Abstract:
:The purpose of this study was to investigate the expression levels of the immune checkpoint proteins, programmed cell death-ligand 1 (PD-L1), B7-H3, B7-H4, and V-domain Ig suppressor of T cell activation (VISTA), as well as the significance thereof, in clear cell carcinoma (CCC) of the cervix (a rare histological subtype of cervical cancer). We also compared the expression statuses of these biomarkers in cervical CCCs with those in cervical squamous cell carcinomas (SCCs). We evaluated the expression of PD-L1, B7-H3, B7-H4, and VISTA in 50 cervical CCCs and 100 SCCs using immunohistochemical staining and investigated the associations between these markers, clinicopathologic features, and survival in patients with CCCs. Of the cervical CCC samples examined, 22%, 16%, 32%, and 34% were positive for PD-L1, B7-H3, B7-H4, and VISTA, respectively. Nineteen samples (38%) were negative for all 4 of these markers, whereas 31 (62%) expressed at least 1 marker. None of these markers was associated with the investigated clinicopathologic variables or patient survival. PD-L1, B7-H3, and VISTA were observed significantly more frequently in SCCs than in CCCs of the cervix. Our study confirmed the expression of immune checkpoint proteins in cervical CCCs and indicated their nonredundant and complementary roles. As such, our data suggest that monotherapeutic immune checkpoint blockade may not be sufficiently effective in patients with cervical CCC.
journal_name
J Immunol Resjournal_title
Journal of immunology researchauthors
Zong L,Zhang Q,Zhou Y,Kong Y,Yu S,Chen J,Zhang Y,Xiang Ydoi
10.1155/2020/1283632subject
Has Abstractpub_date
2020-04-03 00:00:00pages
1283632eissn
2314-8861issn
2314-7156journal_volume
2020pub_type
杂志文章abstract::In organ transplantation, alloantigens are taken up by antigen presenting cells and presented via the indirect pathway to T-cells which in turn can induce allograft rejection. Monitoring of these T-cells is of major importance; however no reliable assay is available to routinely monitor indirect allorecognition. Recen...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2016/4215684
更新日期:2016-01-01 00:00:00
abstract:Background and Objectives:Pneumocystis pneumonia (PCP) is a common opportunistic infection in acquired immune deficiency syndrome (AIDS) patients that continues to result in a high mortality rate. To develop a better treatment strategy and improve PCP prognosis, a cohort study was conducted to evaluate the therapeutic ...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2019/8105075
更新日期:2019-12-01 00:00:00
abstract:Objective:Rheumatoid arthritis (RA) multidrug resistance is associated with P-glycoprotein (P-gp) overexpression. We investigated the effects of methotrexate (MTX) alone and combined with 4-hydroperoxycyclophosphamide (4-HC) on P-gp expression in fibroblast-like synoviocytes (FLSs) from patients with RA and examined th...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2018/3619320
更新日期:2018-02-18 00:00:00
abstract::Although it is known that systemic form of lupus erythematosus (LE) and metabolic syndrome (MetS) are frequently observed together, there are no published reports on MetS in patients with skin-restricted LE. We aimed to compare the frequencies of MetS and its components in discoid LE (DLE) with the non-DLE control gro...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2017/3972706
更新日期:2017-01-01 00:00:00
abstract::Chloroquine (CQ) and hydroxychloroquine (HCQ) are derivatives of 4-aminoquinoline compounds with over 60 years of safe clinical usage. CQ and HCQ are able to inhibit the production of cytokines such as interleukin- (IL-) 1, IL-2, IL-6, IL-17, and IL-22. Also, CQ and HCQ inhibit the production of interferon- (IFN-) α a...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2020/4582612
更新日期:2020-09-25 00:00:00
abstract::The interferon-inducible DNA sensor IFI16 is involved in the modulation of cellular survival, proliferation, and differentiation. In the hematopoietic system, IFI16 is consistently expressed in the CD34+ stem cells and in peripheral blood lymphocytes; however, little is known regarding its regulation during maturation...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2015/747645
更新日期:2015-01-01 00:00:00
abstract::Lycium barbarum polysaccharide (LBP) is isolated from the fruit of Chinese herbal Lycium barbarum. Previous studies had demonstrated that LBP could inhibit tumor growth and enhance the immunity in mice. However, the effect of LBP on systemic and local immune responses in vivo, especially on phenotypic and functional c...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2018/3431782
更新日期:2018-06-03 00:00:00
abstract::Extracellular matrix metalloproteases and the fibrinolytic system are important protease systems interacting with each other in charge of remodeling and recycling of tissues. Their role in tumor invasion and metastasis is often discussed. In this study several metalloproteases such as MMP-1, MMP-3, MMP-9, and TIMP-1 t...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2016/8519648
更新日期:2016-01-01 00:00:00
abstract::Antibody-secreting cells (ASCs) play a fundamental role in humoral immunity. The aberrant function of ASCs is related to a number of disease states, including autoimmune diseases and cancer. Recent insights into activated B cell subsets, including naïve B cell to ASC stages and their resultant cellular disturbances, s...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2020/9518137
更新日期:2020-03-23 00:00:00
abstract::Chemokine (C-X-C motif) ligand (CXCL)10 and other CXCR3 chemokines are involved in the pathogenesis of acute and "chronic hepatitis C virus (HCV) infection" (CHC). Here, we review the scientific literature about HCV and CXCL10. The combination of circulating CXCL10 and single nucleotide polymorphisms (SNPs) in IL-28B ...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2019/5878960
更新日期:2019-08-08 00:00:00
abstract::Vaccination against human papillomavirus (HPV) has been progressively implemented in most developed countries for approximately 10 years. In order to increase the protection of the vaccines, a 9-valent vaccine (HPV9) was developed, which provides protection against nine types of the virus. Studies evaluating its safet...
journal_title:Journal of immunology research
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2017/3736201
更新日期:2017-01-01 00:00:00
abstract::Intestinal inflammation is a harmful condition in fish that can be triggered by the ingestion of soybean meal. Due to the positive costs-benefits ratio of including soybean meal in farmed fish diets, identifying additives with intestinal anti-inflammatory effects could contribute to solving the issues caused by this p...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2016/1639720
更新日期:2016-01-01 00:00:00
abstract::Toll/IL-1R-domain-containing adaptor-inducing IFN-β (TRIF) is an important adaptor for TLR3- and TLR4-mediated inflammatory signaling pathways. Recent studies have shown that TRIF plays a key role in vessel inflammation and atherosclerosis; however, the precise mechanisms are unclear. We investigated the mechanisms of...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2018/6249085
更新日期:2018-06-07 00:00:00
abstract::Rheumatoid arthritis (RA) is an inflammatory autoimmune disorder; abnormal T cell immunity plays a critical role in the development of RA. Recently, A20 was identified as a key negative regulator for T cell activation and inflammatory signaling and may be involved in RA pathogenesis. In this study, we analyzed the exp...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2014/492872
更新日期:2014-01-01 00:00:00
abstract::Bullous systemic lupus erythematosus (BSLE) is an autoantibody-mediated vesiculobullous disease in patients with SLE. Autoimmunity in BSLE is characterized by the presence of circulating anti-type VII collagen antibodies. BSLE patients often present with multiple, tense, clear fluid-filled vesicles and bullae overlyin...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2015/167064
更新日期:2015-01-01 00:00:00
abstract::Aims. In the present study, we aimed to assess the concentrations of IL-13 and IL-17 in serum of patients with early rheumatoid arthritis (eRA), the investigation of correlation between the concentrations of these cytokines and disease activity score, and the concentration of some autoantibodies and the evaluation of ...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2016/3109135
更新日期:2016-01-01 00:00:00
abstract::Although cancer immunotherapy has shown significant promise in mediating efficacious responses, it remains encumbered by tumor heterogeneity, loss of tumor-specific antigen targets, and the regulatory milieu both regionally and systemically. Cross talk between the innate and adaptive immune response may be requisite t...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2017/3145742
更新日期:2017-01-01 00:00:00
abstract::T follicular helper cells (TFH) are a subset of recently discovered CD4+ T cells. Their major function is to participate in the formation of germinal centres (GCs) and promote B cell proliferation and differentiation to play important roles in the production of antibodies. Currently, the functions of TFH cells are cle...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2018/7281453
更新日期:2018-07-02 00:00:00
abstract:Objective:To evaluate the efficacy and safety of rituximab in multiple sclerosis in a clinical practice setting. Methods:Clinical data for all adult patients with multiple sclerosis (MS) treated with off-label rituximab at a single MS center in Lebanon between March 2008 and April 2017 were retrospectively collected f...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2018/9084759
更新日期:2018-11-12 00:00:00
abstract::Schmallenberg virus (SBV), discovered in continental Europe in late 2011, causes mild clinical signs in adult ruminants, including diarrhoea and reduced milk yield. However, fetal infection can lead to severe malformation in newborn offspring. To develop improved reagents for SBV serology, a high-level yeast expressio...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2014/160316
更新日期:2014-01-01 00:00:00
abstract:PURPOSES:To investigate the possible changes in B cell subsets and in B cell expression patterns of lipid rafts (LRs) and F-actin in patients with SLE and whether leflunomide treatment may have effect on these changes. METHODS:The B cell subsets and LRs expression were determined by flow cytometry and confocal microsc...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2015/832916
更新日期:2015-01-01 00:00:00
abstract::The phenotype and functional properties of antigen-presenting cells (APC), that is, circulating monocytes and generated in vitro macrophages and dendritic cells, were investigated in the patients with pulmonary tuberculosis (TB) differing in lymphocyte reactivity to M. tuberculosis antigens (PPD-reactive versus PPD-an...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2015/793292
更新日期:2015-01-01 00:00:00
abstract::Ischemia/reperfusion injury (IRI) remains a major problem in organ transplantation, which represents the main cause of graft dysfunction posttransplantation. Hepatic IRI is characterized by an excessive inflammatory response within the liver. Mesenchymal stem cells (MSCs) have been shown to be immunomodulatory cells a...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2018/7283703
更新日期:2018-12-03 00:00:00
abstract::C-type lectin receptors (CLRs) on antigen-presenting cells (APCs) facilitate uptake of carbohydrate antigens for antigen presentation, modulating the immune response in infection, homeostasis, autoimmunity, allergy, and cancer. In this review, we focus on the role of the macrophage galactose type C-type lectin (MGL) i...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2015/450695
更新日期:2015-01-01 00:00:00
abstract::The present study was aimed at determining the activity of aqueous and methanolic extracts of Tinospora cordifolia (AETC and METC) against Salmonella typhimurium. In vitro anti-Salmonella activity of T. cordifolia was determined through the broth dilution and agar well diffusion assays. The immune-stimulating potentia...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2017/1787803
更新日期:2017-01-01 00:00:00
abstract::Adverse drug reactions (ADRs) remain a common and major problem in healthcare. Severe cutaneous adverse drug reactions (SCARs), such as Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) with mortality rate ranges from 10% to more than 30%, can be life threatening. A number of recent studies demonstrated ...
journal_title:Journal of immunology research
pub_type: 杂志文章,评审
doi:10.1155/2017/3186328
更新日期:2017-01-01 00:00:00
abstract::Toll-like receptors (TLRs) are known to detect a defined spectrum of microbial structures. However, the knowledge about the specificity of teleost Tlr factors for distinct pathogens is limited so far. We measured baseline expression profiles of 18 tlr genes and associated signaling factors in four immune-relevant tiss...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2015/901015
更新日期:2015-01-01 00:00:00
abstract::Background. Millions of people are infected with hepatitis C virus (HCV) worldwide and 30% spontaneously clear the infection. Reasons for HCV clearance without antiviral treatment are not well understood. Methods. Blood was collected for DNA analysis from patients with chronic HCV infection or evidence of spontaneous ...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2016/6530436
更新日期:2016-01-01 00:00:00
abstract::Cationic protein is a cytotoxic protein secreted by eosinophils and takes part in the damage of airway epithelium in asthma. Poly-L-arginine (PLA), a synthetic cationic protein, is widely used to mimic the biological function of the natural cationic protein in vitro. Previous studies demonstrated the damage of the air...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2018/3651743
更新日期:2018-06-14 00:00:00
abstract::Molecular dynamics was used to simulate large molecules of the immune system (major histocompatibility complex class I, presented epitope, T-cell receptor, and a CD8 coreceptor.) To characterize the relative orientation and movements of domains local coordinate systems (based on principal component analysis) were gene...
journal_title:Journal of immunology research
pub_type: 杂志文章
doi:10.1155/2015/210675
更新日期:2015-01-01 00:00:00