been found to regulate immune responses via immune regulatory mechanisms. T regulatory (Treg) cells, T helper cell balances, dendritic cells, macrophages, B cells, and natural killer (NK) cells can be considered as the most determinant dysregulated mediators in immunomodulatory status. Recently, fecal microbiota transplantation (FMT) has been defined as the transfer of distal gut microbial communities from a healthy individual to a patient's intestinal tract to cure some immune disorders (mainly inflammatory bowel diseases). The aim of this review was followed through the recent literature survey on immunomodulatory effects and mechanisms of probiotics and FMT and also efficacy and safety of probiotics and FMT in clinical trials and applications.

journal_name

J Immunol Res

authors

Zeng W,Shen J,Bo T,Peng L,Xu H,Nasser MI,Zhuang Q,Zhao M

doi

10.1155/2019/1603758

subject

Has Abstract

pub_date

2019-04-16 00:00:00

pages

1603758

eissn

2314-8861

issn

2314-7156

journal_volume

2019

pub_type

杂志文章,评审
  • The Interplay of Renin-Angiotensin System and Toll-Like Receptor 4 in the Inflammation of Diabetic Nephropathy.

    abstract::Diabetic nephropathy (DN) is one of the most serious chronic kidney diseases and the major cause of end-stage renal failure worldwide. The underlying mechanisms of DN are complex and required to be further investigated. Both innate immunity and renin-angiotensin system (RAS) play critical roles in the pathogenesis of ...

    journal_title:Journal of immunology research

    pub_type: 杂志文章,评审

    doi:10.1155/2020/6193407

    authors: Feng Q,Liu D,Lu Y,Liu Z

    更新日期:2020-04-30 00:00:00

  • Lactobacillus acidophilus suppresses colitis-associated activation of the IL-23/Th17 axis.

    abstract::The aim of this paper is to determine the modulatory effects of Lactobacillus acidophilus on the IL-23/Th17 immune axis in experimental colitis. DSS-induced mouse models of UC were to be saline, hormones, and different concentrations of Lactobacillus acidophilus intervention. The expression of interleukin- (IL-) 17, t...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2015/909514

    authors: Chen L,Zou Y,Peng J,Lu F,Yin Y,Li F,Yang J

    更新日期:2015-01-01 00:00:00

  • Immunoinformatics Approach for Epitope-Based Peptide Vaccine Design and Active Site Prediction against Polyprotein of Emerging Oropouche Virus.

    abstract::Oropouche virus (OROV) is an emerging pathogen which causes Oropouche fever and meningitis in humans. Several outbreaks of OROV in South America, especially in Brazil, have changed its status as an emerging disease, but no vaccine or specific drug target is available yet. Our approach was to identify the epitope-based...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2018/6718083

    authors: Adhikari UK,Tayebi M,Rahman MM

    更新日期:2018-10-08 00:00:00

  • Computer-Aided Design of an Epitope-Based Vaccine against Epstein-Barr Virus.

    abstract::Epstein-Barr virus is a very common human virus that infects 90% of human adults. EBV replicates in epithelial and B cells and causes infectious mononucleosis. EBV infection is also linked to various cancers, including Burkitt's lymphoma and nasopharyngeal carcinomas, and autoimmune diseases such as multiple sclerosis...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2017/9363750

    authors: Alonso-Padilla J,Lafuente EM,Reche PA

    更新日期:2017-01-01 00:00:00

  • Elucidating the Pivotal Immunomodulatory and Anti-Inflammatory Potentials of Chloroquine and Hydroxychloroquine.

    abstract::Chloroquine (CQ) and hydroxychloroquine (HCQ) are derivatives of 4-aminoquinoline compounds with over 60 years of safe clinical usage. CQ and HCQ are able to inhibit the production of cytokines such as interleukin- (IL-) 1, IL-2, IL-6, IL-17, and IL-22. Also, CQ and HCQ inhibit the production of interferon- (IFN-) α a...

    journal_title:Journal of immunology research

    pub_type: 杂志文章,评审

    doi:10.1155/2020/4582612

    authors: Richard SA,Kampo S,Hechavarria ME,Sackey M,Buunaaim ADB,Kuugbee ED,Anabah TW

    更新日期:2020-09-25 00:00:00

  • ChIP-seq Profiling Identifies Histone Deacetylase 2 Targeting Genes Involved in Immune and Inflammatory Regulation Induced by Calcitonin Gene-Related Peptide in Microglial Cells.

    abstract::Calcitonin gene-related peptide (CGRP) is a mediator of microglial activation at the transcriptional level. The involvement of the epigenetic mechanism in this process is largely undefined. Histone deacetylase (HDAC)1/2 are considered important epigenetic regulators of gene expression in activated microglia. In this s...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2020/4384696

    authors: Guo X,Chen D,An S,Wang Z

    更新日期:2020-08-04 00:00:00

  • Circulating miRNAs as Biomarkers for Prostate Cancer Diagnosis in Subjects with Benign Prostatic Hyperplasia.

    abstract::Body fluids often contain freely circulating nucleic acids, many of which can be exploited as noninvasive tools for the diagnosis of cancer as well as for clinical prognostication. Identifying microRNAs (miRNAs) in subjects' blood with various malignancies means that they can serve as novel biomarkers for prostate can...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2020/5873056

    authors: Jin W,Fei X,Wang X,Chen F,Song Y

    更新日期:2020-05-08 00:00:00

  • Comparison of Inhibitory Effects of Safflower Decoction and Safflower Injection on Protein and mRNA Expressions of iNOS and IL-1β in LPS-Activated RAW264.7 Cells.

    abstract:Objective:Safflower has antioxidant and anti-inflammatory activities. The two forms of preparations for safflower which are widely used in China are injection and decoction. The first step of the process for preparing an injection involves extracting safflower with water, which actually yields a decoction. This study i...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2019/1018274

    authors: Liao H,Li Y,Zhai X,Zheng B,Banbury L,Zhao X,Li R

    更新日期:2019-05-06 00:00:00

  • Analysis of Toll-Like Receptors in Human Milk: Detection of Membrane-Bound and Soluble Forms.

    abstract::The bioactive and anti-inflammatory role of human milk components has been recognized; active milk components include soluble forms of Toll-like receptors (TLRs). Preterm babies are more susceptible to infections and may succumb to necrotizing enterocolitis (NEC), a gastrointestinal disease which is exacerbated by an ...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2019/4078671

    authors: Cattaneo C,Caramaschi A,Uga E,Braghin M,Cosi G,Peila C,Strozzi MC,Sabatini M,Gazzolo D,Manfredi M,Cavaletto M

    更新日期:2019-12-04 00:00:00

  • Genetic Manipulation of Calcium Release-Activated Calcium Channel 1 Modulates the Multipotency of Human Cartilage-Derived Mesenchymal Stem Cells.

    abstract::Calcium is a ubiquitous intracellular messenger that has a crucial role in determining the proliferation, differentiation, and functions of multipotent mesenchymal stem cells (MSCs). Our study is aimed at elucidating the influence of genetically manipulating Ca2+ release-activated Ca2+ (CRAC) channel-mediated intercel...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2019/7510214

    authors: Liu S,Takahashi M,Kiyoi T,Toyama K,Mogi M

    更新日期:2019-02-17 00:00:00

  • Gastrospheres as a Model of Gastric Cancer Stem Cells Skew Th17/Treg Balance toward Antitumor Th17 Cells.

    abstract:Background:Gastrosphere, an enriched cellular population with stem-like properties believed to be responsible for an escape from immune-mediated destruction. Th17 and Treg cells play a major role in gastric cancer; however, their interaction with gastrospheres remained elusive. Method:Peripheral blood mononuclear cell...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2020/6261814

    authors: Rezalotfi A,Solgi G,Ebrahimi M

    更新日期:2020-12-23 00:00:00

  • Anti-VEGF for the management of diabetic macular edema.

    abstract::Diabetic retinopathy (DR) is an important cause of vision loss around the world, being the leading cause in the population between 20 and 60 years old. Among patients with DR, diabetic macular edema (DME) is the most frequent cause of vision impairment and represents a significant public health issue. Macular photocoa...

    journal_title:Journal of immunology research

    pub_type: 杂志文章,评审

    doi:10.1155/2014/632307

    authors: Stefanini FR,Badaró E,Falabella P,Koss M,Farah ME,Maia M

    更新日期:2014-01-01 00:00:00

  • Pathogenic Roles of Glutamic Acid Decarboxylase 65 Autoantibodies in Cerebellar Ataxias.

    abstract::Reports suggesting a pathogenic role of autoantibodies directed against glutamic acid decarboxylase 65 (GAD65Abs) in cerebellar ataxias (CAs) are reviewed, and debatable issues such as internalization of antibodies by neurons and roles of epitopes are discussed. GAD65 is one of two enzymes that catalyze the conversion...

    journal_title:Journal of immunology research

    pub_type: 杂志文章,评审

    doi:10.1155/2017/2913297

    authors: Mitoma H,Manto M,Hampe CS

    更新日期:2017-01-01 00:00:00

  • The Immune Epitope Database: How Data Are Entered and Retrieved.

    abstract::Easy access to a vast collection of experimental data on immune epitopes can greatly facilitate the development of therapeutics and vaccines. The Immune Epitope Database and Analysis Resource (IEDB) was developed to provide such a resource as a free service to the biomedical research community. The IEDB contains epito...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2017/5974574

    authors: Fleri W,Vaughan K,Salimi N,Vita R,Peters B,Sette A

    更新日期:2017-01-01 00:00:00

  • Expression of PD-1 on CD4+ Tumor-Infiltrating Lymphocytes in Tumor Microenvironment Associated with Pathological Characteristics of Breast Cancer.

    abstract:Objective:This study aimed to investigate the correlation of CD4+/PD-1+ or CD4+/PD-1- tumor-infiltrating lymphocytes with pathological characteristics in breast cancer patients. Methods:A cross-sectional study consecutively recruited 133 patients with invasive ductal breast cancer. The expression of CD4, programmed ce...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2018/5690258

    authors: Zhao YJ,Zhang J,Shi F,Hu ZP,Wu JP,Wu GJ,Wang RB,Zhou Q,Chang H,Li YN,Song QK

    更新日期:2018-07-04 00:00:00

  • sB7H3 in Children with Acute Appendicitis: Its Diagnostic Value and Association with Histological Findings.

    abstract:Background:Several efforts have been made to find out a valuable marker to assist the diagnosis and differentiation of gangrenous/perforated appendicitis. We aimed to determine the diagnostic capacity of soluble B7H3 (sB7H3) in acute appendicitis (AA) and its accuracy as a predictor of the severity of appendicitis. Me...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2020/2670527

    authors: Du X,Chen Y,Zhu J,Bai Z,Hua J,Li Y,Lv H,Zhang G

    更新日期:2020-09-01 00:00:00

  • IL-7 is a Key Driver Cytokine in Spondyloarthritis?

    abstract::The rationale for a type 17 signature in the pathogenesis of spondyloarthritis (SpA) has been increasing and being ratified in studies recently. IL-7 is a cytokine whose ability to stimulate IL-17 production in both innate and adaptive immunity cells has made it a promising target not only for a better understanding o...

    journal_title:Journal of immunology research

    pub_type: 杂志文章,评审

    doi:10.1155/2019/7453236

    authors: Gonçalves RSG,Duarte ALBP

    更新日期:2019-05-29 00:00:00

  • FOXP3 in Melanoma with Regression: Between Tumoral Expression and Regulatory T Cell Upregulation.

    abstract::Cutaneous melanoma is a significant immunogenic tumoral model, the most frequently described immune phenomenon being tumor regression, as a result of the interaction of tumoral antigens and stromal microenvironment. We present a retrospective cohort study including 52 cases of melanoma with regression. There were eval...

    journal_title:Journal of immunology research

    pub_type: 杂志文章,评审

    doi:10.1155/2020/5416843

    authors: Cioplea M,Nichita L,Georgescu D,Sticlaru L,Cioroianu A,Nedelcu R,Turcu G,Rauta A,Mogodici C,Zurac S,Popp C

    更新日期:2020-10-23 00:00:00

  • Lipopolysaccharide Increases Immune Activation and Alters T Cell Homeostasis in SHIVB'WHU Chronically Infected Chinese Rhesus Macaque.

    abstract::Immune activation plays a significant role in the disease progression of HIV. Microbial products, especially bacterial lipopolysaccharide (LPS), contribute to immune activation. Increasing evidence indicates that T lymphocyte homeostasis disruptions are associated with immune activation. However, the mechanism by whic...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2015/202738

    authors: Zhang GH,Wu RD,Zheng HY,Zhang XL,Zhang MX,Tian RR,Liu GM,Pang W,Zheng YT

    更新日期:2015-01-01 00:00:00

  • IL-34 Suppresses Candida albicans Induced TNFα Production in M1 Macrophages by Downregulating Expression of Dectin-1 and TLR2.

    abstract::Candida albicans is a fungus that is an opportunistic pathogen of humans. Normally, C. albicans exists as a harmless commensal and does not trigger inflammatory responses by resident macrophages in skin mucosa, which may be caused by a tolerance of skin macrophage to C. albicans. IL-34 is a recently discovered cytokin...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2015/328146

    authors: Xu R,Sun HF,Williams DW,Jones AV,Al-Hussaini A,Song B,Wei XQ

    更新日期:2015-01-01 00:00:00

  • Assessing the Role of DNA Methylation-Derived Neutrophil-to-Lymphocyte Ratio in Rheumatoid Arthritis.

    abstract::Rheumatoid arthritis (RA) is a disease of chronic systemic inflammation (SI). In the present study, we used four datasets to explore whether methylation-derived neutrophil-to-lymphocyte ratio (mdNLR) might be a marker of SI in new onset, untreated, and treated prevalent RA cases and/or a marker of treatment response t...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2018/2624981

    authors: Ambatipudi S,Sharp GC,Clarke SLN,Plant D,Tobias JH,Evans DM,Barton A,Relton CL

    更新日期:2018-08-14 00:00:00

  • Hepatitis B Vaccination Induced TNF-α- and IL-2-Producing T Cell Responses in HIV- Healthy Individuals Higher than in HIV+ Individuals Who Received the Same Vaccination Regimen.

    abstract::We investigated cytokine production and expression of degranulation marker CD107a after different strategies of hepatitis B virus (HBV) vaccination in human immunodeficiency virus-infected individuals, which were three doses of 20 μg (standard dose group), four doses of 20 μg (four doses group), or four doses of 40 μg...

    journal_title:Journal of immunology research

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2018/8350862

    authors: Chawansuntati K,Chaiklang K,Chaiwarith R,Praparattanapan J,Supparatpinyo K,Wipasa J

    更新日期:2018-02-27 00:00:00

  • Osteoprotegerin Polymorphisms in a Mexican Population with Rheumatoid Arthritis and Generalized Osteoporosis: A Preliminary Report.

    abstract::Bone disease in rheumatoid arthritis (RA) is a complex phenomenon where genetic risk factors have been partially evaluated. The system formed by receptor activator for nuclear factor-κB (RANK), receptor activator for nuclear factor-κB ligand (RANKL), and osteoprotegerin (OPG): RANK/RANKL/OPG is a crucial molecular pat...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2015/376197

    authors: Zavala-Cerna MG,Moran-Moguel MC,Cornejo-Toledo JA,Gonzalez-Montoya NG,Sanchez-Corona J,Salazar-Paramo M,Nava-Zavala AH,Aguilar-Chavez EA,Alcaraz-Lopez MF,Gonzalez-Sanchez AG,Gonzalez-Lopez L,Gamez-Nava JI

    更新日期:2015-01-01 00:00:00

  • Modulation of Th1/Th2 immune responses by killed Propionibacterium acnes and its soluble polysaccharide fraction in a type I hypersensitivity murine model: induction of different activation status of antigen-presenting cells.

    abstract::Propionibacterium acnes (P. acnes) is a gram-positive anaerobic bacillus present in normal human skin microbiota, which exerts important immunomodulatory effects, when used as heat- or phenol-killed suspensions. We previously demonstrated that heat-killed P. acnes or its soluble polysaccharide (PS), extracted from the...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2015/132083

    authors: Squaiella-Baptistão CC,Teixeira D,Mussalem JS,Ishimura ME,Longo-Maugéri IM

    更新日期:2015-01-01 00:00:00

  • Increased Performances of the Biological Diagnosis of the Antiphospholipid Syndrome by the Use of a Multiplex Assay.

    abstract::Antiphospholipid syndrome (APS) is characterized by development of venous and/or arterial thrombosis and pregnancy morbidity. Biological criteria are the persistent presence of lupus anticoagulant (LA) and/or anti-cardiolipin (aCL) and/or anti-B2GP1 autoantibodies' positivity. The assays' performances are of crucial i...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2015/983094

    authors: Sénant M,Rostane H,Fernani-Oukil F,Hosking F,Bellery F,Courchinoux A,Tartour E,Darnige L,Dragon-Durey MA

    更新日期:2015-01-01 00:00:00

  • Peripheral B Cell Subsets in Autoimmune Diseases: Clinical Implications and Effects of B Cell-Targeted Therapies.

    abstract::Antibody-secreting cells (ASCs) play a fundamental role in humoral immunity. The aberrant function of ASCs is related to a number of disease states, including autoimmune diseases and cancer. Recent insights into activated B cell subsets, including naïve B cell to ASC stages and their resultant cellular disturbances, s...

    journal_title:Journal of immunology research

    pub_type: 杂志文章,评审

    doi:10.1155/2020/9518137

    authors: Jin W,Luo Z,Yang H

    更新日期:2020-03-23 00:00:00

  • Early Differentiation of Human CD11c+NK Cells with γδ T Cell Activation Properties Is Promoted by Dialyzable Leukocyte Extracts.

    abstract::Reconstitution of the hematopoietic system during immune responses and immunological and neoplastic diseases or upon transplantation depends on the emergent differentiation of hematopoietic stem/progenitor cells within the bone marrow. Although in the last decade the use of dialyzable leukocyte extracts (DLE) as suppo...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2016/4097642

    authors: Ramírez-Ramírez D,Vadillo E,Arriaga-Pizano LA,Mayani H,Estrada-Parra S,Velasco-Velázquez MA,Pérez-Tapia SM,Pelayo R

    更新日期:2016-01-01 00:00:00

  • Immunosuppressive Role of Myeloid-Derived Suppressor Cells and Therapeutic Targeting in Lung Cancer.

    abstract::Lung cancer is the leading cause of cancer death worldwide due to its late diagnosis and poor outcome. Immunotherapy is becoming more and more encouraging and promising in lung cancer therapy. Myeloid-derived suppressor cells (MDSCs) are the main tumor suppressor factors, and the treatment strategy of targeting MDSCs ...

    journal_title:Journal of immunology research

    pub_type: 杂志文章,评审

    doi:10.1155/2018/6319649

    authors: Ma J,Xu H,Wang S

    更新日期:2018-03-25 00:00:00

  • Clinical Correlations of Novel Autoantibodies in Patients with Dry Eye.

    abstract:Background:Diagnostic criteria for Sjögren's syndrome (SS) are continually being updated in pursuit of more precise and earlier diagnosis to prevent its complications. Owing to the high rate of false negative traditional serological markers, the need for better serological testing remains. Objective:To investigate the...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2019/7935451

    authors: Karakus S,Baer AN,Akpek EK

    更新日期:2019-01-13 00:00:00

  • The Relationship of Cytokines IL-13 and IL-17 with Autoantibodies Profile in Early Rheumatoid Arthritis.

    abstract::Aims. In the present study, we aimed to assess the concentrations of IL-13 and IL-17 in serum of patients with early rheumatoid arthritis (eRA), the investigation of correlation between the concentrations of these cytokines and disease activity score, and the concentration of some autoantibodies and the evaluation of ...

    journal_title:Journal of immunology research

    pub_type: 杂志文章

    doi:10.1155/2016/3109135

    authors: Siloşi I,Boldeanu MV,Cojocaru M,Biciuşcă V,Pădureanu V,Bogdan M,Badea RG,Avramescu C,Petrescu IO,Petrescu F,Siloşi CA

    更新日期:2016-01-01 00:00:00