Anticancer Drugs Induced Severe Adverse Cutaneous Drug Reactions: An Updated Review on the Risks Associated with Anticancer Targeted Therapy or Immunotherapies.

abstract：:Bone diseases are associated with great morbidity; thus, the understanding of the mechanisms leading to their development represents a great challenge to improve bone health. Recent reports suggest that a large number of molecules produced by immune cells affect bone cell activity. However, the mechanisms are incomple...

journal_title：Journal of immunology research

authors： Mori G,D'Amelio P,Faccio R,Brunetti G

更新日期：2015-01-01 00:00:00

abstract：Background:Kawasaki disease (KD) is a systemic form of self-limited vasculitis in children less than five years old, and the main complication is coronary artery injury. However, the etiology of KD remains unclear. The IL-1B polymorphisms rs16944 GG and rs1143627 AA and their diplotype GA/GA have been associated with s...

journal_title：Journal of immunology research

authors： Fu LY,Qiu X,Deng QL,Huang P,Pi L,Xu Y,Che D,Zhou H,Lu Z,Tan Y,Jiang Z,Zhang L,Liu T,Gu X

更新日期：2019-04-09 00:00:00

abstract：:We recently have proved that excessive fecal DCA caused by high-fat diet may serve as an endogenous danger-associated molecular pattern to activate NLRP3 inflammasome and thus contributes to the development of inflammatory bowel disease (IBD). Moreover, the effect of DCA on inflammasome activation is mainly mediated t...

journal_title：Journal of immunology research

authors： Zhao S,Gong Z,Du X,Tian C,Wang L,Zhou J,Xu C,Chen Y,Cai W,Wu J

更新日期：2018-05-09 00:00:00

abstract：Background:RNA helicases have various essential functions in basically all aspects of RNA metabolism, not only unwinding RNA but also disturbing the interaction of RNA with proteins. Recently, RNA helicases have been considered potential targets in cancers. So far, there has been no detailed investigation of the biolog...

journal_title：Journal of immunology research

authors： Xu Y,Jiang Q,Liu H,Xiao X,Yang D,Saw PE,Luo B

更新日期：2020-12-30 00:00:00

abstract：:Propionibacterium acnes (P. acnes) is a gram-positive anaerobic bacillus present in normal human skin microbiota, which exerts important immunomodulatory effects, when used as heat- or phenol-killed suspensions. We previously demonstrated that heat-killed P. acnes or its soluble polysaccharide (PS), extracted from the...

journal_title：Journal of immunology research

authors： Squaiella-Baptistão CC,Teixeira D,Mussalem JS,Ishimura ME,Longo-Maugéri IM

更新日期：2015-01-01 00:00:00

abstract：:C-type lectin receptors (CLRs) on antigen-presenting cells (APCs) facilitate uptake of carbohydrate antigens for antigen presentation, modulating the immune response in infection, homeostasis, autoimmunity, allergy, and cancer. In this review, we focus on the role of the macrophage galactose type C-type lectin (MGL) i...

journal_title：Journal of immunology research

authors： Zizzari IG,Napoletano C,Battisti F,Rahimi H,Caponnetto S,Pierelli L,Nuti M,Rughetti A

更新日期：2015-01-01 00:00:00

abstract：:The gastrointestinal microbiota plays a critical role in nutritional, metabolic, and immune functions in infants and young children and has implications for future lung health status. Understanding the role of intestinal dysbiosis in chronic lung disease progression will provide opportunities to design early intervent...

journal_title：Journal of immunology research

authors： Ranucci G,Buccigrossi V,de Freitas MB,Guarino A,Giannattasio A

更新日期：2017-01-01 00:00:00

abstract：:Diabetic nephropathy (DN) is one of the most serious chronic kidney diseases and the major cause of end-stage renal failure worldwide. The underlying mechanisms of DN are complex and required to be further investigated. Both innate immunity and renin-angiotensin system (RAS) play critical roles in the pathogenesis of ...

journal_title：Journal of immunology research

authors： Feng Q,Liu D,Lu Y,Liu Z

更新日期：2020-04-30 00:00:00

abstract：:Dopamine (DA), a neurotransmitter in the central nervous system (CNS), has modulatory functions at the systemic level. The peripheral and central nervous systems have independent dopaminergic system (DAS) that share mechanisms and molecular machinery. In the past century, experimental evidence has accumulated on the p...

journal_title：Journal of immunology research

authors： Arreola R,Alvarez-Herrera S,Pérez-Sánchez G,Becerril-Villanueva E,Cruz-Fuentes C,Flores-Gutierrez EO,Garcés-Alvarez ME,de la Cruz-Aguilera DL,Medina-Rivero E,Hurtado-Alvarado G,Quintero-Fabián S,Pavón L

更新日期：2016-01-01 00:00:00

abstract：:We assessed the immune response against recombinant proteins of two related, albeit functionally different, peroxidoxins from Leishmania donovani: peroxidoxin 1 (LdPxn1) and peroxidoxin 2 (LdPxn2) in BALB/c mice. We also evaluated the effect of coadministration of TLR agonists (CpG ODN and GLA-SE) on the antigen-speci...

journal_title：Journal of immunology research

authors： Daifalla NS,Bayih AG,Gedamu L

更新日期：2015-01-01 00:00:00

abstract：:The roots of Euphorbia kansui, which belong to the family Euphorbiaceae, have been used as a traditional medicine for the treatment of various diseases such as diabetes, ascites, and leukemia. Recently, it was reported that the methylene chloride fraction of E. kansui radix (EKC) regulated the differentiation of Th17 ...

journal_title：Journal of immunology research

authors： Kim SJ,Jang YW,Hyung KE,Lee DK,Hyun KH,Park SY,Park ES,Hwang KW

更新日期：2017-01-01 00:00:00

abstract：:Gram-negative bacterial sepsis accounts for up to 50% worldwide sepsis that causes hospital mortality. Acute kidney injury (AKI), a common complication of Gram-negative bacterial sepsis, is caused by Toll-like receptor 4 (TLR4) activation. Lipopolysaccharide (LPS) is an endotoxin in Gram-negative bacteria and is recog...

journal_title：Journal of immunology research

authors： Li Q,Wu C,Liu Z,Zhang H,Du Y,Liu Y,Song K,Shi Q,Li R

更新日期：2019-02-19 00:00:00

abstract：:Intestinal inflammation is a harmful condition in fish that can be triggered by the ingestion of soybean meal. Due to the positive costs-benefits ratio of including soybean meal in farmed fish diets, identifying additives with intestinal anti-inflammatory effects could contribute to solving the issues caused by this p...

journal_title：Journal of immunology research

authors： Ulloa PE,Solís CJ,De la Paz JF,Alaurent TG,Caruffo M,Hernández AJ,Dantagnan P,Feijóo CG

更新日期：2016-01-01 00:00:00

abstract：:Accumulating evidence has pointed out that metastasis is the leading cause of death in several malignant tumor, including CRC. During CRC, metastatic capacity is closely correlated with reprogrammed energy metabolism. Mitochondrial Pyruvate Carrier 1 (MPC1), as the carrier of transporting pyruvate into mitochondria, l...

journal_title：Journal of immunology research

authors： Tian GA,Xu CJ,Zhou KX,Zhang ZG,Gu JR,Zhang XL,Wang YH

更新日期：2020-08-19 00:00:00

abstract：:Schmallenberg virus (SBV), discovered in continental Europe in late 2011, causes mild clinical signs in adult ruminants, including diarrhoea and reduced milk yield. However, fetal infection can lead to severe malformation in newborn offspring. To develop improved reagents for SBV serology, a high-level yeast expressio...

journal_title：Journal of immunology research

authors： Lazutka J,Zvirbliene A,Dalgediene I,Petraityte-Burneikiene R,Spakova A,Sereika V,Lelesius R,Wernike K,Beer M,Sasnauskas K

更新日期：2014-01-01 00:00:00

abstract：:Irritant Contact Dermatitis (ICD) is characterized by epidermal hyperplasia and inflammatory cytokine release. IL-6 has been shown to be involved in the pathogenesis of ICD; however, the involvement of the IL-22/IL-22Rα axis and its relation to IL-6 in the inflammatory response following irritant exposure are unknown....

journal_title：Journal of immunology research

authors： Frempah B,Luckett-Chastain LR,Gallucci RM

更新日期：2019-10-29 00:00:00

abstract：:Oropouche virus (OROV) is an emerging pathogen which causes Oropouche fever and meningitis in humans. Several outbreaks of OROV in South America, especially in Brazil, have changed its status as an emerging disease, but no vaccine or specific drug target is available yet. Our approach was to identify the epitope-based...

journal_title：Journal of immunology research

authors： Adhikari UK,Tayebi M,Rahman MM

更新日期：2018-10-08 00:00:00

abstract：BACKGROUND:Systemic lupus erythematosus (SLE) is a multisystem disease that is characterized by the appearance of serum autoantibodies. No effective treatment for SLE currently exists. METHODS:We used human umbilical cord mesenchymal stem cell (H-UC-MSC) transplantation to treat B6.Fas mice. RESULTS:After four rounds...

journal_title：Journal of immunology research

authors： Ruan GP,Yao X,Yang SJ,Wang JX,Shu F,Li ZA,Liu JF,Pang RQ,Pan XH

更新日期：2014-01-01 00:00:00

abstract：:The present study was aimed at determining the activity of aqueous and methanolic extracts of Tinospora cordifolia (AETC and METC) against Salmonella typhimurium. In vitro anti-Salmonella activity of T. cordifolia was determined through the broth dilution and agar well diffusion assays. The immune-stimulating potentia...

journal_title：Journal of immunology research

authors： Alsuhaibani S,Khan MA

更新日期：2017-01-01 00:00:00

abstract：Background:Gastrosphere, an enriched cellular population with stem-like properties believed to be responsible for an escape from immune-mediated destruction. Th17 and Treg cells play a major role in gastric cancer; however, their interaction with gastrospheres remained elusive. Method:Peripheral blood mononuclear cell...

journal_title：Journal of immunology research

authors： Rezalotfi A,Solgi G,Ebrahimi M

更新日期：2020-12-23 00:00:00

abstract：:Ovarian cancer is the most important cause of gynecological cancer-related mortality, with the majority of women presenting with advanced disease. Although surgery and chemotherapy can improve survival rates, it is necessary to integrate alternative strategies to improve the outcomes. Advances in understanding the rol...

journal_title：Journal of immunology research

authors： De Felice F,Marchetti C,Palaia I,Musio D,Muzii L,Tombolini V,Panici PB

更新日期：2015-01-01 00:00:00

abstract：:Primary Sjogren's syndrome (pSS) is a chronic autoimmune disease. The aim of the study was to establish whether in patients with pSS without central nervous system (CNS) involvement, the function of the central portion of the sensory pathway can be challenged. In 33 patients with pSS without clinical features of CNS d...

journal_title：Journal of immunology research

authors： Dziadkowiak E,Sebastian A,Wieczorek M,Kusińska E,Waliszewska-Prosół M,Wiland P,Ejma M

更新日期：2018-04-05 00:00:00

abstract：:Objective. It has been shown that podocyte injury represents an important pathological basis that contributes to proteinuria and eventually leads to kidney failure. High glucose (HG) activates macrophage polarization, further exacerbating HG-induced podocyte injury. Our previous study on diabetic nephropathy rats indi...

journal_title：Journal of immunology research

authors： Liao H,Li Y,Zhang X,Zhao X,Zheng D,Shen D,Li R

更新日期：2020-08-27 00:00:00

abstract：Background:Psoriasis is a chronic systemic inflammatory disease associated with a wide range of comorbidities, including metabolic syndrome (MetS). Serum calprotectin, ANGPTL8, and oxidative damage to nucleic acids might be associated with both diseases. The presented study describes the influence of psoriasis and MetS...

journal_title：Journal of immunology research

authors： Holmannova D,Borska L,Andrys C,Borsky P,Kremlacek J,Hamakova K,Rehacek V,Malkova A,Svadlakova T,Palicka V,Krejsek J,Fiala Z

更新日期：2020-05-20 00:00:00

abstract：:In organ transplantation, alloantigens are taken up by antigen presenting cells and presented via the indirect pathway to T-cells which in turn can induce allograft rejection. Monitoring of these T-cells is of major importance; however no reliable assay is available to routinely monitor indirect allorecognition. Recen...

journal_title：Journal of immunology research

authors： Breman E,Ruben JM,Franken KL,Heemskerk MH,Roelen DL,Claas FH,van Kooten C

更新日期：2016-01-01 00:00:00

abstract：:Aims. In the present study, we aimed to assess the concentrations of IL-13 and IL-17 in serum of patients with early rheumatoid arthritis (eRA), the investigation of correlation between the concentrations of these cytokines and disease activity score, and the concentration of some autoantibodies and the evaluation of ...

journal_title：Journal of immunology research

authors： Siloşi I,Boldeanu MV,Cojocaru M,Biciuşcă V,Pădureanu V,Bogdan M,Badea RG,Avramescu C,Petrescu IO,Petrescu F,Siloşi CA

更新日期：2016-01-01 00:00:00

abstract：Aims:This study is aimed at exploring the relation between IL-33 single-nucleotide polymorphisms (SNPs) and the risk of systemic lupus erythematosus (SLE). Methods:SNPStats (online software) was used to test the Hardy-Weinberg equilibrium in controls. Generalized multifactor dimensionality reduction (GMDR) was adopted...

journal_title：Journal of immunology research

authors： Zhu X,Xie L,Qin H,Liang J,Yang Y,Xu J,Zhang T

更新日期：2019-03-11 00:00:00

abstract：:The bioactive and anti-inflammatory role of human milk components has been recognized; active milk components include soluble forms of Toll-like receptors (TLRs). Preterm babies are more susceptible to infections and may succumb to necrotizing enterocolitis (NEC), a gastrointestinal disease which is exacerbated by an ...

journal_title：Journal of immunology research

authors： Cattaneo C,Caramaschi A,Uga E,Braghin M,Cosi G,Peila C,Strozzi MC,Sabatini M,Gazzolo D,Manfredi M,Cavaletto M

更新日期：2019-12-04 00:00:00

abstract：:We evaluated the association between anti-cyclic citrullinated peptide antibodies (anti-CCP) and anti-mutated citrullinated vimentin antibodies (anti-MCV) with the presence of extra-articular (ExRA) manifestations in 225 patients with rheumatoid arthritis (RA). Ninety-five patients had ExRA and 130 had no ExRA. There ...

journal_title：Journal of immunology research

authors： Gonzalez-Lopez L,Rocha-Muñoz AD,Ponce-Guarneros M,Flores-Chavez A,Salazar-Paramo M,Nava A,Cardona-Muñoz EG,Fajardo-Robledo NS,Zavaleta-Muñiz SA,Garcia-Cobian T,Gamez-Nava JI

更新日期：2014-01-01 00:00:00

abstract：:Recruitment of human NK cells to porcine tissues has been demonstrated in pig organs perfused ex vivo with human blood in the early 1990s. Subsequently, the molecular mechanisms leading to adhesion and cytotoxicity in human NK cell-porcine endothelial cell (pEC) interactions have been elucidated in vitro to identify t...

journal_title：Journal of immunology research

authors： Puga Yung G,Schneider MKJ,Seebach JD

更新日期：2017-01-01 00:00:00